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Pesquisa : B04.820.069 [Categoria DeCS]
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  1 / 110 MEDLINE  
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[PMID]:29088279
[Au] Autor:Schmidt K; Butt J; Mauter P; Vogel K; Erles-Kemna A; Pawlita M; Nicklas W
[Ad] Endereço:Microbiological Diagnostics, Center for Preclinical Research, German Cancer Research Center, Heidelberg, Germany.
[Ti] Título:Development of a multiplex serological assay reveals a worldwide distribution of murine astrovirus infections in laboratory mice.
[So] Source:PLoS One;12(10):e0187174, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Laboratory mice play a tremendous role in biomedical research in studies on immunology, infection, cancer and therapy. In the course of standardization of mice used in animal experiments, health monitoring constitutes an important instrument towards microbiological standardization. Infections with murine astroviruses (MuAstV) were only recently discovered and are, therefore, still relatively unknown in laboratory animal science. In rodent health monitoring viral infections within a population are commonly assessed in terms of specific antibodies by serological testing, as active infection and excretion of virus is often temporary and can easily be missed. So far only ongoing infections with astroviruses can be detected by PCR. The objective of this work was the development of a sensitive and specific MuAstV multiplex serological assay with a high-throughput capability to be used in routine testing of laboratory mice. Four different MuAstV proteins were recombinantly expressed and used as antigens. The best reacting antigen, the capsid spike protein VP27, was selected and tested with a panel of 400 sera of mice from units with a known MuAstV status. Assay sensitivity and specificity resulted in 98.5% and 100%, respectively, compared to RT-PCR results. Eventually this assay was used to test 5529 serum samples in total, during routine diagnostics at the German Cancer Research Center (DKFZ) in Heidelberg between 2015 and 2017. High sero-prevalence rates of up to 98% were detected in units with open cages indicating that the virus is highly infectious and circulates within these populations virtually infecting all animals regardless of the mouse strain. In addition, data collected from 312 mice purchased from commercial breeders and from 661 mice from 58 research institutes in 15 countries worldwide allowed the conclusion that MuAstV is widespread in contemporary laboratory mouse populations.
[Mh] Termos MeSH primário: Animais de Laboratório/virologia
Infecções por Astroviridae/veterinária
Astroviridae
Camundongos/virologia
Reação em Cadeia da Polimerase Multiplex
Testes Sorológicos/métodos
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/imunologia
Astroviridae/imunologia
Infecções por Astroviridae/epidemiologia
Infecções por Astroviridae/imunologia
Infecções por Astroviridae/virologia
Reação em Cadeia da Polimerase Multiplex/métodos
Reação em Cadeia da Polimerase Multiplex/veterinária
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Sensibilidade e Especificidade
Estudos Soroepidemiológicos
Testes Sorológicos/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187174


  2 / 110 MEDLINE  
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[PMID]:28537544
[Au] Autor:To KKW; Chan WM; Li KSM; Lam CSF; Chen Z; Tse H; Lau SKP; Woo PCY; Yuen KY
[Ad] Endereço:1​Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China 2​State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, PR China 4​Research Centre of Infection and Immunology, The University of Hon
[Ti] Título:High prevalence of four novel astrovirus genotype species identified from rodents in China.
[So] Source:J Gen Virol;98(5):1004-1015, 2017 May.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astroviruses cause gastrointestinal and neurological infections in humans and animals. Since astrovirus is genetically diverse and different astrovirus genotypes can be found in the same animal species, astrovirus is a potential zoonotic threat to humans. In this study, we screened for astroviruses in rodents from Hong Kong, Hunan and Guangxi. Astrovirus was detected in 11.9 % (67/562) of rectal swab specimens. Phylogenetic analysis of the ORF1b region, which encodes the RdRp, showed that there were four distinct clusters (clusters A, B, C and D). Whole genome sequencing was performed for 11 representative strains from each of these four clusters. The mean amino acid genetic distances (p-dist) of full-length ORF2 were >0.634 between clusters A, B, C and other known astroviruses. The p-dist between clusters A and B, A and C, and B and C were 0.371-0.375, 0.517-0.549 and 0.524-0.555, respectively. Within cluster C, the p-dist between HN-014 and GX-006 was 0.372. Since strains with p-dist of ≥0.368 in ORF2 are now considered to be of separate genotypes species, cluster A, cluster B, cluster C-HN-014 and cluster C-GX-006 can be classified as novel genotype species. Cluster D was most closely related to the rodent astrovirus previously identified in Hong Kong. Since rodents live in close proximity to humans, interspecies jumping of these novel astroviruses may represent a threat to human health.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Astroviridae/classificação
Astroviridae/isolamento & purificação
Genótipo
Doenças dos Roedores/epidemiologia
Doenças dos Roedores/virologia
[Mh] Termos MeSH secundário: Animais
Astroviridae/genética
Infecções por Astroviridae/epidemiologia
Infecções por Astroviridae/virologia
Análise por Conglomerados
Genoma Viral
Hong Kong/epidemiologia
Filogenia
Prevalência
RNA Replicase/genética
Reto/virologia
Roedores
Análise de Sequência de DNA
Homologia de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000766


  3 / 110 MEDLINE  
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[PMID]:28117758
[Au] Autor:Johnson C; Hargest V; Cortez V; Meliopoulos VA; Schultz-Cherry S
[Ad] Endereço:Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Cydney.Johnson@stjude.org.
[Ti] Título:Astrovirus Pathogenesis.
[So] Source:Viruses;9(1), 2017 Jan 22.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.
[Mh] Termos MeSH primário: Infecções por Astroviridae/virologia
Astroviridae/fisiologia
Interações Hospedeiro-Patógeno
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


  4 / 110 MEDLINE  
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[PMID]:28106800
[Au] Autor:Selimovic-Hamza S; Boujon CL; Hilbe M; Oevermann A; Seuberlich T
[Ad] Endereço:Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern CH-3012, Switzerland. senija.selimovic@vetsuisse.unibe.ch.
[Ti] Título:Frequency and Pathological Phenotype of Bovine Astrovirus CH13/NeuroS1 Infection in Neurologically-Diseased Cattle: Towards Assessment of Causality.
[So] Source:Viruses;9(1), 2017 Jan 18.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of cattle with non-suppurative encephalitis. Only a few studies are available on neurotropic astroviruses and a causal relationship between BoAstV CH13/NeuroS1 infections and neurological disease has been postulated, but remains unproven. Aiming at making a step forward towards assessing the causality, we collected brain samples of 97 cases of cattle diagnosed with unresolved non-suppurative encephalitis, and analyzed them by in situ hybridization and immunohistochemistry, to determine the frequency and neuropathological distribution of the BoAstV CH13/NeuroS1 and its topographical correlation to the pathology. We detected BoAstV CH13/NeuroS1 RNA or proteins in neurons throughout all parts of the central nervous system (CNS) in 34% of all cases, but none were detected in cattle of the control group. In general, brain lesions had a high correlation with the presence of the virus. These findings show that a substantial proportion of cattle with non-suppurative encephalitis are infected with BoAstV CH13/NeuroS1 and further substantiate the causal relationship between neurological disease and astrovirus infections.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Astroviridae/isolamento & purificação
Doenças dos Bovinos/patologia
Doenças dos Bovinos/virologia
Encefalite Viral/veterinária
[Mh] Termos MeSH secundário: Animais
Infecções por Astroviridae/patologia
Bovinos
Sistema Nervoso Central/patologia
Sistema Nervoso Central/virologia
Encefalite Viral/patologia
Imuno-Histoquímica
Hibridização In Situ
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


  5 / 110 MEDLINE  
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[PMID]:28100306
[Au] Autor:Ao YY; Yu JM; Li LL; Cao JY; Deng HY; Xin YY; Liu MM; Lin L; Lu S; Xu JG; Duan ZJ
[Ad] Endereço:1​National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, PR China.
[Ti] Título:Diverse novel astroviruses identified in wild Himalayan marmots.
[So] Source:J Gen Virol;98(4):612-623, 2017 Apr.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:With advances in viral surveillance and next-generation sequencing, highly diverse novel astroviruses (AstVs) and different animal hosts had been discovered in recent years. However, the existence of AstVs in marmots had yet to be shown. Here, we identified two highly divergent strains of AstVs (tentatively named Qinghai Himalayanmarmot AstVs, HHMAstV1 and HHMAstV2), by viral metagenomic analysis in liver tissues isolated from wild Marmota himalayana in China. Overall, 12 of 99 (12.1 %) M. himalayana faecal samples were positive for the presence of genetically diverse AstVs, while only HHMAstV1 and HHMAstV2 were identified in 300 liver samples. The complete genomic sequences of HHMAstV1 and HHMAstV2 were 6681 and 6610 nt in length, respectively, with the typical genomic organization of AstVs. Analysis of the complete ORF 2 sequence showed that these novel AstVs are most closely related to the rabbit AstV, mamastrovirus 23 (with 31.0 and 48.0 % shared amino acid identity, respectively). Phylogenetic analysis of the amino acid sequences of ORF1a, ORF1b and ORF2 indicated that HHMAstV1 and HHMAstV2 form two distinct clusters among the mamastroviruses, and may share a common ancestor with the rabbit-specific mamastrovirus 23. These results suggest that HHMAstV1 and HHMAstV2 are two novel species of the genus Mamastrovirus in the Astroviridae. The remarkable diversity of these novel AstVs will contribute to a greater understanding of the evolution and ecology of AstVs, although additional studies will be needed to understand the clinical significance of these novel AstVs in marmots, as well as in humans.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Astroviridae/classificação
Astroviridae/isolamento & purificação
Marmota/virologia
[Mh] Termos MeSH secundário: Animais
Astroviridae/genética
Infecções por Astroviridae/virologia
China
Análise por Conglomerados
Fezes/virologia
Ordem dos Genes
Genoma Viral
Fígado/virologia
Metagenômica
Filogenia
Análise de Sequência de DNA
Homologia de Sequência de Aminoácidos
Sintenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000709


  6 / 110 MEDLINE  
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[PMID]:28085120
[Au] Autor:Pérot P; Lecuit M; Eloit M
[Ad] Endereço:Institut Pasteur, Biology of Infection Unit, Inserm U1117, Laboratory of Pathogen Discovery, 75015 Paris, France. philippe.perot@pasteur.fr.
[Ti] Título:Astrovirus Diagnostics.
[So] Source:Viruses;9(1), 2017 Jan 12.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, novel human astrovirus (HAstV) strains have been found in immunocompromised individuals in association with central nervous system (CNS) infections. This work reviews the past and current methods for astrovirus detection and their uses in both research laboratories and for medical diagnostic purposes.
[Mh] Termos MeSH primário: Infecções por Astroviridae/diagnóstico
Astroviridae/isolamento & purificação
Testes Diagnósticos de Rotina/métodos
Técnicas Microbiológicas/métodos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE


  7 / 110 MEDLINE  
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[PMID]:28056776
[Au] Autor:Halczok TK; Fischer K; Gierke R; Zeus V; Meier F; Treß C; Balkema-Buschmann A; Puechmaille SJ; Kerth G
[Ad] Endereço:Ernst-Moritz-Arndt Universität Greifswald, Zoological Institute and Museum, Soldmannstr. 14, 17489, Greifswald, Germany. Halczokt@uni-greifswald.de.
[Ti] Título:Evidence for genetic variation in Natterer's bats (Myotis nattereri) across three regions in Germany but no evidence for co-variation with their associated astroviruses.
[So] Source:BMC Evol Biol;17(1):5, 2017 Jan 05.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: As bats have recently been described to harbor many different viruses, several studies have investigated the genetic co-variation between viruses and different bat species. However, little is known about the genetic co-variation of viruses and different populations of the same bat species, although such information is needed for an understanding of virus transmission dynamics within a given host species. We hypothesized that if virus transmission between host populations depends on events linked to gene flow in the bats, genetic co-variation should exist between host populations and astroviruses. RESULTS: We used 19 nuclear and one mitochondrial microsatellite loci to analyze the genetic population structure of the Natterer's bat (Myotis nattereri) within and among populations at different geographical scales in Germany. Further, we correlated the observed bat population structure to that of partial astrovirus sequences (323-394 nt fragments of the RNA-dependent RNA polymerase gene) obtained from the same bat populations. Our analyses revealed that the studied bat colonies can be grouped into three distinct genetic clusters, corresponding to the three geographic regions sampled. Furthermore, we observed an overall isolation-by-distance pattern, while no significant pattern was observed within a geographic region. Moreover, we found no correlation between the genetic distances among the bat populations and the astrovirus sequences they harbored. Even though high genetic similarity of some of the astrovirus haplotypes found in several different regions was detected, identical astrovirus haplotypes were not shared between different sampled regions. CONCLUSIONS: The genetic population structure of the bat host suggests that mating sites where several local breeding colonies meet act as stepping-stones for gene flow. Identical astrovirus haplotypes were not shared between different sampled regions suggesting that astroviruses are mostly transmitted among host colonies at the local scale. Nevertheless, high genetic similarity of some of the astrovirus haplotypes found in several different regions implies that occasional transmission across regions with subsequent mutations of the virus haplotypes does occur.
[Mh] Termos MeSH primário: Astroviridae/genética
Quirópteros/genética
Quirópteros/virologia
[Mh] Termos MeSH secundário: Animais
Fluxo Gênico
Variação Genética
Genética Populacional
Alemanha
Haplótipos
Especificidade de Hospedeiro
Repetições de Microssatélites
Filogenia
RNA Replicase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-016-0856-0


  8 / 110 MEDLINE  
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[PMID]:27871796
[Au] Autor:Lacroix A; Duong V; Hul V; San S; Davun H; Omaliss K; Chea S; Hassanin A; Theppangna W; Silithammavong S; Khammavong K; Singhalath S; Afelt A; Greatorex Z; Fine AE; Goldstein T; Olson S; Joly DO; Keatts L; Dussart P; Frutos R; Buchy P
[Ad] Endereço:Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia.
[Ti] Título:Diversity of bat astroviruses in Lao PDR and Cambodia.
[So] Source:Infect Genet Evol;47:41-50, 2017 Jan.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Astroviruses are known to infect humans and a wide range of animal species, and can cause gastroenteritis in their hosts. Recent studies have reported astroviruses in bats in Europe and in several locations in China. We sampled 1876 bats from 17 genera at 45 sites from 14 and 13 provinces in Cambodia and Lao PDR respectively, and tested them for astroviruses. Our study revealed a high diversity of astroviruses among various Yangochiroptera and Yinpterochiroptera bats. Evidence for varying degrees of host restriction for astroviruses in bats was found. Furthermore, additional Pteropodid hosts were detected. The astroviruses formed distinct phylogenetic clusters within the genus Mamastrovirus, most closely related to other known bat astroviruses. The astrovirus sequences were found to be highly saturated indicating that phylogenetic relationships should be interpreted carefully. An astrovirus clustering in a group with other viruses from diverse hosts, including from ungulates and porcupines, was found in a Rousettus bat. These findings suggest that diverse astroviruses can be found in many species of mammals, including bats.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Infecções por Astroviridae/virologia
Astroviridae/genética
Quirópteros/virologia
Variação Genética/genética
[Mh] Termos MeSH secundário: Animais
Astroviridae/classificação
Camboja
Fezes/virologia
Laos
Pulmão/virologia
Boca/virologia
Filogenia
Reto/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


  9 / 110 MEDLINE  
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[PMID]:28042824
[Au] Autor:Marvin SA
[Ad] Endereço:Biology Department, Drake University, Des Moines, IA 50311, USA. shauna.marvin@drake.edu.
[Ti] Título:The Immune Response to Astrovirus Infection.
[So] Source:Viruses;9(1), 2016 Dec 30.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Astroviruses are one of the leading causes of pediatric gastroenteritis worldwide and are clinically importantly pathogens in the elderly and immunocompromised populations. Although the use of cell culture systems and small animal models have enhanced our understanding of astrovirus infection and pathogenesis, little is known about the immune response to astrovirus infection. Studies from humans and animals suggest that adaptive immunity is important in restricting classic and novel astrovirus infections, while studies from animal models and cell culture systems suggest that an innate immune system plays a role in limiting astrovirus replication. The relative contribution of each arm of the immune system in restricting astrovirus infection remains unknown. This review summarizes our current understanding of the immune response to astrovirus infection and highlights some of the key questions that stem from these studies. A full understanding of the immune response to astrovirus infection is required to be able to treat and control astrovirus-induced gastroenteritis.
[Mh] Termos MeSH primário: Infecções por Astroviridae/imunologia
Astroviridae/imunologia
[Mh] Termos MeSH secundário: Imunidade Adaptativa
Animais
Seres Humanos
Evasão da Resposta Imune
Imunidade Inata
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


  10 / 110 MEDLINE  
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[PMID]:27928918
[Au] Autor:Rougeron V; Suquet E; Maganga GD; Jiolle D; Mombo IM; Bourgarel M; Motsch P; Arnathau C; Durand P; Drexler F; Drosten C; Renaud F; Prugnolle F; Leroy EM
[Ti] Título:Characterization and phylogenetic analysis of new bat astroviruses detected in Gabon, Central Africa.
[So] Source:Acta Virol;60(4):386-392, 2016.
[Is] ISSN:0001-723X
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:Astroviruses are emerging RNA viruses that cause enteropathogenic infections in humans and in other mammals. The identification of astroviruses in a wide range of animals highlights the zoonotic importance of these viruses. Bats can harbor many different viruses, among which some are highly pathogenic for humans (for instance, Nipah, Ebola and SARS coronavirus), and also several astroviruses. As some RNA viruses can be directly transmitted from bats to humans, it is crucial to collect data about their frequency, genetic diversity and phylogenetic characterization. In this study, we report the molecular identification of 44 new astroviruses (with a detection rate of 4.5%) in 962 apparently healthy bats that belong to five different species and that were captured in different caves in North-East Gabon, Central Africa. Our results show that bat astroviruses form a group that is genetically distinct from astroviruses infecting other mammals. Moreover, these astroviruses showed an important genetic diversity and low host restriction in bat species.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Astroviridae/genética
Quirópteros/virologia
Filogenia
[Mh] Termos MeSH secundário: Animais
Astroviridae/classificação
Astroviridae/isolamento & purificação
Infecções por Astroviridae/virologia
Gabão
Variação Genética
Seres Humanos
Mamíferos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE



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