Base de dados : MEDLINE
Pesquisa : B04.820.087 [Categoria DeCS]
Referências encontradas : 888 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 89 ir para página                         

  1 / 888 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28885138
[Au] Autor:Rogers MB; Gulino KM; Tesh RB; Cui L; Fitch A; Unnasch TR; Popov VL; Travassos da Rosa APA; Guzman H; Carrera JP; Vasilakis N; Ghedin E
[Ad] Endereço:2​Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 1​Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
[Ti] Título:Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas.
[So] Source:J Gen Virol;98(9):2258-2266, 2017 Sep.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Bunyaviridae family is made up of a diverse range of viruses, some of which cause disease and are a cause for concern in human and veterinary health. Here, we report the genomic and antigenic characterization of five previously uncharacterized bunyaviruses. Based on their ultrastructure, antigenic relationships and phylogenomic relationships, the five viruses are classified as members of the Orthobunyavirus genus. Three are viruses in the California encephalitis virus serogroup and are related to Trivittatus virus; the two others are most similar to the Mermet virus in the Simbu serogroup, and to the Tataguine virus, which is not currently assigned to a serogroup. Each of these five viruses was pathogenic to newborn mice, indicating their potential to cause illness in humans and other animals.
[Mh] Termos MeSH primário: Aedes/virologia
Doenças das Aves/virologia
Infecções por Bunyaviridae/veterinária
Bunyaviridae/isolamento & purificação
[Mh] Termos MeSH secundário: África
Américas
Animais
Bunyaviridae/classificação
Bunyaviridae/genética
Bunyaviridae/ultraestrutura
Infecções por Bunyaviridae/virologia
Camundongos
Passeriformes/virologia
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000899


  2 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28678811
[Au] Autor:Hu J; Li Z; Hong L; Bao C; Zhang Z; Zhang H; He H; Wang X; Liu W; Peng Z; Shi L; Zhu F
[Ad] Endereço:Department of Acute Infectious Disease Control and Prevention, Jiangsu provincial Center for Disease Control and Prevention, Nanjing, China.
[Ti] Título:Preliminary fast diagnosis of severe fever with thrombocytopenia syndrome with clinical and epidemiological parameters.
[So] Source:PLoS One;12(7):e0180256, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To identify specific clinical and epidemiological parameters for clinical diagnosis of SFTSV infection with relatively higher accuracy. METHODS: 231 suspected cases of SFTS were reported by various medical institutions from 2011 to 2013 in Jiangsu Province, China. They were followed with SFTSV diagnosis tests and interview-administered questionnaires about demographic characteristics, clinical symptoms and epidemiological exposure factors. Univariate and multivariable logistic regression analysis were used to examine the diagnostic value of these parameters. RESULTS: SFTSV infection occurred only from April to October annually and usually in hilly areas of specific regions. Three prediction models of SFTSV infection were constructed. Model 3 with clinical and epidemiological parameters combined the benefits of both Model 1and Model 2, which was optimal and had an overall accuracy of 80.2%. Independent indicators for clinical diagnosis of SFTSV infection in Model 3 were as follows: lymphadenopathy (P = 0.01), leucopenia (P<0.01), age >50 years (P = 0.01), tick bites (P<0.01), raising domestic animals in the residential areas (P<0.01) and farming (P = 0.03). CONCLUSIONS: Our results show that using a combination of clinical and epidemiological parameters may be a feasible strategy to provide preliminary fast diagnosis as differentiating SFTSV infection from SFTS-like diseases, thus reducing the risk of misdiagnosis.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/diagnóstico
Programas de Rastreamento/métodos
Febre por Flebótomos/diagnóstico
Trombocitopenia/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Agricultura
Animais
Bunyaviridae/fisiologia
Infecções por Bunyaviridae/epidemiologia
Infecções por Bunyaviridae/virologia
China/epidemiologia
Estudos de Viabilidade
Feminino
Geografia
Interações Hospedeiro-Patógeno
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Febre por Flebótomos/epidemiologia
Febre por Flebótomos/virologia
Inquéritos e Questionários
Síndrome
Trombocitopenia/epidemiologia
Trombocitopenia/virologia
Picadas de Carrapatos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180256


  3 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28542435
[Au] Autor:Schneeberger PHH; Pothier JF; Bühlmann A; Duffy B; Beuret C; Utzinger J; Frey JE
[Ad] Endereço:Agroscope, Department of Methods Development and Analytics, Wädenswil, Switzerland.
[Ti] Título:Development and evaluation of a bioinformatics approach for designing molecular assays for viral detection.
[So] Source:PLoS One;12(5):e0178195, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Viruses belonging to the Flaviviridae and Bunyaviridae families show considerable genetic diversity. However, this diversity is not necessarily taken into account when developing diagnostic assays, which are often based on the pairwise alignment of a limited number of sequences. Our objective was to develop and evaluate a bioinformatics workflow addressing two recurrent issues of molecular assay design: (i) the high intraspecies genetic diversity in viruses and (ii) the potential for cross-reactivity with close relatives. METHODOLOGY: The workflow developed herein was based on two consecutive BLASTn steps; the first was utilized to select highly conserved regions among the viral taxon of interest, and the second was employed to assess the degree of similarity of these highly-conserved regions to close relatives. Subsequently, the workflow was tested on a set of eight viral species, including various strains from the Flaviviridae and Bunyaviridae families. PRINCIPAL FINDINGS: The genetic diversity ranges from as low as 0.45% variable sites over the complete genome of the Japanese encephalitis virus to more than 16% of variable sites on segment L of the Crimean-Congo hemorrhagic fever virus. Our proposed bioinformatics workflow allowed the selection-based on computing scores-of the best target for a diagnostic molecular assay for the eight viral species investigated. CONCLUSIONS/SIGNIFICANCE: Our bioinformatics workflow allowed rapid selection of highly conserved and specific genomic fragments among the investigated viruses, while considering up to several hundred complete genomic sequences. The pertinence of this workflow will increase in parallel to the number of sequences made publicly available. We hypothesize that our workflow might be utilized to select diagnostic molecular markers for higher organisms with more complex genomes, provided the sequences are made available.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/diagnóstico
Bunyaviridae/genética
Biologia Computacional/métodos
Infecções por Flaviviridae/diagnóstico
Flaviviridae/genética
[Mh] Termos MeSH secundário: Infecções por Bunyaviridae/virologia
Infecções por Flaviviridae/virologia
Seres Humanos
Análise de Sequência com Séries de Oligonucleotídeos
Filogenia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178195


  4 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28111322
[Au] Autor:Guterres A; de Oliveira RC; Fernandes J; de Lemos ER; Schrago CG
[Ad] Endereço:Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil; Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: guterres@ioc.fiocruz.br.
[Ti] Título:New bunya-like viruses: Highlighting their relations.
[So] Source:Infect Genet Evol;49:164-173, 2017 Apr.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The standard virus classification scheme for arenaviruses and bunyaviruses shifted dramatically when several groups reported the detection and isolation of divergent groups of viruses in a variety of insect collections. Although these viral families can differ in terms of morphology, structure and genetics, recent findings indicate these viruses may have a shared evolutionary origin. To determine the phylogenetic relations among these families, we inferred phylogenetic trees using three methods. The Maximum Likelihood and Bayesian trees were rooted as suggested by the (molecular clock-rooted) BEAST tree. Our results highlight a noteworthy relation among these viral supergroups of different genome organizations. Our study suggests that the best scenario is the existence of at least three monophyletic supergroups, all of them well supported. The recent data indicate that these viruses are evolutionarily and genetically interconnected. While these supergroups appear to be closely related in our phylogenetic analysis, other viruses should be investigated in future research. In sum, our results also provide insights into the classification scheme, thereby providing a new perspective about the fundamental questions of family origins, diversity and genome evolution.
[Mh] Termos MeSH primário: Evolução Biológica
Bunyaviridae/genética
Genoma Viral
Filogenia
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Bunyaviridae/classificação
Insetos/virologia
Funções Verossimilhança
Mamíferos/virologia
Plantas/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE


  5 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28082165
[Au] Autor:Marshall SH; Adegbola RO; Adkins S; Naidu RA
[Ad] Endereço:Washington State University, Department of Plant Pathology, Irrigated Agricultural Research and Extension Center, Prosser, WA 99350, United States.
[Ti] Título:An efficient and high fidelity method for amplification, cloning and sequencing of complete tospovirus genomic RNA segments.
[So] Source:J Virol Methods;242:22-26, 2017 Apr.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Tospoviruses (genus Tospovirus, family Bunyaviridae) are responsible for major losses in an extensive range of crops worldwide. New species of these single-stranded, ambisense RNA viruses regularly emerge and have been shown to maintain heterogeneous populations with individual isolates having quite variable biological and virulence characteristics. Most tospovirus phylogenetic studies have focused on analysis of a single gene, most often the nucleocapsid protein gene. Complete genomic RNA segment amplification as a single fragment would facilitate more detailed analyses of genome-wide sequence variability, but obtaining such sequences for a large number of tospovirus isolates using traditional methods of amplification and cloning of small overlapping fragments is tedious, time consuming and expensive. In this study, protocols were optimized to amplify, clone and sequence full-length M- and S-RNA genome segments of Tomato spotted wilt virus and Impatiens necrotic spot virus. The strategy presented here is straightforward, scalable and offers several advantages over the previously commonplace and overlapping amplicon-based approach. Use of whole genome segments, instead of individual gene sequences or defined portions of genome segments, will facilitate a better understanding of the underlying molecular diversity of tospoviruses in mixed infections.
[Mh] Termos MeSH primário: Clonagem Molecular/métodos
Genoma Viral
Técnicas de Amplificação de Ácido Nucleico
RNA Viral/genética
Tospovirus/genética
[Mh] Termos MeSH secundário: Bunyaviridae/genética
Nucleocapsídeo/genética
Filogenia
RNA Viral/isolamento & purificação
Análise de Sequência de DNA/métodos
Tospovirus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE


  6 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27979594
[Au] Autor:Kumarasamy D; Roy BG; Rocha-Pereira J; Neyts J; Nanjappan S; Maity S; Mookerjee M; Naesens L
[Ad] Endereço:Department of Pharmaceutical Chemistry, NSHM College of Pharmaceutical Technology, 124, B.L Saha Road, Kolkata 700053, India. Electronic address: dhanabalrx@gmail.com.
[Ti] Título:Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones.
[So] Source:Bioorg Med Chem Lett;27(2):139-142, 2017 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR, H NMR, C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. Compound 4m, which possesses a long lipophilic side chain, was found to be a potent and selective inhibitor of Punta Toro virus, a member of the Bunyaviridae. For Rift Valley fever virus, which is another Bunyavirus, the activity of 4m was negligible. DHPMs with a C-4 aryl moiety bearing halogen substitution (4b, 4c and 4d) were found to be cytotoxic in MT4 cells.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Vírus de DNA/efeitos dos fármacos
Pirimidinonas/farmacologia
Vírus de RNA/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antivirais/síntese química
Antivirais/toxicidade
Bunyaviridae/efeitos dos fármacos
Gatos
Cercopithecus aethiops
Sulfato de Dextrana/farmacologia
Cães
Células HeLa
Seres Humanos
Ácido Micofenólico/farmacologia
Pirimidinonas/síntese química
Pirimidinonas/toxicidade
Ribavirina/farmacologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Pyrimidinones); 0 (ethyl 6-methyl-2-oxo-4-undecyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate); 49717AWG6K (Ribavirin); 9042-14-2 (Dextran Sulfate); HU9DX48N0T (Mycophenolic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


  7 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27764175
[Au] Autor:Briese T; Williams DT; Kapoor V; Diviney SM; Certoma A; Wang J; Johansen CA; Chowdhary R; Mackenzie JS; Lipkin WI
[Ad] Endereço:Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
[Ti] Título:Analysis of Arbovirus Isolates from Australia Identifies Novel Bunyaviruses Including a Mapputta Group Virus from Western Australia That Links Gan Gan and Maprik Viruses.
[So] Source:PLoS One;11(10):e0164868, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Mapputta group comprises antigenically related viruses indigenous to Australia and Papua New Guinea that are included in the family Bunyaviridae but not currently assigned to a specific genus. We determined and analyzed the genome sequences of five Australian viruses isolated from mosquitoes collected during routine arbovirus surveillance in Western Australia (K10441, SW27571, K13190, and K42904) and New South Wales (12005). Based on matching sequences of all three genome segments to prototype MRM3630 of Trubanaman virus (TRUV), NB6057 of Gan Gan virus (GGV), and MK7532 of Maprik virus (MPKV), isolates K13190 and SW27571 were identified as TRUV, 12005 as GGV, and K42904 as a Mapputta group virus from Western Australia linking GGV and MPKV. The results confirmed serum neutralization data that had linked SW27571 to TRUV. The fifth virus, K10441 from Willare, was most closely related to Batai orthobunyavirus, presumably representing an Australian variant of the virus. Phylogenetic analysis also confirmed the close relationship of our TRUV and GGV isolates to two other recently described Australian viruses, Murrumbidgee virus and Salt Ash virus, respectively. Our findings indicate that TRUV has a wide circulation throughout the Australian continent, demonstrating for the first time its presence in Western Australia. Similarly, the presence of a virus related to GGV, which had been linked to human disease and previously known only from the Australian southeast, was demonstrated in Western Australia. Finally, a Batai virus isolate was identified in Western Australia. The expanding availability of genomic sequence for novel Australian bunyavirus variants supports the identification of suitably conserved or diverse primer-binding target regions to establish group-wide as well as virus-specific nucleic acid tests in support of specific diagnostic and surveillance efforts throughout Australasia.
[Mh] Termos MeSH primário: Arbovirus/genética
Bunyaviridae/genética
[Mh] Termos MeSH secundário: Animais
Arbovirus/classificação
Arbovirus/isolamento & purificação
Bunyaviridae/classificação
Culicidae/virologia
Sequenciamento de Nucleotídeos em Larga Escala
Papua Nova Guiné
Filogenia
RNA Viral/química
RNA Viral/isolamento & purificação
RNA Viral/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de RNA
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164868


  8 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27517952
[Au] Autor:Kohl A; Brennan B; Weber F
[Ad] Endereço:MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK. alain.kohl@glasgow.ac.uk.
[Ti] Título:Homage to Richard M. Elliott.
[So] Source:Viruses;8(8), 2016 Aug 10.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the last 25 years, the scientific and public attention paid to bunyaviruses has increased considerably.[...].
[Mh] Termos MeSH primário: Bunyaviridae/fisiologia
Bunyaviridae/patogenicidade
Interações Hospedeiro-Patógeno
Virologia/história
Replicação Viral
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
Proteínas da Matriz Viral
Vírus
[Pt] Tipo de publicação:BIOGRAPHY; EDITORIAL; HISTORICAL ARTICLE
[Ps] Nome de pessoa como assunto:Elliott RM
[Nm] Nome de substância:
0 (Viral Matrix Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE


  9 / 888 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27287214
[Au] Autor:Lee H; Jeong H; Park S; Yang MS; Kim J; Bae J; Kwon Y; Kim MS; Oem JK; Lee MH; Lim CW; Kim B
[Ad] Endereço:College of Veterinary Medicine, Chonbuk National University, Iksan, 54596, Korea.
[Ti] Título:Experimental infection of cows with newly isolated Akabane virus strain (AKAV-7) causing encephalomyelitis.
[So] Source:Vet Res;47(1):62, 2016 Jun 10.
[Is] ISSN:1297-9716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Akabane virus (AKAV), an arthropod-transmitted bunyavirus, is a major cause of congenital abnormalities and encephalomyelitis in ruminants. In 2010, there was a major outbreak of encephalomyelitis in Korea and fifteen AKAV strains, including AKAV-7, were isolated from cows. To identify the neuropathogenicity of AKAV-7, we performed experimental infection of cows. Six-month-old female Korean Holstein dairy cattle were inoculated with AKAV-7 by various routes, including intracerebral (IC), intrasubarachnoid space (IS), subcutaneous (SC) and intravenous (IV); a separate group was vaccinated before intravenous infection. Five of the six cows in the IC group and two of the six cows in the IS group showed clinical signs such as locomotor ataxia and paralysis of the hind limbs. Three of six cows died after IC infection 9-12 days post infection (dpi). Histopathologic changes such as nonsuppurative encephalomyelitis were confirmed in various parts of the central nervous system in the IC, IS and SC groups. Early onset of neutralizing antibodies in the serum and lower viral mRNA levels in the peripheral blood mononuclear cells (PBMCs) and various tissues in the vaccinated group was noticeable compared to the unvaccinated group (IV group). We suggest that the AKAV vaccine currently used in Korea may be partially effective for protection against AKAV-7 in cows.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/veterinária
Bunyaviridae
Doenças dos Bovinos/virologia
Encefalomielite/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/imunologia
Infecções por Bunyaviridae/patologia
Infecções por Bunyaviridae/virologia
Bovinos
Doenças dos Bovinos/patologia
Sistema Nervoso Central/patologia
Sistema Nervoso Central/virologia
Encefalomielite/patologia
Encefalomielite/virologia
Ensaio de Imunoadsorção Enzimática/veterinária
Feminino
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Viremia/veterinária
Viremia/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160612
[St] Status:MEDLINE
[do] DOI:10.1186/s13567-016-0349-6


  10 / 888 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27213430
[Au] Autor:Albornoz A; Hoffmann AB; Lozach PY; Tischler ND
[Ad] Endereço:Molecular Virology Laboratory, Fundación Ciencia & Vida, Av. Zañartu 1482, 7780272 Santiago, Chile. aalbornoz@cienciavida.org.
[Ti] Título:Early Bunyavirus-Host Cell Interactions.
[So] Source:Viruses;8(5), 2016 May 24.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely uncharacterized. The focus of this review is on the early steps of bunyavirus infection, from virus binding to penetration from endosomes. We address current knowledge and advances for members from each genus in the Bunyaviridae family regarding virus receptors, uptake, intracellular trafficking and fusion.
[Mh] Termos MeSH primário: Bunyaviridae/fisiologia
Interações Hospedeiro-Patógeno
Ligação Viral
Internalização do Vírus
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE



página 1 de 89 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde