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[PMID]:29261651
[Au] Autor:Goedhals D; Paweska JT; Burt FJ
[Ad] Endereço:Division of Virology, National Health Laboratory Service/University of the Free State, Bloemfontein, South Africa.
[Ti] Título:Long-lived CD8+ T cell responses following Crimean-Congo haemorrhagic fever virus infection.
[So] Source:PLoS Negl Trop Dis;11(12):e0006149, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo haemorrhagic fever virus (CCHFV) is a member of the Orthonairovirus genus of the Nairoviridae family and is associated with haemorrhagic fever in humans. Although T lymphocyte responses are known to play a role in protection from and clearance of viral infections, specific T cell epitopes have yet to be identified for CCHFV following infection. A panel of overlapping peptides covering the CCHFV nucleoprotein and the structural glycoproteins, GN and GC, were screened by ELISpot assay to detect interferon gamma (IFN-γ) production in vitro by peripheral blood mononuclear cells from eleven survivors with previous laboratory confirmed CCHFV infection. Reactive peptides were located predominantly on the nucleoprotein, with only one survivor reacting to two peptides from the glycoprotein GC. No single epitope was immunodominant, however all but one survivor showed reactivity to at least one T cell epitope. The responses were present at high frequency and detectable several years after the acute infection despite the absence of continued antigenic stimulation. T cell depletion studies confirmed that IFN-γ production as detected using the ELISpot assay was mediated chiefly by CD8+ T cells. This is the first description of CD8+ T cell epitopic regions for CCHFV and provides confirmation of long-lived T cell responses in survivors of CCHFV infection.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Vírus da Febre Hemorrágica da Crimeia-Congo/imunologia
Febre Hemorrágica da Crimeia/imunologia
Imunidade Inata
[Mh] Termos MeSH secundário: Adulto
Idoso
Sequência de Aminoácidos
Estudos de Coortes
ELISPOT
Epitopos/imunologia
Feminino
Glicoproteínas/imunologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Leucócitos Mononucleares/imunologia
Masculino
Meia-Idade
Nucleoproteínas/imunologia
Biblioteca de Peptídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Epitopes); 0 (Glycoproteins); 0 (Nucleoproteins); 0 (Peptide Library)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006149


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[PMID]:29028804
[Au] Autor:Bonney LC; Watson RJ; Afrough B; Mullojonova M; Dzhuraeva V; Tishkova F; Hewson R
[Ad] Endereço:National Infection Service, Public Health England, Porton Down, Salisbury, United Kingdom.
[Ti] Título:A recombinase polymerase amplification assay for rapid detection of Crimean-Congo Haemorrhagic fever Virus infection.
[So] Source:PLoS Negl Trop Dis;11(10):e0006013, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crimean-Congo Haemorrhagic fever Virus (CCHFV) is a rapidly emerging vector-borne pathogen and the cause of a virulent haemorrhagic fever affecting large parts of Europe, Africa, the Middle East and Asia. METHODOLOGY/PRINCIPLE FINDINGS: An isothermal recombinase polymerase amplification (RPA) assay was successfully developed for molecular detection of CCHFV. The assay showed rapid (under 10 minutes) detection of viral extracts/synthetic virus RNA of all 7 S-segment clades of CCHFV, with high target specificity. The assay was shown to tolerate the presence of inhibitors in crude preparations of mock field samples, indicating that this assay may be suitable for use in the field with minimal sample preparation. The CCHFV RPA was successfully used to screen and detect CCHFV positives from a panel of clinical samples from Tajikistan. CONCLUSIONS/SIGNIFICANCE: The assay is a rapid, isothermal, simple-to-perform molecular diagnostic, which can be performed on a light, portable real-time detection device. It is ideally placed therefore for use as a field-diagnostic or in-low resource laboratories, for monitoring of CCHF outbreaks at the point-of-need, such as in remote rural regions in affected countries.
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/diagnóstico
Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Sistemas Automatizados de Assistência Junto ao Leito
[Mh] Termos MeSH secundário: África/epidemiologia
Ásia/epidemiologia
Europa (Continente)/epidemiologia
Vírus da Febre Hemorrágica da Crimeia-Congo/enzimologia
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Febre Hemorrágica da Crimeia/epidemiologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Oriente Médio/epidemiologia
Técnicas de Diagnóstico Molecular/economia
Técnicas de Diagnóstico Molecular/instrumentação
Técnicas de Amplificação de Ácido Nucleico/economia
Técnicas de Amplificação de Ácido Nucleico/instrumentação
RNA Viral/análise
RNA Viral/genética
Recombinases/metabolismo
Sensibilidade e Especificidade
Tadjiquistão/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral); 0 (Recombinases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006013


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[PMID]:28922426
[Au] Autor:Garrison AR; Shoemaker CJ; Golden JW; Fitzpatrick CJ; Suschak JJ; Richards MJ; Badger CV; Six CM; Martin JD; Hannaman D; Zivcec M; Bergeron E; Koehler JW; Schmaljohn CS
[Ad] Endereço:Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
[Ti] Título:A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models.
[So] Source:PLoS Negl Trop Dis;11(9):e0005908, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. There are currently no licensed vaccines to prevent CCHFV-associated disease. We developed a DNA vaccine expressing the M-segment glycoprotein precursor gene of CCHFV and assessed its immunogenicity and protective efficacy in two lethal mouse models of disease: type I interferon receptor knockout (IFNAR-/-) mice; and a novel transiently immune suppressed (IS) mouse model. Vaccination of mice by muscle electroporation of the M-segment DNA vaccine elicited strong antigen-specific humoral immune responses with neutralizing titers after three vaccinations in both IFNAR-/- and IS mouse models. To compare the protective efficacy of the vaccine in the two models, groups of vaccinated mice (7-10 per group) were intraperitoneally (IP) challenged with a lethal dose of CCHFV strain IbAr 10200. Weight loss was markedly reduced in CCHFV DNA-vaccinated mice as compared to controls. Furthermore, whereas all vector-control vaccinated mice succumbed to disease by day 5, the DNA vaccine protected >60% of the animals from lethal disease. Mice from both models developed comparable levels of antibodies, but the IS mice had a more balanced Th1/Th2 response to vaccination. There were no statistical differences in the protective efficacies of the vaccine in the two models. Our results provide the first comparison of these two mouse models for assessing a vaccine against CCHFV and offer supportive data indicating that a DNA vaccine expressing the glycoprotein genes of CCHFV elicits protective immunity against CCHFV.
[Mh] Termos MeSH primário: Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Vírus da Febre Hemorrágica da Crimeia-Congo/imunologia
Febre Hemorrágica da Crimeia/prevenção & controle
Imunogenicidade da Vacina
Vacinas de DNA/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Glicoproteínas/genética
Glicoproteínas/imunologia
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/imunologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Imunidade Humoral
Hospedeiro Imunocomprometido
Camundongos
Camundongos Knockout
Receptor de Interferon alfa e beta/deficiência
Receptor de Interferon alfa e beta/genética
Células Th1/imunologia
Células Th2/imunologia
Vacinação
Vacinas de DNA/administração & dosagem
Proteínas Virais/genética
Proteínas Virais/imunologia
Vacinas Virais/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Glycoproteins); 0 (Vaccines, DNA); 0 (Viral Proteins); 0 (Viral Vaccines); 156986-95-7 (Receptor, Interferon alpha-beta)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005908


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[PMID]:28922369
[Au] Autor:Jeeva S; Pador S; Voss B; Ganaie SS; Mir MA
[Ad] Endereço:Western University of Health Sciences, Pomona, California, United States of America.
[Ti] Título:Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes.
[So] Source:PLoS One;12(9):e0184935, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean Congo hemorrhagic fever, a zoonotic viral disease, has high mortality rate in humans. There is currently no vaccine for Crimean Congo hemorrhagic fever virus (CCHFV) and chemical interventions are limited. The three negative sense genomic RNA segments of CCHFV are specifically encapsidated by the nucleocapsid protein into three ribonucleocapsids, which serve as templates for the viral RNA dependent RNA polymerase. Here we demonstrate that CCHFV nucleocapsid protein has two distinct binding modes for double and single strand RNA. In the double strand RNA binding mode, the nucleocapsid protein preferentially binds to the vRNA panhandle formed by the base pairing of complementary nucleotides at the 5' and 3' termini of viral genome. The CCHFV nucleocapsid protein does not have RNA helix unwinding activity and hence does not melt the duplex vRNA panhandle after binding. In the single strand RNA binding mode, the nucleocapsid protein does not discriminate between viral and non-viral RNA molecules. Binding of both vRNA panhandle and single strand RNA induce a conformational change in the nucleocapsid protein. Nucleocapsid protein remains in a unique conformational state due to simultaneously binding of structurally distinct vRNA panhandle and single strand RNA substrates. Although the role of dual RNA binding modes in the virus replication cycle is unknown, their involvement in the packaging of viral genome and regulation of CCHFV replication in conjunction with RdRp and host derived RNA regulators is highly likely.
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo
Conformação de Ácido Nucleico
Proteínas do Nucleocapsídeo
RNA Viral
Proteínas de Ligação a RNA
[Mh] Termos MeSH secundário: Vírus da Febre Hemorrágica da Crimeia-Congo/química
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Vírus da Febre Hemorrágica da Crimeia-Congo/metabolismo
Proteínas do Nucleocapsídeo/química
Proteínas do Nucleocapsídeo/genética
Proteínas do Nucleocapsídeo/metabolismo
Ligação Proteica
RNA Viral/química
RNA Viral/genética
RNA Viral/metabolismo
Proteínas de Ligação a RNA/química
Proteínas de Ligação a RNA/genética
Proteínas de Ligação a RNA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nucleocapsid Proteins); 0 (RNA, Viral); 0 (RNA-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184935


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[PMID]:28886039
[Au] Autor:Fletcher TE; Gulzhan A; Ahmeti S; Al-Abri SS; Asik Z; Atilla A; Beeching NJ; Bilek H; Bozkurt I; Christova I; Duygu F; Esen S; Khanna A; Kader Ç; Mardani M; Mahmood F; Mamuchishvili N; Pshenichnaya N; Sunbul M; Yalcin TY; Leblebicioglu H
[Ad] Endereço:Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
[Ti] Título:Infection prevention and control practice for Crimean-Congo hemorrhagic fever-A multi-center cross-sectional survey in Eurasia.
[So] Source:PLoS One;12(9):e0182315, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crimean Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection that presents significant risk of nosocomial transmission to healthcare workers. AIM: Evaluation of CCHF infection prevention and control (IP&C) practices in healthcare facilities that routinely manage CCHF cases in Eurasia. METHODS: A cross-sectional CCHF IP&C survey was designed and distributed to CCHF centers in 10 endemic Eurasian countries in 2016. RESULTS: Twenty-three responses were received from centers in Turkey, Pakistan, Russia, Georgia, Kosovo, Bulgaria, Oman, Iran, India and Kazakhstan. All units had dedicated isolation rooms for CCHF, with cohorting of confirmed cases in 15/23 centers and cohorting of suspect and confirmed cases in 9/23 centers. There was adequate personal protective equipment (PPE) in 22/23 facilities, with 21/23 facilities reporting routine use of PPE for CCHF patients. Adequate staffing levels to provide care reported in 14/23 locations. All centers reported having a high risk CCHFV nosocomial exposure in last five years, with 5 centers reporting more than 5 exposures. Education was provided annually in most centers (13/23), with additional training requested in PPE use (11/23), PPE donning/doffing (12/23), environmental disinfection (12/23) and waste management (14/23). CONCLUSIONS: Staff and patient safety must be improved and healthcare associated CCHF exposure and transmission eliminated. Improvements are recommended in isolation capacity in healthcare facilities, use of PPE and maintenance of adequate staffing levels. We recommend further audit of IP&C practice at individual units in endemic areas, as part of national quality assurance programs.
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo
Febre Hemorrágica da Crimeia/prevenção & controle
Vigilância em Saúde Pública
[Mh] Termos MeSH secundário: Ásia/epidemiologia
Estudos Transversais
Desinfecção
Europa (Continente)/epidemiologia
Geografia
Febre Hemorrágica da Crimeia/epidemiologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Equipamento de Proteção Individual
Gerenciamento de Resíduos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182315


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[PMID]:28836897
[Au] Autor:Cajimat MNB; Rodriguez SE; Schuster IUE; Swetnam DM; Ksiazek TG; Habela MA; Negredo AI; Estrada-Peña A; Barrett ADT; Bente DA
[Ad] Endereço:1 Galveston National Laboratory, Department of Microbiology & Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch , Galveston, Texas.
[Ti] Título:Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014.
[So] Source:Vector Borne Zoonotic Dis;17(10):714-719, 2017 Oct.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from Cáceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in Cáceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Ixodidae/virologia
[Mh] Termos MeSH secundário: Animais
Feminino
Genoma Viral
Espanha
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2017.2190


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[PMID]:28719259
[Au] Autor:Maiga O; Sas MA; Rosenke K; Kamissoko B; Mertens M; Sogoba N; Traore A; Sangare M; Niang M; Schwan TG; Maiga HM; Traore SF; Feldmann H; Safronetz D; Groschup MH
[Ad] Endereço:International Center for Excellence in Research, Malaria Research and Training Center, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
[Ti] Título:Serosurvey of Crimean-Congo Hemorrhagic Fever Virus in Cattle, Mali, West Africa.
[So] Source:Am J Trop Med Hyg;96(6):1341-1345, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractCrimean-Congo hemorrhagic fever is a tick-borne disease caused by the arbovirus Crimean-Congo hemorrhagic fever virus (CCHFV, family Bunyaviridae, genus ). CCHFV can cause a severe hemorrhagic fever with high-case fatality rates in humans. CCHFV has a wide geographic range and has been described in around 30 countries in the Middle East, Asia, Europe, and Africa including Mali and neighboring countries. To date, little is known about the prevalence rates of CCHFV in Mali. Here, using banked bovine serum samples from across the country, we describe the results of a seroepidemiological study for CCHFV aimed at identifying regions of circulation in Mali. In total, 1,074 serum samples were tested by a modified in-house CCHFV-IgG-enzyme-linked immunosorbent assay (ELISA) with confirmatory testing by commercial ELISA and immunofluorescence assay. Overall, 66% of samples tested were positive for CCHFV-specific IgG antibodies. Regional seroprevalence rates ranged from 15% to 95% and seemed to correlate with cattle density. Our results demonstrate that CCHFV prevalence is high in many regions in Mali and suggest that CCHFV surveillance should be established.
[Mh] Termos MeSH primário: Doenças dos Bovinos/epidemiologia
Bovinos/virologia
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/epidemiologia
Febre Hemorrágica da Crimeia/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Doenças dos Bovinos/virologia
Imunofluorescência
Febre Hemorrágica da Crimeia/virologia
Imunoglobulina G/sangue
Mali/epidemiologia
Reprodutibilidade dos Testes
Estudos Soroepidemiológicos
Carrapatos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0818


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[PMID]:28700846
[Au] Autor:Spengler JR; Bente DA
[Ad] Endereço:From the Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta (J.R.S.); and the Department of Microbiology and Immunology and Galveston National Laboratory, University of Texas Medical Branch, Galveston (D.A.B.).
[Ti] Título:Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident?
[So] Source:N Engl J Med;377(2):106-108, 2017 Jul 13.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Endêmicas
Vírus da Febre Hemorrágica da Crimeia-Congo
Febre Hemorrágica da Crimeia
[Mh] Termos MeSH secundário: Animais
Vetores Aracnídeos
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/transmissão
Seres Humanos
Ixodidae/virologia
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1707436


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[PMID]:28700843
[Au] Autor:Negredo A; de la Calle-Prieto F; Palencia-Herrejón E; Mora-Rillo M; Astray-Mochales J; Sánchez-Seco MP; Bermejo Lopez E; Menárguez J; Fernández-Cruz A; Sánchez-Artola B; Keough-Delgado E; Ramírez de Arellano E; Lasala F; Milla J; Fraile JL; Ordobás Gavín M; Martinez de la Gándara A; López Perez L; Diaz-Diaz D; López-García MA; Delgado-Jimenez P; Martín-Quirós A; Trigo E; Figueira JC; Manzanares J; Rodriguez-Baena E; Garcia-Comas L; Rodríguez-Fraga O; García-Arenzana N; Fernández-Díaz MV; Cornejo VM; Emmerich P; Schmidt-Chanasit J; Arribas JR; Crimean Congo Hemorrhagic Fever@Madrid Working Group
[Ad] Endereço:From the Arbovirus and Imported Viral Diseases Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III (A.N., M.P.S.-S., E.R.A., F.L.), Red de Investigación Colaborativa en Enfermedades Tropicales (A.N., M.P.S.-S., E.R.A., F.L.), High Level Isolation Unit (F.C.-P., M.M.-R., A.M.-Q., E.
[Ti] Título:Autochthonous Crimean-Congo Hemorrhagic Fever in Spain.
[So] Source:N Engl J Med;377(2):154-161, 2017 07 13.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus. (Funded by Red de Investigación Cooperativa en Enfermedades Tropicales [RICET] and Efficient Response to Highly Dangerous and Emerging Pathogens at EU [European Union] Level [EMERGE].).
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia
[Mh] Termos MeSH secundário: Colo/patologia
Busca de Comunicante
Evolução Fatal
Feminino
Vírus da Febre Hemorrágica da Crimeia-Congo/classificação
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Febre Hemorrágica da Crimeia/patologia
Febre Hemorrágica da Crimeia/transmissão
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Transmissão de Doença Infecciosa do Paciente para o Profissional
Fígado/patologia
Masculino
Meia-Idade
Necrose
Reação em Cadeia da Polimerase
Espanha
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1615162


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[PMID]:28605299
[Au] Autor:Sas MA; Mertens M; Isselmou E; Reimer N; El Mamy BO; Doumbia B; Groschup MH
[Ad] Endereço:1 Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald - Isle of Riems, Germany .
[Ti] Título:Crimean-Congo Hemorrhagic Fever Virus-Specific Antibody Detection in Cattle in Mauritania.
[So] Source:Vector Borne Zoonotic Dis;17(8):582-587, 2017 Aug.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crimean-Congo hemorrhagic fever virus (CCHFV) was detected for the first time in Mauritania in 1983 and several CCHFV outbreaks were reported in the following years. The last human case was diagnosed in 2015. However, no recent data exist about the prevalence of CCHFV in animals, although it is already described that prevalence studies in animals serve as good risk indicators. CCHFV can cause a severe hemorrhagic fever with a high case fatality rate in humans. Therefore, a precise risk assessment on the basis of updated data is very important. This article gives an overview about the current CCHFV prevalence in cattle in Mauritania. METHODS AND FINDINGS: A seroprevalence study was carried out using 495 cattle sera from Mauritania, which were collected in the year 2013. The sera were analyzed by an inhouse CCHFV-IgG-ELISA. As second screening test, an adapted commercial CCHFV-IgG-ELISA was performed. Inconclusive sera were additionally tested by a modified commercial CCHFV-IgG-IFA. All assays showed high diagnostic sensitivity (>95%) and specificity (>98%). The overall prevalence of CCHFV-specific antibodies found in Mauritanian cattle was 67%, ranging from 56% to 90% in different provinces. CONCLUSION: This study shows a very high CCHFV-specific antibody prevalence in cattle in Mauritania. It is the highest seroprevalence detected in Mauritania so far. This strengthens the hypothesis that CCHFV is a serious and ongoing threat for public health in Mauritania.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Doenças dos Bovinos/virologia
Vírus da Febre Hemorrágica da Crimeia-Congo
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/sangue
Doenças dos Bovinos/epidemiologia
Imunofluorescência
Imunoglobulina G/sangue
Mauritânia/epidemiologia
Estudos Soroepidemiológicos
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2016.2084



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