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[PMID]:28628941
[Au] Autor:Wilson MR; Suan D; Duggins A; Schubert RD; Khan LM; Sample HA; Zorn KC; Rodrigues Hoffman A; Blick A; Shingde M; DeRisi JL
[Ad] Endereço:Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
[Ti] Título:A novel cause of chronic viral meningoencephalitis: Cache Valley virus.
[So] Source:Ann Neurol;82(1):105-114, 2017 Jul.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Immunodeficient patients are particularly vulnerable to neuroinvasive infections that can be challenging to diagnose. Metagenomic next generation sequencing can identify unusual or novel microbes and is therefore well suited for investigating the etiology of chronic meningoencephalitis in immunodeficient patients. METHODS: We present the case of a 34-year-old man with X-linked agammaglobulinemia from Australia suffering from 3 years of meningoencephalitis that defied an etiologic diagnosis despite extensive conventional testing, including a brain biopsy. Metagenomic next generation sequencing of his cerebrospinal fluid and brain biopsy tissue was performed to identify a causative pathogen. RESULTS: Sequences aligning to multiple Cache Valley virus genes were identified via metagenomic next generation sequencing. Reverse transcription polymerase chain reaction and immunohistochemistry subsequently confirmed the presence of Cache Valley virus in the brain biopsy tissue. INTERPRETATION: Cache Valley virus, a mosquito-borne orthobunyavirus, has only been identified in 3 immunocompetent North American patients with acute neuroinvasive disease. The reported severity ranges from a self-limiting meningitis to a rapidly fatal meningoencephalitis with multiorgan failure. The virus has never been known to cause a chronic systemic or neurologic infection in humans. Cache Valley virus has also never previously been detected on the Australian continent. Our research subject traveled to North and South Carolina and Michigan in the weeks prior to the onset of his illness. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. Ann Neurol 2017;82:105-114.
[Mh] Termos MeSH primário: Encéfalo/virologia
Vírus Bunyamwera/patogenicidade
Encefalite Viral/virologia
Meningoencefalite/virologia
[Mh] Termos MeSH secundário: Adulto
Vírus Bunyamwera/genética
Encefalite Viral/líquido cefalorraquidiano
Seres Humanos
Masculino
Meningoencefalite/líquido cefalorraquidiano
Metagenômica
Análise de Sequência de DNA
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24982


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[PMID]:28545111
[Au] Autor:Armstrong PM; Andreadis TG; Shepard JJ; Thomas MC
[Ad] Endereço:Department of Environmental Sciences, Center for Vector Biology and Zoonotic Diseases, The Connecticut Agricultural Experiment Station, New Haven, Connecticut, United States of America.
[Ti] Título:Northern range expansion of the Asian tiger mosquito (Aedes albopictus): Analysis of mosquito data from Connecticut, USA.
[So] Source:PLoS Negl Trop Dis;11(5):e0005623, 2017 May.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Asian tiger mosquito (Aedes albopictus) is an invasive species and important arbovirus vector that was introduced into the U.S. in the 1980's where it continues to expand its range. Winter temperature is an important constraint to its northward expansion, with potential range limits located between the 0° and -5°C mean cold month isotherm. Connecticut is located within this climatic zone and therefore, Ae. albopictus was monitored statewide to assess its northern range expansion and to delineate where populations can stably persist. METHODOLOGY/PRINCIPAL FINDINGS: Ae. albopictus females were monitored at fixed trapping sites throughout Connecticut from June-October over a 20-year period, 1997-2016. In addition, Ae. albopictus larvae and pupae were collected from tire habitats and tires were retrieved from the field in the spring and flooded to evaluate overwintering success of hatching larvae. Ae. albopictus was first detected during statewide surveillance when a single adult female was collected in 2006. This species was not collected again until 2010 and was subsequently detected each successive year with increasing abundance and distribution except following the unusually cold winters of 2014 and 2015. Ae. albopictus mosquitoes were most abundant in urban and suburban locations along the southwestern shoreline of Connecticut; however, single specimens were occasionally detected in central parts of the state. Field-collected females were also screened for arbovirus infection yielding two isolations of Cache Valley virus and one isolation of West Nile virus, highlighting the threat posed by this mosquito. Ae. albopictus overwintered in Connecticut under mild winter conditions as shown by recovery of hatched larvae from field collected tires in spring and by early season detection of larvae and pupae. CONCLUSIONS/SIGNIFICANCE: This study documents the establishment and expansion of Ae. albopictus at the northern boundary of its range in the northeastern U.S. and provides a baseline for monitoring the future spread of this species anticipated under climate change.
[Mh] Termos MeSH primário: Aedes/crescimento & desenvolvimento
Mosquitos Vetores/crescimento & desenvolvimento
Filogeografia
[Mh] Termos MeSH secundário: Aedes/virologia
Animais
Vírus Bunyamwera/isolamento & purificação
Connecticut
Feminino
Mosquitos Vetores/virologia
Vírus do Nilo Ocidental/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005623


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[PMID]:27734222
[Au] Autor:Zhang L; Zhang Q; Wang J; An N; Cao Y; Fu G; Hu X; Huang Y; Su J
[Ad] Endereço:Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
[Ti] Título:Characterization of Batai virus isolated from a domestic Muscovy duck (Cairina moschate).
[So] Source:Virus Genes;53(1):121-125, 2017 Feb.
[Is] ISSN:1572-994X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Batai virus (BATV) belongs to the genus Orthobunyavirus of the family Bunyaviridae. It has been isolated from mosquitos, pigs, cattle, and humans throughout Africa, Asia, and Europe, and causes clinical signs in domestic animals and humans. Here, we report the isolation of BATV from a domestic duck flock. Genome sequence analysis revealed clustering of this isolate in the Africa-Asia lineage. The virus replicated in mosquitos and vertebrate host cells, showing different phenotypic characteristics, and showed the potential to infect mice. This is the first report of BATV in domestic birds and indicates the wide circulation of BATV in China.
[Mh] Termos MeSH primário: Animais Domésticos
Vírus Bunyamwera/classificação
Patos/virologia
[Mh] Termos MeSH secundário: Animais
Vírus Bunyamwera/genética
Vírus Bunyamwera/isolamento & purificação
Vírus Bunyamwera/ultraestrutura
Infecções por Bunyaviridae/virologia
Técnicas de Cultura de Células
Linhagem Celular
Efeito Citopatogênico Viral
Genoma Viral
Camundongos
Filogenia
RNA Viral
Análise de Sequência de DNA
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1007/s11262-016-1400-4


  4 / 265 MEDLINE  
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[PMID]:27332734
[Au] Autor:Pingen M; Bryden SR; Pondeville E; Schnettler E; Kohl A; Merits A; Fazakerley JK; Graham GJ; McKimmie CS
[Ad] Endereço:Virus Host Interaction Team, Section of Infection and Immunity, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK.
[Ti] Título:Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection.
[So] Source:Immunity;44(6):1455-69, 2016 06 21.
[Is] ISSN:1097-4180
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aedes aegypti mosquitoes are responsible for transmitting many medically important viruses such as those that cause Zika and dengue. The inoculation of viruses into mosquito bite sites is an important and common stage of all mosquito-borne virus infections. We show, using Semliki Forest virus and Bunyamwera virus, that these viruses use this inflammatory niche to aid their replication and dissemination in vivo. Mosquito bites were characterized by an edema that retained virus at the inoculation site and an inflammatory influx of neutrophils that coordinated a localized innate immune program that inadvertently facilitated virus infection by encouraging the entry and infection of virus-permissive myeloid cells. Neutrophil depletion and therapeutic blockade of inflammasome activity suppressed inflammation and abrogated the ability of the bite to promote infection. This study identifies facets of mosquito bite inflammation that are important determinants of the subsequent systemic course and clinical outcome of virus infection.
[Mh] Termos MeSH primário: Infecções por Arbovirus/imunologia
Vírus Bunyamwera/fisiologia
Inflamação/imunologia
Mordeduras e Picadas de Insetos/imunologia
Neutrófilos/imunologia
Vírus da Floresta de Semliki/fisiologia
Replicação Viral
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Células Cultivadas
Culicidae/imunologia
Seres Humanos
Imunidade Inata
Inflamassomos/metabolismo
Inflamação/virologia
Mordeduras e Picadas de Insetos/virologia
Camundongos
Neutrófilos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Inflammasomes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE


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[PMID]:27027481
[Au] Autor:Liu H; Li XT; Hu B; Zhang L; Xue XH; Lv S; Lu RG; Shi N; Yan XJ
[Ad] Endereço:1 Division of Infectious Diseases of Special Economic Animal, State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Animal and Plant Sciences , Chinese Academy of Agricultural Sciences, Changchun, China .
[Ti] Título:Development of Reverse Transcription Loop-Mediated Isothermal Amplification for Rapid Detection of Batai Virus in Cattle and Mosquitoes.
[So] Source:Vector Borne Zoonotic Dis;16(6):415-22, 2016 Jun.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Batai virus (BATV) is an arthropod-borne single-stranded RNA virus belonging to the genus Orthobunyavirus of the family Bunyaviridae that is primarily transmitted by mosquitoes. Methods for detecting BATV are currently limited to serological surveillance, virus isolation, and conventional reverse transcription-polymerase chain reaction (RT-PCR) assay. In this study, we sought to develop a BATV detection assay that needs no specialized equipment and is highly specific, sensitive, and simple. We first developed and optimized a reverse transcription loop-mediated isothermal amplification (RT-LAMP) for rapid detection of BATV that uses two pairs of primers to amplify a conserved region of the BATV M gene. The optimal reaction conditions for this RT-LAMP BATV detection assay were 40 min at 65°C. The amplification products could be visualized directly for color changes. This RT-LAMP method has a detection limit of 2.86 copies/µL and a sensitivity that was approximately 10- and 100-fold greater than real-time and conventional RT-PCR, respectively. RT-LAMP for BATV detection showed no cross-reactivity with other viruses and its sensitivity was validated with cattle blood and mosquito specimens. Our results suggest that this RT-LAMP method was simpler and faster than conventional RT-PCR or real-time RT-PCR. Moreover, RT-LAMP represents a potential tool to test for BATV in clinical and mosquito samples, especially in rural areas of China. This method also shows promise as a diagnostic tool due to its rapid and sensitive detection without the need for sophisticated equipment or complicated protocols.
[Mh] Termos MeSH primário: Vírus Bunyamwera/isolamento & purificação
Infecções por Bunyaviridae/veterinária
Doenças dos Bovinos/diagnóstico
Culex/virologia
Técnicas de Amplificação de Ácido Nucleico/métodos
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Infecções por Bunyaviridae/diagnóstico
Infecções por Bunyaviridae/virologia
Bovinos
Doenças dos Bovinos/sangue
Doenças dos Bovinos/virologia
Cercopithecus aethiops
Feminino
Reprodutibilidade dos Testes
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2015.1882


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[PMID]:26677217
[Au] Autor:Hover S; King B; Hall B; Loundras EA; Taqi H; Daly J; Dallas M; Peers C; Schnettler E; McKimmie C; Kohl A; Barr JN; Mankouri J
[Ad] Endereço:From the School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT.
[Ti] Título:Modulation of Potassium Channels Inhibits Bunyavirus Infection.
[So] Source:J Biol Chem;291(7):3411-22, 2016 Feb 12.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity. Bunyaviruses are transmitted via a diverse range of arthropod vectors, as well as rodents, and have established a global disease range with massive importance in healthcare, animal welfare, and economics. There are no vaccines or anti-viral therapies available to treat human bunyavirus infections and so development of new anti-viral strategies is urgently required. Bunyamwera virus (BUNV; genus Orthobunyavirus) is the model bunyavirus, sharing aspects of its molecular and cellular biology with all Bunyaviridae family members. Here, we show for the first time that BUNV activates and requires cellular potassium (K(+)) channels to infect cells. Time of addition assays using K(+) channel modulating agents demonstrated that K(+) channel function is critical to events shortly after virus entry but prior to viral RNA synthesis/replication. A similar K(+) channel dependence was identified for other bunyaviruses namely Schmallenberg virus (Orthobunyavirus) as well as the more distantly related Hazara virus (Nairovirus). Using a rational pharmacological screening regimen, two-pore domain K(+) channels (K2P) were identified as the K(+) channel family mediating BUNV K(+) channel dependence. As several K2P channel modulators are currently in clinical use, our work suggests they may represent a new and safe drug class for the treatment of potentially lethal bunyavirus disease.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Vírus Bunyamwera/efeitos dos fármacos
Infecções por Bunyaviridae/tratamento farmacológico
Interações Hospedeiro-Patógeno/efeitos dos fármacos
Bloqueadores dos Canais de Potássio/farmacologia
Canais de Potássio de Domínios Poros em Tandem/antagonistas & inibidores
Integração Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aedes
Animais
Vírus Bunyamwera/crescimento & desenvolvimento
Vírus Bunyamwera/fisiologia
Infecções por Bunyaviridae/metabolismo
Infecções por Bunyaviridae/virologia
Linhagem Celular
Cercopithecus aethiops
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Mesocricetus
Nairovirus/efeitos dos fármacos
Nairovirus/crescimento & desenvolvimento
Nairovirus/fisiologia
Orthobunyavirus/efeitos dos fármacos
Orthobunyavirus/crescimento & desenvolvimento
Orthobunyavirus/fisiologia
Canais de Potássio de Domínios Poros em Tandem/genética
Canais de Potássio de Domínios Poros em Tandem/metabolismo
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (KCNK1 protein, human); 0 (KCNK7 protein, human); 0 (KCNK9 protein, human); 0 (Potassium Channel Blockers); 0 (Potassium Channels, Tandem Pore Domain); 0 (potassium channel protein TREK-1)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M115.692673


  7 / 265 MEDLINE  
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[PMID]:26118981
[Au] Autor:Odhiambo C; Venter M; Lwande O; Swanepoel R; Sang R
[Ad] Endereço:Human Health Division,International Centre of Insect Physiology and Ecology,Nairobi,Kenya.
[Ti] Título:Phylogenetic analysis of Bunyamwera and Ngari viruses (family Bunyaviridae, genus Orthobunyavirus) isolated in Kenya.
[So] Source:Epidemiol Infect;144(2):389-95, 2016 Jan.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Orthobunyaviruses, tri-segmented, negative-sense RNA viruses, have long been associated with mild to severe human disease in Africa, but not haemorrhagic fever. However, during a Rift Valley fever outbreak in East Africa in 1997-1998, Ngari virus was isolated from two patients and antibody detected in several others with haemorrhagic fever. The isolates were used to identify Ngari virus as a natural Orthobunyavirus reassortant. Despite their potential to reassort and cause severe human disease, characterization of orthobunyaviruses is hampered by paucity of genetic sequences. Our objective was to obtain complete gene sequences of two Bunyamwera virus and three Ngari virus isolates from recent surveys in Kenya and to determine their phylogenetic positioning within the Bunyamwera serogroup. Newly sequenced Kenyan Bunyamwera virus isolates clustered closest to a Bunyamwera virus isolate from the same locality and a Central African Republic isolate indicating that similar strains may be circulating regionally. Recent Kenyan Ngari isolates were closest to the Ngari isolates associated with the 1997-1998 haemorrhagic fever outbreak. We observed a temporal/geographical relationship among Ngari isolates in all three gene segments suggesting a geographical/temporal association with genetic diversity. These sequences in addition to earlier sequences can be used for future analyses of this neglected but potentially deadly group of viruses.
[Mh] Termos MeSH primário: Vírus Bunyamwera/classificação
Vírus Bunyamwera/genética
Fases de Leitura Aberta
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Vírus Bunyamwera/isolamento & purificação
Quênia
Dados de Sequência Molecular
Filogenia
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151209
[Lr] Data última revisão:
151209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150630
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268815001338


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[PMID]:26675463
[Au] Autor:Reeves WK; Szymczak MS; Burkhalter KL; Miller MM
[Ad] Endereço:1 U.S Air Force School of Aerospace Medicine, Epidemiology Consult Service, 2510 5th Street, Wright-Patterson AFB, OH 45433.
[Ti] Título:Laboratory Validation of the Sand Fly Fever Virus Antigen Assay.
[So] Source:J Am Mosq Control Assoc;31(4):380-3, 2015 Dec.
[Is] ISSN:8756-971X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sandfly fever group viruses in the genus Phlebovirus (family Bunyaviridae) are widely distributed across the globe and are a cause of disease in military troops and indigenous peoples. We assessed the laboratory sensitivity and specificity of the Sand Fly Fever Virus Antigen Assay, a rapid dipstick assay designed to detect sandfly fever Naples virus (SFNV) and Toscana virus (TOSV) against a panel of phleboviruses. The assay detected SFNV and TOSV, as well as other phleboviruses including Aguacate, Anahanga, Arumowot, Chagres, and Punta Toro viruses. It did not detect sandfly fever Sicilian, Heartland, Rio Grande, or Rift Valley fever viruses. It did not produce false positive results in the presence of uninfected sand flies (Lutzomyia longipalpis) or Cache Valley virus, a distantly related bunyavirus. Results from this laboratory evaluation suggest that this assay may be used as a rapid field-deployable assay to detect sand flies infected with TOSV and SFNV, as well as an assortment of other phleboviruses.
[Mh] Termos MeSH primário: Imunoensaio/métodos
Psychodidae/virologia
Vírus da Febre do Flebótomo Napolitano/imunologia
[Mh] Termos MeSH secundário: Animais
Vírus Bunyamwera/imunologia
Phlebovirus/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151217
[Lr] Data última revisão:
151217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE
[do] DOI:10.2987/moco-31-04-380-383.1


  9 / 265 MEDLINE  
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[PMID]:26565774
[Au] Autor:Meyers MT; Bahnson CS; Hanlon M; Kopral C; Srisinlapaudom S; Cochrane ZN; Sabas CE; Saiyasombat R; Burrough ER; Plummer PJ; O'Connor AM; Marshall KL; Blitvich BJ
[Ad] Endereço:1 Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University , Ames, Iowa.
[Ti] Título:Management Factors Associated with Operation-Level Prevalence of Antibodies to Cache Valley Virus and Other Bunyamwera Serogroup Viruses in Sheep in the United States.
[So] Source:Vector Borne Zoonotic Dis;15(11):683-93, 2015 Nov.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A cross-sectional study was performed to identify operation-level risk factors associated with prevalence of antibody to Bunyamwera (BUN) serogroup viruses in sheep in the United States. Sera were obtained from 5150 sheep in 270 operations located in 22 states (three in the west, nine central states, and 10 in the east) and tested at a dilution of 1:20 by a plaque reduction neutralization test (PRNT) using Cache Valley virus (CVV). Antibodies that neutralized CVV were identified in 1455 (28%) sheep. Animal-level seroprevalence was higher in the east (49%) than the central (17%) and western (10%) states. A convenient subset (n = 509) of sera with antibodies that neutralized CVV was titrated and further analyzed by PRNT using all six BUN serogroup viruses that occur in the United States: CVV, Lokern virus (LOKV), Main Drain virus (MDV), Northway virus (NORV), Potosi virus (POTV), and Tensaw virus (TENV). Antibodies to CVV and LOKV were identified in sheep in all three geographic regions; MDV and POTV activity was detected in the central and eastern states, NORV activity was restricted to the west, and antibodies to TENV were not detected in any sheep. Several management factors were significantly associated with the presence of antibodies to BUN serogroup viruses. For instance, sheep housed during the lambing season inside structures that contained four walls and a roof and a door closed most of the time were more likely to be seropositive than other sheep. In contrast, herded/open-range sheep were less likely to be seropositive than their counterparts. These data can be used by producers to implement strategies to reduce the likelihood of BUN serogroup virus infection and improve the health and management practices of sheep.
[Mh] Termos MeSH primário: Vírus Bunyamwera/imunologia
Infecções por Bunyaviridae/veterinária
Doenças dos Ovinos/imunologia
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Animais
Anticorpos Antivirais/sangue
Infecções por Bunyaviridae/epidemiologia
Infecções por Bunyaviridae/imunologia
Estudos Transversais
Prevalência
Estudos Soroepidemiológicos
Ovinos
Doenças dos Ovinos/epidemiologia
Carneiro Doméstico
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151114
[Lr] Data última revisão:
151114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151114
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2015.1810


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[PMID]:26183295
[Au] Autor:Tauro LB; Rivarola ME; Lucca E; Mariño B; Mazzini R; Cardoso JF; Barrandeguy ME; Teixeira Nunes MR; Contigiani MS
[Ad] Endereço:Laboratorio de Arbovirus, Instituto de Virología Dr. J.M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, CP: X5016 GRA Ciudad Universitaria, Córdoba, Argentina. Electronic address: lauratauro@gmail.com.
[Ti] Título:First isolation of Bunyamwera virus (Bunyaviridae family) from horses with neurological disease and an abortion in Argentina.
[So] Source:Vet J;206(1):111-4, 2015 Oct.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bunyamwera virus (BUNV) is the prototype virus for both the Orthobunyavirus genus and the Bunyaviridae family. Different strains of BUNV have been associated with clinical diseases in domestic animals, mainly ruminants. During 2013, in Argentina's Santa Fe Province, three new isolates of BUNV were recovered from the brain and spleen of two horses with encephalitis, and from the brain of an aborted equine fetus. This isolation of BUNV from domestic animals provided the first association of BUNV infection with disease of the central nervous system and abortion in equines in Argentina.
[Mh] Termos MeSH primário: Vírus Bunyamwera/isolamento & purificação
Infecções por Bunyaviridae/veterinária
Encefalite Viral/veterinária
Doenças dos Cavalos/virologia
[Mh] Termos MeSH secundário: Feto Abortado/virologia
Animais
Argentina/epidemiologia
Vírus Bunyamwera/genética
Infecções por Bunyaviridae/epidemiologia
Infecções por Bunyaviridae/virologia
Encefalite Viral/epidemiologia
Encefalite Viral/virologia
Doenças dos Cavalos/epidemiologia
Cavalos
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE



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