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[PMID]: 29281639 [Au] Autor: Alkan C; Moin Vaziri V; Ayhan N; Badakhshan M; Bichaud L; Rahbarian N; Javadian EA; Alten B; de Lamballerie X; Charrel RN [Ad] Endereço: UMR "Unité des Virus Emergents" (UVE Aix-Marseille Univ-IRD 190-Inserm 1207-EHESP), Marseille, France. [Ti] Título: Isolation and sequencing of Dashli virus, a novel Sicilian-like virus in sandflies from Iran; genetic and phylogenetic evidence for the creation of one novel species within the Phlebovirus genus in the Phenuiviridae family. [So] Source: PLoS Negl Trop Dis;11(12):e0005978, 2017 12. [Is] ISSN: 1935-2735 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Phlebotomine sandflies are vectors of phleboviruses that cause sandfly fever or meningitis with significant implications for public health. Although several strains of these viruses had been isolated in Iran in the late 1970's, there was no recent data about the present situation at the outset of this study. Entomological investigations performed in 2009 and 2011 in Iran collected 4,770 sandflies from 10 different regions. Based on morphological identification, they were sorted into 315 pools according to species, sex, trapping station and date of capture. A phlebovirus, provisionally named Dashli virus (DASHV), was isolated from one pool of Sergentomyia spp, and subsequently DASHV RNA was detected in a second pool of Phlebotomus papatasi. Genetic and phylogenetic analyses based on complete coding genomic sequences indicated that (i) DASHV is most closely related to the Iranian isolates of Sandfly fever Sicilian virus [SFSV], (ii) there is a common ancestor to DASHV, Sandfly fever Sicilian- (SFS) and SFS-like viruses isolated in Italy, India, Turkey, and Cyprus (lineage I), (iii) DASHV is more distantly related with Corfou and Toros viruses (lineage II) although common ancestry is supported with 100% bootstrap, (iii) lineage I can be subdivided into sublineage Ia including all SFSV, SFCV and SFTV except those isolated in Iran which forms sublineage Ib (DASHV). Accordingly, we suggest to approve Sandfly fever Sicilian virus species consisting of the all aforementioned viruses. Owing that most of these viruses have been identified in human patients with febrile illness, DASHV should be considered as a potential human pathogen in Iran. [Mh] Termos MeSH primário: Genoma Viral/genética Phlebovirus Psychodidae/virologia RNA Viral/genética [Mh] Termos MeSH secundário: Animais Sequência de Bases Feminino Seres Humanos Insetos Vetores/virologia Irã (Geográfico) Masculino Febre por Flebótomos/transmissão Febre por Flebótomos/virologia Phlebovirus/classificação Phlebovirus/genética Phlebovirus/isolamento & purificação Filogenia Análise de Sequência de RNA [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (RNA, Viral) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180130 [Lr] Data última revisão: 180130 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171228 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pntd.0005978

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[PMID]: 29190712 [Au] Autor: Feng Y; Xu C; Li C; Lin J; Wang Z; Zhang Y; Jiang J; Lu Y [Ad] Endereço: Key Laboratory of Emergency Detection for Public Health of Zhejiang province, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang province, China. [Ti] Título: Replication capacity and adaptability of a severe fever with thrombocytopenia syndrome virus at different temperatures. [So] Source: PLoS One;12(11):e0188462, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by the SFTS virus (SFTSV). Although fever and thrombocytopenia are the typical manifestations of SFTS, a specific SFTS case with no fever was observed in Zhejiang, China. In this report, we aimed to explore the probable reason for the absence of fever by analyzing the genetic characteristics and temperature sensitivity (ts) of the SFTSV strain ZJ2013-06, which was isolated from the specific case. Phylogenetically, different clusters of SFTSV strains circulated in Zhejiang. ZJ2013-06 was farthest from ZJ2014-02, an isolate belonging to a Chinese dominant cluster, and nearest to the coastal strain NB24/CHN/2013. Ts tests, performed on Vero cells at 37°C and 39°C, indicated that ZJ2013-06 had restricted replication at 39°C. Its viral loads were substantially reduced at 39°C compared with that at 37°C (approximately 100-fold reduction) and were significantly lower than that of ZJ2014-02 at 39°C (P < 0.01). By adaptive culture at 39°C, the induced strain ZJ2013-06-P7 was obtained. Owing to a reverse mutation (S1616), ZJ2013-06-P7 lost the ts of the original strain, displaying similar replication processes with NB24/CHN/2013. The results indicated that the amino acid residue 1616 was related to the ts characteristics of ZJ2013-06. Our study revealed that ZJ2013-06 was temperature-sensitive and may be related to the absence of fever in our case. [Mh] Termos MeSH primário: Phlebovirus/fisiologia Temperatura Ambiente Replicação Viral [Mh] Termos MeSH secundário: Animais Cercopithecus aethiops Seres Humanos Filogenia Células Vero [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171226 [Lr] Data última revisão: 171226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171201 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0188462

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[PMID]: 28937979 [Au] Autor: Yun SM; Park SJ; Park SW; Choi W; Jeong HW; Choi YK; Lee WJ [Ad] Endereço: Division of Arboviruses, National Research Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju-si, Republic of Korea. [Ti] Título: Molecular genomic characterization of tick- and human-derived severe fever with thrombocytopenia syndrome virus isolates from South Korea. [So] Source: PLoS Negl Trop Dis;11(9):e0005893, 2017 Sep. [Is] ISSN: 1935-2735 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease caused by the SFTS virus (SFTSV) from Bunyaviridae that is endemic in East Asia. However, the genetic and evolutionary characteristics shared between tick- and human-derived Korean SFTSV strains are still limited. METHODOLOGY/PRINCIPAL FINDINGS: In this study we identify, for the first time, the genome sequence of a tick (Haemaphysalis longicornis)-derived Korean SFTSV strain (designated as KAGWT) and compare this virus with recent human SFTSV isolates to identify the genetic variations and relationships among SFTSV strains. The genome of the KAGWT strain is consistent with the described genome of other members of the genus Phlebovirus with 6,368 nucleotides (nt), 3,378 nt, and 1,746 nt in the Large (L), Medium (M) and Small (S) segments, respectively. Compared with other completely sequenced human-derived Korean SFTSV strains, the KAGWT strain had highest sequence identities at the nucleotide and deduced amino acid level in each segment with the KAGWH3 strain which was isolated from SFTS patient within the same region, although there is one unique amino acid substitution in the Gn protein (A66S). Phylogenetic analyses of complete genome sequences revealed that at least four different genotypes of SFTSV are co-circulating in South Korea, and that the tick- and human-derived Korean SFTSV strains (genotype B) are closely related to one another. Although we could not detect reassortant, which are commonly observed in segmented viruses, further large-scale surveillance and detailed genomic analysis studies are needed to better understand the molecular epidemiology, genetic diversity, and evolution of SFTSV. CONCLUSIONS/SIGNIFICANCE: Full-length sequence analysis revealed a clear association between the genetic origins of tick- and human-derived SFTSV strains. While the most prevalent Korean SFTSV is genotype B, at least four different genotypes of SFTSV strains are co-circulating in South Korea. These findings provide information regarding the molecular epidemiology, genetic diversity, and evolution of SFTSV in East Asia. [Mh] Termos MeSH primário: Genoma Viral Phlebovirus/genética Phlebovirus/isolamento & purificação [Mh] Termos MeSH secundário: Animais Infecções por Bunyaviridae/complicações Infecções por Bunyaviridae/epidemiologia Infecções por Bunyaviridae/virologia Variação Genética Genótipo Seres Humanos Ixodidae/virologia Orthobunyavirus/genética Phlebovirus/patogenicidade Filogenia República da Coreia/epidemiologia Análise de Sequência de DNA Síndrome Trombocitopenia/complicações Trombocitopenia/epidemiologia Trombocitopenia/virologia Doenças Transmitidas por Carrapatos/epidemiologia Doenças Transmitidas por Carrapatos/virologia Carrapatos/virologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171025 [Lr] Data última revisão: 171025 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170923 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pntd.0005893

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[PMID]: 28934195 [Au] Autor: Jia B; Yan X; Chen Y; Wang G; Liu Y; Xu B; Song P; Li Y; Xiong Y; Wu W; Hao Y; Xia J; Zhang Z; Huang R; Wu C [Ad] Endereço: Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China. [Ti] Título: A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome. [So] Source: PLoS Negl Trop Dis;11(9):e0005909, 2017 Sep. [Is] ISSN: 1935-2735 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease caused by the SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate of 12.7% to 32.6%. Currently, the disease has been reported in mainland China, Japan, Korea, and the United States. At present, there is no specific antiviral therapy for SFTSV infection. Considering the higher mortality rate and rapid clinical progress of SFTS, supporting the appropriate treatment in time to SFTS patients is critical. Therefore, it is very important for clinicians to predict these SFTS cases who are more likely to have a poor prognosis or even more likely to decease. In the present study, we established a simple and feasible model for assessing the severity and predicting the prognosis of SFTS patients with high sensitivity and specificity. This model may aid the physicians to immediately initiate prompt treatment to block the rapid development of the illness and reduce the fatality of SFTS patients. [Mh] Termos MeSH primário: Infecções por Bunyaviridae/diagnóstico Infecções por Bunyaviridae/patologia Técnicas de Apoio para a Decisão Trombocitopenia/diagnóstico Trombocitopenia/patologia [Mh] Termos MeSH secundário: Adulto Idoso Infecções por Bunyaviridae/virologia China Feminino Hospitais Seres Humanos Masculino Meia-Idade Phlebovirus/isolamento & purificação Prognóstico Sensibilidade e Especificidade Trombocitopenia/virologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171018 [Lr] Data última revisão: 171018 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170922 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pntd.0005909

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[PMID]: 28926632 [Au] Autor: Ly HJ; Lokugamage N; Nishiyama S; Ikegami T [Ad] Endereço: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America. [Ti] Título: Risk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain. [So] Source: PLoS One;12(9):e0185194, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF outbreaks in ruminants and humans in endemic countries, and effective vaccination of animals and humans may minimize the impact of this disease. A live-attenuated MP-12 vaccine strain is one of the best characterized RVFV strains, and was conditionally approved as a veterinary vaccine in the U.S. Live-attenuated RVF vaccines including MP-12 strain may form reassortant strains with other bunyavirus species. This study thus aimed to characterize the occurrence of genetic reassortment between the MP-12 strain and bunyavirus species closely related to RVFV. The Arumowot virus (AMTV) and Gouleako goukovirus (GOLV), are transmitted by mosquitoes in Africa. The results of this study showed that GOLV does not form detectable reassortant strains with the MP-12 strain in co-infected C6/36 cells. The AMTV also did not form any reassortant strains with MP-12 strain in co-infected C6/36 cells, due to the incompatibility among N, L, and Gn/Gc proteins. A lack of reassortant formation could be due to a functional incompatibility of N and L proteins derived from heterologous species, and due to a lack of packaging via heterologous Gn/Gc proteins. The MP-12 strain did, however, randomly exchange L-, M-, and S-segments with a genetic variant strain, rMP12-GM50, in culture cells. The MP-12 strain is thus unlikely to form any reassortant strains with AMTV or GOLV in nature. [Mh] Termos MeSH primário: Phlebovirus/fisiologia Vírus da Febre do Vale do Rift/fisiologia [Mh] Termos MeSH secundário: Animais Sequência de Bases Cercopithecus aethiops Genótipo Seres Humanos Phlebovirus/genética RNA Viral/genética RNA Viral/metabolismo Vírus Reordenados/genética Vírus Reordenados/fisiologia Febre do Vale de Rift/prevenção & controle Febre do Vale de Rift/virologia Vírus da Febre do Vale do Rift/genética Células Vero Proteínas não Estruturais Virais/genética Proteínas não Estruturais Virais/metabolismo Replicação Viral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (RNA, Viral); 0 (Viral Nonstructural Proteins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171020 [Lr] Data última revisão: 171020 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170920 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0185194

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[PMID]: 28854793 [Au] Autor: Zhang S; Zheng B; Wang T; Li A; Wan J; Qu J; Li CH; Li D; Liang M [Ti] Título: NSs protein of severe fever with thrombocytopenia syndrome virus suppresses interferon production through different mechanism than Rift Valley fever virus. [So] Source: Acta Virol;61(3):289-298, 2017. [Is] ISSN: 0001-723X [Cp] País de publicação: Slovakia [La] Idioma: eng [Ab] Resumo: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified Phlebovirus that causes severe fever with thrombocytopenia syndrome. Our study demonstrated that SFTSV NSs functioned as IFN antagonist mainly by suppressing TBK1/IKKε-IRF3 signaling pathway. NSs interacted with and relocalized TANK-binding kinase 1 (TBK1) into NSs-induced cytoplasmic structures and this interaction could effectively inhibit downstream phosphorylation and dimerization of interferon regulatory factor 3 (IRF3), resulting in the suppression of antiviral signaling and IFN induction. Functional sites of SFTSV NSs binding with TBK1 were then studied and results showed that NSs had lost their IFN-inhibiting activity after deleting the 25 amino acids in N-terminal. Furthermore, the mechanism of Rift Valley fever virus (RVFV) NSs blocking IFN-ß response were also investigated. Preliminary results showed that RVFV NSs proteins could neither interact nor co-localize with TBK1 in cytoplasm, but suppressed its expression levels, phosphorylation and dimerization of IRF3 in the subsequent steps, resulting in inhibition of the IFN-ß production. Altogether, our data demonstrated the probable mechanism used by SFTSV to inhibit IFN responses which was different from RVFV and pointed toward a novel mechanism for RVFV suppressing IFN responses. [Mh] Termos MeSH primário: Febre/virologia Phlebovirus/metabolismo Vírus da Febre do Vale do Rift/metabolismo Proteínas não Estruturais Virais/metabolismo [Mh] Termos MeSH secundário: Animais Antivirais/metabolismo Linhagem Celular Cercopithecus aethiops Células HEK293 Seres Humanos Fator Regulador 3 de Interferon/metabolismo Interferons/metabolismo Fosforilação/fisiologia Proteínas Serina-Treonina Quinases/metabolismo Transdução de Sinais/fisiologia Células Vero [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antiviral Agents); 0 (Interferon Regulatory Factor-3); 0 (Viral Nonstructural Proteins); 9008-11-1 (Interferons); EC 2.7.11.1 (Protein-Serine-Threonine Kinases) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171103 [Lr] Data última revisão: 171103 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170901 [St] Status: MEDLINE [do] DOI: 10.4149/av_2017_307

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[PMID]: 28848048 [Au] Autor: Ning YJ; Feng K; Min YQ; Deng F; Hu Z; Wang H [Ad] Endereço: From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and. [Ti] Título: Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. [So] Source: J Biol Chem;292(40):16722-16733, 2017 Oct 06. [Is] ISSN: 1083-351X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Heartland virus (HRTV) is a pathogenic phlebovirus related to the severe fever with thrombocytopenia syndrome virus (SFTSV), another phlebovirus causing life-threatening disease in humans. Previous findings have suggested that SFTSV can antagonize the host interferon (IFN) system via viral nonstructural protein (NSs)-mediated sequestration of antiviral signaling proteins into NSs-induced inclusion bodies. However, whether and how HRTV counteracts the host innate immunity is unknown. Here, we report that HRTV NSs (HNSs) also antagonizes IFN and cytokine induction and bolsters viral replication, although no noticeable inclusion body formation was observed in HNSs-expressing cells. Furthermore, HNSs inhibited the virus-triggered activation of IFN-ß promoter by specifically targeting the IFN-stimulated response element but not the NF-κB response element. Consistently, HNSs blocked the phosphorylation and nuclear translocation of IFN regulatory factor 3 (IRF3, an IFN-stimulated response element-activating transcription factor). Reporter gene assays next showed that HNSs blockades the antiviral signaling mediated by RIG-I-like receptors likely at the level of TANK-binding kinase 1 (TBK1). Indeed, HNSs strongly interacts with TBK1 as indicated by confocal microscopy and pulldown analyses, and we also noted that the scaffold dimerization domain of TBK1 is required for the TBK1-HNSs interaction. Finally, pulldown assays demonstrated that HNSs expression dose-dependently diminishes a TBK1-IRF3 interaction, further explaining the mechanism for HNSs function. Collectively, these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 and thereby hinders the association of TBK1 with its substrate IRF3, thus blocking IRF3 activation and transcriptional induction of the cellular antiviral responses. [Mh] Termos MeSH primário: Infecções por Bunyaviridae/imunologia Imunidade Inata Fator Regulador 3 de Interferon/imunologia Interferon beta/imunologia Phlebovirus/imunologia Proteínas Serina-Treonina Quinases/imunologia Transdução de Sinais/imunologia Proteínas não Estruturais Virais/imunologia [Mh] Termos MeSH secundário: Animais Infecções por Bunyaviridae/genética Cercopithecus aethiops Células HEK293 Células HeLa Células Hep G2 Seres Humanos Fator Regulador 3 de Interferon/genética Interferon beta/genética Phlebovirus/genética Fosforilação Proteínas Serina-Treonina Quinases/genética Transdução de Sinais/genética Células Vero Proteínas não Estruturais Virais/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (IRF3 protein, human); 0 (Interferon Regulatory Factor-3); 0 (Viral Nonstructural Proteins); 77238-31-4 (Interferon-beta); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (TBK1 protein, human) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171011 [Lr] Data última revisão: 171011 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170830 [St] Status: MEDLINE [do] DOI: 10.1074/jbc.M117.805127

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[PMID]: 28820686 [Au] Autor: Silvas JA; Aguilar PV [Ad] Endereço: Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas. [Ti] Título: The Emergence of Severe Fever with Thrombocytopenia Syndrome Virus. [So] Source: Am J Trop Med Hyg;97(4):992-996, 2017 Oct. [Is] ISSN: 1476-1645 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Severe fever with thrombocytopenia syndrome (SFTS) is a newly recognized hemorrhagic fever disease found throughout Asia with a case fatality rate between 12% and 30%. Since 2009, SFTS has been reported in China throughout 14 Chinese Provinces. In addition, SFTS has been recognized in South Korea and Japan with the first confirmed cases reported in 2012. A similar disease, caused by the closely related Heartland virus, was also reported in the United States in 2009. SFTS is caused by SFTS virus, a novel tick-borne virus in the family , genus . Unlike other mosquito- and sandfly-borne bunyaviruses, SFTS virus has not been extensively studied due to its recent emergence and many unknowns regarding its pathogenesis, life cycle, transmission, and options for therapeutics remains. In this review, we report the most current findings in SFTS virus research. [Mh] Termos MeSH primário: Infecções por Bunyaviridae/fisiopatologia Doenças Transmissíveis Emergentes/fisiopatologia Febre por Flebótomos/fisiopatologia Phlebovirus/fisiologia Trombocitopenia/fisiopatologia Doenças Transmitidas por Carrapatos/fisiopatologia Zoonoses/fisiopatologia [Mh] Termos MeSH secundário: Animais Vetores Artrópodes Ásia/epidemiologia Infecções por Bunyaviridae/epidemiologia Doenças Transmissíveis Emergentes/epidemiologia Doenças Transmissíveis Emergentes/virologia Seres Humanos Doenças Transmitidas por Carrapatos/epidemiologia Carrapatos Zoonoses/epidemiologia Zoonoses/virologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171025 [Lr] Data última revisão: 171025 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170819 [St] Status: MEDLINE [do] DOI: 10.4269/ajtmh.16-0967

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[PMID]: 28806760 [Au] Autor: Li XK; Yang ZD; Du J; Xing B; Cui N; Zhang PH; Li H; Zhang XA; Lu QB; Liu W [Ad] Endereço: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China. [Ti] Título: Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome. [So] Source: PLoS Negl Trop Dis;11(8):e0005746, 2017 Aug. [Is] ISSN: 1935-2735 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identify the biomarkers reflecting endothelial dysfunction. METHODOLOGY/PRINCIPAL FINDINGS: In a case-control study of 134 SFTS patients and 68 healthy controls, serum levels of plasminogen activator inhibitor 1, tissue plasminogen activator, P-selectin, platelet endothelial cell adhesion molecular, CD40 ligand, E-selectin, vascular endothelial growth factor A, serum amyloid antigen 1 (SAA-1) and vascular cell adhesion molecular 1 were significantly enhanced in the patients than the controls (all P<0.05), indicating the occurrence of endothelial activation/dysfunction in SFTS. The intercellular adhesion molecular 1 (ICAM-1) and SAA-1 at the convalescent phase were also significantly associated with severe patients, after adjusting for the potential confounders. The odds ratio was estimated to be 3.364 (95% CI 1.074-10.534) for ICAM-1, and 1.881 (95% CI 1.166-3.034) for SAA-1, respectively. Cutoff value of 1.1×107 pg/mL SAA-1 or 1.2×106 pg/mL ICAM-1 were found to have moderate power of predicting fatal cases. CONCLUSIONS: The endothelial dysfunction may be one of the pathogenic mechanism of SFTS. The serum levels of ICAM-1 and SAA-1 might be used to predict adverse outcome. [Mh] Termos MeSH primário: Biomarcadores/sangue Infecções por Bunyaviridae/fisiopatologia Células Endoteliais/fisiologia Células Endoteliais/virologia Molécula 1 de Adesão Intercelular/sangue Phlebovirus/fisiologia Proteína Amiloide A Sérica/análise [Mh] Termos MeSH secundário: Infecções por Bunyaviridae/virologia Estudos de Casos e Controles Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (SAA1 protein, human); 0 (Serum Amyloid A Protein); 126547-89-5 (Intercellular Adhesion Molecule-1) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170917 [Lr] Data última revisão: 170917 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170815 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pntd.0005746

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[PMID]: 28796786 [Au] Autor: Moriconi M; Rugna G; Calzolari M; Bellini R; Albieri A; Angelini P; Cagarelli R; Landini MP; Charrel RN; Varani S [Ad] Endereço: Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. [Ti] Título: Phlebotomine sand fly-borne pathogens in the Mediterranean Basin: Human leishmaniasis and phlebovirus infections. [So] Source: PLoS Negl Trop Dis;11(8):e0005660, 2017 Aug. [Is] ISSN: 1935-2735 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Pathogens transmitted to humans by phlebotomine sand flies are neglected, as they cause infectious diseases that are not on the priority list of national and international public health systems. However, the infections caused by protozoa of the Leishmania genus and viruses belonging to the Phlebovirus genus (family Phenuiviridae)-the most significant group of viruses transmitted by sand flies-have a relevant role for human pathology. These infections are emerging in the Mediterranean region and will likely spread in forthcoming decades, posing a complex threat to human health. Four species and 2 hybrid strains of Leishmania are pathogenic for humans in the Mediterranean Basin, with an estimated annual incidence of 239,500-393,600 cases of cutaneous leishmaniasis and 1,200-2,000 cases of visceral leishmaniasis. Among the phleboviruses, Toscana virus can cause neuroinvasive infections, while other phleboviruses are responsible for a typical "3-day fever"; the actual incidence of Phlebovirus infections in the Mediterranean area is unknown, although at least 250 million people are exposed. Here, we reviewed the current literature on epidemiology of sand fly-borne infections in the Mediterranean Basin, with a focus on humans. Our analysis indicates the need for increased public health activities directed to determine the disease burden of these infections as well as to improve their surveillance. Among the emerging challenges concerning sand fly-borne pathogens, the relationships between sand fly-borne protozoa and viruses should be considered in future studies, including epidemiological links between Leishmania and phleboviruses as well as the conditional capacity for these pathogens to be involved in interactions that may evolve towards increased virulence. [Mh] Termos MeSH primário: Infecções por Bunyaviridae/epidemiologia Leishmaniose/epidemiologia Psychodidae/parasitologia Psychodidae/virologia [Mh] Termos MeSH secundário: Animais Cães Seres Humanos Insetos Vetores/parasitologia Insetos Vetores/virologia Leishmania Região do Mediterrâneo/epidemiologia Phlebovirus/classificação [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170827 [Lr] Data última revisão: 170827 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170811 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pntd.0005660

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