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  1 / 1120 MEDLINE  
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[PMID]:28446680
[Au] Autor:Drappier M; Opperdoes FR; Michiels T
[Ad] Endereço:Université Catholique de Louvain, de Duve Institute, Brussels, Belgium.
[Ti] Título:Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus.
[So] Source:J Virol;91(14), 2017 Jul 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vilyuisk human encephalitis virus (VHEV) is a picornavirus related to Theiler's murine encephalomyelitis virus (TMEV). VHEV was isolated from human material passaged in mice. Whether this VHEV is of human or mouse origin is therefore unclear. We took advantage of the species-specific activity of the nonstructural L* protein of theiloviruses to track the origin of TMEV isolates. TMEV L* inhibits RNase L, the effector enzyme of the interferon pathway. By using coimmunoprecipitation and functional RNase L assays, the species specificity of RNase L antagonism was tested for L* from mouse (DA) and rat (RTV-1) TMEV strains as well as for VHEV. Coimmunoprecipitation and functional assay data confirmed the species specificity of L* activity and showed that L* from rat strain RTV-1 inhibited rat but not mouse or human RNase L. Next, we showed that the VHEV L* protein was phylogenetically related to L* of mouse viruses and that it failed to inhibit human RNase L but readily antagonized mouse RNase L, unambiguously showing the mouse origin of VHEV. Defining the natural host of a virus can be a thorny issue, especially when the virus was isolated only once or when the isolation story is complex. The species includes Theiler's murine encephalomyelitis virus (TMEV), infecting mice and rats, and Saffold virus (SAFV), infecting humans. One TMEV strain, Vilyuisk human encephalitis virus (VHEV), however, was isolated from mice that were inoculated with cerebrospinal fluid of a patient presenting with chronic encephalitis. It is therefore unclear whether VHEV was derived from the human sample or from the inoculated mouse. The L* protein encoded by TMEV inhibits RNase L, a cellular enzyme involved in innate immunity, in a species-specific manner. Using binding and functional assays, we show that this species specificity even allows discrimination between TMEV strains of mouse and of rat origins. The VHEV L* protein clearly inhibited mouse but not human RNase L, indicating that this virus originates from mice.
[Mh] Termos MeSH primário: Vírus da Encefalite/genética
Vírus da Encefalite/fisiologia
Endorribonucleases/antagonistas & inibidores
Picornaviridae/genética
Picornaviridae/fisiologia
Especificidade da Espécie
Proteínas não Estruturais Virais/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Nonstructural Proteins); EC 3.1.- (Endoribonucleases); EC 3.1.26.- (2-5A-dependent ribonuclease)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  2 / 1120 MEDLINE  
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[PMID]:27564679
[Au] Autor:Diaz LA; Quaglia AI; Konigheim BS; Boris AS; Aguilar JJ; Komar N; Contigiani MS
[Ad] Endereço:Laboratorio de Arbovirus-Instituto de Virología "Dr. J. M. Vanella"-Facultad de Ciencias Médicas-Universidad Nacional de Córdoba, Córdoba, Argentina.
[Ti] Título:Activity Patterns of St. Louis Encephalitis and West Nile Viruses in Free Ranging Birds during a Human Encephalitis Outbreak in Argentina.
[So] Source:PLoS One;11(8):e0161871, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:St. Louis encephalitis virus (SLEV) (Flavivirus) is a reemerging arbovirus in the southern cone of South America. In 2005, an outbreak of SLEV in central Argentina resulted in 47 human cases with 9 deaths. In Argentina, the ecology of SLEV is poorly understood. Because certain birds are the primary amplifiers in North America, we hypothesized that birds amplify SLEV in Argentina as well. We compared avian SLEV seroprevalence in a variety of ecosystems in and around Córdoba city from 2004 (before the epidemic) and 2005 (during the epidemic). We also explored spatial patterns to better understand the local ecology of SLEV transmission. Because West Nile virus (WNV) was also detected in Argentina in 2005, all analyses were also conducted for WNV. A total of 980 birds were sampled for detection of SLEV and WNV neutralizing antibodies. SLEV seroprevalence in birds increased 11-fold from 2004 to 2005. Our study demonstrated that a high proportion (99.3%) of local birds were susceptible to SLEV infection immediately prior to the 2005 outbreak, indicating that the vertebrate host population was primed to amplify SLEV. SLEV was found distributed in a variety of environments throughout the city of Córdoba. However, the force of viral transmission varied among sites. Fine scale differences in populations of vectors and vertebrate hosts would explain this variation. In summary, we showed that in 2005, both SLEV and to a lesser extent WNV circulated in the avian population. Eared Dove, Picui Ground-Dove and Great Kiskadee are strong candidates to amplify SLEV because of their exposure to the pathogen at the population level, and their widespread abundance. For the same reasons, Rufous Hornero may be an important maintenance host for WNV in central Argentina. Competence studies and vector feeding studies are needed to confirm these relationships.
[Mh] Termos MeSH primário: Doenças das Aves/epidemiologia
Doenças das Aves/virologia
Aves/virologia
Vírus da Encefalite/patogenicidade
Encefalite de St. Louis/epidemiologia
Encefalite de St. Louis/virologia
Febre do Nilo Ocidental/epidemiologia
Vírus do Nilo Ocidental/patogenicidade
[Mh] Termos MeSH secundário: Animais
Argentina/epidemiologia
Surtos de Doenças
Vírus da Encefalite de St. Louis
Seres Humanos
Estudos Soroepidemiológicos
Febre do Nilo Ocidental/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161871


  3 / 1120 MEDLINE  
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[PMID]:27256022
[Au] Autor:Wang Y; Ostlund EN; Jun Y; Nie FP; Li YG; Johnson DJ; Lin R; Li ZG
[Ad] Endereço:School of Life Sciences, Chongqing University, Chongqing 400030, China; Technical Center of Chongqing Entry Inspection and Quarantine Bureau, Engineering Research Center for Import and Export Food Safety, Chongqing 400020, China.
[Ti] Título:Combining reverse-transcription multiplex PCR and microfluidic electrophoresis to simultaneously detect seven mosquito-transmitted zoonotic encephalomyelitis viruses.
[So] Source:Vet J;212:27-35, 2016 Jun.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several mosquito-transmitted viruses are causative agents for zoonotic encephalomyelitis. Rapid identification of these viruses in mosquito populations is an effective method for surveying these diseases. To detect multiple mosquito-transmitted viral agents, including West Nile virus, Saint Louis encephalitis virus, Venezuelan equine encephalomyelitis virus, Western equine encephalomyelitis virus, Eastern equine encephalomyelitis virus, Highlands J virus and Japanese encephalitis virus, an assay using multiplex reverse-transcription PCR combined with microfluidic electrophoresis was developed and evaluated. Tailed nested primers were used in the assay to amplify specific viral genomic segments, and products with specific length were further analyzed by using a microfluidic electrophoresis chip. The assay exhibited good specificity and analytical sensitivity (10(2) copies/µL). This technology can be helpful in the quarantine and surveillance of exotic encephalomyelitis viruses which are transmitted by mosquitoes.
[Mh] Termos MeSH primário: Culicidae/virologia
Eletroforese em Microchip/veterinária
Vírus da Encefalite/isolamento & purificação
Monitoramento Epidemiológico/veterinária
Reação em Cadeia da Polimerase Multiplex/veterinária
Reação em Cadeia da Polimerase Via Transcriptase Reversa/veterinária
[Mh] Termos MeSH secundário: Animais
Análise de Sequência de RNA/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE


  4 / 1120 MEDLINE  
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[PMID]:26160487
[Au] Autor:Sawleshwarkar S; Dwyer DE
[Ad] Endereço:Western Sydney Sexual Health Centre, University of Sydney, Parramatta, NSW, 2150, Australia shailendra.sawleshwarkar@sydney.edu.au.
[Ti] Título:Antivirals for herpes simplex viruses.
[So] Source:BMJ;351:h3350, 2015 Jul 09.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Antivirais/administração & dosagem
Vírus da Encefalite/efeitos dos fármacos
Herpes Simples/tratamento farmacológico
Simplexvirus/efeitos dos fármacos
Eliminação de Partículas Virais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Análise Custo-Benefício
Esquema de Medicação
Herpes Simples/transmissão
Seres Humanos
Hospedeiro Imunocomprometido
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150710
[Lr] Data última revisão:
150710
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150711
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.h3350


  5 / 1120 MEDLINE  
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[PMID]:25290724
[Au] Autor:Lee KY; Yeh HR
[Ad] Endereço:Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
[Ti] Título:Continuous myocloni and tonic spasms in a 2-month-old infant with enterovirus 71 brain stem encephalitis.
[So] Source:Neuropediatrics;46(1):52-5, 2015 Feb.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Brain stem encephalitis is a cardinal presentation of central nervous system involvement in enterovirus 71 infection, and manifests as myoclonus, ataxia, tremor, and autonomic dysfunction. A 2-month-old infant with enterovirus 71 brain stem encephalitis demonstrated continuous myocloni and tonic spasms. On admission, the patient's myoclonus, which mainly involved the shoulders and the arms, was considerably worse during wakefulness and occurred once or twice a minute. Several hours after admission, the myoclonic jerks steadily worsened, appeared ceaselessly every 1 to 2 seconds, and were intermixed with tonic spasms of all four extremities accompanied by crying. Video electroencephalography revealed a normal background without epileptiform discharges and no ictal electroencephalographic changes during the myoclonic jerks and tonic spasms. Complete remission was achieved without complications after completion of a 3-day immunoglobulin therapy. This case suggests that the brain stem may be a major origin site for not only myoclonus but also tonic spasm.
[Mh] Termos MeSH primário: Tronco Encefálico/virologia
Vírus da Encefalite/patogenicidade
Encefalite por Arbovirus/complicações
Encefalite por Arbovirus/patologia
Mioclonia/complicações
Espasmos Infantis/complicações
[Mh] Termos MeSH secundário: Tronco Encefálico/patologia
Eletroencefalografia
Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150120
[Lr] Data última revisão:
150120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141008
[St] Status:MEDLINE
[do] DOI:10.1055/s-0034-1389896


  6 / 1120 MEDLINE  
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[PMID]:25015510
[Au] Autor:Abdullah S; Tan CT
[Ad] Endereço:Division of Neurology, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Henipavirus encephalitis.
[So] Source:Handb Clin Neurol;123:663-70, 2014.
[Is] ISSN:0072-9752
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Vírus da Encefalite/patogenicidade
Infecções por Henipavirus
[Mh] Termos MeSH secundário: Encéfalo/patologia
Encéfalo/virologia
Infecções por Henipavirus/epidemiologia
Infecções por Henipavirus/patologia
Infecções por Henipavirus/terapia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140712
[Lr] Data última revisão:
140712
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140713
[St] Status:MEDLINE


  7 / 1120 MEDLINE  
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[PMID]:24349254
[Au] Autor:Raveh A; Delekta PC; Dobry CJ; Peng W; Schultz PJ; Blakely PK; Tai AW; Matainaho T; Irani DN; Sherman DH; Miller DJ
[Ad] Endereço:Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.
[Ti] Título:Discovery of potent broad spectrum antivirals derived from marine actinobacteria.
[So] Source:PLoS One;8(12):e82318, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural products provide a vast array of chemical structures to explore in the discovery of new medicines. Although secondary metabolites produced by microbes have been developed to treat a variety of diseases, including bacterial and fungal infections, to date there has been limited investigation of natural products with antiviral activity. In this report, we used a phenotypic cell-based replicon assay coupled with an iterative biochemical fractionation process to identify, purify, and characterize antiviral compounds produced by marine microbes. We isolated a compound from Streptomyces kaviengensis, a novel actinomycetes isolated from marine sediments obtained off the coast of New Ireland, Papua New Guinea, which we identified as antimycin A1a. This compound displays potent activity against western equine encephalitis virus in cultured cells with half-maximal inhibitory concentrations of less than 4 nM and a selectivity index of greater than 550. Our efforts also revealed that several antimycin A analogues display antiviral activity, and mechanism of action studies confirmed that these Streptomyces-derived secondary metabolites function by inhibiting the cellular mitochondrial electron transport chain, thereby suppressing de novo pyrimidine synthesis. Furthermore, we found that antimycin A functions as a broad spectrum agent with activity against a wide range of RNA viruses in cultured cells, including members of the Togaviridae, Flaviviridae, Bunyaviridae, Picornaviridae, and Paramyxoviridae families. Finally, we demonstrate that antimycin A reduces central nervous system viral titers, improves clinical disease severity, and enhances survival in mice given a lethal challenge with western equine encephalitis virus. Our results provide conclusive validation for using natural product resources derived from marine microbes as source material for antiviral drug discovery, and they indicate that host mitochondrial electron transport is a viable target for the continued development of broadly active antiviral compounds.
[Mh] Termos MeSH primário: Actinobacteria/química
Antivirais/farmacologia
Sedimentos Geológicos/microbiologia
[Mh] Termos MeSH secundário: Animais
Antimicina A/química
Antimicina A/farmacologia
Antimicina A/uso terapêutico
Antivirais/química
Antivirais/isolamento & purificação
Produtos Biológicos/química
Produtos Biológicos/isolamento & purificação
Produtos Biológicos/farmacologia
Linhagem Celular
Sistema Nervoso Central/efeitos dos fármacos
Sistema Nervoso Central/patologia
Sistema Nervoso Central/virologia
Fracionamento Químico
Transporte de Elétrons/efeitos dos fármacos
Vírus da Encefalite/efeitos dos fármacos
Encefalite por Arbovirus/tratamento farmacológico
Encefalite por Arbovirus/patologia
Encefalite por Arbovirus/virologia
Ensaios de Triagem em Larga Escala
Seres Humanos
Camundongos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
RNA Viral/metabolismo
Padrões de Referência
Reprodutibilidade dos Testes
Streptomyces/química
Análise de Sobrevida
Transcrição Genética/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Biological Products); 0 (RNA, Viral); 642-15-9 (Antimycin A)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0082318


  8 / 1120 MEDLINE  
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[PMID]:23894573
[Au] Autor:Durand B; Lecollinet S; Beck C; Martínez-López B; Balenghien T; Chevalier V
[Ad] Endereço:Anses, Laboratoire de Santé Animale, Maisons-Alfort, France. benoit.durand@anses.fr
[Ti] Título:Identification of hotspots in the European union for the introduction of four zoonotic arboviroses by live animal trade.
[So] Source:PLoS One;8(7):e70000, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Live animal trade is considered a major mode of introduction of viruses from enzootic foci into disease-free areas. Due to societal and behavioural changes, some wild animal species may nowadays be considered as pet species. The species diversity of animals involved in international trade is thus increasing. This could benefit pathogens that have a broad host range such as arboviruses. The objective of this study was to analyze the risk posed by live animal imports for the introduction, in the European Union (EU), of four arboviruses that affect human and horses: Eastern and Western equine encephalomyelitis, Venezuelan equine encephalitis and Japanese encephalitis. Importation data for a five-years period (2005-2009, extracted from the EU TRACES database), environmental data (used as a proxy for the presence of vectors) and horses and human population density data (impacting the occurrence of clinical cases) were combined to derive spatially explicit risk indicators for virus introduction and for the potential consequences of such introductions. Results showed the existence of hotspots where the introduction risk was the highest in Belgium, in the Netherlands and in the north of Italy. This risk was higher for Eastern equine encephalomyelitis (EEE) than for the three other diseases. It was mainly attributed to exotic pet species such as rodents, reptiles or cage birds, imported in small-sized containments from a wide variety of geographic origins. The increasing species and origin diversity of these animals may have in the future a strong impact on the risk of introduction of arboviruses in the EU.
[Mh] Termos MeSH primário: Animais Selvagens/virologia
Comércio
Vírus da Encefalite/isolamento & purificação
Encefalite por Arbovirus/veterinária
Doenças dos Cavalos/epidemiologia
Espécies Introduzidas
Animais de Estimação/virologia
Zoonoses/epidemiologia
[Mh] Termos MeSH secundário: Animais
Encefalite por Arbovirus/epidemiologia
Encefalite por Arbovirus/virologia
Europa (Continente)/epidemiologia
União Europeia
Doenças dos Cavalos/virologia
Cavalos
Seres Humanos
Fatores de Risco
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1403
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130730
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0070000


  9 / 1120 MEDLINE  
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[PMID]:22416351
[Au] Autor:He B; Wang HY; Zhang C; Wang M; Qin M; Wang KX; Ma XJ
[Ad] Endereço:School of Medicine, AnHui University of Science and Technology, Huainan 232001 China.
[Ti] Título:[Development of a GeXP based multiplex RT-PCR assay for simultaneous detection of eight arboviruses related to encephalitis].
[So] Source:Bing Du Xue Bao;28(1):57-62, 2012 Jan.
[Is] ISSN:1000-8721
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Multiplex reverse transcription-polymerase chain reaction (mRT-PCR) is currently available in virus detection and defined as the simultaneous amplification of two or more DNA/RNA targets in a single reaction vessel. In this study, we attempted to modify the conventional mRT-PCR technique on a basis of GenomeLab Genetic Analysis System (GeXP). Initially, we optimized the analytical validation of the GeXP analyzer and its design of workflow and simultaneously detected eight arboviruses that related to epidemic encephalitis by verifying the specificity of mRT-PCR with Japanese encephalitis virus(JEV) cell cultures and positive strains identified previously and determining the sensitivity with in vitro-transcribed RNA of serial dilutions. The GeXP system after optimization could amplify the specific fragments related to the viruses and exposed specifically a total of 13 target genes out of eight types of arboviruses at the level of 10(2) copies/microL, and the findings suggest that the novel protocol we developed can be high-throughput and highly specific and sensitive as well as quickness in screening of the encephalitis viruses, and is promising in detection of encephalitis-associated viruses for molecular epidemiological studies.
[Mh] Termos MeSH primário: Arbovirus/isolamento & purificação
Vírus da Encefalite Japonesa (Espécie)/genética
Vírus da Encefalite/isolamento & purificação
Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos
[Mh] Termos MeSH secundário: Arbovirus/genética
Vírus da Encefalite/genética
Sensibilidade e Especificidade
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1204
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120316
[St] Status:MEDLINE


  10 / 1120 MEDLINE  
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[PMID]:21441007
[Au] Autor:Arakawa C; Endo A; Kohira R; Fujita Y; Fuchigami T; Mugishima H; Ohtake A; Murayama K; Mori M; Miyata R; Hatai Y
[Ad] Endereço:Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan. chi-ka@sage.ocn.ne.jp
[Ti] Título:Liver-specific mitochondrial respiratory chain complex I deficiency in fatal influenza encephalopathy.
[So] Source:Brain Dev;34(2):115-7, 2012 Feb.
[Is] ISSN:1872-7131
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report on a 4-year-old boy who died from influenza encephalopathy. The clinical course and microscopic findings of the autopsied liver were compatible with Reye's syndrome. We examined the mitochondrial respiratory chain function by blue native polyacrylamide gel electrophoresis (BN-PAGE), western blotting, and respiratory chain enzyme activity assays. The activity of liver respiratory chain complex (CO) I was markedly decreased (7.2% of the respective control activity); whereas, the other respiratory chain complex activities were substantially normal (CO II, 57.9%; CO III, 122.3%; CO IV, 161.0%). The activities of CO I-IV in fibroblasts were normal (CO I, 82.0%; CO II, 83.1%; CO III, 72.9%; CO IV, 97.3%). The patient was diagnosed with liver-specific complex I deficiency. This inborn disorder may have contributed to the fatal outcome. We propose that relying only on fibroblast respiratory chain complex activities may lead to the misdiagnosis of liver-specific complex I deficiency.
[Mh] Termos MeSH primário: Complexo IV da Cadeia de Transporte de Elétrons/metabolismo
Vírus da Encefalite/patogenicidade
Influenza Humana/complicações
Fígado/enzimologia
Doenças Mitocondriais
[Mh] Termos MeSH secundário: Pré-Escolar
Complexo I de Transporte de Elétrons/deficiência
Complexo I de Transporte de Elétrons/metabolismo
Seres Humanos
Masculino
Doenças Mitocondriais/complicações
Doenças Mitocondriais/metabolismo
Doenças Mitocondriais/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.6.5.3 (Electron Transport Complex I); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:120113
[Lr] Data última revisão:
120113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110329
[St] Status:MEDLINE
[do] DOI:10.1016/j.braindev.2011.03.002



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