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[PMID]:28452107
[Au] Autor:Hartmann CA; Vikram HR; Seville MT; Orenstein R; Kusne S; Blair JE; Grys TE; Patron RL
[Ad] Endereço:Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ.
[Ti] Título:Neuroinvasive St. Louis Encephalitis Virus Infection in Solid Organ Transplant Recipients.
[So] Source:Am J Transplant;17(8):2200-2206, 2017 Aug.
[Is] ISSN:1600-6143
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In summer 2015, three unrelated solid organ transplant recipients in Phoenix, Arizona, had meningoencephalitis suggestive of West Nile virus (WNV) infection. Testing was inconclusive but was later confirmed as St. Louis encephalitis (SLE). We retrospectively reviewed clinical manifestations, treatment, and outcomes of these transplant recipients. Common symptoms were fever, rigors, diarrhea, headache, and confusion. One patient died 3 days after hospitalization. Therapy for the other two patients was initiated with interferon α-2b (IFN) and intravenous IgG (IVIG; IFN plus IVIG in combination). Both patients tested positive for WNV by serologic assay, but SLE virus (SLEV) infection was later confirmed by plaque reduction neutralization test at a reference laboratory. Clinical improvement was observed within 72 h after initiation of IFN plus IVIG. SLEV has been an uncommon cause of neuroinvasive disease in the United States. Accurate, timely diagnosis is hindered because of clinical presentation similar to neuroinvasive WNV and SLE, serologic cross-reactivity, and lack of a commercially available serologic assay for SLEV. There is currently no approved therapy for flaviviral neuroinvasive disease. Anecdotal reports indicate varying success with IFN, IVIG, or IFN plus IVIG in WNV neuroinvasive disease. The same regimen might be of value for immunocompromised persons with neuroinvasive SLEV infection.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Surtos de Doenças
Vírus da Encefalite de St. Louis/efeitos dos fármacos
Encefalite de St. Louis/epidemiologia
Sobrevivência de Enxerto/efeitos dos fármacos
Transplante de Órgãos
[Mh] Termos MeSH secundário: Idoso
Anticorpos Antivirais/sangue
Encefalite de St. Louis/tratamento farmacológico
Encefalite de St. Louis/virologia
Seguimentos
Seres Humanos
Imunoglobulinas Intravenosas/administração & dosagem
Interferon-alfa/uso terapêutico
Masculino
Meia-Idade
Prevalência
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Transplantados
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antiviral Agents); 0 (Immunoglobulins, Intravenous); 0 (Interferon-alpha)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/ajt.14336


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[PMID]:28330482
[Au] Autor:Marques RE; Del Sarto JL; Rocha RP; Gomes GF; Cramer A; Rachid MA; Souza DG; Nogueira ML; Teixeira MM
[Ad] Endereço:Immunopharmacology, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. rafael.marques@lnbio.cnpem.br.
[Ti] Título:Development of a model of Saint Louis encephalitis infection and disease in mice.
[So] Source:J Neuroinflammation;14(1):61, 2017 Mar 22.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Flaviviruses are a genre of closely related viral pathogens which emerged in the last decades in Brazil and in the world. Saint (St.) Louis encephalitis virus (SLEV) is a neglected flavivirus that can cause a severe neurological disease that may lead to death or sequelae. St. Louis encephalitis pathogenesis is poorly understood, which hinders the development of specific treatment or vaccine. METHODS: To address this problem, we developed a model of SLEV infection in mice to study mechanisms involved in the pathogenesis of severe disease. The model consists in the intracranial inoculation of the SLEV strain BeH 355964, a strain isolated from a symptomatic human patient in Brazil, in adult immunocompetent mice. RESULTS: Inoculated mice presented SLEV replication in the brain, accompanied by tissue damage, disease signs, and mortality approximately 7 days post infection. Infection was characterized by the production of proinflammatory cytokines and interferons and by leukocyte recruitment to the brain, composed mainly by neutrophils and lymphocytes. In vitro experiments indicated that SLEV is able to replicate in both neurons and glia and caused neuronal death and cytokine production, respectively. CONCLUSIONS: Altogether, intracranial SLEV infection leads to meningoencephalitis in mice, recapitulating several aspects of St. Louis encephalitis in humans. Our study indicates that the central nervous system (CNS) inflammation is a major component of SLEV-induced disease. This model may be useful to identify mechanisms of disease pathogenesis or resistance to SLEV infection.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Modelos Animais de Doenças
Vírus da Encefalite de St. Louis/fisiologia
Encefalite de St. Louis/patologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Linhagem Celular Transformada
Encefalite de St. Louis/virologia
Peroxidase de Eosinófilo/metabolismo
Hexosaminidases/metabolismo
Leucócitos/metabolismo
Leucócitos/virologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Peroxidase/metabolismo
Fatores de Tempo
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); EC 1.11.1.- (Eosinophil Peroxidase); EC 1.11.1.7 (Peroxidase); EC 3.2.1.- (Hexosaminidases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0837-2


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[PMID]:28284278
[Au] Autor:Griesemer SB; Kramer LD; Van Slyke GA; Pata JD; Gohara DW; Cameron CE; Ciota AT
[Ad] Endereço:1​The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY, USA.
[Ti] Título:Mutagen resistance and mutation restriction of St. Louis encephalitis virus.
[So] Source:J Gen Virol;98(2):201-211, 2017 Feb.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The error rate of the RNA-dependent RNA polymerase (RdRp) of RNA viruses is important in maintaining genetic diversity for viral adaptation and fitness. Numerous studies have shown that mutagen-resistant RNA virus variants display amino acid mutations in the RdRp and other replicase subunits, which in turn exhibit an altered fidelity phenotype affecting viral fitness, adaptability and pathogenicity. St. Louis encephalitis virus (SLEV), like its close relative West Nile virus, is a mosquito-borne flavivirus that has the ability to cause neuroinvasive disease in humans. Here, we describe the successful generation of multiple ribavirin-resistant populations containing a shared amino acid mutation in the SLEV RdRp (E416K). These E416K mutants also displayed resistance to the antiviral T-1106, an RNA mutagen similar to ribavirin. Structural modelling of the E416K polymerase mutation indicated its location in the pinky finger domain of the RdRp, distant from the active site. Deep sequencing of the E416K mutant revealed lower genetic diversity than wild-type SLEV after growth in both vertebrate and invertebrate cells. Phenotypic characterization showed that E416K mutants displayed similar or increased replication in mammalian cells, as well as modest attenuation in mosquito cells, consistent with previous work with West Nile virus high-fidelity variants. In addition, attenuation was limited to mosquito cells with a functional RNA interference response, suggesting an impaired capacity to escape RNA interference could contribute to attenuation of high-fidelity variants. Our results provide increased evidence that RNA mutagen resistance arises through modulation of the RdRp and give further insight into the consequences of altered fidelity of flaviviruses.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Farmacorresistência Viral/genética
Vírus da Encefalite de St. Louis/efeitos dos fármacos
Vírus da Encefalite de St. Louis/genética
Encefalite de St. Louis/virologia
Mutagênicos/farmacologia
RNA Replicase/genética
Ribavirina/farmacologia
Proteínas não Estruturais Virais/genética
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Vírus da Encefalite de St. Louis/enzimologia
Ácido Glutâmico/genética
Células HeLa
Seres Humanos
Lisina/genética
Modelos Moleculares
Mutação
Nucleosídeos/farmacologia
Domínios Proteicos
Pirazinas/farmacologia
RNA Replicase/química
Proteínas não Estruturais Virais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Mutagens); 0 (NS5 protein, flavivirus); 0 (Nucleosides); 0 (Pyrazines); 0 (T 1106); 0 (Viral Nonstructural Proteins); 3KX376GY7L (Glutamic Acid); 49717AWG6K (Ribavirin); EC 2.7.7.48 (RNA Replicase); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000682


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[PMID]:28279829
[Au] Autor:Rivarola ME; Albrieu-Llinás G; Pisano MB; Tauro LB; Gorosito-Serrán M; Beccaria CG; Díaz LA; Vázquez A; Quaglia A; López C; Spinsanti L; Gruppi A; Contigiani MS
[Ad] Endereço:Laboratorio de Arbovirus, Instituto de Virología ''Dr. J. M. Vanella'', Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez S/N. CP, 5016, Ciudad Universitaria, Córdoba, Argentina; Instituto de Investigaciones Biológicas y Tecnológicas, CONICET-Universidad Naciona
[Ti] Título:Tissue tropism of Saint Louis encephalitis virus: Histopathology triggered by epidemic and non-epidemic strains isolated in Argentina.
[So] Source:Virology;505:181-192, 2017 May.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Saint Louis encephalitis virus (SLEV) reemerged in South America, and caused encephalitis outbreaks at the beginning of the 21st century. To enhance our knowledge about SLEV virulence, we performed comparative pathogenesis studies in Swiss albino mice inoculated with two different variants, the epidemic strain CbaAr-4005 and the non-epidemic strain CorAn-9275. Only the infection of mice with SLEV strain CbaAr-4005 resulted in high viremia, invasion of peripheral tissues including the lungs, kidney, and spleen, and viral neuroinvasion. This was associated with inflammatory pathology in the lungs, spleen, and brain as well as morbidity and mortality. In contrast, neither signs of desease nor viral replication were observed in mice infected with strain CorAn-9275. Interestingly, important loss of B cells and development of altered germinal centers (GC) were detected in the spleen of mice infected with strain CbaAr-4005, whereas mice infected with SLEV CorAn-9275 developed prominent GC with conserved follicular architecture, and neutralizing antibodies.
[Mh] Termos MeSH primário: Encéfalo/virologia
Vírus da Encefalite de St. Louis/patogenicidade
Encefalite de St. Louis/epidemiologia
Rim/virologia
Pulmão/virologia
Baço/virologia
Tropismo Viral/fisiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Argentina/epidemiologia
Linfócitos B/citologia
Vírus da Encefalite de St. Louis/classificação
Vírus da Encefalite de St. Louis/isolamento & purificação
Encefalite de St. Louis/mortalidade
Encefalite de St. Louis/virologia
Contagem de Linfócitos
Camundongos
Carga Viral
Viremia/virologia
Replicação Viral/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


  5 / 373 MEDLINE  
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Teixeira, Mauro Martins
Texto completo
[PMID]:28068627
[Au] Autor:Pacca CC; Marques RE; Espindola JWP; Filho GBOO; Leite ACL; Teixeira MM; Nogueira ML
[Ad] Endereço:Laboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitarias, Faculdade de Medicina de São José do Rio Preto - FAMERP, 15090-000, São José do Rio Preto, SP, Brazil; Faceres Medical School, 15090-305, São José do Rio Preto, SP, Brazil.
[Ti] Título:Thiosemicarbazones and Phthalyl-Thiazoles compounds exert antiviral activity against yellow fever virus and Saint Louis encephalitis virus.
[So] Source:Biomed Pharmacother;87:381-387, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Arboviruses, arthropod-borneviruses, are frequency associated to human outbreak and represent a serious health problem. The genus Flavivirus, such as Yellow Fever Virus (YFV) and Saint Louis Encephalitis Virus (SLEV), are important pathogens with high morbidity and mortality worldwide. In Brazil, YFV is maintained in sylvatic cycle, but many cases are notified annually, despite the efficiency of vaccine. SLEV causes an acute encephalitis and is widely distributed in the Americas. There is no specific antiviral drugs for these viruses, only supporting treatment that can alleviate symptoms and prevent complications. Here, we evaluated the potential anti-YFV and SLEV activity of a series of thiosemicarbazones and phthalyl-thiazoles. Plaque reduction assay, flow cytometry, immunofluorescence and cellular viability were used to test the compounds in vitro. Treated cells showed efficient inhibition of the viral replication at concentrations that presented minimal toxicity to cells. The assays showed that phthalyl-thiazole and phenoxymethyl-thiosemicarbazone reduced 60% of YFV replication and 75% of SLEV replication.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Vírus da Encefalite de St. Louis/efeitos dos fármacos
Tiazóis/farmacologia
Tiossemicarbazonas/farmacologia
Vírus da Febre Amarela/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Brasil
Linhagem Celular
Cercopithecus aethiops
Células Vero
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Thiazoles); 0 (Thiosemicarbazones)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170710
[Lr] Data última revisão:
170710
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


  6 / 373 MEDLINE  
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[PMID]:27918946
[Au] Autor:AlShebly MM; AlQahtani FS; Govindarajan M; Gopinath K; Vijayan P; Benelli G
[Ad] Endereço:Department of Obstetrics and Gynecology, College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia.
[Ti] Título:Toxicity of ar-curcumene and epi-ß-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors.
[So] Source:Ecotoxicol Environ Saf;137:149-157, 2017 Mar.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mosquitoes act as vectors of key pathogens and parasites. Plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms. In this research, we evaluated the larvicidal and oviposition deterrence activity of Hedychium larsenii essential oil (EO) and its major compounds ar-curcumene and epi-ß-bisabolol. Both molecules showed high toxicity against early third instars of Anopheles stephensi (LC =10.45 and 14.68µg/ml), Aedes aegypti (LC =11.24 and 15.83µg/ml) and Culex quinquefasciatus (LC =12.24 and 17.27µg/ml). In addition, low doses of ar-curcumene and epi-ß-bisabolol were effective as oviposition deterrents against the three tested mosquito species. Notably, the acute toxicity of H. larsenii oil and its major compounds against the mosquito biocontrol agent Poecilia reticulata was low, with LC higher than 1500ppm. Overall, the results from this study revealed that ar-curcumene and epi-ß-bisabolol from the H. larsenii oil can be considered for the development of novel and effective mosquito larvicides.
[Mh] Termos MeSH primário: Inseticidas/química
Mosquitos Vetores/crescimento & desenvolvimento
Óleos Voláteis/farmacologia
Sesquiterpenos/farmacologia
Zingiberaceae/química
[Mh] Termos MeSH secundário: Aedes/crescimento & desenvolvimento
Aedes/parasitologia
Aedes/virologia
Animais
Anopheles/crescimento & desenvolvimento
Anopheles/parasitologia
Anopheles/virologia
Culex/crescimento & desenvolvimento
Culex/parasitologia
Culex/virologia
Relação Dose-Resposta a Droga
Vírus da Encefalite de St. Louis
Larva
Dose Letal Mediana
Mosquitos Vetores/parasitologia
Mosquitos Vetores/virologia
Oviposição
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 24WE03BX2T (bisabolol); 644-30-4 (alpha-curcumene)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27564679
[Au] Autor:Diaz LA; Quaglia AI; Konigheim BS; Boris AS; Aguilar JJ; Komar N; Contigiani MS
[Ad] Endereço:Laboratorio de Arbovirus-Instituto de Virología "Dr. J. M. Vanella"-Facultad de Ciencias Médicas-Universidad Nacional de Córdoba, Córdoba, Argentina.
[Ti] Título:Activity Patterns of St. Louis Encephalitis and West Nile Viruses in Free Ranging Birds during a Human Encephalitis Outbreak in Argentina.
[So] Source:PLoS One;11(8):e0161871, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:St. Louis encephalitis virus (SLEV) (Flavivirus) is a reemerging arbovirus in the southern cone of South America. In 2005, an outbreak of SLEV in central Argentina resulted in 47 human cases with 9 deaths. In Argentina, the ecology of SLEV is poorly understood. Because certain birds are the primary amplifiers in North America, we hypothesized that birds amplify SLEV in Argentina as well. We compared avian SLEV seroprevalence in a variety of ecosystems in and around Córdoba city from 2004 (before the epidemic) and 2005 (during the epidemic). We also explored spatial patterns to better understand the local ecology of SLEV transmission. Because West Nile virus (WNV) was also detected in Argentina in 2005, all analyses were also conducted for WNV. A total of 980 birds were sampled for detection of SLEV and WNV neutralizing antibodies. SLEV seroprevalence in birds increased 11-fold from 2004 to 2005. Our study demonstrated that a high proportion (99.3%) of local birds were susceptible to SLEV infection immediately prior to the 2005 outbreak, indicating that the vertebrate host population was primed to amplify SLEV. SLEV was found distributed in a variety of environments throughout the city of Córdoba. However, the force of viral transmission varied among sites. Fine scale differences in populations of vectors and vertebrate hosts would explain this variation. In summary, we showed that in 2005, both SLEV and to a lesser extent WNV circulated in the avian population. Eared Dove, Picui Ground-Dove and Great Kiskadee are strong candidates to amplify SLEV because of their exposure to the pathogen at the population level, and their widespread abundance. For the same reasons, Rufous Hornero may be an important maintenance host for WNV in central Argentina. Competence studies and vector feeding studies are needed to confirm these relationships.
[Mh] Termos MeSH primário: Doenças das Aves/epidemiologia
Doenças das Aves/virologia
Aves/virologia
Vírus da Encefalite/patogenicidade
Encefalite de St. Louis/epidemiologia
Encefalite de St. Louis/virologia
Febre do Nilo Ocidental/epidemiologia
Vírus do Nilo Ocidental/patogenicidade
[Mh] Termos MeSH secundário: Animais
Argentina/epidemiologia
Surtos de Doenças
Vírus da Encefalite de St. Louis
Seres Humanos
Estudos Soroepidemiológicos
Febre do Nilo Ocidental/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161871


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[PMID]:27330092
[Au] Autor:Burkett-Cadena ND; Gibson J; Lauth M; Stenn T; Acevedo C; Xue RD; McNelly J; Northey E; Hassan HK; Fulcher A; Bingham AM; van Olphen J; van Olphen A; Unnasch TR
[Ad] Endereço:University of Florida IFAS, Florida Medical Entomology Laboratory, 200 9th St. SE, Vero Beach, FL 32962 (nburkettcadena@ufl.edu; tanise@ufl.edu; c.acevedo@ufl.edu) nburkettcadena@ufl.edu.
[Ti] Título:Evaluation of the Honey-Card Technique for Detection of Transmission of Arboviruses in Florida and Comparison With Sentinel Chicken Seroconversion.
[So] Source:J Med Entomol;53(6):1449-1457, 2016 11.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Zoonotic mosquito-borne viruses, such as the West Nile virus (WNV) and eastern equine encephalitis virus (EEEV), are major public health threats in the United States. Early detection of virus transmission and targeted vector management are critical to protect humans against these pathogens. Sentinel chickens and pool screening of mosquitoes, the most widely used methods of arbovirus early detection, have technical time-lags that compromise their early-detection value. The exploitation of sugar-feeding by trapped mosquitoes for arbovirus surveillance may represent a viable alternative to other methods. Here we compared effectiveness of sugar-impregnated nucleic-acid preserving substrates (SIPS) and sentinel chicken program for detecting WNV, EEEV, and St. Louis encephalitis virus in gravid traps, CO -baited light traps, and resting traps at 10 locations in two Florida counties. In St. Johns County, comparable numbers of EEEV detections were made by SIPS traps (18) and sentinel chickens (22), but fewer WNV detections were made using SIPS (1) than sentinel chickens (13). In Volusia County, seven arbovirus detections were made via the sentinel chicken program (one EEEV and six WNV), whereas only one arbovirus detection (WNV) was made using SIPS. CO -baited light traps captured >90% of total mosquitoes, yet yielded <30% of arbovirus detections. Resting traps and gravid traps captured a fraction of total mosquitoes, yet yielded roughly equivalent numbers of arbovirus detections, as did light traps. Challenges to successful deployment of SIPS include optimization of traps for collecting all vector species, increasing sugar-feeding rates of trapped vectors, and developing tractable methods for arbovirus detection.
[Mh] Termos MeSH primário: Arbovirus/isolamento & purificação
Galinhas
Culicidae/virologia
Mel
Vigilância de Evento Sentinela/veterinária
[Mh] Termos MeSH secundário: Animais
Arbovirus/classificação
Carboidratos
Vírus da Encefalite Equina do Leste/isolamento & purificação
Vírus da Encefalite de St. Louis/isolamento & purificação
Feminino
Florida
Mel/utilização
Reação em Cadeia da Polimerase
Soroconversão
Vírus do Nilo Ocidental/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbohydrates)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE


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[PMID]:27162269
[Au] Autor:Pedersen K; Marks DR; Wang E; Eastwood G; Weaver SC; Goldstein SM; Sinnett DR; DeLiberto TJ
[Ad] Endereço:U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, Fort Collins, Colorado. kerri.pedersen@aphis.usda.gov.
[Ti] Título:Widespread Detection of Antibodies to Eastern Equine Encephalitis, West Nile, St. Louis Encephalitis, and Turlock Viruses in Various Species of Wild Birds from Across the United States.
[So] Source:Am J Trop Med Hyg;95(1):206-11, 2016 Jul 06.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wild birds serve as amplifying hosts for many arboviruses, and are thought to be responsible for introducing these viruses into new areas during migration as well as reintroducing them to places where winter temperatures disrupt mosquito-borne transmission. To learn more about four mosquito-borne arboviruses of concern to human or animal health, we tested sera from 997 wild birds of 54 species and 17 families across 44 states of the United States collected from January 1, 2013, through September 30, 2013. Samples were tested for antibody against eastern equine encephalitis, St. Louis encephalitis, West Nile, and Turlock viruses using plaque reduction neutralization tests with an endpoint of 80% or greater. Of the 333 (33.4%) birds that tested positive for antibody to at least one arbovirus, 29.7% were exposed to two or more arboviruses. Exposure to all four arboviruses was detected in Canada geese, double-crested cormorants, mallards, mute swans, laughing gulls, and American coots. Our results suggest that exposure to arboviruses is widespread in the United States across a diversity of wild bird species.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Doenças das Aves/epidemiologia
Encefalite de St. Louis/epidemiologia
Encefalomielite Equina do Leste/epidemiologia
Orthobunyavirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Animais Selvagens/virologia
Doenças das Aves/virologia
Aves/virologia
Culicidae/virologia
Vírus da Encefalite Equina do Leste/isolamento & purificação
Vírus da Encefalite de St. Louis/isolamento & purificação
Encefalite de St. Louis/veterinária
Encefalomielite Equina do Leste/veterinária
Feminino
Interações Hospedeiro-Patógeno
Masculino
Orthobunyavirus/classificação
Estados Unidos/epidemiologia
Vírus do Nilo Ocidental/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.15-0840


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[PMID]:26974395
[Au] Autor:Reisen WK; Wheeler SS
[Ad] Endereço:Department of Pathology, Microbiology and Immunology, Center for Vectorborne Diseases, School of Veterinary Medicine, University of California , Davis, California.
[Ti] Título:Surveys for Antibodies Against Mosquitoborne Encephalitis Viruses in California Birds, 1996-2013.
[So] Source:Vector Borne Zoonotic Dis;16(4):264-82, 2016 Apr.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:From 1996 through 2013, 54,546 individual birds comprising 152 species and 7 orders were banded, bled, and released at four study areas within California, from which 28,388 additional serum samples were collected at one or more recapture encounters. Of these, 142, 99, and 1929 birds from 41 species were positive for neutralizing antibodies against western equine encephalomyelitis virus (WEEV), St. Louis encephalitis virus (SLEV), or West Nile virus (WNV) at initial capture or recapture, respectively. Overall, 83% of the positive serum samples were collected from five species: House Finch, House Sparrow, Mourning Dove, California Quail, and Western Scrub-Jay. Temporal data supported concurrent arbovirus surveillance and documented the disappearance of birds positive for WEEV in 2008 and SLEV in 2003 and the appearance of birds positive for WNV after its invasion in 2003. Results of these serosurveys agreed well with the host selection patterns of the Culex vectors as described from bloodmeal sequencing data and indicated that transmission of WNV seemed most effective within urban areas where avian and mosquito host diversity was limited to relatively few competent species.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Doenças das Aves/virologia
Aves/virologia
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/epidemiologia
Doenças das Aves/imunologia
California/epidemiologia
Vírus da Encefalite de St. Louis/imunologia
Vírus da Encefalite Equina do Oeste/imunologia
Encefalite de St. Louis/sangue
Encefalite de St. Louis/imunologia
Encefalite de St. Louis/veterinária
Encefalomielite Equina/sangue
Encefalomielite Equina/imunologia
Encefalomielite Equina/veterinária
Vigilância da População
Estudos Soroepidemiológicos
Febre do Nilo Ocidental/sangue
Febre do Nilo Ocidental/imunologia
Febre do Nilo Ocidental/veterinária
Vírus do Nilo Ocidental/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2015.1888



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