Base de dados : MEDLINE
Pesquisa : B04.820.250 [Categoria DeCS]
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  1 / 1158 MEDLINE  
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[PMID]:28910347
[Au] Autor:Horemheb-Rubio G; Ramos-Cervantes P; Arroyo-Figueroa H; Ávila-Ríos S; García-Morales C; Reyes-Terán G; Escobedo G; Estrada G; García-Iglesias T; Muñoz-Saucedo N; Kershenobich D; Ostrosky-Wegman P; Ruiz-Palacios GM
[Ad] Endereço:Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
[Ti] Título:High HPgV replication is associated with improved surrogate markers of HIV progression.
[So] Source:PLoS One;12(9):e0184494, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human Pegivirus (HPgV) may have a beneficial effect on HIV disease progression in co-infected patients; however, the virologic characteristics of this infection are not well defined. In this study, we determined HPgV viremia prevalence in Mexico and provide new insights to understand HPgV infection and HPgV/HIV co-infection. METHODS: We analyzed and quantified 7,890 serum samples for HPgV viremia by One-Step RT-Real-Time PCR, 6,484 from healthy blood donors and 1,406 from HIV-infected patients. Data on HIV progression were obtained from patients' records. HPgV genotyping was performed in 445 samples by nested PCR of the 5'URT region. Finite Mixture Models were used to identify clustering patterns of HPgV viremia in blood donors and co-infected antiretroviral (ART)-naïve patients. RESULTS: HPgV was detected in 2.98% of blood donors and 33% of HIV patients, with a wide range of viral loads. The most prevalent genotypes were 3 (58.6%)and 2 (33.7%). HPgV viral loads from healthy blood donors and HPgV/HIV+ ART-naïve co-infected patients were clustered into two component distributions, low and high, with a cut-off point of 5.07log10 and 5.06log10, respectively. High HPgV viremia was associated with improved surrogate markers of HIV infection, independent of the estimated duration of HIV infection or HIV treatment. CONCLUSIONS: HPgV prevalence in Mexico was similar to that reported for other countries. The prevalent genotypes could be related to Mexico's geographic location and ethnicity, since genotype 2 is frequent in the United States and Europe and genotype 3 in Asia and Amerindian populations. HPgV viral load demonstrated two patterns of replication, low and high. The more pronounced beneficial response observed in co-infected patients with high HPgV viremia may explain discrepancies found between other studies. Mechanisms explaining high and low HPgV replication should be explored to determine whether the persistently elevated replication depends on host or viral factors.
[Mh] Termos MeSH primário: Coinfecção/virologia
Infecções por Flaviviridae/diagnóstico
Flaviviridae/fisiologia
Infecções por HIV/complicações
Viremia/virologia
[Mh] Termos MeSH secundário: Biomarcadores/análise
Contagem de Linfócito CD4
Progressão da Doença
Flaviviridae/genética
Infecções por Flaviviridae/epidemiologia
Infecções por Flaviviridae/imunologia
Genótipo
Infecções por HIV/imunologia
Infecções por HIV/virologia
Seres Humanos
México/epidemiologia
Prevalência
Carga Viral
Viremia/imunologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184494


  2 / 1158 MEDLINE  
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[PMID]:28850669
[Au] Autor:Lei J; Hilgenfeld R
[Ad] Endereço:Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Germany.
[Ti] Título:RNA-virus proteases counteracting host innate immunity.
[So] Source:FEBS Lett;591(20):3190-3210, 2017 Oct.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Virus invasion triggers host immune responses, in particular, innate immune responses. Pathogen-associated molecular patterns of viruses (such as dsRNA, ssRNA, or viral proteins) released during virus replication are detected by the corresponding pattern-recognition receptors of the host, and innate immune responses are induced. Through production of type-I and type-III interferons as well as various other cytokines, the host innate immune system forms the frontline to protect host cells and inhibit virus infection. Not surprisingly, viruses have evolved diverse strategies to counter this antiviral system. In this review, we discuss the multiple strategies used by proteases of positive-sense single-stranded RNA viruses of the families Picornaviridae, Coronaviridae, and Flaviviridae, when counteracting host innate immune responses.
[Mh] Termos MeSH primário: Evasão da Resposta Imune
Imunidade Inata
Interferons/imunologia
Receptores Toll-Like/imunologia
Proteínas Virais/imunologia
Viroses/imunologia
[Mh] Termos MeSH secundário: Animais
Coronaviridae/genética
Coronaviridae/imunologia
Citocinas/genética
Citocinas/imunologia
Flaviviridae/genética
Flaviviridae/imunologia
Regulação da Expressão Gênica
Seres Humanos
Interferons/genética
Picornaviridae/genética
Picornaviridae/imunologia
Estrutura Secundária de Proteína
Transdução de Sinais
Receptores Toll-Like/genética
Proteínas Virais/química
Proteínas Virais/genética
Viroses/genética
Viroses/patologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Toll-Like Receptors); 0 (Viral Proteins); 9008-11-1 (Interferons)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12827


  3 / 1158 MEDLINE  
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[PMID]:28630001
[Au] Autor:Simón D; Fajardo A; Sóñora M; Delfraro A; Musto H
[Ad] Endereço:Laboratorio de Organización y Evolución del Genoma, Unidad de Genómica Evolutiva, Facultad de Ciencias (FC), Universidad de la República (UDELAR), Iguá 4225, Montevideo 11400, Uruguay. Electronic address: dsimon@fcien.edu.uy.
[Ti] Título:Host influence in the genomic composition of flaviviruses: A multivariate approach.
[So] Source:Biochem Biophys Res Commun;492(4):572-578, 2017 Oct 28.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Flaviviruses present substantial differences in their host range and transmissibility. We studied the evolution of base composition, dinucleotide biases, codon usage and amino acid frequencies in the genus Flavivirus within a phylogenetic framework by principal components analysis. There is a mutual interplay between the evolutionary history of flaviviruses and their respective vectors and/or hosts. Hosts associated to distinct phylogenetic groups may be driving flaviviruses at different pace and through various sequence landscapes, as can be seen for viruses associated with Aedes or Culex spp., although phylogenetic inertia cannot be ruled out. In some cases, viruses face even opposite forces. For instance, in tick-borne flaviviruses, while vertebrate hosts exert pressure to deplete their CpG, tick vectors drive them to exhibit GC-rich codons. Within a vertebrate environment, natural selection appears to be acting on the viral genome to overcome the immune system. On the other side, within an arthropod environment, mutational biases seem to be the dominant forces.
[Mh] Termos MeSH primário: Evolução Biológica
Flaviviridae/genética
Genoma Viral/genética
Insetos Vetores/genética
Insetos Vetores/virologia
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Animais
Códon/genética
Ilhas de CpG/genética
Interpretação Estatística de Dados
Evolução Molecular
Estudos de Associação Genética
Modelos Genéticos
Modelos Estatísticos
Análise Multivariada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon); 0 (Viral Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


  4 / 1158 MEDLINE  
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[PMID]:28542435
[Au] Autor:Schneeberger PHH; Pothier JF; Bühlmann A; Duffy B; Beuret C; Utzinger J; Frey JE
[Ad] Endereço:Agroscope, Department of Methods Development and Analytics, Wädenswil, Switzerland.
[Ti] Título:Development and evaluation of a bioinformatics approach for designing molecular assays for viral detection.
[So] Source:PLoS One;12(5):e0178195, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Viruses belonging to the Flaviviridae and Bunyaviridae families show considerable genetic diversity. However, this diversity is not necessarily taken into account when developing diagnostic assays, which are often based on the pairwise alignment of a limited number of sequences. Our objective was to develop and evaluate a bioinformatics workflow addressing two recurrent issues of molecular assay design: (i) the high intraspecies genetic diversity in viruses and (ii) the potential for cross-reactivity with close relatives. METHODOLOGY: The workflow developed herein was based on two consecutive BLASTn steps; the first was utilized to select highly conserved regions among the viral taxon of interest, and the second was employed to assess the degree of similarity of these highly-conserved regions to close relatives. Subsequently, the workflow was tested on a set of eight viral species, including various strains from the Flaviviridae and Bunyaviridae families. PRINCIPAL FINDINGS: The genetic diversity ranges from as low as 0.45% variable sites over the complete genome of the Japanese encephalitis virus to more than 16% of variable sites on segment L of the Crimean-Congo hemorrhagic fever virus. Our proposed bioinformatics workflow allowed the selection-based on computing scores-of the best target for a diagnostic molecular assay for the eight viral species investigated. CONCLUSIONS/SIGNIFICANCE: Our bioinformatics workflow allowed rapid selection of highly conserved and specific genomic fragments among the investigated viruses, while considering up to several hundred complete genomic sequences. The pertinence of this workflow will increase in parallel to the number of sequences made publicly available. We hypothesize that our workflow might be utilized to select diagnostic molecular markers for higher organisms with more complex genomes, provided the sequences are made available.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/diagnóstico
Bunyaviridae/genética
Biologia Computacional/métodos
Infecções por Flaviviridae/diagnóstico
Flaviviridae/genética
[Mh] Termos MeSH secundário: Infecções por Bunyaviridae/virologia
Infecções por Flaviviridae/virologia
Seres Humanos
Análise de Sequência com Séries de Oligonucleotídeos
Filogenia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178195


  5 / 1158 MEDLINE  
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[PMID]:28322784
[Au] Autor:Valdés JJ; Butterill PT; Ruzek D
[Ad] Endereço:Institute of Parasitology, The Czech Academy of Sciences, Branisovská 31, CZ-37005 Ceské Budejovice, Czechia; Department of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czechia. Electronic address: valdjj@gmail.com.
[Ti] Título:Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.
[So] Source:Biochem Biophys Res Commun;492(4):652-658, 2017 Oct 28.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The RNA-dependent RNA polymerases of Flaviviridae viruses are crucial for replication. The Flaviviridae polymerase is organized into structural motifs (A-G), with motifs F, A, C and E containing interrogating, priming and catalytic substrate-interacting sites. Modified nucleoside analogues act as antiviral drugs by targeting Flaviviridae polymerases and integrating into the synthesized product causing premature termination. A threonine mutation of a conserved serine residue in motif B of Flaviviridae polymerases renders resistance to 2'-C-methylated nucleoside analogues. The mechanism how this single mutation causes Flaviviridae viruses to escape nucleoside analogues is not yet known. Given the pivotal position of the serine residue in motif B that supports motif F, we hypothesized the threonine mutation causes alterations in nucleoside exploration within the entry tunnel. Implementing a stochastic molecular software showed the all-atom 2'-C-methylated analogue reaction within the active sites of wild type and serine-threonine mutant polymerases from Hepacivirus and Flavivirus. Compared with the wild type, the serine-threonine mutant polymerases caused a significant decrease of analogue contacts with conserved interrogating residues in motif F and a displacement of metal ion cofactors. The simulations significantly showed that during the analogue exploration of the active site the hydrophobic methyl group in the serine-threonine mutant repels water-mediated hydrogen bonds with the 2'-C-methylated analogue, causing a concentration of water-mediated bonds at the substrate-interacting sites. Collectively, the data are an insight into a molecular escape mechanism by Flaviviridae viruses from 2'-C-methylated nucleoside analogue inhibitors.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/química
Flaviviridae/química
Flaviviridae/enzimologia
Nucleosídeos/química
RNA Replicase/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Ativação Enzimática
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Nucleosides); EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


  6 / 1158 MEDLINE  
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[PMID]:28282567
[Au] Autor:Larena M; Lobigs M
[Ad] Endereço:Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, Canberra, Australia; Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: maximilian.larena@gu.se.
[Ti] Título:Partial dysfunction of STAT1 profoundly reduces host resistance to flaviviral infection.
[So] Source:Virology;506:1-6, 2017 Jun.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genetic basis for a dramatically increased virus susceptibility phenotype of MHC-II knockout mice acquired during routine maintenance of the mouse strain was determined. Segregation of the susceptibility allele from the defective MHC-II locus combined with sequence capture and sequencing showed that a Y37L substitution in STAT1 accounted for high flavivirus susceptibility of a newly derived mouse strain, designated Tuara. Interestingly, the mutation in STAT1 gene gave only partial inactivation of the type I interferon antiviral pathway. Accordingly, merely a relatively small impairment of interferon α/ß signalling is sufficient to overcome the ability of the host to control the infection.
[Mh] Termos MeSH primário: Infecções por Flaviviridae/virologia
Flaviviridae/fisiologia
Fator de Transcrição STAT1/imunologia
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Substituição de Aminoácidos
Animais
Flaviviridae/genética
Infecções por Flaviviridae/genética
Infecções por Flaviviridae/imunologia
Seres Humanos
Interferon Tipo I/genética
Interferon Tipo I/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Fator de Transcrição STAT1/química
Fator de Transcrição STAT1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon Type I); 0 (STAT1 Transcription Factor); 0 (Stat1 protein, mouse)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


  7 / 1158 MEDLINE  
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[PMID]:28218572
[Au] Autor:Simmonds P; Becher P; Bukh J; Gould EA; Meyers G; Monath T; Muerhoff S; Pletnev A; Rico-Hesse R; Smith DB; Stapleton JT; Ictv Report Consortium
[Ad] Endereço:1​Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
[Ti] Título:ICTV Virus Taxonomy Profile: Flaviviridae.
[So] Source:J Gen Virol;98(1):2-3, 2017 Jan.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Flaviviridae is a family of small enveloped viruses with RNA genomes of 9000-13 000 bases. Most infect mammals and birds. Many flaviviruses are host-specific and pathogenic, such as hepatitis C virus in the genus Hepacivirus. The majority of known members in the genus Flavivirus are arthropod borne, and many are important human and veterinary pathogens (e.g. yellow fever virus, dengue virus). This is a summary of the current International Committee on Taxonomy of Viruses (ICTV) report on the taxonomy of the Flaviviridae, which is available at www.ictv.global/report/flaviviridae.
[Mh] Termos MeSH primário: Flaviviridae/classificação
[Mh] Termos MeSH secundário: Animais
Vetores Artrópodes/virologia
Flaviviridae/genética
Flaviviridae/fisiologia
Flaviviridae/ultraestrutura
Infecções por Flaviviridae/transmissão
Infecções por Flaviviridae/veterinária
Infecções por Flaviviridae/virologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000672


  8 / 1158 MEDLINE  
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[PMID]:28212298
[Au] Autor:Miao Z; Gao L; Song Y; Yang M; Zhang M; Lou J; Zhao Y; Wang X; Feng Y; Dong X; Xia X
[Ad] Endereço:Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. miaozhijiang@yeah.net.
[Ti] Título:Prevalence and Clinical Impact of Human Pegivirus-1 Infection in HIV-1-Infected Individuals in Yunnan, China.
[So] Source:Viruses;9(2), 2017 Feb 15.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity of HPgV-1 and its relevance to the progression of HIV-1 disease remains limited. A total of 1062 HIV-1-infected individuals were recruited in all sixteen prefectures of Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, and clinical data analyses were used to detect HPgV-1 infection, determine genotype, and analyze HPgV-1 genotype impact on HIV-1 disease progression. The overall positive rate of HPgV-1 RNA was 23.4% (248/1062), and the frequency of HPgV-1 infection in injecting drug users (IDUs) (28.5%, 131/460) was significantly higher than in heterosexuals (19.4%, 117/602). Multiple genotypes were identified in 212 subjects with successful sequencing for the gene, including genotype 7 (55.7%), genotype 3 (34.9%), genotype 4 (4.7%), genotype 2 (3.3%), and an unclassified group (1.4%). Moreover, genotype 7 predominated in IDUs, whereas genotype 3 was the most common in heterosexuals. Our results revealed that HPgV-1 genotype 7 groups exhibited significantly lower HIV-1 viral load and higher CD4⁺ cell counts. This finding suggests that HPgV-1 genotype 7 may be associated with a better progression of HIV-1 disease.
[Mh] Termos MeSH primário: Infecções por Flaviviridae/epidemiologia
Flaviviridae/isolamento & purificação
Infecções por HIV/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
China/epidemiologia
Progressão da Doença
Estudos Epidemiológicos
Feminino
Flaviviridae/classificação
Flaviviridae/genética
Infecções por Flaviviridae/patologia
Infecções por Flaviviridae/virologia
Genótipo
Infecções por HIV/patologia
HIV-1/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Filogenia
Reação em Cadeia da Polimerase
Prevalência
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Carga Viral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


  9 / 1158 MEDLINE  
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[PMID]:27995661
[Au] Autor:Ramsay JD
[Ad] Endereço:Department of Veterinary Microbiology and Pathology, and Washington Animal Disease Diagnostic Laboratory, Washington State University, Pullman, Washington, USA.
[Ti] Título:Science-in-brief: Equine viral hepatitis.
[So] Source:Equine Vet J;49(2):138-140, 2017 Mar.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Cardiovirus/veterinária
Infecções por Flaviviridae/veterinária
Hepatite C/veterinária
Hepatite Viral Animal/virologia
Doenças dos Cavalos/virologia
[Mh] Termos MeSH secundário: Animais
Flaviviridae
Infecções por Flaviviridae/virologia
Hepacivirus
Hepatite C/virologia
Cavalos
Theilovirus
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12652


  10 / 1158 MEDLINE  
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[PMID]:27819397
[Au] Autor:Llopis IV; Tomassone L; Grego E; Silvano F; Rossi L
[Ad] Endereço:Dipartimento di Scienze Veterinarie, University of Turin-Italy.
[Ti] Título:Investigation into Usutu and West Nile viruses in ticks from wild birds in Northwestern Italy, 2012-2014.
[So] Source:New Microbiol;40(1):56-57, 2017 Jan.
[Is] ISSN:1121-7138
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:To assess the potential role of ticks as carriers of West Nile virus (WNV) and Usutu virus (USUV), we tested 1721 ticks from 379 wild birds in Northwestern Italy between 2012 and 2014. Ticks were analyzed in pools using a pan-flavivirus real-time RT-PCR and positive pools were subjected to RT-PCR for USUV and WNV genome detection. All the tested samples resulted negative, suggesting that Ixodes spp. ticks, at least in our study area, are not competent vectors and not even exploitable sentinels for USUV and WNV.
[Mh] Termos MeSH primário: Doenças das Aves/parasitologia
Flaviviridae/isolamento & purificação
Infestações por Carrapato/veterinária
Carrapatos/virologia
[Mh] Termos MeSH secundário: Animais
Animais Selvagens
Doenças das Aves/epidemiologia
Doenças das Aves/virologia
Aves
Flaviviridae/classificação
Itália/epidemiologia
Infestações por Carrapato/epidemiologia
Infestações por Carrapato/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE



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