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  1 / 1089 MEDLINE  
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[PMID]:28749337
[Au] Autor:Dorigatti I; Hamlet A; Aguas R; Cattarino L; Cori A; Donnelly CA; Garske T; Imai N; Ferguson NM
[Ad] Endereço:MRC Centre for Outbreak analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
[Ti] Título:International risk of yellow fever spread from the ongoing outbreak in Brazil, December 2016 to May 2017.
[So] Source:Euro Surveill;22(28), 2017 Jul 13.
[Is] ISSN:1560-7917
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:States in south-eastern Brazil were recently affected by the largest Yellow Fever (YF) outbreak seen in a decade in Latin America. Here we provide a quantitative assessment of the risk of travel-related international spread of YF indicating that the United States, Argentina, Uruguay, Spain, Italy and Germany may have received at least one travel-related YF case capable of seeding local transmission. Mitigating the risk of imported YF cases seeding local transmission requires heightened surveillance globally.
[Mh] Termos MeSH primário: Surtos de Doenças/prevenção & controle
Modelos Teóricos
Risco
Viagem
Febre Amarela/prevenção & controle
Febre Amarela/transmissão
Vírus da Febre Amarela/isolamento & purificação
Vírus da Febre Amarela/patogenicidade
[Mh] Termos MeSH secundário: Animais
Argentina
Brasil/epidemiologia
Alemanha
Saúde Global
Seres Humanos
Insetos Vetores
Itália
Fatores de Risco
Espanha
Estados Unidos
Uruguai
Febre Amarela/epidemiologia
Vacina contra Febre Amarela/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Yellow Fever Vaccine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


  2 / 1089 MEDLINE  
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[PMID]:29385205
[Au] Autor:Di Paola N; Freire CCM; Zanotto PMA
[Ad] Endereço:Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil.
[Ti] Título:Does adaptation to vertebrate codon usage relate to flavivirus emergence potential?
[So] Source:PLoS One;13(1):e0191652, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Codon adaptation index (CAI) is a measure of synonymous codon usage biases given a usage reference. Through mutation, selection, and drift, viruses can optimize their replication efficiency and produce more offspring, which could increase the chance of secondary transmission. To evaluate how higher CAI towards the host has been associated with higher viral titers, we explored temporal trends of several historic and extensively sequenced zoonotic flaviviruses and relationships within the genus itself. To showcase evolutionary and epidemiological relationships associated with silent, adaptive synonymous changes of viruses, we used codon usage tables from human housekeeping and antiviral immune genes, as well as tables from arthropod vectors and vertebrate species involved in the flavivirus maintenance cycle. We argue that temporal trends of CAI changes could lead to a better understanding of zoonotic emergences, evolutionary dynamics, and host adaptation. CAI appears to help illustrate historically relevant trends of well-characterized viruses, in different viral species and genetic diversity within a single species. CAI can be a useful tool together with in vivo and in vitro kinetics, phylodynamics, and additional functional genomics studies to better understand species trafficking and viral emergence in a new host.
[Mh] Termos MeSH primário: Códon/genética
Flavivirus/genética
Flavivirus/patogenicidade
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Aedes/genética
Aedes/virologia
Animais
Culex/genética
Culex/virologia
Vírus da Dengue/genética
Vírus da Dengue/patogenicidade
Vírus da Dengue/fisiologia
Evolução Molecular
Flavivirus/fisiologia
Genes Essenciais
Genoma Viral
Interações Hospedeiro-Patógeno/genética
Seres Humanos
Mosquitos Vetores/genética
Mosquitos Vetores/virologia
Filogenia
Vírus do Mosaico do Tabaco/genética
Vírus do Mosaico do Tabaco/patogenicidade
Vírus do Mosaico do Tabaco/fisiologia
Vertebrados/genética
Vertebrados/virologia
Vírus do Nilo Ocidental/genética
Vírus do Nilo Ocidental/patogenicidade
Vírus do Nilo Ocidental/fisiologia
Vírus da Febre Amarela/genética
Vírus da Febre Amarela/patogenicidade
Vírus da Febre Amarela/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Codon)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191652


  3 / 1089 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:29185596
[Au] Autor:Vasconcelos PF
[Ad] Endereço:Instituto Evandro Chagas, Ananindeua, PA, Brasil.
[Ti] Título:Single shot of 17D vaccine may not confer life-long protection against yellow fever.
[So] Source:Mem Inst Oswaldo Cruz;113(2):135-137, 2018 Feb.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The yellow fever (YF) vaccine has been used since the 1930s to prevent YF, which is a severe infectious disease caused by the yellow fever virus (YFV), and mainly transmitted by Culicidae mosquitoes from the genera Aedes and Haemagogus . Until 2013, the World Health Organization (WHO) recommended the administration of a vaccine dose every ten years. A new recommendation of a single vaccine dose to confer life-long protection against YFV infection has since been established. Recent evidence published elsewhere suggests that at least a second dose is needed to fully protect against YF disease. Here, we discuss the feasibility of administering multiple doses, the necessity for a new and modern vaccine, and recommend that the WHO conveys a meeting to discuss YFV vaccination strategies for people living in or travelling to endemic areas.
[Mh] Termos MeSH primário: Anticorpos Neutralizantes/imunologia
Esquemas de Imunização
Vacina contra Febre Amarela/administração & dosagem
Febre Amarela/prevenção & controle
Vírus da Febre Amarela/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
Vacina contra Febre Amarela/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Yellow Fever Vaccine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  4 / 1089 MEDLINE  
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Vicente, Ana Carolina P
Texto completo SciELO Brasil
[PMID]:29211109
[Au] Autor:Conteville LC; Filippis AMB; Nogueira RMR; Mendonça MCL; Vicente ACP
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Genética Molecular de Microrganismos, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Metagenomic analysis reveals Hepatitis A virus in suspected yellow fever cases in Brazil.
[So] Source:Mem Inst Oswaldo Cruz;113(1):66-67, 2018 Jan.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Using a metagenomic approach, we identified hepatitis A virus among cases of acute febrile illnesses that occurred in 2008-2012 in Brazil suspected as yellow fever. These findings reinforce the challenge facing routine clinical diagnosis in complex epidemiological scenarios.
[Mh] Termos MeSH primário: Hepatite A/diagnóstico
Febre Amarela/diagnóstico
[Mh] Termos MeSH secundário: Brasil/epidemiologia
Genótipo
Hepatite A/epidemiologia
Vírus da Hepatite A/genética
Seres Humanos
Metagenômica
Febre Amarela/epidemiologia
Vírus da Febre Amarela/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  5 / 1089 MEDLINE  
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[PMID]:29040304
[Au] Autor:Varjak M; Donald CL; Mottram TJ; Sreenu VB; Merits A; Maringer K; Schnettler E; Kohl A
[Ad] Endereço:MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom.
[Ti] Título:Characterization of the Zika virus induced small RNA response in Aedes aegypti cells.
[So] Source:PLoS Negl Trop Dis;11(10):e0006010, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RNA interference (RNAi) controls arbovirus infections in mosquitoes. Two different RNAi pathways are involved in antiviral responses: the PIWI-interacting RNA (piRNA) and exogenous short interfering RNA (exo-siRNA) pathways, which are characterized by the production of virus-derived small RNAs of 25-29 and 21 nucleotides, respectively. The exo-siRNA pathway is considered to be the key mosquito antiviral response mechanism. In Aedes aegypti-derived cells, Zika virus (ZIKV)-specific siRNAs were produced and loaded into the exo-siRNA pathway effector protein Argonaute 2 (Ago2); although the knockdown of Ago2 did not enhance virus replication. Enhanced ZIKV replication was observed in a Dcr2-knockout cell line suggesting that the exo-siRNA pathway is implicated in the antiviral response. Although ZIKV-specific piRNA-sized small RNAs were detected, these lacked the characteristic piRNA ping-pong signature motif and were bound to Ago3 but not Piwi5 or Piwi6. Silencing of PIWI proteins indicated that the knockdown of Ago3, Piwi5 or Piwi6 did not enhance ZIKV replication and only Piwi4 displayed antiviral activity. We also report that the expression of ZIKV capsid (C) protein amplified the replication of a reporter alphavirus; although, unlike yellow fever virus C protein, it does not inhibit the exo-siRNA pathway. Our findings elucidate ZIKV-mosquito RNAi interactions that are important for understanding its spread.
[Mh] Termos MeSH primário: Aedes/virologia
Interações Hospedeiro-Patógeno
Proteínas de Insetos/genética
Interferência de RNA
RNA Interferente Pequeno
Zika virus/fisiologia
[Mh] Termos MeSH secundário: Aedes/citologia
Alphavirus/genética
Animais
Proteínas do Capsídeo/genética
Linhagem Celular
Proteínas de Insetos/metabolismo
Replicação Viral
Vírus da Febre Amarela/genética
Zika virus/genética
Infecção pelo Zika virus/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (Insect Proteins); 0 (RNA, Small Interfering)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006010


  6 / 1089 MEDLINE  
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[PMID]:28934479
[Au] Autor:Afik S; Yates KB; Bi K; Darko S; Godec J; Gerdemann U; Swadling L; Douek DC; Klenerman P; Barnes EJ; Sharpe AH; Haining WN; Yosef N
[Ad] Endereço:Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
[Ti] Título:Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state.
[So] Source:Nucleic Acids Res;45(16):e148, 2017 Sep 19.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provide effective immunity against pathogens. However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state. Single cell RNA-sequencing (scRNA-seq) can allow simultaneous measurement of TCR sequence and global transcriptional profile from single cells. However, current methods for TCR inference from scRNA-seq are limited in their sensitivity and require long sequencing reads, thus increasing the cost and decreasing the number of cells that can be feasibly analyzed. Here we present TRAPeS, a publicly available tool that can efficiently extract TCR sequence information from short-read scRNA-seq libraries. We apply it to investigate heterogeneity in the CD8+ T cell response in humans and mice, and show that it is accurate and more sensitive than existing approaches. Coupling TRAPeS with transcriptome analysis of CD8+ T cells specific for a single epitope from Yellow Fever Virus (YFV), we show that the recently described 'naive-like' memory population have significantly longer CDR3 regions and greater divergence from germline sequence than do effector-memory phenotype cells. This suggests that TCR usage is associated with the differentiation state of the CD8+ T cell response to YFV.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Regiões Determinantes de Complementaridade/química
Receptores de Antígenos de Linfócitos T/química
Análise de Sequência de RNA/métodos
Software
[Mh] Termos MeSH secundário: Algoritmos
Animais
Linfócitos T CD8-Positivos/citologia
Diferenciação Celular
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Masculino
Camundongos Endogâmicos C57BL
Meia-Idade
Receptores de Antígenos de Linfócitos T/metabolismo
Análise de Célula Única
Vírus da Febre Amarela/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complementarity Determining Regions); 0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx615


  7 / 1089 MEDLINE  
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[PMID]:28886023
[Au] Autor:Hamrick PN; Aldighieri S; Machado G; Leonel DG; Vilca LM; Uriona S; Schneider MC
[Ad] Endereço:PAHO Health Emergencies Department, Pan American Health Organization, Washington D.C., United States of America.
[Ti] Título:Geographic patterns and environmental factors associated with human yellow fever presence in the Americas.
[So] Source:PLoS Negl Trop Dis;11(9):e0005897, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the Americas, yellow fever virus transmission is a latent threat due to the proximity between urban and wild environments. Although yellow fever has nearly vanished from North and Central America, there are still 13 countries in the Americas considered endemic by the World Health Organization. Human cases usually occur as a result of the exposure to sylvatic yellow fever in tropical forested environments; but urban outbreaks reported during the last decade demonstrate that the risk in this environment still exists. The objective of this study was to identify spatial patterns and the relationship between key geographic and environmental factors with the distribution of yellow fever human cases in the Americas. METHODOLOGY/PRINCIPAL FINDINGS: An ecological study was carried out to analyze yellow fever human cases reported to the Pan American Health Organization from 2000 to 2014, aggregated by second administrative level subdivisions (counties). Presence of yellow fever by county was used as the outcome variable and eight geo-environmental factors were used as independent variables. Spatial analysis was performed to identify and examine natural settings per county. Subsequently, a multivariable logistic regression model was built. During the study period, 1,164 cases were reported in eight out of the 13 endemic countries. Nearly 83.8% of these cases were concentrated in three countries: Peru (37.4%), Brazil (28.1%) and Colombia (18.4%); and distributed in 57 states/provinces, specifically in 286 counties (3.4% of total counties). Yellow fever presence was significantly associated with altitude, rain, diversity of non-human primate hosts and temperature. A positive spatial autocorrelation revealed a clustered geographic pattern in 138/286 yellow fever positive counties (48.3%). CONCLUSIONS/SIGNIFICANCE: A clustered geographic pattern of yellow fever was identified mostly along the Andes eastern foothills. This risk map could support health policies in endemic countries. Geo-environmental factors associated with presence of yellow fever could help predict and adjust the limits of other risk areas of epidemiological concern.
[Mh] Termos MeSH primário: Meio Ambiente
Febre Amarela/epidemiologia
Febre Amarela/transmissão
Vírus da Febre Amarela/isolamento & purificação
[Mh] Termos MeSH secundário: Américas/epidemiologia
Animais
Brasil/epidemiologia
Colômbia/epidemiologia
Surtos de Doenças/prevenção & controle
Surtos de Doenças/estatística & dados numéricos
Doenças Endêmicas/prevenção & controle
Doenças Endêmicas/estatística & dados numéricos
Geografia
Seres Humanos
Modelos Estatísticos
Organização Pan-Americana da Saúde
Peru/epidemiologia
Primatas/virologia
Chuvas
Análise Espaço-Temporal
Temperatura Ambiente
Organização Mundial da Saúde
Febre Amarela/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005897


  8 / 1089 MEDLINE  
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[PMID]:28684491
[Au] Autor:Griffin DE
[Ad] Endereço:Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. dgriffi6@jhmi.edu.
[Ti] Título:Why are neurons susceptible to Zika virus?
[So] Source:Science;357(6346):33-34, 2017 07 07.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neurônios/virologia
Zika virus
[Mh] Termos MeSH secundário: Vírus da Dengue
Seres Humanos
Transmissão Vertical de Doença Infecciosa
Microcefalia/virologia
Complicações Infecciosas na Gravidez/virologia
Inquéritos e Questionários
Viagem
Vírus do Nilo Ocidental
Vírus da Febre Amarela
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1126/science.aan8626


  9 / 1089 MEDLINE  
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Bonaldo, Myrna C
Castro, Marcia Gonçalves de
Texto completo SciELO Brasil
[PMID]:28591405
[Au] Autor:Bonaldo MC; Gómez MM; Dos Santos AA; Abreu FVS; Ferreira-de-Brito A; Miranda RM; Castro MG; Lourenço-de-Oliveira R
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular de Flavivírus, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Genome analysis of yellow fever virus of the ongoing outbreak in Brazil reveals polymorphisms.
[So] Source:Mem Inst Oswaldo Cruz;112(6):447-451, 2017 Jun.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The current yellow fever outbreak in Brazil is the most severe one in the country in recent times. It has rapidly spread to areas where YF virus (YFV) activity has not been observed for more than 70 years and vaccine coverage is almost null. Here, we sequenced the whole YFV genome of two naturally infected howler-monkeys (Alouatta clamitans) obtained from the Municipality of Domingos Martins, state of Espírito Santo, Brazil. These two ongoing-outbreak genome sequences are identical. They clustered in the 1E sub-clade (South America genotype I) along with the Brazilian and Venezuelan strains recently characterised from infections in humans and non-human primates that have been described in the last 20 years. However, we detected eight unique amino acid changes in the viral proteins, including the structural capsid protein (one change), and the components of the viral replicase complex, the NS3 (two changes) and NS5 (five changes) proteins, that could impact the capacity of viral infection in vertebrate and/or invertebrate hosts and spreading of the ongoing outbreak.
[Mh] Termos MeSH primário: Alouatta/virologia
Genoma Viral/genética
Doenças dos Macacos/virologia
Polimorfismo Genético/genética
Febre Amarela/veterinária
Vírus da Febre Amarela/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Brasil/epidemiologia
Surtos de Doenças
Genótipo
Doenças dos Macacos/epidemiologia
Filogenia
Alinhamento de Sequência
Febre Amarela/epidemiologia
Febre Amarela/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  10 / 1089 MEDLINE  
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[PMID]:28562615
[Au] Autor:Mercier-Delarue S; Durier C; Colin de Verdière N; Poveda JD; Meiffrédy V; Fernandez Garcia MD; Lastère S; Césaire R; Manuggera JC; Molina JM; Amara A; Simon F
[Ad] Endereço:Department of Microbiology, Saint Louis University Hospital, Paris, France.
[Ti] Título:Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype.
[So] Source:PLoS One;12(5):e0177882, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Given the possibility of yellow fever virus reintroduction in epidemiologically receptive geographic areas, the risk of vaccine supply disruption is a serious issue. New strategies to reduce the doses of injected vaccines should be evaluated very carefully in terms of immunogenicity. The plaque reduction test for the determination of neutralizing antibodies (PRNT) is particularly time-consuming and requires the use of a confinement laboratory. We have developed a new test based on the use of a non-infectious pseudovirus (WN/YF17D). The presence of a reporter gene allows sensitive determination of neutralizing antibodies by flow cytometry. This WN/YF17D test was as sensitive as PRNT for the follow-up of yellow fever vaccinees. Both tests lacked specificity with sera from patients hospitalized for acute Dengue virus infection. Conversely, both assays were strictly negative in adults never exposed to flavivirus infection or vaccination, and in patients sampled some time after acute Dengue infection. This WN/YF17D test will be particularly useful for large epidemiological studies and for screening for neutralizing antibodies against yellow fever virus.
[Mh] Termos MeSH primário: Anticorpos Neutralizantes/sangue
Vírus da Dengue/imunologia
Vírus da Febre Amarela/imunologia
[Mh] Termos MeSH secundário: Anticorpos Antivirais/sangue
Dengue/imunologia
Células HEK293
Seres Humanos
Limite de Detecção
Ensaio de Placa Viral
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177882



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