Base de dados : MEDLINE
Pesquisa : B04.820.455.149 [Categoria DeCS]
Referências encontradas : 99 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 10 ir para página                        

  1 / 99 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28465146
[Au] Autor:Tokunaga T; Yamamoto Y; Sakai M; Tomonaga K; Honda T
[Ad] Endereço:Laboratory of RNA Viruses, Department of Virus Research, Institute for Frontier Life and Medical Sciences (InFRONT), Kyoto University, Kyoto, Japan; Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
[Ti] Título:Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses.
[So] Source:Antiviral Res;143:237-245, 2017 07.
[Is] ISSN:1872-9096
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bornaviruses, non-segmented, negative-strand RNA viruses, are emerging agents with the potential for causing various types of neurological symptoms. Previous studies have shown that ribavirin, a nucleic acid analog with broad-spectrum antiviral activity, has a potent antiviral effect on infections with a mammalian bornavirus, Borna disease virus (BoDV-1), as well as avian bornaviruses. However, ribavirin-based treatment does not eliminate bornaviruses from persistently infected cells and viral replication resumes after treatment cessation. Therefore, the development of a novel effective anti-bornavirus treatment is needed. To identify such agents, we screened nucleoside/nucleotide mimetics for agents with anti-bornavirus activity. We used Vero cells infected with recombinant BoDV-1 carrying Gaussia luciferase to monitor BoDV-1 replication and found that favipiravir (T-705) is a potent inhibitor of BoDV-1 replication. T-705 suppressed BoDV-1 replication in a dose- and time-dependent manner during the observation period of 4 weeks. Notably, no increase in luciferase activity or in the number of BoDV-1-positive cells was detected in the at least 4 weeks following T-705 removal. Finally, we demonstrated that T-705 effectively suppressed viral replication of both BoDV-1 and an avian bornavirus, suggesting that T-705 may have a strong antiviral activity against a broad range of bornaviruses. Our findings provide a novel and effective option for treating persistent bornavirus infection.
[Mh] Termos MeSH primário: Amidas/farmacologia
Antivirais/farmacologia
Bornaviridae/efeitos dos fármacos
Pirazinas/farmacologia
[Mh] Termos MeSH secundário: Amidas/administração & dosagem
Animais
Antivirais/administração & dosagem
Doenças das Aves/virologia
Doença de Borna/tratamento farmacológico
Doença de Borna/virologia
Vírus da Doença de Borna/genética
Bornaviridae/genética
Linhagem Celular
Cercopithecus aethiops
Testes de Sensibilidade Microbiana
Pirazinas/administração & dosagem
Codorniz
RNA Viral/análise
Fatores de Tempo
Células Vero
Carga Viral/efeitos dos fármacos
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Antiviral Agents); 0 (Pyrazines); 0 (RNA, Viral); EW5GL2X7E0 (favipiravir)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  2 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28301249
[Au] Autor:Heckmann J; Enderlein D; Piepenbring AK; Herzog S; Heffels-Redmann U; Malberg S; Herden C; Lierz M
[Ad] Endereço:A Clinic for Birds, Reptiles, Amphibians and Fish, Justus Liebig University Giessen, Frankfurter Str. 91, 35392 Giessen, Germany.
[Ti] Título:Investigation of Different Infection Routes of Parrot Bornavirus in Cockatiels.
[So] Source:Avian Dis;61(1):90-95, 2017 Mar.
[Is] ISSN:1938-4351
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine the natural infection route of parrot bornavirus (PaBV), the causative agent of proventricular dilatation disease (PDD) in psittacines. For this purpose, nine cockatiels ( Nymphicus hollandicus ) were inoculated orally, and nine cockatiels were inoculated intranasally, with a PaBV-4 isolate. To compare the results of the trials, the same isolate and the same experimental design were used as in a previous study where infection was successful by intravenous as well as intracerebral inoculation. After inoculation, the birds were observed for a period of 6 mo and tested for PaBV RNA shedding, virus replication, presence of inflammatory lesions, and PaBV-4 antigen in tissues, as well as specific antibody production. In contrast to the previous study involving intravenous and intracerebral infections, clinical signs typical for PDD were not observed in this study. Additionally, anti-PaBV antibodies and infectious virus were not detected in any investigated bird during the study. Parrot bornavirus RNA was detected in only four birds early after infection (1-34 days postinfection). Furthermore, histopathologic examination did not reveal lesions typical for PDD, and PaBV antigen was not detected in any organ investigated by immunohistochemistry. In summary, oral or nasal inoculation did not lead to a valid infection with PaBV in these cockatiels. Therefore it seems to be questionable that the formerly proposed fecal-oral transmission is the natural route of infection in immunocompetent adult or subadult cockatiels.
[Mh] Termos MeSH primário: Doenças das Aves/virologia
Bornaviridae/fisiologia
Infecções por Mononegavirales/veterinária
Papagaios/virologia
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/patologia
Bornaviridae/genética
Bornaviridae/isolamento & purificação
Infecções por Mononegavirales/patologia
Infecções por Mononegavirales/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1637/11490-091316-Reg


  3 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28484177
[Au] Autor:Honda T; Tomonaga K
[Ad] Endereço:Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine.
[Ti] Título:Possible roles of endogenous RNA virus elements in RNA virus infection.
[So] Source:Uirusu;66(1):39-46, 2016.
[Is] ISSN:0042-6857
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Endogenous bornavirus-like elements (EBLs) are ancient bornavirus-derived sequence in the genomes of eukaryotes. Expression profile of EBLs suggests that, although most of the EBLs in mammalian genomes have lost their coding potential, many of them are transcribed in a cell-type specific or ubiquitous manner. This observation leads us to speculate that EBLs may have functions in their host cells. Here we describe possible functions of EBLs and their evolutionary significance. Our recent studies revealed that EBLs in some mammals, including humans, play critical roles in viral infection as either RNAs or proteins in previously undescribed mechanisms. Considering that species having EBLs in their genomes appear to be relatively resistance to BDV-mediated pathogenesis, endogenization of RNA viruses might be an evolutionarily inevitable event in the adaptation of hosts to the viruses.
[Mh] Termos MeSH primário: Bornaviridae
Infecções por Vírus de RNA/virologia
Vírus de RNA/genética
Vírus de RNA/patogenicidade
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Animais
Evolução Biológica
Genoma/genética
Seres Humanos
Estabilidade de RNA
Vírus de RNA/fisiologia
RNA Viral
Transcrição Genética
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.2222/jsv.66.39


  4 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27537693
[Au] Autor:Rubbenstroth D; Schmidt V; Rinder M; Legler M; Twietmeyer S; Schwemmer P; Corman VM
[Ad] Endereço:Institute for Virology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Herrmann-Herder Str. 11, D-79104, Freiburg, Germany.
[Ti] Título:Phylogenetic Analysis Supports Horizontal Transmission as a Driving Force of the Spread of Avian Bornaviruses.
[So] Source:PLoS One;11(8):e0160936, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Avian bornaviruses are a genetically diverse group of viruses initially discovered in 2008. They are known to infect several avian orders. Bornaviruses of parrots and related species (Psittaciformes) are causative agents of proventricular dilatation disease, a chronic and often fatal neurologic disease widely distributed in captive psittacine populations. Although knowledge has considerably increased in the past years, many aspects of the biology of avian bornaviruses are still undiscovered. In particular, the precise way of transmission remains unknown. AIMS AND METHODS: In order to collect further information on the epidemiology of bornavirus infections in birds we collected samples from captive and free-ranging aquatic birds (n = 738) and Passeriformes (n = 145) in Germany and tested them for the presence of bornaviruses by PCR assays covering a broad range of known bornaviruses. We detected aquatic bird bornavirus 1 (ABBV-1) in three out of 73 sampled free-ranging mute swans (Cygnus olor) and one out of 282 free-ranging Eurasian oystercatchers (Haematopus ostralegus). Canary bornavirus 1 (CnBV-1), CnBV-2 and CnBV-3 were detected in four, six and one out of 48 captive common canaries (Serinus canaria forma domestica), respectively. In addition, samples originating from 49 bornavirus-positive captive Psittaciformes were used for determination of parrot bornavirus 2 (PaBV-2) and PaBV-4 sequences. Bornavirus sequences compiled during this study were used for phylogenetic analysis together with all related sequences available in GenBank. RESULTS OF THE STUDY: Within ABBV-1, PaBV-2 and PaBV-4, identical or genetically closely related bornavirus sequences were found in parallel in various different avian species, suggesting that inter-species transmission is frequent relative to the overall transmission of these viruses. Our results argue for an important role of horizontal transmission, but do not exclude the additional possibility of vertical transmission. Furthermore we defined clearly separated sequence clusters within several avian bornaviruses, providing a basis for an improved interpretation of transmission events within and between wild bird populations and captive bird collections.
[Mh] Termos MeSH primário: Doenças das Aves/transmissão
Doenças das Aves/virologia
Bornaviridae/genética
Infecções por Mononegavirales/veterinária
Passeriformes/virologia
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/epidemiologia
Bornaviridae/isolamento & purificação
Canários/virologia
Alemanha/epidemiologia
Infecções por Mononegavirales/epidemiologia
Infecções por Mononegavirales/transmissão
Infecções por Mononegavirales/virologia
Filogenia
RNA Viral/genética
RNA Viral/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160936


  5 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27518265
[Au] Autor:Kobayashi Y; Horie M; Nakano A; Murata K; Itou T; Suzuki Y
[Ad] Endereço:Nihon University Veterinary Research Center, Fujisawa, Kanagawa, Japan.
[Ti] Título:Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians.
[So] Source:PLoS Pathog;12(8):e1005785, 2016 Aug.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endogenous bornavirus-like nucleoprotein elements (EBLNs), the nucleotide sequence elements derived from the nucleoprotein gene of ancient bornavirus-like viruses, have been identified in many animal genomes. Here we show evidence that EBLNs encode functional proteins in their host. Some afrotherian EBLNs were observed to have been maintained for more than 83.3 million years under negative selection. Splice variants were expressed from the genomic loci of EBLNs in elephant, and some were translated into proteins. The EBLN proteins appeared to be localized to the rough endoplasmic reticulum in African elephant cells, in contrast to the nuclear localization of bornavirus N. These observations suggest that afrotherian EBLNs have acquired a novel function in their host. Interestingly, genomic sequences of the first exon and its flanking regions in these EBLN loci were homologous to those of transmembrane protein 106B (TMEM106B). The upstream region of the first exon in the EBLN loci exhibited a promoter activity, suggesting that the ability of these EBLNs to be transcribed in the host cell was gained through capturing a partial duplicate of TMEM106B. In conclusion, our results strongly support for exaptation of EBLNs to encode host proteins in afrotherians.
[Mh] Termos MeSH primário: Evolução Biológica
Elefantes/virologia
Retrovirus Endógenos/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Western Blotting
Bornaviridae/genética
Elefantes/genética
Imuno-Histoquímica
Nucleoproteínas/genética
Filogenia
Reação em Cadeia da Polimerase
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nucleoproteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1005785


  6 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27499253
[Au] Autor:Horie M; Akasaka T; Matsuda S; Ogawa H; Imai K
[Ad] Endereço:Transboundary Animal Diseases Research Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
[Ti] Título:Establishment and characterization of a cell line derived from Eptesicus nilssonii.
[So] Source:J Vet Med Sci;78(11):1727-1729, 2016 Dec 01.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Bats of the genus Eptesicus have several non-retroviral RNA virus-derived sequences in their genomes, among which an endogenous bornavirus-like L element, named eEBLL-1, was suggested to encode functional proteins in the hosts. However, the function of eEBLL-1 remains unclear due to a lack of appropriate investigation tools, such as cultured cells expressing eEBLL-1. Here, we established a continuous cell line, named HAMOI-EnK cells, from kidney of Eptesicus nilssonii. HAMOI-EnK cells are robust and could be passaged for at least 10 months. eEBLL-1 in the genomes of HAMOI-EnK cells retains an intact open reading frame. Additionally, eEBLL-1 is transcribed in the sense-orientation in cells. To our knowledge, this is the first report to demonstrate that eEBLL-1 is transcribed in cultured cells.
[Mh] Termos MeSH primário: Bornaviridae/genética
Linhagem Celular/metabolismo
Quirópteros
[Mh] Termos MeSH secundário: Animais
Quirópteros/genética
Genes Virais
Genoma Viral
Rim/citologia
Fases de Leitura Aberta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE


  7 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27439314
[Au] Autor:Reuter A; Horie M; Höper D; Ohnemus A; Narr A; Rinder M; Beer M; Staeheli P; Rubbenstroth D
[Ad] Endereço:1​ Institute for Virology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germany.
[Ti] Título:Synergistic antiviral activity of ribavirin and interferon-α against parrot bornaviruses in avian cells.
[So] Source:J Gen Virol;97(9):2096-103, 2016 Sep.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Avian bornaviruses are the causative agents of proventricular dilatation disease (PDD), a widely distributed and often fatal disease in captive psittacines. Because neither specific prevention measures nor therapies against PDD and bornavirus infections are currently available, new antiviral strategies are required to improve animal health. We show here that the nucleoside analogue ribavirin inhibited bornavirus activity in a polymerase reconstitution assay and reduced viral load in avian cell lines infected with two different parrot bornaviruses. Furthermore, we observed that ribavirin enhanced type I IFN signalling in avian cells. Combined treatment of avian bornavirus-infected cells with ribavirin and recombinant IFN-α strongly enhanced the antiviral efficiency compared to either drug alone. The combined use of ribavirin and type I IFN might represent a promising new strategy for therapeutic treatment of captive parrots persistently infected with avian bornaviruses.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Bornaviridae/efeitos dos fármacos
Interferon-alfa/farmacologia
Ribavirina/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Testes de Sensibilidade Microbiana
Papagaios
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Interferon-alpha); 49717AWG6K (Ribavirin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000555


  8 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27166599
[Au] Autor:Komorizono R; Makino A; Horie M; Honda T; Tomonaga K
[Ad] Endereço:Department of Viral Oncology, Institute for Virus Research.
[Ti] Título:Sequence determination of a new parrot bornavirus-5 strain in Japan: implications of clade-specific sequence diversity in the regions interacting with host factors.
[So] Source:Microbiol Immunol;60(6):437-41, 2016 Jun.
[Is] ISSN:1348-0421
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:In this study, the genome sequence of a new parrot bornavirus-5 (PaBV-5) detected in Eclectus roratus was determined. Phylogenetic analysis showed that the genus Bornavirus is divided into three major clades and that PaBV-5 belongs to clade 2, which contains avian viruses that exhibit infectivity to mammalian cells. Sequence comparisons of the regions known to interact with host factors indicated that the clade 2 avian viruses possess sequences intermediate between the clade 1 mammalian viruses and the clade 3 avian viruses, suggesting that the identified regions might contribute to the differences in virological properties between the three clades.
[Mh] Termos MeSH primário: Bornaviridae/genética
Papagaios/virologia
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Doenças das Aves/virologia
Bornaviridae/química
Bornaviridae/classificação
Genoma Viral
Japão
Filogenia
RNA Viral/genética
Análise de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1111/1348-0421.12385


  9 / 99 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27100150
[Au] Autor:Piepenbring AK; Enderlein D; Herzog S; Al-Ibadi B; Heffels-Redmann U; Heckmann J; Lange-Herbst H; Herden C; Lierz M
[Ad] Endereço:a Clinic for Birds, Reptiles, Amphibians and Fish , Justus-Liebig-Universität Giessen , Giessen , Germany.
[Ti] Título:Parrot Bornavirus (PaBV)-2 isolate causes different disease patterns in cockatiels than PaBV-4.
[So] Source:Avian Pathol;45(2):156-68, 2016.
[Is] ISSN:1465-3338
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Psittaciform 1 bornavirus (PaBV) has already been shown to be the aetiologic agent of proventricular dilatation disease, a significant disease of birds. However, the pathogenesis of PaBV infection has not yet been resolved and valid data regarding the pathogenicity of different PaBV species are lacking. Thus, the present study was aimed to characterize the influence of two different PaBV species on the course of disease. Eighteen cockatiels were inoculated intracerebrally (i.c.) or intravenously (i.v.) with a PaBV-2 isolate under the same conditions as in a previous study using PaBV-4. Birds were surveyed and sampled for 33 weeks to analyse the course of infection and disease in comparison to that of PaBV-4. Similar to PaBV-4, PaBV-2 induced a persistent infection with seroconversion (from day 6 p.i. onwards) and shedding of viral RNA (from day 27 p.i. onwards). However, in contrast to PaBV-4, more birds displayed clinical signs and disease progression was more severe. After PaBV-2 infection, 12 birds exhibited clinical signs and 10 birds revealed a dilated proventriculus in necropsy. After PaBV-4 infection only four birds revealed clinical signs and seven birds showed a dilatation of the proventriculus. Clinically, different courses of disease were observed after PaBV-2 infection, mainly affecting the gastrointestinal tract. This had not been detected after PaBV-4 infection where more neurological signs were noted. The results provide evidence for different disease patterns according to different PaBV species, allowing the comparison between the infection with two PaBV species, and thus underlining the role of viral and individual host factors for disease outcome.
[Mh] Termos MeSH primário: Doenças das Aves/virologia
Bornaviridae/patogenicidade
Cacatuas/virologia
Infecções por Mononegavirales/veterinária
Papagaios/virologia
[Mh] Termos MeSH secundário: Animais
Dilatação Patológica/veterinária
Progressão da Doença
Feminino
Masculino
Infecções por Mononegavirales/virologia
Proventrículo/patologia
RNA Viral/genética
Soroconversão
Especificidade da Espécie
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1080/03079457.2015.1137867


  10 / 99 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26346745
[Au] Autor:Horie M; Sassa Y; Iki H; Ebisawa K; Fukushi H; Yanai T; Tomonaga K
[Ad] Endereço:Transboundary Animal Diseases Research Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
[Ti] Título:Isolation of avian bornaviruses from psittacine birds using QT6 quail cells in Japan.
[So] Source:J Vet Med Sci;78(2):305-8, 2016 Feb.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Avian bornaviruses (ABVs) were recently discovered as the causative agents of proventricular dilatation disease (PDD). Although molecular epidemiological studies revealed that ABVs exist in Japan, no Japanese isolate has been reported thus far. In this study, we isolated four strains of Psittaciform 1 bornavirus from psittacine birds affected by PDD using QT6 quail cells. To our knowledge, this is the first report to isolate ABVs in Japan and to show that QT6 cells are available for ABV isolation. These isolates and QT6 cells would be powerful tools for elucidating the fundamental biology and pathogenicity of ABVs.
[Mh] Termos MeSH primário: Bornaviridae/isolamento & purificação
Linhagem Celular/virologia
Coturnix
Psittaciformes/virologia
[Mh] Termos MeSH secundário: Animais
Japão
Cultura de Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150909
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.15-0372



página 1 de 10 ir para página                        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde