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[PMID]:28159006
[Au] Autor:Essa S; Al-Tawalah H; AlShamali S; Al-Nakib W
[Ad] Endereço:Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait. sahar@hsc.edu.kw.
[Ti] Título:The potential influence of human parainfluenza viruses detected during hospitalization among critically ill patients in Kuwait, 2013-2015.
[So] Source:Virol J;14(1):19, 2017 Feb 03.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The four types of human parainfluenza viruses (PIV) are important causes of community-acquired pneumonia, particularly in children; however, limited information exists about the incidence of PIV in critically ill patients. The aim of this study is to describe the spectrum, incidence and clinical features of PIV-associated infections diagnosed during the hospital stay of patients admitted to pediatric intensive care unit (PICU) and intensive care unit (ICU) of 5 medical centers across Kuwait. METHODS: This was a population-based, retrospective study from 2013 to 2015. Specimens were analyzed by molecular methods. This analysis was performed using the database of Virology Unit, Mubarak Al-Kabeer Hospital. Data from 1510 admitted patients with suspected respiratory viral infections was extracted. RESULTS: The database contained a total of 39 (2.6%) patients infected with PIV (53.8% male and 46.2% females) and 20 (51.3%) were under 1 year of age. The most frequently isolated type was type 3 (28, 71.8%) followed by type 1 (9, 23.1%). At admission the most common clinical diagnosis was pneumonia in 12 patients (30.8%, p < 0.05) followed by bronchiolitis in 10 patients (25.6%). CONCLUSION: PIV plays an important yet unrecognized role in the outcomes of PIUC and ICU patients. Our results contribute to the limited epidemiologic data of PIV in PIUC and ICU in this region.
[Mh] Termos MeSH primário: Estado Terminal
Hospitalização
Infecções por Paramyxoviridae/epidemiologia
Paramyxovirinae/classificação
Paramyxovirinae/isolamento & purificação
Pneumonia Viral/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Hospitais
Seres Humanos
Incidência
Lactente
Recém-Nascido
Kuweit/epidemiologia
Masculino
Meia-Idade
Infecções por Paramyxoviridae/patologia
Infecções por Paramyxoviridae/virologia
Pneumonia Viral/patologia
Pneumonia Viral/virologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE
[do] DOI:10.1186/s12985-017-0681-0


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[PMID]:27498841
[Au] Autor:Audsley MD; Jans DA; Moseley GW
[Ad] Endereço:1​Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
[Ti] Título:Roles of nuclear trafficking in infection by cytoplasmic negative-strand RNA viruses: paramyxoviruses and beyond.
[So] Source:J Gen Virol;97(10):2463-2481, 2016 Oct.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Genome replication and virion production by most negative-sense RNA viruses (NSVs) occurs exclusively in the cytoplasm, but many NSV-expressed proteins undergo active nucleocytoplasmic trafficking via signals that exploit cellular nuclear transport pathways. Nuclear trafficking has been reported both for NSV accessory proteins (including isoforms of the rabies virus phosphoprotein, and V, W and C proteins of paramyxoviruses) and for structural proteins. Trafficking of the former is thought to enable accessory functions in viral modulation of antiviral responses including the type I IFN system, but the intranuclear roles of structural proteins such as nucleocapsid and matrix proteins, which have critical roles in extranuclear replication and viral assembly, are less clear. Nevertheless, nuclear trafficking of matrix protein has been reported to be critical for efficient production of Nipah virus and Respiratory syncytial virus, and nuclear localization of nucleocapsid protein of several morbilliviruses has been linked to mechanisms of immune evasion. Together, these data point to the nucleus as a significant host interface for viral proteins during infection by NSVs with otherwise cytoplasmic life cycles. Importantly, several lines of evidence now suggest that nuclear trafficking of these proteins may be critical to pathogenesis and thus could provide new targets for vaccine development and antiviral therapies.
[Mh] Termos MeSH primário: Núcleo Celular/virologia
Citoplasma/virologia
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Paramyxovirinae/genética
Montagem de Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000575


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[PMID]:27304985
[Au] Autor:Burroughs AL; Durr PA; Boyd V; Graham K; White JR; Todd S; Barr J; Smith I; Baverstock G; Meers J; Crameri G; Wang LF
[Ad] Endereço:Commonwealth Scientific and Industrial Research Organisation, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
[Ti] Título:Hendra Virus Infection Dynamics in the Grey-Headed Flying Fox (Pteropus poliocephalus) at the Southern-Most Extent of Its Range: Further Evidence This Species Does Not Readily Transmit the Virus to Horses.
[So] Source:PLoS One;11(6):e0155252, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hendra virus (HeV) is an important emergent virus in Australia known to infect horses and humans in certain regions of the east coast. Whilst pteropid bats ("flying foxes") are considered the natural reservoir of HeV, which of the four mainland species is the principal reservoir has been a source of ongoing debate, particularly as shared roosting is common. To help resolve this, we sampled a colony consisting of just one of these species, the grey-headed flying fox, (Pteropus poliocephalus), at the southernmost extent of its range. Using the pooled urine sampling technique at approximately weekly intervals over a two year period, we determined the prevalence of HeV and related paramyxoviruses using a novel multiplex (Luminex) platform. Whilst all the pooled urine samples were negative for HeV nucleic acid, we successfully identified four other paramyxoviruses, including Cedar virus; a henipavirus closely related to HeV. Collection of serum from individually caught bats from the colony showed that antibodies to HeV, as estimated by a serological Luminex assay, were present in between 14.6% and 44.5% of animals. The wide range of the estimate reflects uncertainties in interpreting intermediate results. Interpreting the study in the context of HeV studies from states to the north, we add support for an arising consensus that it is the black flying fox and not the grey-headed flying fox that is the principal source of HeV in spillover events to horses.
[Mh] Termos MeSH primário: Quirópteros/virologia
Vírus Hendra/fisiologia
Infecções por Henipavirus/virologia
Doenças dos Cavalos/virologia
Cavalos/virologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Anticorpos Antivirais/imunologia
Anticorpos Antivirais/urina
Austrália/epidemiologia
Reservatórios de Doenças/virologia
Geografia
Vírus Hendra/imunologia
Infecções por Henipavirus/epidemiologia
Infecções por Henipavirus/transmissão
Interações Hospedeiro-Patógeno
Seres Humanos
Infecções por Paramyxoviridae/epidemiologia
Infecções por Paramyxoviridae/transmissão
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/imunologia
Paramyxovirinae/fisiologia
Prevalência
Estações do Ano
Fatores de Tempo
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0155252


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[PMID]:27049514
[Au] Autor:Drake MG; Bivins-Smith ER; Proskocil BJ; Nie Z; Scott GD; Lee JJ; Lee NA; Fryer AD; Jacoby DB
[Ad] Endereço:1 Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon.
[Ti] Título:Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.
[So] Source:Am J Respir Cell Mol Biol;55(3):387-94, 2016 Sep.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory viruses cause asthma exacerbations. Because eosinophils are the prominent leukocytes in the airways of 60-70% of patients with asthma, we evaluated the effects of eosinophils on a common respiratory virus, parainfluenza 1, in the lung. Eosinophils recruited to the airways of wild-type mice after ovalbumin sensitization and challenge significantly decreased parainfluenza virus RNA in the lungs 4 days after infection compared with nonsensitized animals. This antiviral effect was also seen in IL-5 transgenic mice with an abundance of airway eosinophils (NJ.1726) but was lost in transgenic eosinophil-deficient mice (PHIL) and in IL-5 transgenic mice crossed with eosinophil-deficient mice (NJ.1726-PHIL). Loss of the eosinophil granule protein eosinophil peroxidase, using eosinophil peroxidase-deficient transgenic mice, did not reduce eosinophils' antiviral effect. Eosinophil antiviral mechanisms were also explored in vitro. Isolated human eosinophils significantly reduced parainfluenza virus titers. This effect did not involve degradation of viral RNA by eosinophil granule RNases. However, eosinophils treated with a nitric oxide synthase inhibitor lost their antiviral activity, suggesting eosinophils attenuate viral infectivity through production of nitric oxide. Consequently, eosinophil nitric oxide production was measured with an intracellular fluorescent probe. Eosinophils produced nitric oxide in response to virus and to a synthetic agonist of the virus-sensing innate immune receptor, Toll-like receptor (TLR) 7. IFNγ increased expression of eosinophil TLR7 and potentiated TLR7-induced nitric oxide production. These results suggest that eosinophils promote viral clearance in the lung and contribute to innate immune responses against respiratory virus infections in humans.
[Mh] Termos MeSH primário: Antivirais/imunologia
Eosinófilos/imunologia
Paramyxovirinae/imunologia
[Mh] Termos MeSH secundário: Animais
Eosinófilos/enzimologia
Feminino
Seres Humanos
Interferon gama/metabolismo
Pulmão/imunologia
Pulmão/patologia
Pulmão/virologia
Macaca mulatta
Camundongos Endogâmicos C57BL
Óxido Nítrico/metabolismo
Ovalbumina/imunologia
Infecções por Paramyxoviridae/imunologia
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/patogenicidade
Peroxidase/metabolismo
Ribonucleases/metabolismo
Receptor 7 Toll-Like/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Toll-Like Receptor 7); 31C4KY9ESH (Nitric Oxide); 82115-62-6 (Interferon-gamma); 9006-59-1 (Ovalbumin); EC 1.11.1.7 (Peroxidase); EC 3.1.- (Ribonucleases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2015-0405OC


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[PMID]:26974891
[Au] Autor:Steffens A; Finelli L; Whitaker B; Fowlkes A
[Ad] Endereço:From the *Influenza Division, and †Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
[Ti] Título:Population-based Surveillance for Medically Attended Human Parainfluenza Viruses From the Influenza Incidence Surveillance Project, 2010-2014.
[So] Source:Pediatr Infect Dis J;35(7):717-22, 2016 07.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parainfluenza viruses (PIV) have been shown to contribute substantially to pediatric hospitalizations in the United States. However, to date, there has been no systematic surveillance to estimate the burden among pediatric outpatients. METHODS: From August 2010 through July 2014, outpatient health care providers with enumerated patient populations in 13 states and jurisdictions participating in the Influenza Incidence Surveillance Project conducted surveillance of patients with influenza-like illness (ILI). Respiratory specimens were collected from the first 10 ILI patients each week with demographic and clinical data. Specimens were tested for multiple respiratory viruses, including PIV1-4, using reverse transcriptase-polymerase chain reaction assays. Cumulative incidence was calculated using provider patient population size as the denominator. RESULTS: PIVs 1-3 were detected in 8.0% of 7716 ILI-related outpatient specimens: 30% were PIV1, 26% PIV2 and 44% PIV3. PIV circulation varied noticeably by year and type, with PIV3 predominating in 2010-2011 (incidence 110 per 100,000 children), PIV1 in 2011-2012 (89 per 100,000), dual predominance of PIV2 and PIV3 (88 and 131 per 100,000) in 2012-2013 and PIV3 (100 per 100,000) in 2013-2014. The highest incidence of PIV detections was among patients aged <5 years (259-1307 per 100,000). The median age at detection for PIV3 (3.4 years) was significantly lower than the median ages for PIV1 (4.5 years) and PIV2 (7.0 years; P < 0.05). CONCLUSIONS: PIVs 1-3 comprise a substantial amount of medically attended pediatric ILI, particularly among children aged <5 years. Distinct seasonal circulation patterns as well as significant differences in rates by age were observed between PIV types.
[Mh] Termos MeSH primário: Influenza Humana/epidemiologia
Infecções por Paramyxoviridae/epidemiologia
Paramyxovirinae/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Fatores Etários
Criança
Pré-Escolar
DNA Viral/análise
Seres Humanos
Incidência
Lactente
Influenza Humana/virologia
Vírus da Parainfluenza 1 Humana/genética
Vírus da Parainfluenza 1 Humana/isolamento & purificação
Vírus da Parainfluenza 3 Humana/genética
Vírus da Parainfluenza 3 Humana/isolamento & purificação
Infecções por Paramyxoviridae/diagnóstico
Paramyxovirinae/genética
Vigilância da População
Infecções por Respirovirus/epidemiologia
Infecções por Respirovirus/virologia
Estações do Ano
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001140


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[PMID]:26956457
[Au] Autor:Bednarska K; Hallmann-Szelinska E; Kondratiuk K; Brydak LB
[Ad] Endereço:Department of Influenza Research, National Influenza Center, National Institute of Public Health - National Institute of Hygiene, 24 Chocimska St., 00-791, Warsaw, Poland. kbednarska@pzh.gov.pl.
[Ti] Título:Antigenic Drift of A/H3N2/Virus and Circulation of Influenza-Like Viruses During the 2014/2015 Influenza Season in Poland.
[So] Source:Adv Exp Med Biol;905:33-8, 2016.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Morbidity rates of influenza could be greatly reduced due to vaccination. However, the virus is able to evolve through genetic mutations, which is why vaccines with updated composition are necessary every season. Their effectiveness depends on whether there is a good antigenic match between circulating viruses and vaccine strains. In Poland, the 2014/2015 influenza epidemic started in week 5 (January/February) of 2015 and continued until week 17 (April) of 2015. The influenza activity was moderate with the highest incidence of influence-like illness at week 10/2015 (March). During that season, antigenic drift of influenza virus A/H3N2/ occurred causing higher rates of A/H3N2/ infections. Among the 2416 tested specimens, 22.6 % of influenza cases were positive for A/H3N2/, while A/H1N1/pdm09 constituted 14.6 % cases. Influenza A viruses were detected in co-circulation with influenza B viruses; the latter amounted to 34.1 % of all influenza detections. Other detected causes of influenza-like illness consisted of respiratory syncytial virus (RSV), being predominant, and, sporadically, human coronavirus, parainfluenza 1-3, rhinovirus, and adenovirus. Despite low vaccine effectiveness of solely one component, A/H3N2/, the vaccine could mitigate or shorten the length of influenza infection and reduce the number of severe outcomes and mortality. Thus, vaccination against influenza remains the most effective way to prevent illness and possibly fatal outcomes.
[Mh] Termos MeSH primário: Antígenos Virais/genética
Epidemias
Deriva Genética
Vírus da Influenza A Subtipo H1N1/genética
Vírus da Influenza A Subtipo H3N2/genética
Influenza Humana/virologia
Estações do Ano
[Mh] Termos MeSH secundário: Infecções por Adenovirus Humanos/epidemiologia
Infecções por Adenovirus Humanos/virologia
Adenovírus Humanos/genética
Adenovírus Humanos/imunologia
Adolescente
Adulto
Idoso
Antígenos Virais/imunologia
Criança
Pré-Escolar
Coronavirus/genética
Coronavirus/imunologia
Infecções por Coronavirus/epidemiologia
Infecções por Coronavirus/virologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Vírus da Influenza A Subtipo H1N1/imunologia
Vírus da Influenza A Subtipo H3N2/imunologia
Vírus da Influenza B/genética
Vírus da Influenza B/imunologia
Vacinas contra Influenza/imunologia
Vacinas contra Influenza/uso terapêutico
Influenza Humana/epidemiologia
Influenza Humana/prevenção & controle
Masculino
Meia-Idade
Reação em Cadeia da Polimerase Multiplex
Infecções por Paramyxoviridae/epidemiologia
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/genética
Paramyxovirinae/imunologia
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/virologia
Polônia/epidemiologia
Reação em Cadeia da Polimerase em Tempo Real
Infecções por Vírus Respiratório Sincicial/epidemiologia
Infecções por Vírus Respiratório Sincicial/virologia
Vírus Sincicial Respiratório Humano/genética
Vírus Sincicial Respiratório Humano/imunologia
Rhinovirus/genética
Rhinovirus/imunologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Viral); 0 (Influenza Vaccines)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.1007/5584_2016_216


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[PMID]:26915013
[Au] Autor:Zeltina A; Bowden TA; Lee B
[Ad] Endereço:Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
[Ti] Título:Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential.
[So] Source:PLoS Pathog;12(2):e1005390, 2016 Feb.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/virologia
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/fisiologia
Receptores Virais/metabolismo
Tropismo
Zoonoses/virologia
[Mh] Termos MeSH secundário: Animais
Glicoproteínas/genética
Glicoproteínas/metabolismo
Henipavirus/classificação
Henipavirus/genética
Henipavirus/fisiologia
Interações Hospedeiro-Patógeno
Seres Humanos
Morbillivirus/classificação
Morbillivirus/genética
Morbillivirus/fisiologia
Paramyxovirinae/classificação
Paramyxovirinae/genética
Filogenia
Proteínas Virais/genética
Proteínas Virais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycoproteins); 0 (Receptors, Virus); 0 (Viral Proteins)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170408
[Lr] Data última revisão:
170408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1005390


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[PMID]:26711050
[Au] Autor:Pees M; Neul A; Müller K; Schmidt V; Truyen U; Leinecker N; Marschang RE
[Ad] Endereço:Clinic for Birds and Reptiles, University of Leipzig, An den Tierkliniken 17, 04103 Leipzig, Germany. Electronic address: pees@vogelklinik.uni-leipzig.de.
[Ti] Título:Virus distribution and detection in corn snakes (Pantherophis guttatus) after experimental infection with three different ferlavirus strains.
[So] Source:Vet Microbiol;182:213-22, 2016 Jan 15.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ferlaviruses are important pathogens of snakes. However, factors influencing the pathogenicity of individual isolates as well as optimal protocols for virus detection in tissues of infected snakes have been insufficiently studied. The objectives of this study were to compare virus detection using previously described PCR and cell culture protocols following infection with three genetically distinct ferlaviruses in corn snakes (Pantherophis guttatus) as a model species. Groups of 12 corn snakes were each inoculated intratracheally with a genogroup A, B, or C ferlavirus. Tracheal washes and cloacal swabs were tested for virus shedding on days 16 and 28. Three animals were each euthanized on days 4, 16, 28, and 49. Beside immunohistochemistry of lung tissue, several organs (lung, intestine, pancreas, kidney, brain) were tested for the presence of ferlavirus. Distinct differences were noted in the pathogenicity of the three viruses, with a genotype B isolate causing the greatest pathology. PCR was more sensitive in comparison to cell culture, but results varied depending on the tissues. Ferlaviruses spread rapidly into the tissues, including the brain. Overall average detection rate was 72%, and was highest on day 16. There were differences between the groups, with the most virulent strain causing 100% positive samples at the end of the study. Some snakes were able to clear the infection. Shedding via cloaca was seen only on day 28. For ante-mortem sampling, a tracheal wash sample is recommended, for post mortem diagnosis, a pooled organ sample should be tested.
[Mh] Termos MeSH primário: Colubridae/virologia
Infecções por Paramyxoviridae/veterinária
Paramyxovirinae/genética
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Modelos Animais de Doenças
Infecções por Paramyxoviridae/genética
Infecções por Paramyxoviridae/fisiopatologia
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/patogenicidade
Paramyxovirinae/fisiologia
Traqueia/virologia
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151229
[Lr] Data última revisão:
151229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151230
[St] Status:MEDLINE


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[PMID]:26703878
[Au] Autor:Audsley MD; Marsh GA; Lieu KG; Tachedjian M; Joubert DA; Wang LF; Jans DA; Moseley GW
[Ad] Endereço:1​ Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
[Ti] Título:The immune evasion function of J and Beilong virus V proteins is distinct from that of other paramyxoviruses, consistent with their inclusion in the proposed genus Jeilongvirus.
[So] Source:J Gen Virol;97(3):581-92, 2016 Mar.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:IFN-antagonist function is a major determinant of pathogenicity and cross-species infection by viruses, but remains poorly defined for many potentially zoonotic viruses resident in animal species. The paramyxovirus family contains several zoonotic viruses, including highly pathogenic viruses such as Nipah virus and Hendra virus, and an increasing number of largely uncharacterized animal viruses. Here, we report the characterization of IFN antagonism by the rodent viruses J virus (JPV) and Beilong virus (BeiPV) of the proposed genus Jeilongvirus of the paramyxoviruses. Infection of cells by JPV and BeiPV was found to inhibit IFN-activated nuclear translocation of signal transducer and activator of transcription 1 (STAT1). However, in contrast to most other paramyxoviruses, the JPV and BeiPV V proteins did not interact with or inhibit signalling by STAT1 or STAT2, suggesting that JPV/BeiPV use an atypical V protein-independent strategy to target STATs, consistent with their inclusion in a separate genus. Nevertheless, the V proteins of both viruses interacted with melanoma differentiation-associated protein 5 (MDA5) and robustly inhibited MDA5-dependent activation of the IFN-ß promoter. This supports a growing body of evidence that MDA5 is a universal target of paramyxovirus V proteins, such that the V-MDA5 interaction represents a potential target for broad-spectrum antiviral approaches.
[Mh] Termos MeSH primário: Evasão da Resposta Imune
Infecções por Paramyxoviridae/imunologia
Paramyxovirinae/imunologia
Proteínas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
RNA Helicases DEAD-box/genética
RNA Helicases DEAD-box/imunologia
Células HEK293
Seres Humanos
Helicase IFIH1 Induzida por Interferon
Interferon-alfa/genética
Interferon-alfa/imunologia
Infecções por Paramyxoviridae/genética
Infecções por Paramyxoviridae/virologia
Paramyxovirinae/classificação
Paramyxovirinae/genética
Fator de Transcrição STAT1/genética
Fator de Transcrição STAT1/imunologia
Fator de Transcrição STAT2/genética
Fator de Transcrição STAT2/imunologia
Transdução de Sinais
Proteínas Virais/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Interferon-alpha); 0 (STAT1 Transcription Factor); 0 (STAT2 Transcription Factor); 0 (V protein, Paramyxovirus); 0 (Viral Proteins); EC 3.6.1.- (IFIH1 protein, human); EC 3.6.4.13 (DEAD-box RNA Helicases); EC 3.6.4.13 (Interferon-Induced Helicase, IFIH1)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000388


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[PMID]:26402433
[Au] Autor:Mortlock M; Kuzmin IV; Weyer J; Gilbert AT; Agwanda B; Rupprecht CE; Nel LH; Kearney T; Malekani JM; Markotter W
[Ti] Título:Novel Paramyxoviruses in Bats from Sub-Saharan Africa, 2007-2012.
[So] Source:Emerg Infect Dis;21(10):1840-3, 2015 Oct.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As part of a larger survey for detection of pathogens among wildlife in sub-Saharan Africa conducted during 2007-2012, multiple diverse paramyxovirus sequences were detected in renal tissues of bats. Phylogenetic analysis supports the presence of at least 2 major viral lineages and suggests that paramyxoviruses are strongly associated with several bat genera.
[Mh] Termos MeSH primário: Quirópteros/virologia
Henipavirus/patogenicidade
Infecções por Paramyxoviridae/epidemiologia
Paramyxovirinae/classificação
Prevalência
[Mh] Termos MeSH secundário: África ao Sul do Saara/epidemiologia
Animais
Infecções por Paramyxoviridae/virologia
Filogenia
Vigilância da População/métodos
RNA Viral/classificação
RNA Viral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151006
[Lr] Data última revisão:
151006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150925
[St] Status:MEDLINE
[do] DOI:10.3201/eid2110.140368



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