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[PMID]:28704440
[Au] Autor:Horton KC; Dueger EL; Kandeel A; Abdallat M; El-Kholy A; Al-Awaidy S; Kohlani AH; Amer H; El-Khal AL; Said M; House B; Pimentel G; Talaat M
[Ad] Endereço:Global Disease Detection Center, U.S. Centers for Disease Control and Prevention, Cairo, Egypt.
[Ti] Título:Viral etiology, seasonality and severity of hospitalized patients with severe acute respiratory infections in the Eastern Mediterranean Region, 2007-2014.
[So] Source:PLoS One;12(7):e0180954, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Little is known about the role of viral respiratory pathogens in the etiology, seasonality or severity of severe acute respiratory infections (SARI) in the Eastern Mediterranean Region. METHODS: Sentinel surveillance for SARI was conducted from December 2007 through February 2014 at 20 hospitals in Egypt, Jordan, Oman, Qatar and Yemen. Nasopharyngeal and oropharyngeal swabs were collected from hospitalized patients meeting SARI case definitions and were analyzed for infection with influenza, respiratory syncytial virus (RSV), adenovirus (AdV), human metapneumovirus (hMPV) and human parainfluenza virus types 1-3 (hPIV1-3). We analyzed surveillance data to calculate positivity rates for viral respiratory pathogens, describe the seasonality of those pathogens and determine which pathogens were responsible for more severe outcomes requiring ventilation and/or intensive care and/or resulting in death. RESULTS: At least one viral respiratory pathogen was detected in 8,753/28,508 (30.7%) samples tested for at least one pathogen and 3,497/9,315 (37.5%) of samples tested for all pathogens-influenza in 3,345/28,438 (11.8%), RSV in 3,942/24,503 (16.1%), AdV in 923/9,402 (9.8%), hMPV in 617/9,384 (6.6%), hPIV1 in 159/9,402 (1.7%), hPIV2 in 85/9,402 (0.9%) and hPIV3 in 365/9,402 (3.9%). Multiple pathogens were identified in 501/9,316 (5.4%) participants tested for all pathogens. Monthly variation, indicating seasonal differences in levels of infection, was observed for all pathogens. Participants with hMPV infections and participants less than five years of age were significantly less likely than participants not infected with hMPV and those older than five years of age, respectively, to experience a severe outcome, while participants with a pre-existing chronic disease were at increased risk of a severe outcome, compared to those with no reported pre-existing chronic disease. CONCLUSIONS: Viral respiratory pathogens are common among SARI patients in the Eastern Mediterranean Region. Ongoing surveillance is important to monitor changes in the etiology, seasonality and severity of pathogens of interest.
[Mh] Termos MeSH primário: Infecções Respiratórias/classificação
Infecções Respiratórias/virologia
[Mh] Termos MeSH secundário: Adenoviridae/classificação
Adenoviridae/isolamento & purificação
Criança
Pré-Escolar
Feminino
Seres Humanos
Vírus da Influenza A/classificação
Vírus da Influenza A/isolamento & purificação
Pacientes Internados
Masculino
Região do Mediterrâneo/epidemiologia
Metapneumovirus/classificação
Metapneumovirus/isolamento & purificação
Vigilância da População
Vírus Sincicial Respiratório Humano/classificação
Vírus Sincicial Respiratório Humano/isolamento & purificação
Infecções Respiratórias/epidemiologia
Respirovirus/classificação
Respirovirus/isolamento & purificação
Estações do Ano
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180954


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[PMID]:28539444
[Au] Autor:Liang B; Ngwuta JO; Surman S; Kabatova B; Liu X; Lingemann M; Liu X; Yang L; Herbert R; Swerczek J; Chen M; Moin SM; Kumar A; McLellan JS; Kwong PD; Graham BS; Collins PL; Munir S
[Ad] Endereço:RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
[Ti] Título:Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.
[So] Source:J Virol;91(15), 2017 Aug 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory tract disease worldwide, but it lacks a licensed vaccine or suitable antiviral drug. A live attenuated chimeric bovine/human parainfluenza virus type 3 (rB/HPIV3) was developed previously as a vector expressing RSV fusion (F) protein to confer bivalent protection against RSV and HPIV3. In a previous clinical trial in virus-naive children, rB/HPIV3 was well tolerated but the immunogenicity of wild-type RSV F was unsatisfactory. We previously modified RSV F with a designed disulfide bond (DS) to increase stability in the prefusion (pre-F) conformation and to be efficiently packaged in the vector virion. Here, we further stabilized pre-F by adding both disulfide and cavity-filling mutations (DS-Cav1), and we also modified RSV F codon usage to have a lower CpG content and a higher level of expression. This RSV F open reading frame was evaluated in rB/HPIV3 in three forms: (i) pre-F without vector-packaging signal, (ii) pre-F with vector-packaging signal, and (iii) secreted pre-F ectodomain trimer. Despite being efficiently expressed, the secreted pre-F was poorly immunogenic. DS-Cav1 stabilized pre-F, with or without packaging, induced higher titers of pre-F specific antibodies in hamsters, and improved the quality of RSV-neutralizing serum antibodies. Codon-optimized RSV F containing fewer CpG dinucleotides had higher F expression, replicated more efficiently , and was more immunogenic. The combination of DS-Cav1 pre-F stabilization, optimized codon usage, reduced CpG content, and vector packaging significantly improved vector immunogenicity and protective efficacy against RSV. This provides an improved vectored RSV vaccine candidate suitable for pediatric clinical evaluation. RSV and HPIV3 are the first and second leading viral causes of severe pediatric respiratory disease worldwide. Licensed vaccines or suitable antiviral drugs are not available. We are developing a chimeric rB/HPIV3 vector expressing RSV F as a bivalent RSV/HPIV3 vaccine and have been evaluating means to increase RSV F immunogenicity. In this study, we evaluated the effects of improved stabilization of F in the pre-F conformation and of codon optimization resulting in reduced CpG content and greater pre-F expression. Reduced CpG content dampened the interferon response to infection, promoting higher replication and increased F expression. We demonstrate that improved pre-F stabilization and strategic manipulation of codon usage, together with efficient pre-F packaging into vector virions, significantly increased F immunogenicity in the bivalent RSV/HPIV3 vaccine. The improved immunogenicity included induction of increased titers of high-quality complement-independent antibodies with greater pre-F site Ø binding and greater protection against RSV challenge.
[Mh] Termos MeSH primário: Portadores de Fármacos
Vacinas contra Vírus Sincicial Respiratório/imunologia
Respirovirus/fisiologia
Proteínas Virais de Fusão/imunologia
Vírion/metabolismo
Montagem de Vírus
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Códon
Cricetinae
Proteínas Mutantes/química
Proteínas Mutantes/genética
Proteínas Mutantes/imunologia
Estabilidade Proteica
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/imunologia
Vacinas contra Vírus Sincicial Respiratório/administração & dosagem
Vacinas contra Vírus Sincicial Respiratório/genética
Respirovirus/genética
Vacinas Sintéticas/administração & dosagem
Vacinas Sintéticas/genética
Vacinas Sintéticas/imunologia
Proteínas Virais de Fusão/química
Proteínas Virais de Fusão/genética
Vírion/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Codon); 0 (Drug Carriers); 0 (F protein, human respiratory syncytial virus); 0 (Mutant Proteins); 0 (Recombinant Proteins); 0 (Respiratory Syncytial Virus Vaccines); 0 (Vaccines, Synthetic); 0 (Viral Fusion Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE


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[PMID]:27879287
[Au] Autor:Abboud G; Desai P; Dastmalchi F; Stanfield J; Tahiliani V; Hutchinson TE; Salek-Ardakani S
[Ad] Endereço:Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.
[Ti] Título:Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection.
[So] Source:J Exp Med;213(13):2897-2911, 2016 Dec 12.
[Is] ISSN:1540-9538
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:How tissue-specific anatomical distribution and phenotypic specialization are linked to protective efficacy of memory T cells against reinfection is unclear. Here, we show that lung environmental cues program recently recruited central-like memory cells with migratory potentials for their tissue-specific functions during lethal respiratory virus infection. After entering the lung, some central-like cells retain their original CD27 CXCR3 phenotype, enabling them to localize near the infected bronchiolar epithelium and airway lumen to function as the first line of defense against pathogen encounter. Others, in response to local cytokine triggers, undergo a secondary program of differentiation that leads to the loss of CXCR3, migration arrest, and clustering within peribronchoarterial areas and in interalveolar septa. Here, the immune system adapts its response to prevent systemic viral dissemination and mortality. These results reveal the striking and unexpected spatial organization of central- versus effector-like memory cells within the lung and how cooperation between these two subsets contributes to host defense.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Memória Imunológica
Alvéolos Pulmonares/imunologia
Infecções Respiratórias/imunologia
Infecções por Respirovirus/imunologia
Respirovirus/imunologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD8-Positivos/patologia
Feminino
Camundongos
Camundongos Transgênicos
Alvéolos Pulmonares/patologia
Infecções Respiratórias/genética
Infecções Respiratórias/patologia
Infecções Respiratórias/virologia
Infecções por Respirovirus/genética
Infecções por Respirovirus/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


  4 / 2139 MEDLINE  
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[PMID]:27439403
[Au] Autor:Esposito S; Bianchini S; Gambino M; Madini B; Di Pietro G; Umbrello G; Presicce ML; Ruggiero L; Terranova L; Principi N
[Ad] Endereço:Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy. susanna.esposito@unimi.it.
[Ti] Título:Measurement of lipocalin-2 and syndecan-4 levels to differentiate bacterial from viral infection in children with community-acquired pneumonia.
[So] Source:BMC Pulm Med;16(1):103, 2016 Jul 20.
[Is] ISSN:1471-2466
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study, we evaluated the lipocalin-2 (LIP2) and syndecan-4 (SYN4) levels in children who were hospitalized for radiologically confirmed CAP in order to differentiate bacterial from viral infection. The results regarding the LIP2 and SYN4 diagnostic outcomes were compared with the white blood cell (WBC) count and C reactive protein (CRP) levels. METHODS: A total of 110 children <14 years old who were hospitalized for radiologically confirmed CAP were enrolled. Serum samples were obtained upon admission and on day 5 to measure the levels of LIP2, SYN4, and CRP as well as the WBC. Polymerase chain reaction of the respiratory secretions and tests on blood samples were performed to detect respiratory viruses, Streptococcus pneumoniae, and Mycoplasma pneumoniae. RESULTS: CAP was considered to be due to a probable bacterial infection in 74 children (67.3 %) and due to a probable viral infection in 16 children (14.5 %). Overall, 84 children (76.4 %) were diagnosed with severe CAP. The mean values of the WBC count and the LIP2 and SYN4 levels did not differ among the probable bacterial, probable viral, and undetermined cases. However, the CRP serum concentrations were significantly higher in children with probable bacterial CAP than in those with probable viral disease (32.2 ± 55.5 mg/L vs 9.4 ± 17.0 mg/L, p < 0.05). The WBC count was the best predictor of severe CAP, but the differences among the studied variables were marginal. The WBC count was significantly lower on day 5 in children with probable bacterial CAP (p < 0.01) and in those with an undetermined etiology (p < 0.01). The CRP and LIP2 levels were significantly lower 5 days after enrollment in all of the studied groups, independent of the supposed etiology of CAP (p < 0.01 for all comparisons). No statistically significant variation was observed for SYN4. CONCLUSIONS: Measuring the LIP2 and SYN4 levels does not appear to solve the problem of the poor reliability of routine laboratory tests in defining the etiology and severity of pediatric CAP. Currently, the CRP levels and WBC, when combined with evaluation of clinical data, can be used to limit the overuse of antibiotics as much as possible and to provide the best treatment to the patient.
[Mh] Termos MeSH primário: Infecções Comunitárias Adquiridas/sangue
Lipocalina-2/sangue
Pneumonia Bacteriana/sangue
Pneumonia Viral/sangue
Sindecana-4/sangue
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Proteína C-Reativa/análise
Criança
Pré-Escolar
Infecções Comunitárias Adquiridas/diagnóstico
Diagnóstico Diferencial
Feminino
Seres Humanos
Lactente
Itália
Contagem de Leucócitos
Modelos Logísticos
Masculino
Mycoplasma pneumoniae/isolamento & purificação
Pneumonia Bacteriana/diagnóstico
Pneumonia Viral/diagnóstico
Curva ROC
Reprodutibilidade dos Testes
Respirovirus/isolamento & purificação
Streptococcus pneumoniae/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Lipocalin-2); 0 (Syndecan-4); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1186/s12890-016-0267-4


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[PMID]:26980833
[Au] Autor:Palermo LM; Uppal M; Skrabanek L; Zumbo P; Germer S; Toussaint NC; Rima BK; Huey D; Niewiesk S; Porotto M; Moscona A
[Ad] Endereço:Departments of Pediatrics, Microbiology and Immunology, and Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, USA.
[Ti] Título:Features of Circulating Parainfluenza Virus Required for Growth in Human Airway.
[So] Source:MBio;7(2):e00235, 2016 Mar 15.
[Is] ISSN:2150-7511
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Respiratory paramyxoviruses, including the highly prevalent human parainfluenza viruses, cause the majority of childhood croup, bronchiolitis, and pneumonia, yet there are currently no vaccines or effective treatments. Paramyxovirus research has relied on the study of laboratory-adapted strains of virus in immortalized cultured cell lines. We show that findings made in such systems about the receptor interaction and viral fusion requirements for entry and fitness-mediated by the receptor binding protein and the fusion protein-can be drastically different from the requirements for infection in vivo. Here we carried out whole-genome sequencing and genomic analysis of circulating human parainfluenza virus field strains to define functional and structural properties of proteins of circulating strains and to identify the genetic basis for properties that confer fitness in the field. The analysis of clinical strains suggests that the receptor binding-fusion molecule pairs of circulating viruses maintain a balance of properties that result in an inverse correlation between fusion in cultured cells and growth in vivo. Future analysis of entry mechanisms and inhibitory strategies for paramyxoviruses will benefit from considering the properties of viruses that are fit to infect humans, since a focus on viruses that have adapted to laboratory work provides a distinctly different picture of the requirements for the entry step of infection. IMPORTANCE: Mechanistic information about viral infection-information that impacts antiviral and vaccine development-is generally derived from viral strains grown under laboratory conditions in immortalized cells. This study uses whole-genome sequencing of clinical strains of human parainfluenza virus 3-a globally important respiratory paramyxovirus-in cell systems that mimic the natural human host and in animal models. By examining the differences between clinical isolates and laboratory-adapted strains, the sequence differences are correlated to mechanistic differences in viral entry. For this ubiquitous and pathogenic respiratory virus to infect the human lung, modulation of the processes of receptor engagement and fusion activation occur in a manner quite different from that carried out by the entry glycoprotein-expressing pair of laboratory strains. These marked contrasts in the viral properties necessary for infection in cultured immortalized cells and in natural host tissues and animals will influence future basic and clinical studies.
[Mh] Termos MeSH primário: Sistema Respiratório/virologia
Respirovirus/fisiologia
Internalização do Vírus
[Mh] Termos MeSH secundário: Animais
Genoma Viral
Seres Humanos
Respirovirus/isolamento & purificação
Respirovirus/patogenicidade
Respirovirus/ultraestrutura
Infecções por Respirovirus/virologia
Análise de Sequência de DNA
Sigmodontinae
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE


  6 / 2139 MEDLINE  
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[PMID]:26968533
[Au] Autor:Waghmare A; Englund JA; Boeckh M
[Ad] Endereço:University of Washington, Seattle, WA; Seattle Children's Hospital, Seattle, WA; and Fred Hutchinson Cancer Research Center, Seattle, WA.
[Ti] Título:How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation.
[So] Source:Blood;127(22):2682-92, 2016 Jun 02.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The widespread use of multiplex molecular diagnostics has led to a significant increase in the detection of respiratory viruses in patients undergoing cytotoxic chemotherapy and hematopoietic cell transplantation (HCT). Respiratory viruses initially infect the upper respiratory tract and then progress to lower respiratory tract disease in a subset of patients. Lower respiratory tract disease can manifest itself as airflow obstruction or viral pneumonia, which can be fatal. Infection in HCT candidates may require delay of transplantation. The risk of progression differs between viruses and immunosuppressive regimens. Risk factors for progression and severity scores have been described, which may allow targeting treatment to high-risk patients. Ribavirin is the only antiviral treatment option for noninfluenza respiratory viruses; however, high-quality data demonstrating its efficacy and relative advantages of the aerosolized versus oral form are lacking. There are significant unmet needs, including data defining the virologic characteristics and clinical significance of human rhinoviruses, human coronaviruses, human metapneumovirus, and human bocavirus, as well as the need for new treatment and preventative options.
[Mh] Termos MeSH primário: Transplante de Células-Tronco Hematopoéticas
Pneumonia Viral/tratamento farmacológico
Infecções por Respirovirus/tratamento farmacológico
Respirovirus
Ribavirina/uso terapêutico
[Mh] Termos MeSH secundário: Aloenxertos
Seres Humanos
Pneumonia Viral/etiologia
Infecções por Respirovirus/etiologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
49717AWG6K (Ribavirin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2016-01-634873


  7 / 2139 MEDLINE  
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[PMID]:26904972
[Au] Autor:Salvatore M; Satlin MJ; Jacobs SE; Jenkins SG; Schuetz AN; Moss RB; Van Besien K; Shore T; Soave R
[Ad] Endereço:Department of Medicine, Weill Cornell Medicine, New York, New York. Electronic address: mis2053@med.cornell.edu.
[Ti] Título:DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center.
[So] Source:Biol Blood Marrow Transplant;22(5):965-70, 2016 May.
[Is] ISSN:1523-6536
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parainfluenza virus (PIV) causes severe respiratory infections in hematopoietic stem cell transplant (HSCT) recipients. Currently, no effective therapies are available. DAS181 is a novel antiviral agent that inhibits attachment of PIV to respiratory cells, but clinical data on the use of DAS181 for PIV infection are limited to case reports. We report the clinical manifestations and outcomes of 16 HSCT recipients who received DAS181 daily for the treatment of PIV infection through a compassionate-use protocol or a single-arm clinical trial. Of the 16 patients (clinical trial: 9; compassionate use: 7), 13 were allogeneic HSCT recipients and 8 had graft-versus-host disease. PIV types were 3 (n = 7), 4 (n = 5), 1 (n = 3), and type 3 and 4 coinfection (n = 1). Fourteen patients had pneumonia. All patients presented with cough, 14 had dyspnea, 11 had hypoxia, and 8 had a fever. Patients received 5 to 10 days of treatment. Nine patients (56%) had a complete clinical response after DAS181 therapy and 4 (25%) had a partial response. The 3 patients without a clinical response had coinfections with other pathogens. Of the 7 patients with virologic and spirometric data, 5 had >1-log reduction in nasopharyngeal swab PIV viral load and 4 had improved forced expiratory volumes by the end of treatment. Three patients (19%) died within 30 days and 2 of these deaths were related to PIV infection. Our data suggest that DAS181 may be an effective therapy for PIV pneumonia in HSCT recipients. Randomized placebo-controlled trials are needed to better evaluate its efficacy.
[Mh] Termos MeSH primário: Infecções por Paramyxoviridae/sangue
Infecções por Paramyxoviridae/tratamento farmacológico
Pneumonia Viral/sangue
Pneumonia Viral/tratamento farmacológico
Proteínas Recombinantes de Fusão/administração & dosagem
Respirovirus
[Mh] Termos MeSH secundário: Adulto
Idoso
Aloenxertos
Feminino
Transplante de Células-Tronco Hematopoéticas
Seres Humanos
Masculino
Meia-Idade
Infecções por Paramyxoviridae/etiologia
Pneumonia Viral/etiologia
Carga Viral
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DAS181); 0 (Recombinant Fusion Proteins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161217
[Lr] Data última revisão:
161217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE


  8 / 2139 MEDLINE  
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[PMID]:26741826
[Au] Autor:Pretorius MA; Tempia S; Walaza S; Cohen AL; Moyes J; Variava E; Dawood H; Seleka M; Hellferscee O; Treurnicht F; Cohen C; Venter M
[Ad] Endereço:National Health Laboratory Service, Tshwane Academic Division, South Africa; Department of Medical Virology, University of Pretoria, South Africa; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, Sou
[Ti] Título:The role of influenza, RSV and other common respiratory viruses in severe acute respiratory infections and influenza-like illness in a population with a high HIV sero-prevalence, South Africa 2012-2015.
[So] Source:J Clin Virol;75:21-6, 2016 Feb.
[Is] ISSN:1873-5967
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Viruses detected in patients with acute respiratory infections may be the cause of illness or asymptomatic shedding. OBJECTIVE: To estimate the attributable fraction (AF) and the detection rate attributable to illness for each of the different respiratory viruses STUDY DESIGN: We compared the prevalence of 10 common respiratory viruses (influenza A and B viruses, parainfluenza virus 1-3; respiratory syncytial virus (RSV); adenovirus, rhinovirus, human metapneumovirus (hMPV) and enterovirus) in both HIV positive and negative patients hospitalized with severe acute respiratory illness (SARI), outpatients with influenza-like illness (ILI), and control subjects who did not report any febrile, respiratory or gastrointestinal illness during 2012-2015 in South Africa. RESULTS: We enrolled 1959 SARI, 3784 ILI and 1793 controls with a HIV sero-prevalence of 26%, 30% and 43%, respectively. Influenza virus (AF: 86.3%; 95%CI: 77.7-91.6%), hMPV (AF: 85.6%; 95%CI: 72.0-92.6%), and RSV (AF: 83.7%; 95%CI: 77.5-88.2%) infections were associated with severe disease., while rhinovirus (AF: 46.9%; 95%CI: 37.6-56.5%) and adenovirus (AF: 36.4%; 95%CI: 20.6-49.0%) were only moderately associated. CONCLUSIONS: Influenza, RSV and hMPV can be considered pathogens if detected in ILI and SARI while rhinovirus and adenovirus were commonly identified in controls suggesting that they may cause only a proportion of clinical disease observed in positive patients. Nonetheless, they may be important contributors to disease.
[Mh] Termos MeSH primário: Adenoviridae
Infecções por HIV/complicações
Orthomyxoviridae
Respirovirus
Rhinovirus
Síndrome Respiratória Aguda Grave/virologia
[Mh] Termos MeSH secundário: Infecções por HIV/sangue
Soropositividade para HIV
Seres Humanos
Influenza Humana/sangue
Influenza Humana/virologia
Prevalência
Síndrome Respiratória Aguda Grave/epidemiologia
Síndrome Respiratória Aguda Grave/etiologia
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160131
[Lr] Data última revisão:
160131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE


  9 / 2139 MEDLINE  
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[PMID]:26711433
[Au] Autor:Richardson L; Brite J; Del Castillo M; Childers T; Sheahan A; Huang YT; Dougherty E; Babady NE; Sepkowitz K; Kamboj M
[Ad] Endereço:Infection Control, New York, NY, USA. Electronic address: britej@mskcc.org.
[Ti] Título:Comparison of respiratory virus shedding by conventional and molecular testing methods in patients with haematological malignancy.
[So] Source:Clin Microbiol Infect;22(4):380.e1-380.e7, 2016 Apr.
[Is] ISSN:1469-0691
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Respiratory viruses (RV) are a leading cause of infection-related morbidity and mortality for patients undergoing treatment for cancer. This analysis compared duration of RV shedding as detected by culture and PCR among patients in a high-risk oncology setting (adult patients with haematological malignancy and/or stem cell transplant and all paediatric oncology patients) and determined risk factors for extended shedding. RV infections due to influenza virus, parainfluenza virus (PIV), human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) from two study periods-January 2009-September 2011 (culture-based testing) and September 2011-April 2013 (PCR-based testing)-were reviewed retrospectively. Data were collected from patients in whom re-testing for viral clearance was carried out within 5-30 days after the most recent test. During the study period 456 patients were diagnosed with RV infection, 265 by PCR and 191 by culture. The median range for duration of shedding (days) by culture and PCR, respectively, were as follows-influenza virus: 13 days (5-38 days) versus 14 days (5-58 days), p 0.5; RSV: 11 days (5-35 days) versus 16 days (5-50 days), p 0.001; PIV: 9 days (5-41 days) versus 17 days (5-45 days), p ≤0.0001; HMPV 10.5 days (5-29 days) versus 14 days (5-42 days), p 0.2. In multivariable analysis, age and underlying disease or transplant were not independently associated with extended shedding regardless of testing method. In high-risk oncology settings for respiratory illness due to RSV and PIV, the virus is detectable by PCR for a longer period of time than by culture and extended shedding is observed.
[Mh] Termos MeSH primário: Neoplasias Hematológicas/complicações
Reação em Cadeia da Polimerase
Infecções Respiratórias/virologia
Cultura de Vírus
Viroses/virologia
Eliminação de Partículas Virais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Metapneumovirus/isolamento & purificação
Meia-Idade
Orthomyxoviridae/isolamento & purificação
Vírus Sinciciais Respiratórios/isolamento & purificação
Respirovirus/isolamento & purificação
Estudos Retrospectivos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151230
[St] Status:MEDLINE


  10 / 2139 MEDLINE  
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[PMID]:26631811
[Au] Autor:Yang L; Li W; Mao L; Hao F; Wang Z; Zhang W; Deng J; Jiang J
[Ad] Endereço:Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing 210014, China; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014,
[Ti] Título:Analysis on the complete genome of a novel caprine parainfluenza virus 3.
[So] Source:Infect Genet Evol;38:29-34, 2016 Mar.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Parainfluenza virus type 3 (PIV3) is one of the most important viral respiratory pathogens for humans and for many animals. One unique caprine PIV3 (CPIV3) strain named JS2013 was isolated in Chinese goat flocks with respiratory diseases in 2013. Now, the complete genome sequence of the strain JS2013 had been determined. A total of 15 overlapping DNA clones, covering the entire genome of the virus, were obtained by primer walking RT-PCR. The sequences of the 3' and 5' termini of the viral genome were amplified by 3' and 5' RACE. The viral genome was 15,618 nucleotides (nt) in length, which was consisted of six genes in the order 5'-leader-N-P/C/V-M-F-HN-L-tailer-3'. The junction sequences between two genes were highly conserved gene start and stop signal sequences, and trinucleotide intergenic regions (IGR) similar to those of other reported PIV3 strains. Phylogenetic analysis based on the complete genomes of JS2013 with other strains of genus Respirovirus demonstrated that the JS2013 obviously differed from HPIV1, Sendai virus, HPIV3 and other reported BPIV3 genotypes. Further analysis of HN genes of JS2013 along with two more CPIV3 strains isolated later indicated that CPIV3 strains formed a separate cluster. The results presented here suggested that CPIV3 is a new member of the genus Respirovirus.
[Mh] Termos MeSH primário: Genoma Viral
Genômica
Doenças das Cabras/virologia
Respirovirus/classificação
Respirovirus/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Linhagem Celular
Genes Virais
Cabras
Dados de Sequência Molecular
Fases de Leitura Aberta
Filogenia
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE



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