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  1 / 29 MEDLINE  
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[PMID]:28514874
[Au] Autor:Velazquez-Salinas L; Naik S; Pauszek SJ; Peng KW; Russell SJ; Rodriguez LL
[Ad] Endereço:1 United States Department of Agriculture, Agricultural Research Services , Foreign Animal Disease Research Unit, Plum Island, New York.
[Ti] Título:Oncolytic Recombinant Vesicular Stomatitis Virus (VSV) Is Nonpathogenic and Nontransmissible in Pigs, a Natural Host of VSV.
[So] Source:Hum Gene Ther Clin Dev;28(2):108-115, 2017 Jun.
[Is] ISSN:2324-8645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus that naturally causes disease in livestock including horses, cattle and pigs. The two main identified VSV serotypes are New Jersey (VSNJV) and Indiana (VSIV). VSV is a rapidly replicating, potently immunogenic virus that has been engineered to develop novel oncolytic therapies for cancer treatment. Swine are a natural host for VSV and provide a relevant and well-established model, amenable to biological sampling to monitor virus shedding and neutralizing antibodies. Previous reports have documented the pathogenicity and transmissibility of wild-type isolates and recombinant strains of VSIV and VSNJV using the swine model. Oncolytic VSV engineered to express interferon-beta (IFNß) and the sodium iodide symporter (NIS), VSV-IFNß-NIS, has been shown to be a potent new therapeutic agent inducing rapid and durable tumor remission following systemic therapy in preclinical mouse models. VSV-IFNß-NIS is currently undergoing clinical evaluation for the treatment of advanced cancer in human and canine patients. To support clinical studies and comprehensively assess the risk of transmission to susceptible species, we tested the pathogenicity and transmissibility of oncolytic VSV-IFNß-NIS using the swine model. Following previously established protocols to evaluate VSV pathogenicity, intradermal inoculation with 10 TCID VSV-IFNß-NIS caused no observable symptoms in pigs. There was no detectable shedding of infectious virus in VSV-IFNß-NIS in biological excreta of inoculated pigs or exposed naive pigs kept in direct contact throughout the experiment. VSV-IFNß-NIS inoculated pigs became seropositive for VSV antibodies, while contact pigs displayed no symptoms of VSV infection, and importantly did not seroconvert. These data indicate that oncolytic VSV is both nonpathogenic and not transmissible in pigs, a natural host. These findings support further clinical development of oncolytic VSV-IFNß-NIS as a safe therapeutic for human and canine cancer.
[Mh] Termos MeSH primário: Terapia Viral Oncolítica/efeitos adversos
Vírus Oncolíticos/patogenicidade
Vírus da Estomatite Vesicular Indiana/patogenicidade
Vírus da Estomatite Vesicular New Jersey/patogenicidade
[Mh] Termos MeSH secundário: Animais
Interferon gama/genética
Interferon gama/metabolismo
Vírus Oncolíticos/genética
Suínos
Simportadores/genética
Simportadores/metabolismo
Vírus da Estomatite Vesicular Indiana/genética
Vírus da Estomatite Vesicular New Jersey/genética
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Symporters); 0 (sodium-iodide symporter); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1089/humc.2017.015


  2 / 29 MEDLINE  
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[PMID]:27312365
[Au] Autor:Mesquita LP; Diaz MH; Howerth EW; Stallknecht DE; Noblet R; Gray EW; Mead DG
[Ad] Endereço:1 Department of Pathology, University of Georgia, Athens, GA, USA.
[Ti] Título:Pathogenesis of Vesicular Stomatitis New Jersey Virus Infection in Deer Mice ( Peromyscus maniculatus) Transmitted by Black Flies ( Simulium vittatum).
[So] Source:Vet Pathol;54(1):74-81, 2017 Jan.
[Is] ISSN:1544-2217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The natural transmission of vesicular stomatitis New Jersey virus (VSNJV), an arthropod-borne virus, is not completely understood. Rodents may have a role as reservoir or amplifying hosts. In this study, juvenile and nestling deer mice ( Peromyscus maniculatus) were exposed to VSNJV-infected black fly ( Simulium vittatum) bites followed by a second exposure to naive black flies on the nestling mice. Severe neurological signs were observed in some juvenile mice by 6 to 8 days postinoculation (DPI); viremia was not detected in 25 juvenile deer mice following exposure to VSNJV-infected fly bites. Both juvenile and nestling mice had lesions and viral antigen in the central nervous system (CNS); in juveniles, their distribution suggested that the sensory pathway was the most likely route to the CNS. In contrast, a hematogenous route was probably involved in nestling mice, since all of these mice developed viremia and had widespread antigen distribution in the CNS and other tissues on 2 DPI. VSNJV was recovered from naive flies that fed on viremic nestling mice. This is the first report of viremia in a potential natural host following infection with VSNJV via insect bite and conversely of an insect becoming infected with VSNJV by feeding on a viremic host. These results, along with histopathology and immunohistochemistry, show that nestling mice have widespread dissemination of VSNJV following VSNJV-infected black fly bite and are a potential reservoir or amplifying host for VSNJV.
[Mh] Termos MeSH primário: Peromyscus/virologia
Infecções por Rhabdoviridae/veterinária
Simuliidae/virologia
Vírus da Estomatite Vesicular New Jersey/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos/virologia
Reservatórios de Doenças/virologia
Feminino
Infecções por Rhabdoviridae/transmissão
Infecções por Rhabdoviridae/virologia
Viremia/transmissão
Viremia/veterinária
Viremia/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.1177/0300985816653172


  3 / 29 MEDLINE  
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[PMID]:27780575
[Au] Autor:Mesquita LP; Bruhn FR; Maiorka PC; Howerth EW
[Ad] Endereço:Department of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, USA.
[Ti] Título:Expression Kinetics of RANTES and MCP-1 in the Brain of Deer Mice (Peromyscus maniculatus) Infected with Vesicular Stomatitis New Jersey Virus.
[So] Source:J Comp Pathol;155(4):326-338, 2016 Nov.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The vesicular stomatitis virus (VSV) causes encephalitis in mice when inoculated intranasally. The deer mouse (Peromyscus maniculatus), a native New World rodent, is also susceptible to VSV infection and develops similar central nervous system (CNS) lesions to those observed in other rodent species. Chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES; CCL-5) and monocyte chemoattractant protein (MCP)-1 (CCL-2), which are important for chemotaxis and activation of inflammatory cells, are expressed during the course of VSV encephalitis. However, the role of CNS resident cells in chemokine expression is poorly characterized. Here, we show that during vesicular stomatitis New Jersey virus (VSNJV) encephalitis in deer mice, RANTES and MCP-1 are expressed only in the olfactory bulb (OB), where the virus was localized. This chemokine expression was followed by the influx of inflammatory cells to the OB later in the course of acute disease. Neurons, astrocytes and microglia expressed RANTES, while MCP-1 was expressed by neurons and astrocytes. Although astrocytes and microglia responded to VSNJV infection by expressing chemokines, neurons were the cell type that was predominantly infected. Therefore, infected neurons may have a critical role in initiating an immune response in the OB. The signalling between neurons and other CNS resident cells is most likely the mechanism by which astrocytes and microglia are activated during the course of VSV encephalitis.
[Mh] Termos MeSH primário: Quimiocina CCL2/biossíntese
Quimiocina CCL5/biossíntese
Encefalite Infecciosa/imunologia
Neurônios/imunologia
Bulbo Olfatório/imunologia
Estomatite Vesicular/imunologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/imunologia
Feminino
Imunofluorescência
Imuno-Histoquímica
Encefalite Infecciosa/metabolismo
Cinética
Bulbo Olfatório/metabolismo
Bulbo Olfatório/virologia
Peromyscus
Estomatite Vesicular/metabolismo
Vírus da Estomatite Vesicular New Jersey
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokine CCL2); 0 (Chemokine CCL5)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE


  4 / 29 MEDLINE  
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[PMID]:27118518
[Au] Autor:Fowler VL; Howson EL; Madi M; Mioulet V; Caiusi C; Pauszek SJ; Rodriguez LL; King DP
[Ad] Endereço:The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, United Kingdom. Electronic address: veronica.fowler@pirbright.ac.uk.
[Ti] Título:Development of a reverse transcription loop-mediated isothermal amplification assay for the detection of vesicular stomatitis New Jersey virus: Use of rapid molecular assays to differentiate between vesicular disease viruses.
[So] Source:J Virol Methods;234:123-31, 2016 Aug.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Vesicular stomatitis (VS) is endemic in Central America and northern regions of South America, where sporadic outbreaks in cattle and pigs can cause clinical signs that are similar to foot-and-mouth disease (FMD). There is therefore a pressing need for rapid, sensitive and specific differential diagnostic assays that are suitable for decision making in the field. RT-LAMP assays have been developed for vesicular diseases such as FMD and swine vesicular disease (SVD) but there is currently no RT-LAMP assay that can detect VS virus (VSV), nor are there any multiplex RT-LAMP assays which permit rapid discrimination between these 'look-a-like' diseases in situ. This study describes the development of a novel RT-LAMP assay for the detection of VSV focusing on the New Jersey (VSNJ) serotype, which has caused most of the recent VS cases in the Americas. This RT-LAMP assay was combined in a multiplex format combining molecular lateral-flow devices for the discrimination between FMD and VS. This assay was able to detect representative VSNJV's and the limit of detection of the singleplex and multiplex VSNJV RT-LAMP assays were equivalent to laboratory based real-time RT-PCR assays. A similar multiplex RT-LAMP assay was developed to discriminate between FMDV and SVDV, showing that FMDV, SVDV and VSNJV could be reliably detected within epithelial suspensions without the need for prior RNA extraction, providing an approach that could be used as the basis for a rapid and low cost assay for differentiation of FMD from other vesicular diseases in the field.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Estomatite Vesicular/diagnóstico
Vírus da Estomatite Vesicular New Jersey/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Bovinos/virologia
Doenças dos Bovinos/diagnóstico
Doenças dos Bovinos/virologia
América Central
Febre Aftosa/virologia
RNA Viral/genética
Sensibilidade e Especificidade
América do Sul
Suínos/virologia
Doenças dos Suínos/diagnóstico
Doenças dos Suínos/virologia
Doença Vesicular Suína/virologia
Temperatura Ambiente
Estomatite Vesicular/virologia
Vírus da Estomatite Vesicular New Jersey/classificação
Vírus da Estomatite Vesicular New Jersey/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE


  5 / 29 MEDLINE  
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[PMID]:24418533
[Au] Autor:Velazquez-Salinas L; Pauszek SJ; Zarate S; Basurto-Alcantara FJ; Verdugo-Rodriguez A; Perez AM; Rodriguez LL
[Ad] Endereço:Foreign Animal Disease Research Unit, USDA/ARS Plum Island Animal Disease Center, PO Box 848, Greenport, NY 11944, USA; Oak Ridge Institute for Science and Education (ORISE), USA.
[Ti] Título:Phylogeographic characteristics of vesicular stomatitis New Jersey viruses circulating in Mexico from 2005 to 2011 and their relationship to epidemics in the United States.
[So] Source:Virology;449:17-24, 2014 Jan 20.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We analyzed the phylogenetic and time-space relationships (phylodynamics) of 181 isolates of vesicular stomatitis New Jersey virus (VSNJV) causing disease in Mexico and the United States (US) from 2005 through 2012. We detail the emergence of a genetic lineage in southern Mexico causing outbreaks in central Mexico spreading into northern Mexico and eventually into the US. That emerging lineage showed higher nucleotide sequence identity (99.5%) than that observed for multiple lineages circulating concurrently in southern Mexico (96.8%). Additionally, we identified 58 isolates from Mexico that, unlike previous isolates from Mexico, grouped with northern Central America clade II viruses. This study provides the first direct evidence for the emergence and northward migration of a specific VSNJV genetic lineage from endemic areas in Mexico causing VS outbreaks in the US. In addition we document the emergence of a Central American VSNJV genetic lineage moving northward and causing outbreaks in central Mexico.
[Mh] Termos MeSH primário: Doenças dos Bovinos/virologia
Filogeografia
Estomatite Vesicular/virologia
Vírus da Estomatite Vesicular New Jersey/genética
Vírus da Estomatite Vesicular New Jersey/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/epidemiologia
Surtos de Doenças
Epidemias
México/epidemiologia
Dados de Sequência Molecular
Filogenia
Estados Unidos/epidemiologia
Vírus da Estomatite Vesicular New Jersey/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140114
[Lr] Data última revisão:
140114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140115
[St] Status:MEDLINE


  6 / 29 MEDLINE  
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[PMID]:23883666
[Au] Autor:McCluskey BJ; Pelzel-McCluskey AM; Creekmore L; Schiltz J
[Ad] Endereço:1Brian J. McCluskey, 2150 Centre Avenue, Building B, Fort Collins, CO 80526. brian.j.mccluskey@aphis.usda.gov.
[Ti] Título:Vesicular stomatitis outbreak in the southwestern United States, 2012.
[So] Source:J Vet Diagn Invest;25(5):608-13, 2013 Sep.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vesicular stomatitis is a viral disease primarily affecting horses and cattle when it occurs in the United States. Outbreaks in the southwestern United States occur sporadically, with initial cases typically occurring in Texas, New Mexico, or Arizona and subsequent cases occurring in a northward progression. The viruses causing vesicular stomatitis can be transmitted by direct contact of lesioned animals with other susceptible animals, but transmission is primarily through arthropod vectors. In 2012, an outbreak of vesicular stomatitis in the United States occurred that was caused by Vesicular stomatitis New Jersey virus serotype. Overall, 51 horses on 36 premises in 2 states were confirmed positive. Phylogenetic analysis of the virus indicated that it was most closely related to viruses detected in the state of Veracruz, Mexico, in 2000.
[Mh] Termos MeSH primário: Surtos de Doenças/veterinária
Doenças dos Cavalos/virologia
Filogenia
Estomatite Vesicular/virologia
Vírus da Estomatite Vesicular New Jersey/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Doenças dos Cavalos/epidemiologia
Doenças dos Cavalos/transmissão
Cavalos
Insetos/virologia
RNA Viral/química
RNA Viral/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa/veterinária
Sudoeste dos Estados Unidos/epidemiologia
Estomatite Vesicular/epidemiologia
Estomatite Vesicular/transmissão
Vírus da Estomatite Vesicular New Jersey/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130726
[St] Status:MEDLINE
[do] DOI:10.1177/1040638713497945


  7 / 29 MEDLINE  
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[PMID]:23207069
[Au] Autor:An HY; Kim GN; Wu K; Kang CY
[Ad] Endereço:Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Siebens-Drake Research Institute, Western University, London, ON N6G 2V4, Canada.
[Ti] Título:Genetically modified VSV(NJ) vector is capable of accommodating a large foreign gene insert and allows high level gene expression.
[So] Source:Virus Res;171(1):168-77, 2013 Jan.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is desirable to develop a RNA virus vector capable of accommodating large foreign genes for high level gene expression. Vesicular stomatitis virus (VSV) has been used as a gene expression vector, especially Indiana serotype (VSV(Ind)), but less with New Jersey serotype (VSV(NJ)). Here, we report constructions of genetically modified rVSV(NJ) vector carrying various lengths of human hepatitis C virus (HCV) non-structural (NS) protein genes, level of inserted gene expression and characterization of rVSV(NJ). We modified the M gene of VSV(NJ) by changing methionine to arginine at positions 48 and 51 (rVSV(NJ)-M) (Kim and Kang, 2007) for construction of rVSV(NJ) with various lengths of HCV non-structural genes. The NS polyprotein genes of HCV were inserted between the G and L genes of the rVSV(NJ)-M vector, and recombinant VSV(NJ)-M viruses with HCV gene inserts were recovered by the reverse genetics. The recombinant VSV(NJ)-M vector with the HCV NS genes express high levels of all different forms of the NS proteins. The electron microscopic examination showed that lengths of recombinant VSV(NJ)-M without gene of interests, VSV(NJ)-M with a gene of HCV NS3 and NS4A (VSV(NJ)-M-NS3/4A), VSV(NJ)-M with a gene of HCV NS4AB plus NS5AB (VSV(NJ)-M-NS4AB/5AB), and VSV(NJ)-M carrying a gene of HCV NS3, NS4AB, and NS5AB (VSV(NJ)-M-NS3/4AB/5AB) were 172±10.5 nm, 201±12.5 nm, 226±12.9 nm, and 247±18.2 nm, respectively. The lengths of recombinant VSVs increased approximately 10nm by insertion of 1kb of foreign genes. The diameter of these recombinant viruses also increased slightly by longer HCV gene inserts. Our results showed that the recombinant VSV(NJ)-M vector can accommodate as much as 6000 bases of the foreign gene. We compared the magnitude of the IFN induction in mouse fibroblast L(Y) cells infected with rVSV(NJ) wild type and rVSV(NJ) M mutant viruses and show that the rVSV(NJ) M mutant virus infection induced a higher level of the IFN-ß compare to the wild type virus. In addition, we showed that the NS protein expression level in IFN-incompetent cells (Mouse-L) infected with rVSV(NJ)-M viruses was higher than in IFN-competent L(Y) cells. In addition, we confirmed that HCV NS protein genes were expressed and properly processed. We also confirmed that NS3 protein expressed from the rVSV(NJ)-M cleaves NS polyprotein at junctions and that NS4A plays an important role as a co-factor for NS3 protease to cleave at the NS4B/5A site and at the NS5A/5B site.
[Mh] Termos MeSH primário: Expressão Gênica
Vetores Genéticos/genética
Vírus da Estomatite Vesicular New Jersey/genética
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte/metabolismo
Linhagem Celular
Cricetinae
Ordem dos Genes
Hepacivirus/genética
Seres Humanos
Interferons/biossíntese
Camundongos
Mutação
Proteólise
Vírus da Estomatite Vesicular New Jersey/crescimento & desenvolvimento
Vírus da Estomatite Vesicular New Jersey/ultraestrutura
Proteínas não Estruturais Virais/genética
Proteínas não Estruturais Virais/metabolismo
Vírion/ultraestrutura
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (NS3 protein, hepatitis C virus); 0 (NS4A cofactor peptide, Hepatitis C virus); 0 (Viral Nonstructural Proteins); 9008-11-1 (Interferons)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:130128
[Lr] Data última revisão:
130128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121205
[St] Status:MEDLINE


  8 / 29 MEDLINE  
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[PMID]:23034141
[Au] Autor:Smith PF; Howerth EW; Carter D; Gray EW; Noblet R; Berghaus RD; Stallknecht DE; Mead DG
[Ad] Endereço:Department of Entomology, College of Agriculture and Environmental Sciences, University of Georgia, 120 Cedar Street, 413 Biological Sciences Building, Athens, GA 30602, USA.
[Ti] Título:Host predilection and transmissibility of vesicular stomatitis New Jersey virus strains in domestic cattle (Bos taurus) and swine (Sus scrofa).
[So] Source:BMC Vet Res;8:183, 2012 Oct 03.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Epidemiologic data collected during epidemics in the western United States combined with limited experimental studies involving swine and cattle suggest that host predilection of epidemic vesicular stomatitis New Jersey virus (VSNJV) strains results in variations in clinical response, extent and duration of virus shedding and transmissibility following infection in different hosts. Laboratory challenge of livestock with heterologous VSNJV strains to investigate potential viral predilections for these hosts has not been thoroughly investigated. In separate trials, homologous VSNJV strains (NJ82COB and NJ82AZB), and heterologous strains (NJ06WYE and NJOSF [Ossabaw Island, sand fly]) were inoculated into cattle via infected black fly bite. NJ82AZB and NJ06WYE were similarly inoculated into swine. RESULTS: Clinical scores among viruses infecting cattle were significantly different and indicated that infection with a homologous virus resulted in more severe clinical presentation and greater extent and duration of viral shedding. No differences in clinical severity or extent and duration of viral shedding were detected in swine. CONCLUSIONS: Differences in clinical presentation and extent and duration of viral shedding may have direct impacts on viral spread during epidemics. Viral transmission via animal-to-animal contact and insect vectored transmission are likely to occur at higher rates when affected animals are presenting severe clinical signs and shedding high concentrations of virus. More virulent viral strains resulting in more severe disease in livestock hosts are expected to spread more rapidly and greater distances during epidemics than those causing mild or inapparent signs.
[Mh] Termos MeSH primário: Doenças dos Bovinos/virologia
Doenças dos Suínos/virologia
Estomatite Vesicular/transmissão
Vírus da Estomatite Vesicular New Jersey/genética
Vírus da Estomatite Vesicular New Jersey/fisiologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/transmissão
Feminino
Insetos Vetores/virologia
Masculino
Simuliidae/virologia
Suínos
Doenças dos Suínos/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1303
[Cu] Atualização por classe:150222
[Lr] Data última revisão:
150222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121005
[St] Status:MEDLINE
[do] DOI:10.1186/1746-6148-8-183


  9 / 29 MEDLINE  
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[PMID]:22825698
[Au] Autor:Pauszek SJ; Rodriguez LL
[Ad] Endereço:Agricultural Research Service, US Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY 11957, USA.
[Ti] Título:Full-length genome analysis of vesicular stomatitis New Jersey virus strains representing the phylogenetic and geographic diversity of the virus.
[So] Source:Arch Virol;157(11):2247-51, 2012 Nov.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Mh] Termos MeSH primário: Genoma Viral
Filogeografia
RNA Viral/genética
Análise de Sequência de DNA
Vírus da Estomatite Vesicular New Jersey/classificação
Vírus da Estomatite Vesicular New Jersey/genética
[Mh] Termos MeSH secundário: Animais
Análise por Conglomerados
New Jersey
Homologia de Sequência
Vírus da Estomatite Vesicular New Jersey/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:121105
[Lr] Data última revisão:
121105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120725
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-012-1420-x


  10 / 29 MEDLINE  
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[PMID]:22464169
[Au] Autor:Nakamoto M; Moy RH; Xu J; Bambina S; Yasunaga A; Shelly SS; Gold B; Cherry S
[Ad] Endereço:Department of Microbiology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
[Ti] Título:Virus recognition by Toll-7 activates antiviral autophagy in Drosophila.
[So] Source:Immunity;36(4):658-67, 2012 Apr 20.
[Is] ISSN:1097-4180
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Innate immunity is highly conserved and relies on pattern recognition receptors (PRRs) such as Toll-like receptors (identified through their homology to Drosophila Toll) for pathogen recognition. Although Drosophila Toll is vital for immune recognition and defense, roles for the other eight Drosophila Tolls in immunity have remained elusive. Here we have shown that Toll-7 is a PRR both in vitro and in adult flies; loss of Toll-7 led to increased vesicular stomatitis virus (VSV) replication and mortality. Toll-7, along with additional uncharacterized Drosophila Tolls, was transcriptionally induced by VSV infection. Furthermore, Toll-7 interacted with VSV at the plasma membrane and induced antiviral autophagy independently of the canonical Toll signaling pathway. These data uncover an evolutionarily conserved role for a second Drosophila Toll receptor that links viral recognition to autophagy and defense and suggest that other Drosophila Tolls may restrict specific as yet untested pathogens, perhaps via noncanonical signaling pathways.
[Mh] Termos MeSH primário: Autofagia
Drosophila melanogaster/imunologia
Receptor 7 Toll-Like/imunologia
Vírus da Estomatite Vesicular Indiana/imunologia
Vírus da Estomatite Vesicular New Jersey/imunologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Membrana Celular/imunologia
Membrana Celular/metabolismo
Cricetinae
Drosophila melanogaster/virologia
Interferência de RNA
RNA Interferente Pequeno
Transdução de Sinais
Receptor 7 Toll-Like/genética
Vírus da Estomatite Vesicular Indiana/fisiologia
Vírus da Estomatite Vesicular New Jersey/fisiologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Small Interfering); 0 (Toll-Like Receptor 7)
[Em] Mês de entrada:1206
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120403
[St] Status:MEDLINE
[do] DOI:10.1016/j.immuni.2012.03.003



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