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  1 / 1607 MEDLINE  
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[PMID]:29377913
[Au] Autor:Zhang SF; Tuo JL; Huang XB; Zhu X; Zhang DM; Zhou K; Yuan L; Luo HJ; Zheng BJ; Yuen KY; Li MF; Cao KY; Xu L
[Ad] Endereço:Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
[Ti] Título:Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou.
[So] Source:PLoS One;13(1):e0191789, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human coronavirus (HCoV) is one of the most common causes of respiratory tract infection throughout the world. To investigate the epidemiological and genetic variation of HCoV in Guangzhou, south China, we collected totally 13048 throat and nasal swab specimens from adults and children with fever and acute upper respiratory infection symptoms in Gunazhou, south China between July 2010 and June 2015, and the epidemiological features of HCoV and its species were studied. Specimens were screened for HCoV by real-time RT-PCR, and 7 other common respiratory viruses were tested simultaneously by PCR or real-time PCR. HCoV was detected in 294 cases (2.25%) of the 13048 samples, with most of them inpatients (251 cases, 85.4% of HCoV positive cases) and young children not in nursery (53.06%, 156 out of 294 HCoV positive cases). Four HCoVs, as OC43, 229E, NL63 and HKU1 were detected prevalent during 2010-2015 in Guangzhou, and among the HCoV positive cases, 60.20% were OC43, 16.67% were 229E, 14.97% were NL63 and 7.82% were HKU1. The month distribution showed that totally HCoV was prevalent in winter, but differences existed in different species. The 5 year distribution of HCoV showed a peak-valley distribution trend, with the detection rate higher in 2011 and 2013 whereas lower in 2010, 2012 and 2014. The age distribution revealed that children (especially those <3 years old) and old people (>50 years) were both high risk groups to be infected by HCoV. Of the 294 HCoV positive patients, 34.69% (101 cases) were co-infected by other common respiratory viruses, and influenza virus was the most common co-infecting virus (30/101, 29.70%). Fifteen HCoV-OC43 positive samples of 2013-2014 were selected for S gene sequencing and phylogenetic analysis, and the results showed that the 15 strains could be divided into 2 clusters in the phylogenetic tree, 12 strains of which formed a separate cluster that was closer to genotype G found in Malaysia. It was revealed for the first time that genotype B and genotype G of HCoV-OC43 co-circulated and the newly defined genotype G was epidemic as a dominant genotype during 2013-2014 in Guanzhou, south China.
[Mh] Termos MeSH primário: Coronavirus/isolamento & purificação
Filogenia
Infecções Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: China/epidemiologia
Coronavirus/classificação
Coronavirus/patogenicidade
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191789


  2 / 1607 MEDLINE  
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[PMID]:28840816
[Au] Autor:Subudhi S; Rapin N; Bollinger TK; Hill JE; Donaldson ME; Davy CM; Warnecke L; Turner JM; Kyle CJ; Willis CKR; Misra V
[Ad] Endereço:1​Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
[Ti] Título:A persistently infecting coronavirus in hibernating Myotis lucifugus, the North American little brown bat.
[So] Source:J Gen Virol;98(9):2297-2309, 2017 Sep.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bats are important reservoir hosts for emerging viruses, including coronaviruses that cause diseases in people. Although there have been several studies on the pathogenesis of coronaviruses in humans and surrogate animals, there is little information on the interactions of these viruses with their natural bat hosts. We detected a coronavirus in the intestines of 53/174 hibernating little brown bats (Myotis lucifugus), as well as in the lungs of some of these individuals. Interestingly, the presence of the virus was not accompanied by overt inflammation. Viral RNA amplified from little brown bats in this study appeared to be from two distinct clades. The sequences in clade 1 were very similar to the archived sequence derived from little brown bats and the sequences from clade 2 were more closely related to the archived sequence from big brown bats. This suggests that two closely related coronaviruses may circulate in little brown bats. Sequence variation among coronavirus detected from individual bats suggested that infection occurred prior to hibernation, and that the virus persisted for up to 4 months of hibernation in the laboratory. Based on the sequence of its genome, the coronavirus was placed in the Alphacoronavirus genus, along with some human coronaviruses, bat viruses and the porcine epidemic diarrhoea virus. The detection and identification of an apparently persistent coronavirus in a local bat species creates opportunities to understand the dynamics of coronavirus circulation in bat populations.
[Mh] Termos MeSH primário: Quirópteros/virologia
Infecções por Coronavirus/veterinária
Coronavirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Coronavirus/genética
Coronavirus/fisiologia
Infecções por Coronavirus/patologia
Infecções por Coronavirus/virologia
Pulmão/patologia
Pulmão/virologia
Filogenia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000898


  3 / 1607 MEDLINE  
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[PMID]:28838146
[Au] Autor:Ogimi C; Greninger AL; Waghmare AA; Kuypers JM; Shean RC; Xie H; Leisenring WM; Stevens-Ayers TL; Jerome KR; Englund JA; Boeckh M
[Ad] Endereço:Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.
[Ti] Título:Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution.
[So] Source:J Infect Dis;216(2):203-209, 2017 Jul 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Recent data suggest that human coronavirus (HCoV) pneumonia is associated with significant mortality in hematopoietic cell transplant (HCT) recipients. Investigation of risk factors for prolonged shedding and intrahost genome evolution may provide critical information for development of novel therapeutics. Methods: We retrospectively reviewed HCT recipients with HCoV detected in nasal samples by polymerase chain reaction (PCR). HCoV strains were identified using strain-specific PCR. Shedding duration was defined as time between first positive and first negative sample. Logistic regression analyses were performed to evaluate factors for prolonged shedding (≥21 days). Metagenomic next-generation sequencing (mNGS) was conducted when ≥4 samples with cycle threshold values of <28 were available. Results: Seventeen of 44 patients had prolonged shedding. Among 31 available samples, 35% were OC43, 32% were NL63, 19% were HKU1, and 13% were 229E; median shedding duration was similar between strains (P = .79). Bivariable logistic regression analyses suggested that high viral load, receipt of high-dose steroids, and myeloablative conditioning were associated with prolonged shedding. mNGS among 5 subjects showed single-nucleotide polymorphisms from OC43 and NL63 starting 1 month following onset of shedding. Conclusions: High viral load, high-dose steroids, and myeloablative conditioning were associated with prolonged shedding of HCoV in HCT recipients. Genome changes were consistent with the expected molecular clock of HCoV.
[Mh] Termos MeSH primário: Infecções por Coronavirus/epidemiologia
Coronavirus/genética
Transplante de Células-Tronco Hematopoéticas
Infecções Respiratórias/epidemiologia
Eliminação de Partículas Virais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Coronavirus/classificação
Feminino
Genoma Viral
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Infecções Respiratórias/virologia
Estudos Retrospectivos
Fatores de Risco
Esteroides/efeitos adversos
Carga Viral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Steroids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix264


  4 / 1607 MEDLINE  
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[PMID]:28802158
[Au] Autor:Park JE; Gallagher T
[Ad] Endereço:Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.
[Ti] Título:Lipidation increases antiviral activities of coronavirus fusion-inhibiting peptides.
[So] Source:Virology;511:9-18, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Coronaviruses (CoVs) can cause life-threatening respiratory diseases. Their infectious entry requires viral spike (S) proteins, which attach to cell receptors, undergo proteolytic cleavage, and then refold in a process that catalyzes virus-cell membrane fusion. Fusion-inhibiting peptides bind to S proteins, interfere with refolding, and prevent infection. Here we conjugated fusion-inhibiting peptides to various lipids, expecting this to secure peptides onto cell membranes and thereby increase antiviral potencies. Cholesterol or palmitate adducts increased antiviral potencies up to 1000-fold. Antiviral effects were evident after S proteolytic cleavage, implying that lipid conjugates affixed the peptides at sites of protease-triggered fusion activation. Unlike lipid-free peptides, the lipopeptides suppressed CoV S protein-directed virus entry taking place within endosomes. Cell imaging revealed intracellular peptide aggregates, consistent with their endocytosis into compartments where CoV entry takes place. These findings suggest that lipidations localize antiviral peptides to protease-rich sites of CoV fusion, thereby protecting cells from diverse CoVs.
[Mh] Termos MeSH primário: Antivirais/metabolismo
Coronavirus/efeitos dos fármacos
Coronavirus/fisiologia
Lipopeptídeos/metabolismo
Internalização do Vírus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cercopithecus aethiops
Endossomos/virologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Lipopeptides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


  5 / 1607 MEDLINE  
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[PMID]:28580734
[Au] Autor:Hammond RG; Tan X; Johnson MA
[Ad] Endereço:Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, 35294.
[Ti] Título:SARS-unique fold in the Rousettus bat coronavirus HKU9.
[So] Source:Protein Sci;26(9):1726-1737, 2017 Sep.
[Is] ISSN:1469-896X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The coronavirus nonstructural protein 3 (nsp3) is a multifunctional protein that comprises multiple structural domains. This protein assists viral polyprotein cleavage, host immune interference, and may play other roles in genome replication or transcription. Here, we report the solution NMR structure of a protein from the "SARS-unique region" of the bat coronavirus HKU9. The protein contains a frataxin fold or double-wing motif, which is an α + ß fold that is associated with protein/protein interactions, DNA binding, and metal ion binding. High structural similarity to the human severe acute respiratory syndrome (SARS) coronavirus nsp3 is present. A possible functional site that is conserved among some betacoronaviruses has been identified using bioinformatics and biochemical analyses. This structure provides strong experimental support for the recent proposal advanced by us and others that the "SARS-unique" region is not unique to the human SARS virus, but is conserved among several different phylogenetic groups of coronaviruses and provides essential functions.
[Mh] Termos MeSH primário: Coronavirus/química
RNA Replicase/química
RNA Replicase/metabolismo
Vírus da SARS/química
Proteínas não Estruturais Virais/química
Proteínas não Estruturais Virais/metabolismo
[Mh] Termos MeSH secundário: Animais
Quirópteros
Modelos Moleculares
Ressonância Magnética Nuclear Biomolecular
Domínios Proteicos
Dobramento de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Nonstructural Proteins); EC 2.7.7.48 (RNA Replicase); EC 2.7.7.48 (nonstructural protein 3, SARS coronovirus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1002/pro.3208


  6 / 1607 MEDLINE  
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[PMID]:28575086
[Au] Autor:VanLeuven JT; Ridenhour BJ; Gonzalez AJ; Miller CR; Miura TA
[Ad] Endereço:Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America.
[Ti] Título:Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses.
[So] Source:PLoS One;12(6):e0178408, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The severity of respiratory viral infections is partially determined by the cellular response mounted by infected lung epithelial cells. Disease prevention and treatment is dependent on our understanding of the shared and unique responses elicited by diverse viruses, yet few studies compare host responses to viruses from different families while controlling other experimental parameters. Murine models are commonly used to study the pathogenesis of respiratory viral infections, and in vitro studies using murine cells provide mechanistic insight into the pathogenesis observed in vivo. We used microarray analysis to compare changes in gene expression of murine lung epithelial cells infected individually by three respiratory viruses causing mild (rhinovirus, RV1B), moderate (coronavirus, MHV-1), and severe (influenza A virus, PR8) disease in mice. RV1B infection caused numerous gene expression changes, but the differential effect peaked at 12 hours post-infection. PR8 altered an intermediate number of genes whose expression continued to change through 24 hours. MHV-1 had comparatively few effects on host gene expression. The viruses elicited highly overlapping responses in antiviral genes, though MHV-1 induced a lower type I interferon response than the other two viruses. Signature genes were identified for each virus and included host defense genes for PR8, tissue remodeling genes for RV1B, and transcription factors for MHV-1. Our comparative approach identified universal and specific transcriptional signatures of virus infection that can be used to distinguish shared and virus-specific mechanisms of pathogenesis in the respiratory tract.
[Mh] Termos MeSH primário: Coronavirus/patogenicidade
Expressão Gênica
Vírus da Influenza A/patogenicidade
Pulmão/citologia
Rhinovirus/patogenicidade
[Mh] Termos MeSH secundário: Animais
Células Epiteliais/metabolismo
Pulmão/metabolismo
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178408


  7 / 1607 MEDLINE  
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[PMID]:28542235
[Au] Autor:Trudeau MP; Verma H; Sampedro F; Urriola PE; Shurson GC; Goyal SM
[Ad] Endereço:Department of Animal Science, University of Minnesota, St. Paul, Minnesota, United States of America.
[Ti] Título:Environmental persistence of porcine coronaviruses in feed and feed ingredients.
[So] Source:PLoS One;12(5):e0178094, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Porcine Epidemic Diarrhea Virus (PEDV), Porcine Delta Corona Virus (PDCoV), and Transmissible Gastroenteritis Virus (TGEV) are major threats to swine health and contaminated feed plays a role in virus transmission. The objective of our study was to characterize inactivation of PEDV, PDCoV, and TGEV in various feed ingredient matrices. Samples of complete feed, spray dried porcine plasma, meat meal, meat and bone meal, blood meal, corn, soybean meal, and corn dried distillers grains with solubles were weighed (5 g/sample) into scintillation vials and inoculated with 1 mL of PEDV, PDCoV, or TGEV. Samples were incubated at room temperature for up to 56 days. Aliquots were removed at various time points followed by preparing serial 10-fold dilutions and inoculating in cell cultures to determine the amount of surviving virus. Inactivation kinetics were determined using the Weibull model, which estimates a delta value indicating the time necessary to reduce virus concentration by 1 log. Delta values of various ingredients were compared and analyzed as to their nutrient composition. Soybean meal had the greatest delta value (7.50 days) for PEDV (P < 0.06) as compared with all other ingredients. High delta values (P < 0.001) were observed in soybean meal for PDCoV (42.04 days) and TGEV (42.00 days). There was a moderate correlation between moisture content and the delta value for PDCoV (r = 0.49, P = 0.01) and TGEV (r = 0.41, P = 0.02). There was also a moderate negative correlation between TGEV survival and ether extract content (r = -0.51, P = 0.01). In conclusion, these results indicate that the first log reduction of PDCoV and TGEV takes the greatest amount of time in soybean meal. In addition to this, moisture and ether content appear to be an important determinant of virus survival in feed ingredients.
[Mh] Termos MeSH primário: Ração Animal/virologia
Coronavirus/isolamento & purificação
Contaminação de Alimentos
Vírus da Diarreia Epidêmica Suína/isolamento & purificação
Vírus da Gastroenterite Transmissível/isolamento & purificação
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Infecções por Coronavirus/transmissão
Infecções por Coronavirus/veterinária
Infecções por Coronavirus/virologia
Gastroenterite Suína Transmissível/transmissão
Feijão de Soja/química
Sus scrofa
Suínos
Doenças dos Suínos/transmissão
Doenças dos Suínos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178094


  8 / 1607 MEDLINE  
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[PMID]:28528587
[Au] Autor:Jeong J; Smith CS; Peel AJ; Plowright RK; Kerlin DH; McBroom J; McCallum H
[Ad] Endereço:Griffith Wildlife Disease Ecology Group,Environmental Futures Research Institute, School of Environment, Griffith University,Nathan, Queensland,Australia.
[Ti] Título:Persistent infections support maintenance of a coronavirus in a population of Australian bats (Myotis macropus).
[So] Source:Epidemiol Infect;145(10):2053-2061, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Understanding viral transmission dynamics within populations of reservoir hosts can facilitate greater knowledge of the spillover of emerging infectious diseases. While bat-borne viruses are of concern to public health, investigations into their dynamics have been limited by a lack of longitudinal data from individual bats. Here, we examine capture-mark-recapture (CMR) data from a species of Australian bat (Myotis macropus) infected with a putative novel Alphacoronavirus within a Bayesian framework. Then, we developed epidemic models to estimate the effect of persistently infectious individuals (which shed viruses for extensive periods) on the probability of viral maintenance within the study population. We found that the CMR data analysis supported grouping of infectious bats into persistently and transiently infectious bats. Maintenance of coronavirus within the study population was more likely in an epidemic model that included both persistently and transiently infectious bats, compared with the epidemic model with non-grouping of bats. These findings, using rare CMR data from longitudinal samples of individual bats, increase our understanding of transmission dynamics of bat viral infectious diseases.
[Mh] Termos MeSH primário: Quirópteros
Doenças Transmissíveis Emergentes/veterinária
Infecções por Coronavirus/veterinária
Coronavirus/fisiologia
[Mh] Termos MeSH secundário: Animais
Austrália/epidemiologia
Teorema de Bayes
Doenças Transmissíveis Emergentes/epidemiologia
Doenças Transmissíveis Emergentes/virologia
Infecções por Coronavirus/epidemiologia
Infecções por Coronavirus/virologia
Reservatórios de Doenças/virologia
Modelos Teóricos
Prevalência
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000991


  9 / 1607 MEDLINE  
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[PMID]:28478775
[Au] Autor:Olarinmoye AO; Olugasa BO; Niphuis H; Herwijnen RV; Verschoor E; Boug A; Ishola OO; Buitendijk H; Fagrouch Z; Al-Hezaimi K
[Ad] Endereço:Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration (GFBR),King Saud University,Riyadh,Saudi Arabia.
[Ti] Título:Serological evidence of coronavirus infections in native hamadryas baboons (Papio hamadryas hamadryas) of the Kingdom of Saudi Arabia.
[So] Source:Epidemiol Infect;145(10):2030-2037, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The hamadryas baboon (Papio hamadryas hamadryas) is the only indigenous species of non-human primates (NHP) found in the Kingdom of Saudi Arabia (KSA). There are no peer-reviewed publications on viral infections of the baboons of KSA. Apart from camels, other animals are likely sources of the novel Middle East Respiratory Syndrome coronavirus (MERSCoV) for humans. We investigated evidence of highly pathogenic coronavirus infections including MERSCoV in a large group of commensal baboons accompanied by feral dogs, on the outskirts of Ta'if city, KSA, in February 2013. Fifty baboons (16 juveniles and 34 adults) were screened for serum antibodies to human coronaviruses (HCoV-043/-NL63/-229) and canine coronaviruses (CCoV-1-3) using direct Enzyme-linked Immunosorbent Assay (ELISA) technique and for MERSCoV antibodies using Serum Neutralization Test (SNT). Of the 50 sampled baboons, 22% (n = 11) were seropositive to HCoVs, 10% (n = 5) were seropositive to CCoVs, while none had detectable MERSCoV antibodies. These findings bear potentially significant implications for public health, canine health and baboon conservation efforts, necessitating follow-up investigations and preventive measures at locations where baboons frequent human habitations, or are regarded as tourist attractions, in KSA.
[Mh] Termos MeSH primário: Infecções por Coronavirus/veterinária
Coronavirus/isolamento & purificação
Doenças dos Macacos/epidemiologia
Papio hamadryas
[Mh] Termos MeSH secundário: Animais
Infecções por Coronavirus/epidemiologia
Infecções por Coronavirus/virologia
Feminino
Masculino
Coronavírus da Síndrome Respiratória do Oriente Médio/isolamento & purificação
Doenças dos Macacos/virologia
Prevalência
Arábia Saudita/epidemiologia
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000905


  10 / 1607 MEDLINE  
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[PMID]:28432925
[Au] Autor:Han X; Qi J; Song H; Wang Q; Zhang Y; Wu Y; Lu G; Yuen KY; Shi Y; Gao GF
[Ad] Endereço:CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein.
[So] Source:Virology;507:101-109, 2017 Jul.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence indicates that MERS-CoV originated from bat coronaviruses (BatCoVs). Previously, we demonstrated that both MERS-CoV and BatCoV HKU4 use CD26 as a receptor, but how the BatCoVs evolved to bind CD26 is an intriguing question. Here, we solved the crystal structure of the S1 subunit C-terminal domain of HKU5 (HKU5-CTD), another BatCoV that is phylogenetically related to MERS-CoV but cannot bind to CD26. We observed that the conserved core subdomain and those of other betacoronaviruses (betaCoVs) have a similar topology of the external subdomain, indicating the same ancestor of lineage C betaCoVs. However, two deletions in two respective loops located in HKU5-CTD result in conformational variations in CD26-binding interface and are responsible for the non-binding of HKU5-CTD to CD26. Combined with sequence variation in the HKU5-CTD receptor binding interface, we propose the necessity for surveilling the mutation in BatCoV HKU5 spike protein in case of bat-to-human interspecies transmission.
[Mh] Termos MeSH primário: Quirópteros/virologia
Infecções por Coronavirus/veterinária
Coronavirus/metabolismo
Glicoproteína da Espícula de Coronavírus/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Quirópteros/genética
Quirópteros/metabolismo
Coronavirus/química
Coronavirus/classificação
Coronavirus/genética
Infecções por Coronavirus/genética
Infecções por Coronavirus/metabolismo
Infecções por Coronavirus/virologia
Dipeptidil Peptidase 4/genética
Dipeptidil Peptidase 4/metabolismo
Dados de Sequência Molecular
Conformação Proteica
Domínios Proteicos
Receptores Virais/genética
Receptores Virais/metabolismo
Alinhamento de Sequência
Glicoproteína da Espícula de Coronavírus/genética
Glicoproteína da Espícula de Coronavírus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Virus); 0 (Spike Glycoprotein, Coronavirus); EC 3.4.14.5 (Dipeptidyl Peptidase 4)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE



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