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[PMID]:28450173
[Au] Autor:Chandler JC; Schaeffer JW; Davidson M; Magzamen SL; Pérez-Méndez A; Reynolds SJ; Goodridge LD; Volckens J; Franklin AB; Shriner SA; Bisha B
[Ad] Endereço:National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, CO, USA.
[Ti] Título:A method for the improved detection of aerosolized influenza viruses and the male-specific (F+) RNA coliphage MS2.
[So] Source:J Virol Methods;246:38-41, 2017 Aug.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The detection of aerosolized viruses can serve as an important surveillance and control tool in agriculture, human health, and environmental settings. Here, we adapted an anion exchange resin-based method, initially developed to concentrate negatively charged viruses from water, to liquid impingement-based bioaerosol sampling. In this method, aerosolized viruses are collected in a 20ml liquid sample contained within widely used impingers, BioSamplers (SKC Inc., Eighty Four, PA), and further concentrated via adsorption to an anion exchange resin that is suspended within this liquid. Viral nucleic acids are then extracted from the resin to facilitate molecular analyses through a reduction in the effective sample volume. For this study, various quantities of two negatively charged viruses, type A and type B influenza viruses (FluMist Quadrivalent vaccine) and the male-specific (F+) RNA coliphage MS2 (MS2), were nebulized into a custom-built bioaerosolization chamber, and sampled using BioSamplers with and without anion exchange resin. Compared to direct testing of the BioSampler liquid, detection was improved by 6.77× and 3.33× for type A and type B influenza viruses, respectively, by using the anion exchange resin. For MS2, the anion exchange resin method allowed for an average improvement in detection of 8.26×.
[Mh] Termos MeSH primário: Microbiologia do Ar
Levivirus/isolamento & purificação
Orthomyxoviridae/isolamento & purificação
Virologia/métodos
[Mh] Termos MeSH secundário: Aerossóis
Resinas de Troca de Ânions
Seres Humanos
Levivirus/genética
Masculino
RNA Viral
Manejo de Espécimes/métodos
Virologia/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Anion Exchange Resins); 0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  2 / 9506 MEDLINE  
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[PMID]:28747342
[Au] Autor:Nguyen TTT; Graf BA; Randall TD; Baumgarth N
[Ad] Endereço:Center for Comparative Medicine, University of California Davis, Davis, CA 95616.
[Ti] Título:sIgM-FcµR Interactions Regulate Early B Cell Activation and Plasma Cell Development after Influenza Virus Infection.
[So] Source:J Immunol;199(5):1635-1646, 2017 09 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies with mice lacking secreted IgM (sIgM) due to a deletion of the splice region ( ) had shown sIgM involvement in normal B cell development and in support of maximal Ag-specific IgG responses. Because of the changes to B cell development, it remains unclear to which extent and how sIgM directly affects B cell responses. In this study, we aimed to explore the underlying mechanisms of sIgM-mediated IgG response regulation during influenza virus infection. Generating mice with normally developed µs-deficient B cells, we demonstrate that sIgM supports IgG responses by enhancing early Ag-specific B cell expansion, not by altering B cell development. Lack of FcµR expression on B cells, but not lack of Fcα/µR expression or complement activation, reduced antiviral IgG responses to the same extent as observed in µs mice. B cell-specific mice lacked robust clonal expansion of influenza hemagglutinin-specific B cells early after infection and developed fewer spleen and bone marrow IgG plasma cells and memory B cells, compared with controls. However, germinal center responses appeared unaffected. Provision of sIgM rescued plasma cell development from µs but not B cells, as demonstrated with mixed bone marrow chimeric mice. Taken together, the data suggest that sIgM interacts with FcµR on B cells to support early B cell activation and the development of long-lived humoral immunity.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Regiões Constantes de Imunoglobulina/metabolismo
Cadeias mu de Imunoglobulina/metabolismo
Infecções por Orthomyxoviridae/imunologia
Orthomyxoviridae/imunologia
Plasmócitos/imunologia
Receptores Fc/metabolismo
[Mh] Termos MeSH secundário: Animais
Linfócitos B/virologia
Diferenciação Celular
Feminino
Glicoproteínas de Hemaglutininação de Vírus da Influenza/imunologia
Imunidade Humoral
Ativação Linfocitária
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Plasmócitos/virologia
Ligação Proteica
Receptores Fc/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Hemagglutinin Glycoproteins, Influenza Virus); 0 (Immunoglobulin Constant Regions); 0 (Immunoglobulin mu-Chains); 0 (Receptors, Fc); 0 (immunoglobulin M receptor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180128
[Lr] Data última revisão:
180128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700560


  3 / 9506 MEDLINE  
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[PMID]:29198893
[Au] Autor:Tsuji M; Sriwilaijaroen N; Inoue H; Miki K; Kinoshita K; Koyama K; Furuhata K; Suzuki Y; Takahashi K
[Ad] Endereço:Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
[Ti] Título:Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.
[So] Source:Bioorg Med Chem;26(1):17-24, 2018 01 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We are interested in new non-natural glycosides with sialic acid conjugates and their biological activities. We report the synthesis of eleven non-natural occurring glycosides, which are triterpene (glycyrrhetinic acid and its derivatives)-sialic acid conjugates, and their inhibitory activities against influenza virus sialidases and influenza virus multiplication in MDCK host cells. Deoxoglycyrrhetol-sialic acid conjugates (6d and 6e) and oleanolic acid-sialic acid conjugates (7d and 7e) showed strong inhibitory activities against three subtypes of influenza virus sialidases. These four compounds (6d, 6e, 7d and 7e) showed clear inhibition to influenza virus multiplication but not to MDCK host cell survival.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Ácido N-Acetilneuramínico/farmacologia
Orthomyxoviridae/efeitos dos fármacos
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antivirais/síntese química
Antivirais/química
Sobrevivência Celular/efeitos dos fármacos
Galinhas
Cães
Relação Dose-Resposta a Droga
Células Madin Darby de Rim Canino
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ácido N-Acetilneuramínico/química
Relação Estrutura-Atividade
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Triterpenes); GZP2782OP0 (N-Acetylneuraminic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  4 / 9506 MEDLINE  
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[PMID]:29203862
[Au] Autor:Alculumbre SG; Saint-André V; Di Domizio J; Vargas P; Sirven P; Bost P; Maurin M; Maiuri P; Wery M; Roman MS; Savey L; Touzot M; Terrier B; Saadoun D; Conrad C; Gilliet M; Morillon A; Soumelis V
[Ad] Endereço:Institut Curie, Centre de Recherche, PSL Research University, Paris, France.
[Ti] Título:Diversification of human plasmacytoid predendritic cells in response to a single stimulus.
[So] Source:Nat Immunol;19(1):63-75, 2018 Jan.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1 CD80 ) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1 CD80 ) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1 CD80 ) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.
[Mh] Termos MeSH primário: Citocinas/imunologia
Células Dendríticas/imunologia
Expressão Gênica/imunologia
Imunidade Inata/imunologia
[Mh] Termos MeSH secundário: Imunidade Adaptativa/imunologia
Antígeno B7-1/imunologia
Antígeno B7-1/metabolismo
Antígeno B7-H1/imunologia
Antígeno B7-H1/metabolismo
Células Cultivadas
Citocinas/genética
Citocinas/metabolismo
Células Dendríticas/metabolismo
Células Dendríticas/ultraestrutura
Perfilação da Expressão Gênica/métodos
Seres Humanos
Interferon Tipo I/genética
Interferon Tipo I/imunologia
Interferon Tipo I/metabolismo
Lúpus Eritematoso Sistêmico/imunologia
Microscopia Eletrônica de Transmissão
Orthomyxoviridae/imunologia
Psoríase/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-1 Antigen); 0 (B7-H1 Antigen); 0 (CD274 protein, human); 0 (Cytokines); 0 (Interferon Type I)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1038/s41590-017-0012-z


  5 / 9506 MEDLINE  
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[PMID]:29190684
[Au] Autor:Pale M; Nacoto A; Tivane A; Nguenha N; Machalele L; Gundane F; Muteto D; Chilundo J; Mavale S; Semá-Baltazar C; Pires G; Augusto O; Mussá T; Gudo E
[Ad] Endereço:Department of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
[Ti] Título:Respiratory syncytial and influenza viruses in children under 2 years old with severe acute respiratory infection (SARI) in Maputo, 2015.
[So] Source:PLoS One;12(11):e0186735, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Although respiratory syncytial virus (RSV) and influenza virus (influenza) infections are one of the leading causes of Severe Acute Respiratory Infections (SARI) and death in young children worldwide, little is known about the burden of these pathogens in Mozambique. MATERIAL AND METHODS: From January 2015 to January 2016, nasopharyngeal swabs from 450 children, aged ≤2 years, who had been admitted to the Pediatric Department of the Maputo Central Hospital (HCM) in Mozambique, suffering with SARI were enrolled and tested for influenza and RSV using a real-time PCR assay. RESULTS: Influenza and RSV were detected in 2.4% (11/450) and 26.7% (113/424) of the participants. Children with influenza were slightly older than those infected with RSV (10 months in influenza-infected children compared to 3 months in RSV-infected children); male children were predominant in both groups (63.6% versus 54.9% in children with influenza and RSV, respectively). There was a trend towards a higher frequency of influenza (72.7%) and RSV (93.8%) cases in the dry season. Bronchopneumonia, bronchitis and respiratory distress were the most common diagnoses at admission. Antibiotics were administered to 27,3% and 15,9% of the children with influenza and RSV, respectively. Two children, of whom, one was positive for RSV (aged 6 months) and another was positive for Influenza (aged 3 months) died; both were children of HIV seropositive mothers and had bronchopneumonia. CONCLUSIONS: Our data demonstrated that RSV, and less frequently influenza, occurs in children with SARI in urban/sub-urban settings from southern Mozambique. The occurrence of deaths in small children suspected of being HIV-infected, suggests that particular attention should be given to this vulnerable population. Our data also provide evidence of antibiotics prescription in children with respiratory viral infection, which represents an important public health problem and calls for urgent interventions.
[Mh] Termos MeSH primário: Influenza Humana/epidemiologia
Orthomyxoviridae/isolamento & purificação
Infecções por Vírus Respiratório Sincicial/epidemiologia
Vírus Sincicial Respiratório Humano/isolamento & purificação
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Moçambique/epidemiologia
Orthomyxoviridae/genética
Vigilância da População
Reação em Cadeia da Polimerase em Tempo Real
Vírus Sincicial Respiratório Humano/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186735


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[PMID]:29106347
[Au] Autor:Pellegrinelli L; Bubba L; Galli C; Anselmi G; Primache V; Binda S; Pariani E
[Ad] Endereço:1​Department of Biomedical Sciences for Health, University of Milan, Via Carlo Pascal, 36 - 20133 Milan, Italy.
[Ti] Título:Epidemiology and molecular characterization of influenza viruses, human parechoviruses and enteroviruses in children up to 5 years with influenza-like illness in Northern Italy during seven consecutive winter seasons (2010-2017).
[So] Source:J Gen Virol;98(11):2699-2711, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Besides the influenza virus (IV), several other viruses are responsible for influenza-like illness (ILI). Although human parechoviruses (HPeVs) and enteroviruses (EVs) may impact on ILI, limited data on their epidemiological characteristics are available. During seven consecutive winter seasons (from 2010-2011 to 2016-2017), within the framework of an influenza surveillance system (InfluNet), 593 respiratory swabs were collected from children ≤5 years of age with ILIs. Molecular detection showed that 58.3 % of swabs were positive for at least one of the viruses under study: 46 % for IV, 13 % for EV and 5.4 % for HPeV. A single virus was identified in 51.3 % of samples while more than one virus was detected in 7 % of the samples. The risk of contracting IV was higher than the risk associated with EV, which in turn was higher than the risk of contracting HPeV. The risk of developing an IV infection was twofold greater in children >3 years than in those ≤3 years, who had higher risk of EV/HPeV infection. The frequency of EV/HPeV-positive swabs increased significantly during the 2016-2017 winter season compared to the previous six seasons. Sixteen EV genotypes were identified belonging to species A and B. HPeV-1 was the most frequently detected genotype, followed by -6 and -3. In this study, IV was mainly responsible for ILI, however EV and HPeV were also involved and particularly affected children ≤3 years of age. Influenza surveillance samples could provide us with valuable insight into the epidemiological features of viruses involved in ILI.
[Mh] Termos MeSH primário: Enterovirus/isolamento & purificação
Variação Genética
Orthomyxoviridae/isolamento & purificação
Parechovirus/isolamento & purificação
Infecções Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Criança
Enterovirus/classificação
Enterovirus/genética
Seres Humanos
Itália/epidemiologia
Epidemiologia Molecular
Orthomyxoviridae/classificação
Orthomyxoviridae/genética
Parechovirus/classificação
Parechovirus/genética
Prevalência
Infecções Respiratórias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000937


  7 / 9506 MEDLINE  
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[PMID]:29049206
[Au] Autor:Saraya T; Kimura H; Kurai D; Ishii H; Takizawa H
[Ad] Endereço:aKyorin University School of Medicine, Department of Respiratory Medicine, Mitaka City bInfectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
[Ti] Título:The molecular epidemiology of respiratory viruses associated with asthma attacks: A single-center observational study in Japan.
[So] Source:Medicine (Baltimore);96(42):e8204, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Few reports have described the significance of viral respiratory infections (VRIs) in exacerbation of asthma in adult patients. The aim of this study was to elucidate the profiles of VRIs in adult patients with asthma along with their molecular epidemiology.A cross-sectional observational study was conducted at Kyorin University Hospital from August 2012 to May 2015. To identify respiratory pathogens in inpatients and outpatients suffering from asthma attacks, RT-PCR/sequencing/phylogenetic analysis methods were applied alongside conventional microbiological methods. Phylogenetic and pairwise distance analyses of 10 viruses were performed.A total of 106 asthma attack patients enrolled in this study in both inpatient (n = 49) and outpatient (n = 57) settings. The total 106 respiratory samples were obtained from nasopharyngeal swab (n = 68) or sputum (n = 38). Among these, patients with virus alone (n = 39), virus and bacterial (n = 5), and bacterial alone (n = 5) were identified. The ratio of virus-positive patients in inpatient or outpatient to the total cases were 31.1% (n = 33) and 10.4% (n = 11), respectively. The frequency of virus-positive patients was significantly higher in inpatients (75.3%, n = 33) than in outpatients (19.3%, n = 11). Major VRIs included human rhinovirus (HRV) (n = 24), human metapneumovirus (hMPV) (n = 9), influenza virus (Inf-V) (n = 8), and respiratory syncytial virus (RSV) (n = 3) infections with seasonal variations. HRV-A and HRV-C were the most commonly detected viruses, with wide genetic divergence on phylogenetic analysis.Asthmatic exacerbations in adults are highly associated with VRIs such as HRV-A or HRV-C, hMPV, RSV, and Inf-V infections with seasonal variations and genetic divergence, but similar frequencies of VRIs occurred in asthma attack patients throughout the seasons.
[Mh] Termos MeSH primário: Asma/virologia
Vírus de RNA/genética
Infecções Respiratórias/epidemiologia
Viroses/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Infecções Bacterianas/complicações
Infecções Bacterianas/epidemiologia
Estudos Transversais
Feminino
Genótipo
Seres Humanos
Pacientes Internados/estatística & dados numéricos
Japão/epidemiologia
Masculino
Metapneumovirus/genética
Metapneumovirus/isolamento & purificação
Meia-Idade
Nasofaringe/virologia
Orthomyxoviridae/genética
Orthomyxoviridae/isolamento & purificação
Pacientes Ambulatoriais/estatística & dados numéricos
Filogenia
Vírus de RNA/isolamento & purificação
Vírus Sinciciais Respiratórios/genética
Vírus Sinciciais Respiratórios/isolamento & purificação
Infecções Respiratórias/virologia
Rhinovirus/genética
Rhinovirus/isolamento & purificação
Estações do Ano
Escarro/virologia
Viroses/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008204


  8 / 9506 MEDLINE  
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[PMID]:29040317
[Au] Autor:Chen SI
[Ad] Endereço:Department of Industrial Engineering and Management, School of Management, National Chiao-Tung University, Hsinchu, Taiwan.
[Ti] Título:Economic benefits of sharing and redistributing influenza vaccines when shortages occurred.
[So] Source:PLoS One;12(10):e0186418, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recurrent influenza outbreak has been a concern for government health institutions in Taiwan. Over 10% of the population is infected by influenza viruses every year, and the infection has caused losses to both health and the economy. Approximately three million free vaccine doses are ordered and administered to high-risk populations at the beginning of flu season to control the disease. The government recommends sharing and redistributing vaccine inventories when shortages occur. While this policy intends to increase inventory flexibility, and has been proven as widely valuable, its impact on vaccine availability has not been previously reported. MATERIAL AND METHODS: This study developed an inventory model adapted to vaccination protocols to evaluate government recommended polices under different levels of vaccine production. Demands were uncertain and stratified by ages and locations according to the demographic data in Taiwan. RESULTS: When vaccine supply is sufficient, sharing pediatric vaccine reduced vaccine unavailability by 43% and overstock by 54%, and sharing adult vaccine reduced vaccine unavailability by 9% and overstock by 15%. Redistributing vaccines obtained greater gains for both pediatrics and adults (by 75%). When the vaccine supply is in short, only sharing pediatric vaccine yielded a 48% reduction of unused inventory, while other polices do not improve performances. CONCLUSIONS: When implementing vaccination activities for seasonal influenza intervention, it is important to consider mismatches of demand and vaccine inventory. Our model confirmed that sharing and redistributing vaccines can substantially increase availability and reduce unused vaccines.
[Mh] Termos MeSH primário: Vacinas contra Influenza/provisão & distribuição
Influenza Humana/economia
Influenza Humana/prevenção & controle
Vacinação em Massa/economia
Participação no Risco Financeiro/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Criança
Feminino
Seres Humanos
Vacinas contra Influenza/economia
Influenza Humana/epidemiologia
Influenza Humana/imunologia
Masculino
Orthomyxoviridae/imunologia
Orthomyxoviridae/patogenicidade
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Influenza Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186418


  9 / 9506 MEDLINE  
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[PMID]:29028165
[Ti] Título:Executive summary of the 6th meeting of the WHO Expert Working Group of the GISRS for Surveillance of Antiviral Susceptibility.
[Ti] Título:Résumé d'orientation de la 6e réunion du groupe de travail d'experts du GISRS pour la surveillance de la sensibilité aux antiviraux..
[So] Source:Wkly Epidemiol Rec;92(41):611-2, 2017 10 13.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Antivirais/farmacologia
Neuraminidase/antagonistas & inibidores
Orthomyxoviridae/efeitos dos fármacos
Organização Mundial da Saúde
[Mh] Termos MeSH secundário: Comitês Consultivos
Fortalecimento Institucional
Farmacorresistência Viral
Técnicas de Genotipagem/normas
Seres Humanos
Testes de Sensibilidade Microbiana
Orthomyxoviridae/enzimologia
Vigilância da População
Controle de Qualidade
[Pt] Tipo de publicação:CONGRESSES
[Nm] Nome de substância:
0 (Antiviral Agents); EC 3.2.1.18 (Neuraminidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  10 / 9506 MEDLINE  
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[PMID]:29023541
[Au] Autor:Mailybayeva A; Yespembetov B; Ryskeldinova S; Zinina N; Sansyzbay A; Renukaradhya GJ; Petrovsky N; Tabynov K
[Ad] Endereço:Laboratory of Infectious Disease Prevention, Research Institute for Biological Safety Problems, Zhambulskaya Oblast, Kordaiskiy Rayon, Gvardeiskiy, Republic of Kazakhstan.
[Ti] Título:Improved influenza viral vector based Brucella abortus vaccine induces robust B and T-cell responses and protection against Brucella melitensis infection in pregnant sheep and goats.
[So] Source:PLoS One;12(10):e0186484, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella Omp16 and L7/L12 proteins (Flu-BA). Our success in the Flu-BA vaccine trial in cattle and results of a pilot study in non-pregnant small ruminants prompted us in the current study to test its efficacy against B. melitensis infection in pregnant sheep and goats. In this study, we improved the Flu-BA vaccine formulation and immunization method to achieve maximum efficacy and safety. The Flu-BA vaccine formulation had two additional proteins Omp19 and SOD, and administered thrice with 20% Montanide Gel01 adjuvant, simultaneously by both subcutaneous and conjunctival routes at 21 days intervals in pregnant sheep and goats. At 42 days post-vaccination (DPV) we detected antigen-specific IgG antibodies predominantly of IgG2a isotype but also IgG1, and also detected a strong lymphocyte recall response with IFN-γ production. Importantly, our candidate vaccine prevented abortion in 66.7% and 77.8% of pregnant sheep and goats, respectively. Furthermore, complete protection (absence of live B. melitensis 16M) was observed in 55.6% and 66.7% of challenged sheep and goats, and 72.7% and 90.0% of their fetuses (lambs/yeanlings), respectively. The severity of B. melitensis 16M infection in vaccinated sheep and goats and their fetuses (index of infection and rates of Brucella colonization in tissues) was significantly lower than in control groups. None of the protection parameters after vaccination with Flu-BA vaccine were statistically inferior to protection seen with the commercial B. melitensis Rev.1 vaccine (protection against abortion and vaccination efficacy, alpha = 0.18-0.34, infection index, P = 0.37-0.77, Brucella colonization, P = 0.16 to P > 0.99). In conclusion, our improved Flu-BA vaccine formulation and delivery method were found safe and effective in protecting pregnant sheep and goats against adverse consequences of B. melitensis infection.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Vacina contra Brucelose/imunologia
Brucella melitensis/genética
Brucelose/prevenção & controle
Orthomyxoviridae/genética
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Aborto Espontâneo/prevenção & controle
Animais
Anticorpos/imunologia
Antígenos de Bactérias/genética
Antígenos de Bactérias/imunologia
Antígenos de Bactérias/metabolismo
Linfócitos B/citologia
Linfócitos B/metabolismo
Proteínas da Membrana Bacteriana Externa/genética
Proteínas da Membrana Bacteriana Externa/imunologia
Proteínas da Membrana Bacteriana Externa/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/imunologia
Proteínas de Bactérias/metabolismo
Vacina contra Brucelose/genética
Vacina contra Brucelose/metabolismo
Brucella melitensis/patogenicidade
Brucelose/imunologia
Feminino
Cabras
Hemaglutininas Virais/imunologia
Imunoglobulina G/imunologia
Interferon gama/metabolismo
Lipoproteínas/genética
Lipoproteínas/imunologia
Lipoproteínas/metabolismo
Gravidez
Ovinos
Superóxido Dismutase-1/genética
Superóxido Dismutase-1/imunologia
Superóxido Dismutase-1/metabolismo
Linfócitos T/citologia
Linfócitos T/metabolismo
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Antigens, Bacterial); 0 (Bacterial Outer Membrane Proteins); 0 (Bacterial Proteins); 0 (Brucella Vaccine); 0 (Hemagglutinins, Viral); 0 (Immunoglobulin G); 0 (Lipoproteins); 0 (OMP19 protein, Brucella abortus); 82115-62-6 (Interferon-gamma); EC 1.15.1.1 (Superoxide Dismutase-1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186484



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