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  1 / 1606 MEDLINE  
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[PMID]:28459542
[Au] Autor:Warden MS; Tonelli M; Cornilescu G; Liu D; Hopersberger LJ; Ponniah K; Pascal SM
[Ad] Endereço:Department of Chemistry and Biochemistry, Old Dominion University , Norfolk, Virginia 23529, United States.
[Ti] Título:Structure of RNA Stem Loop B from the Picornavirus Replication Platform.
[So] Source:Biochemistry;56(20):2549-2557, 2017 05 23.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The presumptive RNA cloverleaf at the start of the 5'-untranslated region of the picornavirus genome is an essential element in replication. Stem loop B (SLB) of the cloverleaf is a recognition site for the host polyC-binding protein, which initiates a switch from translation to replication. Here we present the solution structure of human rhinovirus isotype 14 SLB using nuclear magnetic resonance spectroscopy. SLB adopts a predominantly A-form helical structure. The stem contains five Watson-Crick base pairs and one wobble base pair and is capped by an eight-nucleotide loop. The wobble base pair introduces perturbations into the helical parameters but does not appear to introduce flexibility. However, the helix major groove appears to be accessible. Flexibility is seen throughout the loop and in the terminal nucleotides. The pyrimidine-rich region of the loop, the apparent recognition site for the polyC-binding protein, is the most disordered region of the structure.
[Mh] Termos MeSH primário: Conformação de Ácido Nucleico
Picornaviridae/fisiologia
RNA Viral/química
Replicação Viral
[Mh] Termos MeSH secundário: Regiões 5' não Traduzidas
Picornaviridae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (RNA, Viral)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00141


  2 / 1606 MEDLINE  
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[PMID]:28884666
[Au] Autor:Zell R; Delwart E; Gorbalenya AE; Hovi T; King AMQ; Knowles NJ; Lindberg AM; Pallansch MA; Palmenberg AC; Reuter G; Simmonds P; Skern T; Stanway G; Yamashita T; Ictv Report Consortium
[Ad] Endereço:1​Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
[Ti] Título:ICTV Virus Taxonomy Profile: Picornaviridae.
[So] Source:J Gen Virol;98(10):2421-2422, 2017 Oct.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected in reptiles, amphibians and fish. Many picornaviruses are important human and veterinary pathogens and may cause diseases of the central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. Most picornaviruses are transmitted by the faecal-oral or respiratory routes. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Picornaviridae, which is available at www.ictv.global/report/picornaviridae.
[Mh] Termos MeSH primário: Infecções por Picornaviridae/transmissão
Infecções por Picornaviridae/veterinária
Picornaviridae/classificação
Picornaviridae/genética
[Mh] Termos MeSH secundário: Anfíbios/virologia
Animais
Aves/virologia
Peixes/virologia
Seres Humanos
Mamíferos/virologia
Infecções por Picornaviridae/virologia
Répteis/virologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000911


  3 / 1606 MEDLINE  
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[PMID]:28857036
[Au] Autor:Olendraite I; Lukhovitskaya NI; Porter SD; Valles SM; Firth AE
[Ad] Endereço:1​Division of Virology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
[Ti] Título:Polycipiviridae: a proposed new family of polycistronic picorna-like RNA viruses.
[So] Source:J Gen Virol;98(9):2368-2378, 2017 Sep.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Solenopsis invicta virus 2 is a single-stranded positive-sense picorna-like RNA virus with an unusual genome structure. The monopartite genome of approximately 11 kb contains four open reading frames in its 5' third, three of which encode proteins with homology to picornavirus-like jelly-roll fold capsid proteins. These are followed by an intergenic region, and then a single long open reading frame that covers the 3' two-thirds of the genome. The polypeptide translation of this 3' open reading frame contains motifs characteristic of picornavirus-like helicase, protease and RNA-dependent RNA polymerase domains. An inspection of public transcriptome shotgun assembly sequences revealed five related apparently nearly complete virus genomes isolated from ant species and one from a dipteran insect. By high-throughput sequencing and in silico assembly of RNA isolated from Solenopsis invicta and four other ant species, followed by targeted Sanger sequencing, we obtained nearly complete genomes for four further viruses in the group. Four further sequences were obtained from a recent large-scale invertebrate virus study. The 15 sequences are highly divergent (pairwise amino acid identities of as low as 17 % in the non-structural polyprotein), but possess the same overall polycistronic genome structure, which is distinct from all other characterized picorna-like viruses. Consequently, we propose the formation of a new virus family, Polycipiviridae, to classify this clade of arthropod-infecting polycistronic picorna-like viruses. We further propose that this family be divided into three genera: Chipolycivirus (2 species), Hupolycivirus (2 species) and Sopolycivirus (11 species), with members of the latter infecting ants in at least 3 different subfamilies.
[Mh] Termos MeSH primário: Formigas/virologia
Picornaviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Genoma Viral
Vírus dos Insetos/classificação
Vírus dos Insetos/genética
Vírus dos Insetos/isolamento & purificação
Filogenia
Picornaviridae/classificação
Picornaviridae/genética
RNA Viral/genética
RNA Viral/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000902


  4 / 1606 MEDLINE  
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[PMID]:28850669
[Au] Autor:Lei J; Hilgenfeld R
[Ad] Endereço:Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Germany.
[Ti] Título:RNA-virus proteases counteracting host innate immunity.
[So] Source:FEBS Lett;591(20):3190-3210, 2017 Oct.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Virus invasion triggers host immune responses, in particular, innate immune responses. Pathogen-associated molecular patterns of viruses (such as dsRNA, ssRNA, or viral proteins) released during virus replication are detected by the corresponding pattern-recognition receptors of the host, and innate immune responses are induced. Through production of type-I and type-III interferons as well as various other cytokines, the host innate immune system forms the frontline to protect host cells and inhibit virus infection. Not surprisingly, viruses have evolved diverse strategies to counter this antiviral system. In this review, we discuss the multiple strategies used by proteases of positive-sense single-stranded RNA viruses of the families Picornaviridae, Coronaviridae, and Flaviviridae, when counteracting host innate immune responses.
[Mh] Termos MeSH primário: Evasão da Resposta Imune
Imunidade Inata
Interferons/imunologia
Receptores Toll-Like/imunologia
Proteínas Virais/imunologia
Viroses/imunologia
[Mh] Termos MeSH secundário: Animais
Coronaviridae/genética
Coronaviridae/imunologia
Citocinas/genética
Citocinas/imunologia
Flaviviridae/genética
Flaviviridae/imunologia
Regulação da Expressão Gênica
Seres Humanos
Interferons/genética
Picornaviridae/genética
Picornaviridae/imunologia
Estrutura Secundária de Proteína
Transdução de Sinais
Receptores Toll-Like/genética
Proteínas Virais/química
Proteínas Virais/genética
Viroses/genética
Viroses/patologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Toll-Like Receptors); 0 (Viral Proteins); 9008-11-1 (Interferons)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12827


  5 / 1606 MEDLINE  
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[PMID]:28708843
[Au] Autor:Visseaux B; Burdet C; Voiriot G; Lescure FX; Chougar T; Brugière O; Crestani B; Casalino E; Charpentier C; Descamps D; Timsit JF; Yazdanpanah Y; Houhou-Fidouh N
[Ad] Endereço:IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Laboratoire de Virologie, Hôpital Bichat, AP-HP, Paris, France.
[Ti] Título:Prevalence of respiratory viruses among adults, by season, age, respiratory tract region and type of medical unit in Paris, France, from 2011 to 2016.
[So] Source:PLoS One;12(7):e0180888, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Multiplex PCR tests have improved our understanding of respiratory viruses' epidemiology by allowing their wide range detection. We describe here the burden of these viruses in hospital settings over a five-year period. METHODS: All respiratory samples from adult patients (>20 years old) tested by multiplex-PCR at the request of physicians, from May 1 2011 to April 30 2016, were included retrospectively. Viral findings are reported by season, patient age group, respiratory tract region (upper or lower) and type of clinical unit (intensive care unit, pneumology unit, lung transplantation unit and other medical units). RESULTS: In total, 7196 samples (4958 patients) were included; 29.2% tested positive, with viral co-infections detected in 1.6% of samples. Overall, two viral groups accounted for 60.2% of all viruses identified: picornaviruses (rhinovirus or enterovirus, 34.3%) and influenza (26.6%). Influenza viruses constituted the group most frequently identified in winter (34.4%), in the upper respiratory tract (32%) and in patients over the age of 70 years (36.4%). Picornavirus was the second most frequently identified viral group in these populations and in all other groups, including lower respiratory tract infections (41.3%) or patients in intensive care units (37.6%). CONCLUSION: This study, the largest to date in Europe, provides a broad picture of the distribution of viruses over seasons, age groups, types of clinical unit and respiratory tract regions in the hospital setting. It highlights the burden associated with the neglected picornavirus group. These data have important implications for the future development of vaccines and antiviral drugs.
[Mh] Termos MeSH primário: Infecções Respiratórias/epidemiologia
Estações do Ano
[Mh] Termos MeSH secundário: Adenoviridae/genética
Adenoviridae/isolamento & purificação
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
DNA Viral/isolamento & purificação
DNA Viral/metabolismo
Feminino
França/epidemiologia
Seres Humanos
Unidades de Terapia Intensiva
Masculino
Meia-Idade
Reação em Cadeia da Polimerase Multiplex
Orthomyxoviridae/genética
Orthomyxoviridae/isolamento & purificação
Picornaviridae/genética
Picornaviridae/isolamento & purificação
Prevalência
RNA Viral/isolamento & purificação
RNA Viral/metabolismo
Infecções Respiratórias/diagnóstico
Infecções Respiratórias/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180888


  6 / 1606 MEDLINE  
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[PMID]:28686725
[Au] Autor:Locke B; Semberg E; Forsgren E; de Miranda JR
[Ad] Endereço:Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
[Ti] Título:Persistence of subclinical deformed wing virus infections in honeybees following Varroa mite removal and a bee population turnover.
[So] Source:PLoS One;12(7):e0180910, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deformed wing virus (DWV) is a lethal virus of honeybees (Apis mellifera) implicated in elevated colony mortality rates worldwide and facilitated through vector transmission by the ectoparasitic mite Varroa destructor. Clinical, symptomatic DWV infections are almost exclusively associated with high virus titres during pupal development, usually acquired through feeding by Varroa mites when reproducing on bee pupae. Control of the mite population, generally through acaricide treatment, is essential for breaking the DWV epidemic and minimizing colony losses. In this study, we evaluated the effectiveness of remedial mite control on clearing DWV from a colony. DWV titres in adult bees and pupae were monitored at 2 week intervals through summer and autumn in acaricide-treated and untreated colonies. The DWV titres in Apistan treated colonies was reduced 1000-fold relative to untreated colonies, which coincided with both the removal of mites and also a turnover of the bee population in the colony. This adult bee population turnover is probably more critical than previously realized for effective clearing of DWV infections. After this initial reduction, subclinical DWV titres persisted and even increased again gradually during autumn, demonstrating that alternative non-Varroa transmission routes can maintain the DWV titres at significant subclinical levels even after mite removal. The implications of these results for practical recommendations to mitigate deleterious subclinical DWV infections and improving honeybee health management are discussed.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Abelhas/virologia
Ectoparasitoses/prevenção & controle
Picornaviridae/efeitos dos fármacos
Controle de Ácaros e Carrapatos/métodos
Varroidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Abelhas/parasitologia
Vetores de Doenças
Ectoparasitoses/parasitologia
Ectoparasitoses/virologia
Picornaviridae/crescimento & desenvolvimento
Picornaviridae/patogenicidade
Pupa/parasitologia
Pupa/virologia
RNA Viral/genética
Estações do Ano
Varroidae/virologia
Carga Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180910


  7 / 1606 MEDLINE  
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[PMID]:28650343
[Au] Autor:Miles LA; Burga LN; Gardner EE; Bostina M; Poirier JT; Rudin CM
[Ad] Endereço:Molecular Pharmacology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
[Ti] Título:Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus.
[So] Source:J Clin Invest;127(8):2957-2967, 2017 Aug 01.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. It has shown promise as a cancer therapeutic in preclinical studies and early-phase clinical trials. Here, we have identified anthrax toxin receptor 1 (ANTXR1) as the receptor for SVV using genome-wide loss-of-function screens. ANTXR1 is necessary for permissivity in vitro and in vivo. However, robust SVV replication requires an additional innate immune defect. We found that SVV interacts directly and specifically with ANTXR1, that this interaction is required for SVV binding to permissive cells, and that ANTXR1 expression is necessary and sufficient for infection in cell lines with decreased expression of antiviral IFN genes at baseline. Finally, we identified the region of the SVV capsid that is responsible for receptor recognition using cryoelectron microscopy of the SVV-ANTXR1-Fc complex. These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for SVV.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/química
Proteínas de Neoplasias/química
Picornaviridae
Receptores de Superfície Celular/química
Receptores Virais/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular
Microscopia Crioeletrônica
Feminino
Perfilação da Expressão Gênica
Genoma
Proteínas de Fluorescência Verde/química
Seres Humanos
Camundongos
Camundongos Nus
Terapia Viral Oncolítica
Vírus Oncolíticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ANTXR1 protein, human); 0 (Capsid Proteins); 0 (Neoplasm Proteins); 0 (Receptors, Cell Surface); 0 (Receptors, Virus); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  8 / 1606 MEDLINE  
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[PMID]:28631594
[Au] Autor:Anastasina M; Domanska A; Palm K; Butcher S
[Ad] Endereço:1​Institute of Biotechnology and Department of Biosciences, University of Helsinki, Viikinkaari 1, 00790 Helsinki, Finland 2​Protobios LLC, Mäealuse 4, 12618 Tallinn, Estonia.
[Ti] Título:Human picornaviruses associated with neurological diseases and their neutralization by antibodies.
[So] Source:J Gen Virol;98(6):1145-1158, 2017 Jun.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.
[Mh] Termos MeSH primário: Anticorpos Neutralizantes/imunologia
Anticorpos Antivirais/imunologia
Viroses do Sistema Nervoso Central/imunologia
Infecções por Picornaviridae/imunologia
Picornaviridae/imunologia
[Mh] Termos MeSH secundário: Animais
Viroses do Sistema Nervoso Central/virologia
Modelos Animais de Doenças
Seres Humanos
Picornaviridae/fisiologia
Infecções por Picornaviridae/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000780


  9 / 1606 MEDLINE  
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[PMID]:28566380
[Au] Autor:Qian S; Fan W; Liu T; Wu M; Zhang H; Cui X; Zhou Y; Hu J; Wei S; Chen H; Li X; Qian P
[Ad] Endereço:State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
[Ti] Título:Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.
[So] Source:J Virol;91(16), 2017 Aug 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seneca Valley virus (SVV) is an oncolytic RNA virus belonging to the family. Its nucleotide sequence is highly similar to those of members of the genus. SVV is also a neuroendocrine cancer-selective oncolytic picornavirus that can be used for anticancer therapy. However, the interaction between SVV and its host is yet to be fully characterized. In this study, SVV inhibited antiviral type I interferon (IFN) responses by targeting different host adaptors, including mitochondrial antiviral signaling (MAVS), Toll/interleukin 1 (IL-1) receptor domain-containing adaptor inducing IFN-ß (TRIF), and TRAF family member-associated NF-κB activator (TANK), via viral 3C protease (3C ). SVV 3C mediated the cleavage of MAVS, TRIF, and TANK at specific sites, which required its protease activity. The cleaved MAVS, TRIF, and TANK lost the ability to regulate pattern recognition receptor (PRR)-mediated IFN production. The cleavage of TANK also facilitated TRAF6-induced NF-κB activation. SVV was also found to be sensitive to IFN-ß. Therefore, SVV suppressed antiviral IFN production to escape host antiviral innate immune responses by cleaving host adaptor molecules. Host cells have developed various defenses against microbial pathogen infection. The production of IFN is the first line of defense against microbial infection. However, viruses have evolved many strategies to disrupt this host defense. SVV, a member of the genus, is an oncolytic virus that shows potential functions in anticancer therapy. It has been demonstrated that IFN can be used in anticancer therapy for certain tumors. However, the relationship between oncolytic virus and innate immune response in anticancer therapy is still not well known. In this study, we showed that SVV has evolved as an effective mechanism to inhibit host type I IFN production by using its 3C to cleave the molecules MAVS, TRIF, and TANK directly. These molecules are crucial for the Toll-like receptor 3 (TLR3)-mediated and retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated signaling pathway. We also found that SVV is sensitive to IFN-ß. These findings increase our understanding of the interaction between SVV and host innate immunity.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Proteínas Adaptadoras de Transporte Vesicular/metabolismo
Cisteína Endopeptidases/metabolismo
Evasão da Resposta Imune
Interferon Tipo I/antagonistas & inibidores
Picornaviridae/crescimento & desenvolvimento
Proteínas Virais/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Cricetinae
Interações Hospedeiro-Patógeno
Seres Humanos
Picornaviridae/enzimologia
Proteólise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Adaptor Proteins, Vesicular Transport); 0 (Interferon Type I); 0 (TANK protein, human); 0 (TICAM1 protein, human); 0 (VISA protein, human); 0 (Viral Proteins); EC 3.4.22.- (Cysteine Endopeptidases); EC 3.4.22.28 (3C proteases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


  10 / 1606 MEDLINE  
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[PMID]:28555547
[Au] Autor:Lukashev AN; Corman VM; Schacht D; Gloza-Rausch F; Seebens-Hoyer A; Gmyl AP; Drosten C; Drexler JF
[Ad] Endereço:1​Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia 2​Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
[Ti] Título:Close genetic relatedness of picornaviruses from European and Asian bats.
[So] Source:J Gen Virol;98(5):955-961, 2017 May.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Our investigation of 1004 faecal specimens from European bats for picornaviruses by broadly reactive nested reverse transcription-PCR found picornaviral RNA in 28 samples (2.8 %). Phylogenetic analysis of the partial 3D genomic region suggested that one bat virus belonged to the species Enterovirus G (EV-G, formerly Porcine enterovirus B). Bat infection was supported by relatively high EV-G concentrations of 1.1×106 RNA copies per gram of faeces. All other bat viruses belonged either to the bat-associated genus Mischivirus, or to an unclassified Picornaviridae group distantly related to the genus Sapelovirus. Members of this unclassified sapelovirus-related group had RNA secondary structures in their 3'-nontranslated regions that were typical of enteroviruses and that resembled structures that occur in bat-associated coronaviruses, suggesting ancient recombination events. Based on sequence distances, several picornaviruses from European and Chinese bats were likely conspecific, suggesting connectivity of virus populations. Due to their high mutation rates and their diversity, picornaviruses may be useful tools for studies of bat and virus ecology.
[Mh] Termos MeSH primário: Quirópteros/virologia
Picornaviridae/classificação
Picornaviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Ásia
Análise por Conglomerados
Enterovirus Suínos
Europa (Continente)
Fezes/virologia
Genoma Viral
Filogenia
Picornaviridae/genética
Reação em Cadeia da Polimerase
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Análise de Sequência de DNA
Homologia de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000760



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