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  1 / 5809 MEDLINE  
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[PMID]:29192001
[Au] Autor:Qian G; Zhou CC
[Ad] Endereço:Department of Dermatology, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, China.
[Ti] Título:A child with nail changes.
[So] Source:BMJ;359:j5192, 2017 11 30.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doença de Mão, Pé e Boca/complicações
Doenças da Unha/etiologia
Unhas Malformadas/etiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Enterovirus/isolamento & purificação
Doença de Mão, Pé e Boca/virologia
Seres Humanos
Achados Incidentais
Masculino
Doenças da Unha/patologia
Unhas Malformadas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5192


  2 / 5809 MEDLINE  
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[PMID]:29424218
[Au] Autor:Sergevnin VI; Tryasolobova MA; Kudrevatykh EV; Kuzovnikova EZ
[Ti] Título:[The frequency of detection of non-polio enteroviruses in foul and fecal waste waters, water and some food products].
[So] Source:Gig Sanit;95(6):525-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the Perm Territory from 2010 to 2014 155 samples offoul andfecal waste waters, 293 samples of surface water, 827 samples of supply net water, and 57 vegetable and fruit water-washes were examined for the RNA enterovirus agent with the use of polymerase chain reaction (PCR) method. In parallel 155 wastewater samples, 20 samples of surface water, and 4 samples of supply net water were examined for non-polio enterovirus agent with the use of virological methods. In the samples of foul waste waters the RNA enterovirus agent was detected in 74.8 ± 3.4%, and nonpolio enterovirus agent - in 65.1 ± 3.8%. In the samples of surface water the RNA enterovirus agent was detected in 2.3 ± 0.8%; in the area offoul and fecal waste waters the non-polio enterovirus agent was detected in 20.0 ± 4.4% in the process of virological investigation of RNA-positive water samples. In supply net water the RNA enterovirus agent was detected in 0.8 ± 0.3 %, on the surface of vegetables, fruits, and grapes - in 10.5 ± 3.9 %.
[Mh] Termos MeSH primário: Infecções por Enterovirus
Enterovirus
Água Doce
Frutas/virologia
Verduras/virologia
Águas Residuais/virologia
[Mh] Termos MeSH secundário: Enterovirus/isolamento & purificação
Enterovirus/patogenicidade
Infecções por Enterovirus/epidemiologia
Infecções por Enterovirus/prevenção & controle
Infecções por Enterovirus/virologia
Monitoramento Ambiental/métodos
Água Doce/análise
Água Doce/virologia
Seres Humanos
Saúde Pública/métodos
Saúde Pública/normas
Saúde Pública/estatística & dados numéricos
Federação Russa/epidemiologia
Eliminação de Resíduos Líquidos/normas
Abastecimento de Água/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Waste Water)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  3 / 5809 MEDLINE  
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[PMID]:28942015
[Au] Autor:Chen P; Wang H; Tao Z; Xu A; Lin X; Zhou N; Wang P; Wang Q
[Ad] Endereço:Department of Epidemiology, School of Public Health, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, People's Republic of China.
[Ti] Título:Multiple transmission chains of coxsackievirus A4 co-circulating in China and neighboring countries in recent years: Phylogenetic and spatiotemporal analyses based on virological surveillance.
[So] Source:Mol Phylogenet Evol;118:23-31, 2018 Jan.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Coxsackievirus A4 (CV-A4) has been reported frequently in association with many infectious diseases and cases of hand, foot, and mouth disease potentially associated with CV-A4 infection are also identified. This study summarized the Shandong CV-A4 strains isolated from 25years acute flaccid paralysis surveillance, with an emphasis on exploring the phylogenetic analyses and spatiotemporal dynamics of CV-A4 at the global scale. We sampled 43 CV-A4 isolates and utilized VP1 gene to construct phylogenetic trees. Further extensive Bayesian phylogeographic analysis was carried out to investigate the evolution of CV-A4 and understand the spatiotemporal diffusion around the world using BEAST and SPREAD software. Phylogenetic trees showed that CV-A4 emerged to be more active in recent decades and multiple transmission chains were co-circulating. The molecular clock analysis estimated a mean evolutionary rate of 6.4×10 substitutions/site/year, and the estimated origin of CV-A4 around 1944. The phylogeographic analyses suggested the origin of CV-A4 could be in the USA, however regional dissemination was mainly located around the Asia-Europe region. The spatiotemporal dynamics of CV-A4 exhibited frequent viral traffic among localities, and virus from Shandong province seemed to have played a central role in spreading around China and neighboring countries. Our phylogenetic description and phylogeographic analyses indicate the importance of large spatial- and temporal-scale studies in understanding epidemiological dynamics of CV-A4, particularly the diffusion routes will be of great importance to global control efforts.
[Mh] Termos MeSH primário: Enterovirus/classificação
[Mh] Termos MeSH secundário: Ásia
Teorema de Bayes
Proteínas do Capsídeo/química
Proteínas do Capsídeo/genética
China
Infecções por Coxsackievirus/diagnóstico
Infecções por Coxsackievirus/transmissão
Infecções por Coxsackievirus/virologia
Enterovirus/genética
Europa (Continente)
Seres Humanos
Tipagem Molecular
Filogenia
Filogeografia
RNA Viral/isolamento & purificação
RNA Viral/metabolismo
Análise Espaço-Temporal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


  4 / 5809 MEDLINE  
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[PMID]:27771182
[Au] Autor:Yang L; Liu Y; Li S; Zhao H; Lin Q; Yu H; Huang X; Zheng Q; Cheng T; Xia N
[Ad] Endereço:State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science & School of Public Health, Xiamen University, Xiamen, China.
[Ti] Título:A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice.
[So] Source:Vaccine;34(48):5938-5945, 2016 11 21.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hand, foot, and mouth disease (HFMD) is a highly contagious disease that mainly affects infants and children. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the major pathogens of HFMD. Two EV71 vaccines were recently licensed in China and the administration of the EV71 vaccines is believed to significantly reduce the number of HFMD-related severe or fatal cases. However, a monovalent EV71 vaccine cannot cross-protect against CA16 infection, this may result in that it cannot effectively control the overall HFMD epidemic. In this study, a chimeric EV71, whose VP1/210-225 epitope was replaced by that of CA16, was constructed using a reverse genetics technique to produce a candidate EV71/CA16 bivalent vaccine strain. The chimeric EV71 was infectious and showed similar growth characteristics as its parental strain. The replacement of the VP1/210-225 epitope did not significantly affect the antigenicity and immunogenicity of EV71. More importantly, the chimeric EV71 could induce protective immunity against both EV71 and CA16, and protect neonatal mice against either EV71 or CA16 lethal infections, the chimeric EV71 constructed in this study was shown to be a feasible and promising candidate bivalent vaccine against both EV71 and CA16. The construction of a chimeric enterovirus also provides an alternative platform for broad-spectrum HFMD vaccines development.
[Mh] Termos MeSH primário: Infecções por Coxsackievirus/prevenção & controle
Proteção Cruzada
Infecções por Enterovirus/prevenção & controle
Enterovirus/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Infecções por Coxsackievirus/imunologia
Enterovirus Humano A/genética
Enterovirus Humano A/imunologia
Infecções por Enterovirus/imunologia
Epitopos/imunologia
Doença de Mão, Pé e Boca/prevenção & controle
Seres Humanos
Imunogenicidade da Vacina
Camundongos
Genética Reversa
Vacinas de Produtos Inativados/administração & dosagem
Vacinas de Produtos Inativados/imunologia
Vacinas Virais/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Epitopes); 0 (Vaccines, Inactivated); 0 (Viral Vaccines)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 5809 MEDLINE  
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[PMID]:29029976
[Au] Autor:Martín-Díaz J; Lucena F
[Ad] Endereço:Department of Genetics, Microbiology and Statistics, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain; The Water Research Institute, University of Barcelona, C/Montalegre 6, 08001 Barcelona, Spain. Electronic address: juliamadi@hotmail.com.
[Ti] Título:Extraction and RT-qPCR detection of enteroviruses from solid environmental matrixes: Method decision tree for different sample types and viral concentrations.
[So] Source:J Virol Methods;251:145-150, 2018 Jan.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Quantitative RT-PCR methods (RT-qPCR) are becoming increasingly desirable for the detection of enteric viruses in solid environmental matrixes such as sediments, soils and sewage sludge. However, effective methodologies that allow the extraction of high quality RNA ready for molecular quantification continue to be evaluated. In the present study, four different methods for enterovirus extraction from solid environmental matrixes were compared in terms of viral recovery and inhibitor removal. Three indirect methods based on glycine elution and concentration by ultracentrifugation were tested. The main differences between indirect methods were the sample to glycine buffer ratio, and the ultracentrifugation protocol applied. One commercial direct method was also tested. The indirect methods produced better results than the direct method. The ultracentrifugation led to viral losses in samples with high titers; however, as the virus concentration reduced, the ultracentrifugation became increasingly important for viral recovery. Two commercial RNA extraction kits were also evaluated and it was selected the most effective in removing RT-qPCR inhibitors. The results obtained allowed the development of a method decision tree with three versions that are suitable for different samples and viral concentrations.
[Mh] Termos MeSH primário: Enterovirus/isolamento & purificação
Microbiologia Ambiental
RNA Viral/isolamento & purificação
Reação em Cadeia da Polimerase em Tempo Real/métodos
Carga Viral/métodos
[Mh] Termos MeSH secundário: Árvores de Decisões
Enterovirus/genética
RNA Viral/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  6 / 5809 MEDLINE  
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[PMID]:28471477
[Au] Autor:Ross C; Knox C; Tastan Bishop Ö
[Ad] Endereço:Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
[Ti] Título:Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids.
[So] Source:FEBS Lett;591(12):1687-1701, 2017 06.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA. For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/metabolismo
Enterovirus/metabolismo
Modelos Moleculares
RNA Viral/metabolismo
Rhinovirus/metabolismo
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Sequência de Aminoácidos
Substituição de Aminoácidos
Proteínas do Capsídeo/química
Proteínas do Capsídeo/genética
Biologia Computacional
Sequência Conservada
Cristalografia por Raios X
Bases de Dados de Proteínas
Transferência de Energia
Mutação
Domínios e Motivos de Interação entre Proteínas
Multimerização Proteica
Estabilidade Proteica
Subunidades Proteicas/química
Subunidades Proteicas/genética
Subunidades Proteicas/metabolismo
RNA Viral/química
Especificidade da Espécie
Propriedades de Superfície
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (Protein Subunits); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12663


  7 / 5809 MEDLINE  
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[PMID]:29106347
[Au] Autor:Pellegrinelli L; Bubba L; Galli C; Anselmi G; Primache V; Binda S; Pariani E
[Ad] Endereço:1​Department of Biomedical Sciences for Health, University of Milan, Via Carlo Pascal, 36 - 20133 Milan, Italy.
[Ti] Título:Epidemiology and molecular characterization of influenza viruses, human parechoviruses and enteroviruses in children up to 5 years with influenza-like illness in Northern Italy during seven consecutive winter seasons (2010-2017).
[So] Source:J Gen Virol;98(11):2699-2711, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Besides the influenza virus (IV), several other viruses are responsible for influenza-like illness (ILI). Although human parechoviruses (HPeVs) and enteroviruses (EVs) may impact on ILI, limited data on their epidemiological characteristics are available. During seven consecutive winter seasons (from 2010-2011 to 2016-2017), within the framework of an influenza surveillance system (InfluNet), 593 respiratory swabs were collected from children ≤5 years of age with ILIs. Molecular detection showed that 58.3 % of swabs were positive for at least one of the viruses under study: 46 % for IV, 13 % for EV and 5.4 % for HPeV. A single virus was identified in 51.3 % of samples while more than one virus was detected in 7 % of the samples. The risk of contracting IV was higher than the risk associated with EV, which in turn was higher than the risk of contracting HPeV. The risk of developing an IV infection was twofold greater in children >3 years than in those ≤3 years, who had higher risk of EV/HPeV infection. The frequency of EV/HPeV-positive swabs increased significantly during the 2016-2017 winter season compared to the previous six seasons. Sixteen EV genotypes were identified belonging to species A and B. HPeV-1 was the most frequently detected genotype, followed by -6 and -3. In this study, IV was mainly responsible for ILI, however EV and HPeV were also involved and particularly affected children ≤3 years of age. Influenza surveillance samples could provide us with valuable insight into the epidemiological features of viruses involved in ILI.
[Mh] Termos MeSH primário: Enterovirus/isolamento & purificação
Variação Genética
Orthomyxoviridae/isolamento & purificação
Parechovirus/isolamento & purificação
Infecções Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Criança
Enterovirus/classificação
Enterovirus/genética
Seres Humanos
Itália/epidemiologia
Epidemiologia Molecular
Orthomyxoviridae/classificação
Orthomyxoviridae/genética
Parechovirus/classificação
Parechovirus/genética
Prevalência
Infecções Respiratórias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000937


  8 / 5809 MEDLINE  
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[PMID]:28968427
[Au] Autor:Brazier L; Elguero E; Koumavor CK; Renaud N; Prugnolle F; Thomas F; Ategbo S; Engoba M; Obengui; Leroy EM; Durand P; Renaud F; Becquart P
[Ad] Endereço:UMR 5290 MIVEGEC, Institut de Recherche pour le Développement (IRD), Montpellier, France.
[Ti] Título:Evolution in fecal bacterial/viral composition in infants of two central African countries (Gabon and Republic of the Congo) during their first month of life.
[So] Source:PLoS One;12(10):e0185569, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Few studies have analyzed the gut microbiota of child in unindustrialized countries, but none during the first month of life. Stool samples were collected from healthy newborns in hospitals of Gabon (n = 6) and Republic of the Congo (n = 9) at different time points during the first month of life: meconium, day 2 (D02), day 7 (D07) and day 28 (D28). In addition, one fecal sample was collected from each mother after delivery. Metagenomic sequencing was performed to determine the bacterial communities, and multiplex real-time PCR was used to detect the presence of seven enteric viruses (rotavirus a, adenovirus, norovirus I and II, sapovirus, astrovirus, enterovirus) in these samples. Bacterial diversity was high in the first days of life, and was dominated by the genus Prevotella. Then, it rapidly decreased and remained low up to D28 when the gut flora was composed almost exclusively of strictly anaerobic bacteria. Each infant's fecal bacterial microbiota composition was significantly closer to that of their mother than to that of any other woman in the mothers' group, suggesting an intrauterine, placental or amniotic fluid origin of such bacteria. Moreover, bacterial communities differed according to the delivery mode. Overall, the bacterial microbiota communities displayed a similar diversification and expansion in newborns within and between countries during the first four weeks of life. Moreover, six of the fifteen infants of this study harbored enteric viruses (rotavirus, enterovirus and adenovirus) in fecal samples, but never in the meconium. A maternal source for the viruses detected at D02 and D07 can be excluded because none of them was found also in the child's mother. These findings improve our knowledge on the gut bacterial and viral communities of infants from two Sub-Saharan countries during their first month of life.
[Mh] Termos MeSH primário: Fezes/microbiologia
Fezes/virologia
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/genética
Bactérias/isolamento & purificação
Parto Obstétrico/métodos
República Democrática do Congo
Enterovirus/classificação
Enterovirus/genética
Enterovirus/isolamento & purificação
Feminino
Gabão
Seres Humanos
Recém-Nascido
Masculino
Metagenoma
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185569


  9 / 5809 MEDLINE  
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[PMID]:28950225
[Au] Autor:Flynn CT; Kimura T; Frimpong-Boateng K; Harkins S; Whitton JL
[Ad] Endereço:Dept. of Immunology and Microbiology, SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
[Ti] Título:Immunological and pathological consequences of coxsackievirus RNA persistence in the heart.
[So] Source:Virology;512:104-112, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Type B coxsackieviruses (CVB) can cause myocarditis and dilated cardiomyopathy (DCM), a potentially-fatal sequela that has been correlated to the persistence of viral RNA. Herein, we demonstrate that cardiac RNA persistence can be established even after an inapparent primary infection. Using an inducible Cre/lox mouse model, we ask: (i) Does persistent CVB3 RNA cause ongoing immune activation? (ii) If T1IFN signaling into cardiomyocytes is ablated after RNA persistence is established, is there any change in the abundance of persistent CVB3 RNA and/or does cytopathic infectious virus re-emerge? (iii) Does this loss of T1IFN responsiveness by cardiomyocytes lead to the recurrence/exacerbation of myocarditis? Our findings suggest that persistent enteroviral RNAs probably do not contribute to ongoing myocardial disease, and are more likely to be the fading remnants of a recent, possibly sub-clinical, primary infection which may have set in motion the process that ultimately ends in DCM.
[Mh] Termos MeSH primário: Enterovirus/fisiologia
Miócitos Cardíacos/virologia
RNA Viral/fisiologia
[Mh] Termos MeSH secundário: Animais
Cardiomiopatia Dilatada/virologia
Infecções por Coxsackievirus/virologia
Ativação Enzimática/efeitos dos fármacos
Deleção de Genes
Regulação da Expressão Gênica
Integrases/metabolismo
Interferon Tipo I/genética
Interferon Tipo I/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Miocardite/virologia
Miócitos Cardíacos/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Tamoxifeno/farmacologia
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon Type I); 0 (RNA, Messenger); 0 (RNA, Viral); 094ZI81Y45 (Tamoxifen); EC 2.7.7.- (Cre recombinase); EC 2.7.7.- (Integrases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


  10 / 5809 MEDLINE  
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[PMID]:28943436
[Au] Autor:Qu M; Di S; Zhang S; Xia Z; Quan G
[Ad] Endereço:Harbin Children's Hospital, Harbin 150010, China. Electronic address: drqumeiling@163.com.
[Ti] Título:Vitamin D receptor protects glioblastoma A172 cells against Coxsackievirus A16 infection induced cell death in the pathogenesis of hand, foot, and mouth disease.
[So] Source:Biochem Biophys Res Commun;493(2):952-956, 2017 Nov 18.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hand, foot, and mouth disease (HFMD) was one of the most common children illnesses. Coxsackievirus A16 was one of the major pathogens that cause HFMD. However, the role of vitamin D underlying this common illness has not been elucidated. Our study examined that vitamin D levels was significantly lower in 33 HFMD patients, compared to 36 healthy children. Unexpectedly, both mRNA and protein expression of VDR were significantly decreased in CA16 infected glioblastoma A172 cells. And overexpression of VDR or vitamin D treatment in CA16 infected glioblastoma A172 cells could reverse the CA16 infection induced cell death, apoptosis or mitochondrial membrane rupture. Therefore, our study, for the first time, demonstrated that vitamin D and VDR could associate with the pathogenesis of HFMD. Thus might provide useful information for HFMD prevention and treatments.
[Mh] Termos MeSH primário: Infecções por Coxsackievirus/sangue
Infecções por Coxsackievirus/complicações
Enterovirus/isolamento & purificação
Doença de Mão, Pé e Boca/sangue
Doença de Mão, Pé e Boca/virologia
Receptores de Calcitriol/sangue
[Mh] Termos MeSH secundário: Morte Celular
Linhagem Celular Tumoral
Pré-Escolar
Infecções por Coxsackievirus/genética
Infecções por Coxsackievirus/virologia
Regulação para Baixo
Doença de Mão, Pé e Boca/etiologia
Doença de Mão, Pé e Boca/genética
Seres Humanos
Lactente
RNA Mensageiro/genética
Receptores de Calcitriol/análise
Receptores de Calcitriol/genética
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Receptors, Calcitriol); 0 (VDR protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE



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