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[PMID]:29106347
[Au] Autor:Pellegrinelli L; Bubba L; Galli C; Anselmi G; Primache V; Binda S; Pariani E
[Ad] Endereço:1​Department of Biomedical Sciences for Health, University of Milan, Via Carlo Pascal, 36 - 20133 Milan, Italy.
[Ti] Título:Epidemiology and molecular characterization of influenza viruses, human parechoviruses and enteroviruses in children up to 5 years with influenza-like illness in Northern Italy during seven consecutive winter seasons (2010-2017).
[So] Source:J Gen Virol;98(11):2699-2711, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Besides the influenza virus (IV), several other viruses are responsible for influenza-like illness (ILI). Although human parechoviruses (HPeVs) and enteroviruses (EVs) may impact on ILI, limited data on their epidemiological characteristics are available. During seven consecutive winter seasons (from 2010-2011 to 2016-2017), within the framework of an influenza surveillance system (InfluNet), 593 respiratory swabs were collected from children ≤5 years of age with ILIs. Molecular detection showed that 58.3 % of swabs were positive for at least one of the viruses under study: 46 % for IV, 13 % for EV and 5.4 % for HPeV. A single virus was identified in 51.3 % of samples while more than one virus was detected in 7 % of the samples. The risk of contracting IV was higher than the risk associated with EV, which in turn was higher than the risk of contracting HPeV. The risk of developing an IV infection was twofold greater in children >3 years than in those ≤3 years, who had higher risk of EV/HPeV infection. The frequency of EV/HPeV-positive swabs increased significantly during the 2016-2017 winter season compared to the previous six seasons. Sixteen EV genotypes were identified belonging to species A and B. HPeV-1 was the most frequently detected genotype, followed by -6 and -3. In this study, IV was mainly responsible for ILI, however EV and HPeV were also involved and particularly affected children ≤3 years of age. Influenza surveillance samples could provide us with valuable insight into the epidemiological features of viruses involved in ILI.
[Mh] Termos MeSH primário: Enterovirus/isolamento & purificação
Variação Genética
Orthomyxoviridae/isolamento & purificação
Parechovirus/isolamento & purificação
Infecções Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Criança
Enterovirus/classificação
Enterovirus/genética
Seres Humanos
Itália/epidemiologia
Epidemiologia Molecular
Orthomyxoviridae/classificação
Orthomyxoviridae/genética
Parechovirus/classificação
Parechovirus/genética
Prevalência
Infecções Respiratórias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000937


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[PMID]:28886185
[Au] Autor:Chiang GPK; Chen Z; Chan MCW; Lee SHM; Kwok AK; Yeung ACM; Nelson EAS; Hon KL; Leung TF; Chan PKS
[Ad] Endereço:Departments of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
[Ti] Título:Clinical features and seasonality of parechovirus infection in an Asian subtropical city, Hong Kong.
[So] Source:PLoS One;12(9):e0184533, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The epidemiology of human parechovirus (HPeV) in Asia remains obscure. We elucidated the prevalence, seasonality, type distribution and clinical presentation of HPeV among children in Hong Kong. METHODS: A 24-month prospective study to detect HPeV in children ≤36 months hospitalized for acute viral illnesses. RESULTS: 2.3% of the 3911 children examined had HPeV infection, with most (87.5%) concentrated in September-January (autumn-winter). 81.3% were HPeV1 and 12.5% were HPeV4, while HPeV3 was rare (2.5%). HPeV was a probable cause of the disease in 47.7% (42/88), mostly self-limiting including acute gastroenteritis, upper respiratory tract infection and maculopapular rash. A neonate developed severe sepsis-like illness with HPeV3 as the only pathogen detected. A high proportion (60.0%) of children coinfected with HPeV and other respiratory virus(es) had acute bronchiolitis or pneumonia. Six children with HPeV coinfections developed convulsion / pallid attack. Most rash illnesses exhibited a generalized maculopapular pattern involving the trunk and limbs, and were more likely associated with HPeV4 compared to other syndrome groups (36.4% vs. 3.1%, p = 0.011). CONCLUSIONS: In Hong Kong, HPeV exhibits a clear seasonality (autumn-winter) and was found in a small proportion (2.3%) of young children (≤36 months) admitted with features of acute viral illnesses. The clinical presentation ranged from mild gastroenteritis, upper respiratory tract infection and febrile rash to convulsion and severe sepsis-like illness. HPeV3, which is reported to associate with more severe disease in neonates, is rare in Hong Kong. HPeV coinfection might associate with convulsion and aggravate other respiratory tract infections.
[Mh] Termos MeSH primário: Parechovirus
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/virologia
Estações do Ano
Clima Tropical
[Mh] Termos MeSH secundário: Pré-Escolar
Diarreia/epidemiologia
Diarreia/virologia
Fezes/virologia
Feminino
Gastroenterite/epidemiologia
Gastroenterite/virologia
Hong Kong/epidemiologia
Hospitalização
Seres Humanos
Lactente
Recém-Nascido
Masculino
Parechovirus/classificação
Parechovirus/genética
Filogenia
Estudos Prospectivos
RNA Viral
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184533


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[PMID]:28855493
[Au] Autor:Yamakawa T; Mizuta K; Kurokawa K; Nagasawa H; Yamada T; Suzuki E; Wada M
[Ad] Endereço:Department of Neurology, Yamagata Prefectural Central Hospital.
[Ti] Título:Clinical characteristics of 17 adult patients with epidemic myalgia associated with human parechovirus type 3 infection.
[So] Source:Rinsho Shinkeigaku;57(9):485-491, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients. Tendon reflexes were preserved, and serum creatine kinase level increased in all but 1 patient. Spinal MRI was performed for 3 patients, with normal results. Musculoskeletal MRI scans showed abnormal signals in the femoral muscles in 2 of 5 patients. In a nerve conduction test, the frequency of F wave appearance in the median nerve was 40% or less in 5 of 9 patients, and repeater F waves were seen in 2 patients. Of these, 7 patients had infants in their families, and developed fever around the same time; they may have been infected by these infants. All patients recovered within 1-2 weeks. HPeV3 infection is characterized by severe myalgia, and is frequently observed in summer every 2-3 years.
[Mh] Termos MeSH primário: Parechovirus
Infecções por Picornaviridae/complicações
Infecções por Picornaviridae/virologia
Pleurodinia Epidêmica/etiologia
Pleurodinia Epidêmica/virologia
[Mh] Termos MeSH secundário: Adulto
Surtos de Doenças
Feminino
Febre
Seres Humanos
Lactente
Japão/epidemiologia
Angiografia por Ressonância Magnética
Masculino
Meia-Idade
Debilidade Muscular
Músculo Esquelético/diagnóstico por imagem
Condução Nervosa
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/fisiopatologia
Pleurodinia Epidêmica/epidemiologia
Pleurodinia Epidêmica/fisiopatologia
Reflexo de Estiramento
Estações do Ano
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001035


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[PMID]:28347852
[Au] Autor:Shinomoto M; Kawasaki T; Sugahara T; Nakata K; Kotani T; Yoshitake H; Yuasa K; Saeki M; Fujiwara Y
[Ad] Endereço:Department of Neurology, Matsushita Memorial Hospital, Osaka, Japan. Electronic address: makiko-t@koto.kpu-m.ac.jp.
[Ti] Título:First report of human parechovirus type 3 infection in a pregnant woman.
[So] Source:Int J Infect Dis;59:22-24, 2017 Jun.
[Is] ISSN:1878-3511
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Human parechovirus type 3 (HPeV3) can cause serious conditions in neonates, such as sepsis and encephalitis, but data for adults are lacking. The case of a pregnant woman with HPeV3 infection is reported herein. A 28-year-old woman at 36 weeks of pregnancy was admitted because of myalgia and muscle weakness. Her grip strength was 6.0kg for her right hand and 2.5kg for her left hand. The patient's symptoms, probably due to fasciitis and not myositis, improved gradually with conservative treatment, however labor pains with genital bleeding developed unexpectedly 3 days after admission. An obstetric consultation was obtained and a cesarean section was performed, with no complications. A real-time PCR assay for the detection of viral genomic ribonucleic acid against HPeV showed positive results for pharyngeal swabs, feces, and blood, and negative results for the placenta, umbilical cord, umbilical cord blood, amniotic fluid, and breast milk. The HPeV3 was genotyped by sequencing of the VP1 region. The woman made a full recovery and was discharged with her infant in a stable condition.
[Mh] Termos MeSH primário: Parechovirus/isolamento & purificação
Infecções por Picornaviridae/diagnóstico por imagem
Complicações Infecciosas na Gravidez/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Febre
Genótipo
Seres Humanos
Imagem por Ressonância Magnética
Mialgia
Parechovirus/genética
Infecções por Picornaviridae/virologia
Gravidez
Complicações Infecciosas na Gravidez/virologia
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE


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[PMID]:28232749
[Au] Autor:Shakeel S; Dykeman EC; White SJ; Ora A; Cockburn JJB; Butcher SJ; Stockley PG; Twarock R
[Ad] Endereço:Institute of Biotechnology and Department of Biosciences, University of Helsinki, Helsinki, 00790, Finland.
[Ti] Título:Genomic RNA folding mediates assembly of human parechovirus.
[So] Source:Nat Commun;8(1):5, 2017 02 23.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Assembly of the major viral pathogens of the Picornaviridae family is poorly understood. Human parechovirus 1 is an example of such viruses that contains 60 short regions of ordered RNA density making identical contacts with the protein shell. We show here via a combination of RNA-based systematic evolution of ligands by exponential enrichment, bioinformatics analysis and reverse genetics that these RNA segments are bound to the coat proteins in a sequence-specific manner. Disruption of either the RNA coat protein recognition motif or its contact amino acid residues is deleterious for viral assembly. The data are consistent with RNA packaging signals playing essential roles in virion assembly. Their binding sites on the coat proteins are evolutionarily conserved across the Parechovirus genus, suggesting that they represent potential broad-spectrum anti-viral targets.The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/genética
Genoma Viral
Parechovirus/genética
RNA Viral/genética
Vírion/genética
Montagem de Vírus
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Pareamento de Bases
Sítios de Ligação
Proteínas do Capsídeo/metabolismo
Proteínas do Capsídeo/ultraestrutura
Biologia Computacional
Sequência Conservada
Expressão Gênica
Seres Humanos
Modelos Moleculares
Parechovirus/metabolismo
Parechovirus/ultraestrutura
Ligação Proteica
Dobramento de RNA
RNA Viral/metabolismo
RNA Viral/ultraestrutura
Genética Reversa
Técnica de Seleção de Aptâmeros
Vírion/metabolismo
Vírion/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (RNA, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-016-0011-z


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[PMID]:27977558
[Au] Autor:Braccio S; Kapetanstrataki M; Sharland M; Ladhani SN
[Ad] Endereço:From the *Paediatric Infectious Diseases Research Group, St. George's University of London, and †Public Health England, London, United Kingdom; and ‡Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, United Kingdom.
[Ti] Título:Intensive Care Admissions for Children With Enterovirus and Human Parechovirus Infections in the United Kingdom and The Republic of Ireland, 2010-2014.
[So] Source:Pediatr Infect Dis J;36(3):339-342, 2017 Mar.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Enteroviruses and human parechoviruses usually cause mild, self-limiting illnesses in children but can occasionally cause severe disease. During 2010-2014, 104 children in the United Kingdom and the Republic of Ireland were admitted to a pediatric intensive care unit with severe enterovirus and human parechovirus infection; 40% had neurologic symptoms, 20% respiratory failure, 16% cardiac complications and 11% septic shock. Annual number of cases and incidence increased in the 5-year period, from 0.6/1000 pediatric intensive care unit admissions (12 cases) in 2010 to 1.8/1000 (36 cases) in 2014. Most cases (n = 86, 83%) were younger than 1 year; 77% (n = 80) required invasive ventilation, 40% (n = 42) inotropic support, 4% (n = 4) renal dialysis and 3% (n = 3) extracorporeal membrane oxygenation. Eight children (8%) died, including 4 with cardiac complications.
[Mh] Termos MeSH primário: Infecções por Enterovirus/epidemiologia
Enterovirus
Hospitalização/estatística & dados numéricos
Unidades de Terapia Intensiva Pediátrica/estatística & dados numéricos
Parechovirus
Infecções por Picornaviridae/epidemiologia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Seres Humanos
Lactente
Recém-Nascido
Irlanda/epidemiologia
Estudos Retrospectivos
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001430


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[PMID]:27749661
[Au] Autor:Bubba L; Martinelli M; Pellegrinelli L; Primache V; Tanzi E; Pariani E; Binda S
[Ad] Endereço:From the Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
[Ti] Título:A 4-year Study on Epidemiologic and Molecular Characteristics of Human Parechoviruses and Enteroviruses Circulating in Children Younger Than 5 Years in Northern Italy.
[So] Source:Pediatr Infect Dis J;36(1):13-19, 2017 Jan.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) infections are widespread and can lead to a broad range of symptoms, from the common cold to severe disease (SD). Because of the lack of Italian data, this 4-year retrospective cross-sectional study aimed to investigate the frequency, seasonality and molecular characteristics of EV and HPeV circulating in children younger than 5 years. METHODS: A total of 812 samples were collected from children ≤5 years (56.5% males; median age: 20.6 months; interquartile range: 30.1 months) from September 2010 to August 2014. Two real-time RT-PCR assays were used for EV/HPeV and EV-D68 detection. Phylogenetic analysis was performed on the EV-VP1 gene and the HPeV-VP3/VP1 junction. RESULTS: 16.1% and 5.2% of samples were EV- and HPeV-positive, respectively. One sample was EV-D68-positive. The majority (nearly 80%) of EV/HPeV-positive samples was detected in children ≤3 years, during the summer/autumn seasons. The risk of EV infection was higher in children presenting with SD, whereas the risk of infection from HPeV was higher in infants ≤1 year. Most (61.7%) of molecularly characterized EVs belonged to species B, followed by A (29.4%). The majority (66.7%) of characterized HPeVs were type 1, followed by types 3 (20%) and 6 (13.3%). CONCLUSIONS: This study shows the significant impact of EV/HPeV circulation in children, particularly among those ≤3 years and during and early autumn, with different pattern of viral strains. The implementation of a national surveillance system could clarify the epidemiologic and clinical characteristics of these viruses in the general population.
[Mh] Termos MeSH primário: Infecções por Enterovirus/epidemiologia
Infecções por Enterovirus/virologia
Enterovirus/genética
Parechovirus/genética
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/virologia
[Mh] Termos MeSH secundário: Pré-Escolar
Estudos Transversais
Enterovirus/classificação
Feminino
Seres Humanos
Lactente
Recém-Nascido
Itália/epidemiologia
Masculino
Parechovirus/classificação
Filogenia
Estudos Retrospectivos
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


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[PMID]:27686253
[Au] Autor:Itta KC; Ghargi KV; Kalal S; Patil T; Roy S
[Ad] Endereço:a Department of Health Research , Regional Medical Research Centre (ICMR) , Belagam , Karnataka.
[Ti] Título:First detection of human parechovirus infection with diarrhoea, India.
[So] Source:Infect Dis (Lond);49(2):151-152, 2017 Feb.
[Is] ISSN:2374-4243
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Diarreia/diagnóstico
Diarreia/virologia
Parechovirus/isolamento & purificação
Infecções por Picornaviridae/diagnóstico
Infecções por Picornaviridae/virologia
[Mh] Termos MeSH secundário: Idoso
Análise por Conglomerados
Seres Humanos
Índia
Masculino
Parechovirus/classificação
Parechovirus/genética
Filogenia
Análise de Sequência de DNA
Homologia de Sequência
Proteínas Virais/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE


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[PMID]:27505281
[Au] Autor:Cabrerizo M; Díaz-Cerio M; Muñoz-Almagro C; Rabella N; Tarragó D; Romero MP; Pena MJ; Calvo C; Rey-Cao S; Moreno-Docón A; Martínez-Rienda I; Otero A; Trallero G
[Ad] Endereço:National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
[Ti] Título:Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain.
[So] Source:J Med Virol;89(3):435-442, 2017 Mar.
[Is] ISSN:1096-9071
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The epidemiology and clinical association of enterovirus (EV) and parechovirus (HPeV) infections, as well as the type-distribution-according-to-age, were determined during a 4-year study period in Spain. During 2010-2013, a total of 21,832 clinical samples were screened for EV and the detection frequency was 6.5% (1,430). Of the total EV-negative samples, only 1,873 samples from 2011 to 2013 were available for HPeV testing. HPeV was detected in 42 (2%) of them. Positive samples were genotyped using PCR and sequencing. EV infections occurred in all age groups of patients: neonates (17%), children 28 days to 2 years (29%), children 2-14 years (40%), and adults (14%). Thirty-four different EV types were identified. HPeV infections were detected exclusively in infants <8 m (70% neonates, P < 0.05). All but one HPeV were HPeV-3. Differences in type frequency detection were found according to age and clinical manifestation. Coxsackievirus (CV)-B4 (61%), CV-B5 (83%), and HPeV-3 (64%) were more frequent in neonates than in older patients (P < 0.05). Echovirus (E)-3 (60%), E-18 (47%), E-25 (62%), CV-A6 (61%), CV-A16 (72%), and EV-71 (75%) were mainly detected in children 28 days to 2 years (P < 0.05), whereas, E-6 (79%), E-20 (88%), and E-30 (85%) were predominant in children >2 years and adults (P < 0.05). Clinically, meningitis was associated with EV (P < 0.01) whereas, encephalitis was more frequent in HPeV-infected patients. CV-B types were associated with myocarditis (90%; P < 0.05) and EV species A with hand-foot-mouth-disease/atypical exanthema (88%; P < 0.05). J. Med. Virol. 89:435-442, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Infecções por Enterovirus/epidemiologia
Enterovirus/classificação
Enterovirus/genética
Genótipo
Parechovirus/classificação
Parechovirus/genética
Infecções por Picornaviridae/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Enterovirus/isolamento & purificação
Infecções por Enterovirus/patologia
Infecções por Enterovirus/virologia
Feminino
Técnicas de Genotipagem
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Epidemiologia Molecular
Parechovirus/isolamento & purificação
Infecções por Picornaviridae/patologia
Infecções por Picornaviridae/virologia
Reação em Cadeia da Polimerase
Prevalência
Análise de Sequência de DNA
Espanha/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.24658


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[PMID]:27283793
[Au] Autor:Warvsten A; Björnfors M; Arvidsson M; Vaziri-Sani F; Jönsson I; Olsson GE; Ahlm C; Larsson HE; Lernmark Å; Nilsson AL
[Ad] Endereço:Department of Clinical Sciences, Skåne University Hospital SUS, Lund University/CRC, Malmö, Sweden.
[Ti] Título:Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden.
[So] Source:J Med Virol;89(1):24-31, 2017 Jan.
[Is] ISSN:1096-9071
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bank voles are known reservoirs for Puumala hantavirus and probably also for Ljungan virus (LV), a suggested candidate parechovirus in type 1 diabetes etiology and pathogenesis. The aim of this study was to determine whether wild bank voles had been exposed to LV and if exposure associated to autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), or islet autoantigen-2 (IA-2A). Serum samples from bank voles (Myodes glareolus) captured in early summer or early winter of 1997 and 1998, respectively, were analyzed in radio binding assays for antibodies against Ljungan virus (LVA) and Puumala virus (PUUVA) as well as for IAA, GADA, and IA-2A. LVA was found in 25% (189/752), IAA in 2.5% (18/723), GADA in 2.6% (15/615), and IA-2A in 2.5% (11/461) of available bank vole samples. LVA correlated with both IAA (P = 0.007) and GADA (P < 0.001), but not with IA-2A (P = 0.999). There were no correlations with PUUVA, detected in 17% of the bank voles. Compared to LVA negative bank voles, LVA positive animals had higher levels of both IAA (P = 0.002) and GADA (P < 0.001), but not of IA-2A (P = 0.205). Levels of LVA as well as IAA and GADA were higher in samples from bank voles captured in early summer. In conclusion, LVA was detected in bank voles and correlated with both IAA and GADA but not with IA-2A. These observations suggest that exposure to LV may be associated with islet autoimmunity. It remains to be determined if islet autoantibody positive bank voles may develop diabetes in the wild. J. Med. Virol. 89:24-31, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Glutamato Descarboxilase/imunologia
Insulina/imunologia
Parechovirus/isolamento & purificação
Infecções por Picornaviridae/veterinária
Proteínas Tirosina Fosfatases Classe 8 Semelhantes a Receptores/imunologia
Doenças dos Roedores/patologia
[Mh] Termos MeSH secundário: Animais
Arvicolinae
Feminino
Masculino
Infecções por Picornaviridae/imunologia
Infecções por Picornaviridae/virologia
Doenças dos Roedores/imunologia
Doenças dos Roedores/virologia
Suécia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Insulin); EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 8); EC 4.1.1.15 (Glutamate Decarboxylase); EC 4.1.1.15 (glutamate decarboxylase 2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.24597



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