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[PMID]:28323884
[Au] Autor:Baker SL; Hogg JR
[Ad] Endereço:Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
[Ti] Título:A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay.
[So] Source:PLoS One;12(3):e0173980, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins. This activity positions the pathway as a regulator of the severity of genetic diseases caused by nonsense mutations. Because many genetic diseases result from nonsense alleles, therapeutics inducing readthrough of premature termination codons and/or inhibition of NMD have been of great interest. Several means of enhancing translational readthrough have been reported to concomitantly inhibit NMD efficiency, but tools for systematic analysis of mammalian NMD inhibition by translational readthrough are lacking. Here, we introduce a system that allows concurrent analysis of translational readthrough and mRNA decay. We use this system to show that diverse readthrough-promoting RNA elements have similar capacities to inhibit NMD. Further, we provide evidence that the level of translational readthrough required for protection from NMD depends on the distance of the suppressed termination codon from the end of the mRNA.
[Mh] Termos MeSH primário: Códon sem Sentido/genética
Degradação do RNAm Mediada por Códon sem Sentido/genética
Biossíntese de Proteínas/genética
Estabilidade de RNA/genética
RNA Mensageiro/metabolismo
[Mh] Termos MeSH secundário: Sequência de Bases
Linhagem Celular Tumoral
Vírus da Febre do Carrapato do Colorado/genética
Epidermólise Bolhosa/genética
Doenças Genéticas Inatas/genética
Células HEK293
Células HeLa
Seres Humanos
Sequências Repetidas Invertidas/genética
Vírus da Leucemia Murina de Moloney/genética
Regiões Promotoras Genéticas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Nonsense); 0 (RNA, Messenger)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173980


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[PMID]:25988440
[Au] Autor:Yendell SJ; Fischer M; Staples JE
[Ad] Endereço:1Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado.
[Ti] Título:Colorado tick fever in the United States, 2002-2012.
[So] Source:Vector Borne Zoonotic Dis;15(5):311-6, 2015 May.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Colorado tick fever (CTF) is an acute systemic febrile illness caused by the CTF virus (CTFV). The last national summary of CTF cases in the United States included cases reported through 2001. This study summarizes national surveillance data for CTF from 2002 through 2012 and examines trends in the epidemiology and testing of identified CTF cases. METHODS: Because CTF is not nationally notifiable, we identified CTF cases through solicited reports from state health departments and diagnostic laboratory records. For all cases, we collected data on age, sex, county of residence, travel history, symptom onset date, laboratory testing, and clinical outcome. Poisson regression was used to examine trends over time in case counts, and simple linear regression and logistic regression were used to examine trends in case characteristics. RESULTS: From 2002 through 2012, 75 CTF cases were identified with a median of five cases per year (range 3-14). Forty-seven (63%) cases occurred in males and 49 (65%) occurred in people aged ≥40 years. The majority (80%) of cases had onset of illness during May through July. Cases occurred in residents of 14 states but the infections were acquired in six western states. Wyoming had the highest annual incidence of CTF among residents (3.4 cases per million population), followed by Montana (1.5 per million), and Utah (0.5 per million). Over the 11 years, there was an increase in the proportion of cases diagnosed by RT-PCR testing and in the proportion of cases among travelers to another state. CONCLUSIONS: CTF cases continue to occur annually among residents and visitors to the western United States. Public health prevention messages about decreasing tick exposure should be targeted to residents and travelers who will spend time outdoors in an endemic region during the spring and summer months.
[Mh] Termos MeSH primário: Febre do Carrapato do Colorado/epidemiologia
Vírus da Febre do Carrapato do Colorado/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Masculino
Vigilância da População
Estações do Ano
Estados Unidos/epidemiologia
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150520
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2014.1755


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[PMID]:25229706
[Au] Autor:Geissler AL; Thorp E; Van Houten C; Lanciotti RS; Panella N; Cadwell BL; Murphy T; Staples JE
[Ad] Endereço:1 Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, Georgia .
[Ti] Título:Infection with Colorado tick fever virus among humans and ticks in a national park and forest, Wyoming, 2010.
[So] Source:Vector Borne Zoonotic Dis;14(9):675-80, 2014 Sep.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Colorado tick fever (CTF) is an underreported tick-borne viral disease occurring in the western United States. CTF illness includes fever, headache, and severe myalgia lasting for weeks. Wyoming has one of the highest CTF incidence rates with approximately 30% of infected persons reporting tick exposure in a Wyoming National Park or Forest before symptom onset. We assessed CTF virus infections among humans and Dermacentor andersoni ticks in Grand Teton National Park (GRTE) and Bridger-Teton National Forest (BTNF). METHODS: In June of 2010, 526 eligible employees were approached to participate in a baseline and 3-month follow-up serosurvey and risk behavior survey. Seropositivity was defined as antibody titers against CTF virus ≥10, as measured by the plaque reduction neutralization test. Ticks were collected at 27 sites within GRTE/BTNF and tested by RT-PCR for the CTF virus. RESULTS: A total of 126 (24%) employees participated in the baseline and follow-up study visits. Three (2%) employees were seropositive for CTF virus infection at baseline. During the study, 47 (37%) participants found unattached ticks on themselves, and 12 (10%) found attached ticks; however, no participants seroconverted against CTF virus. Walking through sagebrush (p=0.04) and spending time at ≥7000 feet elevation (p<0.01) were significantly associated with tick exposure. Ninety-nine percent (174/176) of ticks were D. andersoni, and all were found at ≥7000 feet elevation in sagebrush areas; 37 (21%) ticks tested positive for CTF virus and were found at 10 (38%) of 26 sites sampled. CONCLUSIONS: Although no GRTE or BTNF employees were infected with CTF virus during the study period, high rates of infected ticks were identified in areas with sagebrush at ≥7000 feet. CTF education and personal protection measures against tick exposure should be targeted to visitors and employees traveling to the high-risk environs identified in this study.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Febre do Carrapato do Colorado/epidemiologia
Vírus da Febre do Carrapato do Colorado/imunologia
Dermacentor/virologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Febre do Carrapato do Colorado/virologia
Vírus da Febre do Carrapato do Colorado/isolamento & purificação
Feminino
Seguimentos
Florestas
Seres Humanos
Masculino
Meia-Idade
Wyoming/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:140918
[Lr] Data última revisão:
140918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140918
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2013.1568


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[PMID]:22190746
[Au] Autor:Napthine S; Yek C; Powell ML; Brown TD; Brierley I
[Ad] Endereço:Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
[Ti] Título:Characterization of the stop codon readthrough signal of Colorado tick fever virus segment 9 RNA.
[So] Source:RNA;18(2):241-52, 2012 Feb.
[Is] ISSN:1469-9001
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Termination codon readthrough is utilized as a mechanism of expression of a growing number of viral and cellular proteins, but in many cases the mRNA signals that promote readthrough are poorly characterized. Here, we investigated the readthrough signal of Colorado tick fever virus (CTFV) segment 9 RNA (Seg-9). CTFV is the type-species of the genus Coltivirus within the family Reoviridae and is a tick-borne, double-stranded, segmented RNA virus. Seg-9 encodes a 36-kDa protein VP9, and by readthrough of a UGA stop codon, a 65-kDa product, VP9'. Using a reporter system, we defined the minimal sequence requirements for readthrough and confirmed activity in both mammalian and insect cell-free translation systems, and in transfected mammalian cells. Mutational analysis revealed that readthrough was UGA specific, and that the local sequence context around the UGA influenced readthrough efficiency. Readthrough was also dependent upon a stable RNA stem-loop structure beginning eight bases downstream from the UGA codon. Mutational analysis of this stem-loop revealed a requirement for the stem region but not for substructures identified within the loop. Unexpectedly, we were unable to detect a ribosomal pause during translation of the CTFV signal, suggesting that the mechanism of readthrough, at least at this site, is unlikely to be dependent upon RNA secondary-structure induced ribosomal pausing at the recoded stop codon.
[Mh] Termos MeSH primário: Códon de Terminação/genética
Vírus da Febre do Carrapato do Colorado/genética
Terminação Traducional da Cadeia Peptídica/genética
RNA/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Sistema Livre de Células
Códon de Terminação/metabolismo
Vírus da Febre do Carrapato do Colorado/metabolismo
Dermacentor/genética
Dermacentor/metabolismo
Insetos/genética
Insetos/metabolismo
Dados de Sequência Molecular
Mutação
Biossíntese de Proteínas/genética
RNA/metabolismo
Ribossomos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Codon, Terminator); 63231-63-0 (RNA)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111223
[St] Status:MEDLINE
[do] DOI:10.1261/rna.030338.111


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[PMID]:18755390
[Au] Autor:Romero JR; Simonsen KA
[Ad] Endereço:Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Nebraska Medical Center, 982162 Nebraska Medical Center, Omaha, NE 68198-2162, USA. jrromero@unmc.edu
[Ti] Título:Powassan encephalitis and Colorado tick fever.
[So] Source:Infect Dis Clin North Am;22(3):545-59, x, 2008 Sep.
[Is] ISSN:0891-5520
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article discusses two tick-borne illnesses: Powassan encephalitis, a rare cause of central nervous system infection caused by the Powassan virus, and Colorado tick fever, an acute febrile illness caused by the Colorado tick fever virus common to the Rocky Mountain region of North America.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Vetores Aracnídeos/virologia
Febre do Carrapato do Colorado/epidemiologia
Encefalite Transmitida por Carrapatos/epidemiologia
Ixodes/virologia
[Mh] Termos MeSH secundário: Animais
Colorado/epidemiologia
Febre do Carrapato do Colorado/patologia
Vírus da Febre do Carrapato do Colorado/imunologia
Vírus da Febre do Carrapato do Colorado/patogenicidade
Diagnóstico Diferencial
Vírus da Encefalite Transmitidos por Carrapatos/imunologia
Vírus da Encefalite Transmitidos por Carrapatos/patogenicidade
Encefalite Transmitida por Carrapatos/patologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:0811
[Cu] Atualização por classe:080829
[Lr] Data última revisão:
080829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080830
[St] Status:MEDLINE
[do] DOI:10.1016/j.idc.2008.03.001


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[PMID]:17126919
[Au] Autor:Lambert AJ; Kosoy O; Velez JO; Russell BJ; Lanciotti RS
[Ad] Endereço:National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampert Road, Fort Collins, CO 80521, USA. ahk7@cdc.gov
[Ti] Título:Detection of Colorado Tick Fever viral RNA in acute human serum samples by a quantitative real-time RT-PCR assay.
[So] Source:J Virol Methods;140(1-2):43-8, 2007 Mar.
[Is] ISSN:0166-0934
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A quantitative real-time RT-PCR assay for the detection of Colorado Tick Fever (CTF) viral RNA in human clinical samples is presented. The sensitivity of this assay has been shown to be greater than that of the isolation of virus in Vero cells by standard plaque assay in a direct comparison. The specificity of the CTF quantitative real-time RT-PCR assay was determined by the exclusive detection of CTF viral RNAs when applied to a diverse panel of CTF viral isolates and reference strain agents known to circulate in areas of CTF virus transmission. Lastly, the quantitative real-time RT-PCR assay demonstrated exceptional sensitivity for the detection of CTF viral RNA in acute human serum. The quantitative real-time RT-PCR assay is efficient, sensitive and specific and as such is useful for the detection of CTF viral RNA in the diagnostic or research laboratory.
[Mh] Termos MeSH primário: Febre do Carrapato do Colorado/diagnóstico
Febre do Carrapato do Colorado/virologia
Vírus da Febre do Carrapato do Colorado/genética
Vírus da Febre do Carrapato do Colorado/isolamento & purificação
Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos
[Mh] Termos MeSH secundário: Febre do Carrapato do Colorado/sangue
Seres Humanos
RNA Viral/sangue
Sensibilidade e Especificidade
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:0704
[Cu] Atualização por classe:070205
[Lr] Data última revisão:
070205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061128
[St] Status:MEDLINE


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[PMID]:15269364
[Au] Autor:Mohd Jaafar F; Attoui H; De Micco P; De Lamballerie X
[Ad] Endereço:Unité des Virus Emergents: EFS Alpes-Méditerranée and Université de la Méditerranée, Faculté de Médecine de Marseille, Marseille 13005, France.
[Ti] Título:Termination and read-through proteins encoded by genome segment 9 of Colorado tick fever virus.
[So] Source:J Gen Virol;85(Pt 8):2237-44, 2004 Aug.
[Is] ISSN:0022-1317
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Genome segment 9 (Seg-9) of Colorado tick fever virus (CTFV) is 1884 bp long and contains a large open reading frame (ORF; 1845 nt in length overall), although a single in-frame stop codon (at nt 1052-1054) reduces the ORF coding capacity by approximately 40 %. However, analyses of highly conserved RNA sequences in the vicinity of the stop codon indicate that it belongs to a class of 'leaky terminators'. The third nucleotide positions in codons situated both before and after the stop codon, shows the highest variability, suggesting that both regions are translated during virus replication. This also suggests that the stop signal is functionally leaky, allowing read-through translation to occur. Indeed, both the truncated 'termination' protein and the full-length 'read-through' protein (VP9 and VP9', respectively) were detected in CTFV-infected cells, in cells transfected with a plasmid expressing only Seg-9 protein products, and in the in vitro translation products from undenatured Seg-9 ssRNA. The ratios of full-length and truncated proteins generated suggest that read-through may be down-regulated by other viral proteins. Western blot analysis of infected cells and purified CTFV showed that VP9 is a structural component of the virion, while VP9' is a non-structural protein.
[Mh] Termos MeSH primário: Vírus da Febre do Carrapato do Colorado/genética
Genoma Viral
Biossíntese de Proteínas
[Mh] Termos MeSH secundário: Animais
Western Blotting
Cercopithecus aethiops
Códon de Terminação
Imunofluorescência
Fases de Leitura Aberta
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Codon, Terminator)
[Em] Mês de entrada:0408
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040723
[St] Status:MEDLINE


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[PMID]:14518442
[Au] Autor:Hassler D; Oehme R; Kimmig P; Dobler G
[Ti] Título:[Eyach virus: relative of the Colorado tick fever virus rediscovered in Baden-Württemberg].
[Ti] Título:Eyach-Virus: Verwandter des Colorado-Zeckenfieber-Virus in Baden-Württemberg wiederentdeckt..
[So] Source:Dtsch Med Wochenschr;128(37):1874, 2003 Sep 12.
[Is] ISSN:0012-0472
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Vetores Aracnídeos/virologia
Coltivirus/isolamento & purificação
Infecções por Reoviridae
Carrapatos/virologia
[Mh] Termos MeSH secundário: Animais
Vírus da Febre do Carrapato do Colorado/classificação
Coltivirus/classificação
Coltivirus/ultraestrutura
Reservatórios de Doenças
Alemanha/epidemiologia
Seres Humanos
Infecções por Reoviridae/diagnóstico
Infecções por Reoviridae/tratamento farmacológico
Infecções por Reoviridae/epidemiologia
Infecções por Reoviridae/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:0310
[Cu] Atualização por classe:041117
[Lr] Data última revisão:
041117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031002
[St] Status:MEDLINE


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[PMID]:12734255
[Au] Autor:Mohd Jaafar F; Attoui H; Gallian P; Biagini P; Cantaloube JF; de Micco P; de Lamballerie X
[Ad] Endereço:Unité des Virus Emergents, EA 3292, IFR 48, Université de la Méditerranée, Faculté de Médecine de Marseille, Marseille 13005, France.
[Ti] Título:Recombinant VP7-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Colorado tick fever virus.
[So] Source:J Clin Microbiol;41(5):2102-5, 2003 May.
[Is] ISSN:0095-1137
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:VP6, VP7, VP9, VP10, VP11, and VP12 of Colorado tick fever virus (CTF virus), a virus member of the genus Coltivirus, family Reoviridae, were expressed in bacteria with the pGEX-4T-2 vector. A partial sequence of VP7 (designated pVP7) was chosen to elaborate an enzyme-linked immunosorbent assay (ELISA) for detecting anti-CTF virus immunoglobulin G (IgG) antibodies in humans. This was based on two observations: (i) among all expressed proteins, pVP7 showed the highest immunoreactivity to an anti-CTF virus hyperimmune ascitic fluid; (ii) to provide the highest selectivity of antibody detection, the expressed sequence was chosen within a region which is highly divergent (49% amino acid identity) from the homologous sequence of another coltivirus, the Eyach virus. The pVP7 ELISA was evaluated with 368 serum samples from French blood donors and found to provide 98.1% specificity. Assays with the Calisher set of human serum samples, positive for anti-CTF virus antibodies (C. H. Calisher, J. D. Poland, S. B. Calisher, and L. A Warmoth, J. Clin. Microbiol. 22:84-88, 1985), showed that the pVP7 ELISA provided 100% sensitivity for the tested population. After elaboration of recombinant-protein-based ELISAs for diagnosis of infections with members of the viral genera Orbivirus, Orthoreovirus, and Rotavirus, it was shown that a recombinant protein could be used to detect antibodies to the human pathogen Colorado tick fever virus.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Proteínas do Capsídeo/imunologia
Vírus da Febre do Carrapato do Colorado/imunologia
Ensaio de Imunoadsorção Enzimática/métodos
Imunoglobulina G/sangue
[Mh] Termos MeSH secundário: Antígenos Virais/genética
Sequência de Bases
Proteínas do Capsídeo/genética
Febre do Carrapato do Colorado/imunologia
Febre do Carrapato do Colorado/virologia
Vírus da Febre do Carrapato do Colorado/genética
DNA Viral/genética
Ensaio de Imunoadsorção Enzimática/estatística & dados numéricos
Seres Humanos
Proteínas Recombinantes/genética
Proteínas Recombinantes/imunologia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Capsid Proteins); 0 (DNA, Viral); 0 (Immunoglobulin G); 0 (Recombinant Proteins)
[Em] Mês de entrada:0310
[Cu] Atualização por classe:170219
[Lr] Data última revisão:
170219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030508
[St] Status:MEDLINE


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[PMID]:11982311
[Au] Autor:Klasco R
[Ad] Endereço:Micromedex, Inc, Department of Surgery, Division of Emergency Medicine, University of Colorado School of Medicine, Greenwood Village, Colorado, USA. Rich.klasco@mdx.com
[Ti] Título:Colorado tick fever.
[So] Source:Med Clin North Am;86(2):435-40, ix, 2002 Mar.
[Is] ISSN:0025-7125
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Colorado tick fever, also known as mountain fever and mountain tick fever, is a well-described, viral, tick-borne disease common to the Rocky Mountain region of the United States and Canada. The Rocky Mountain wood tick, Dermacentor andersoni, is the primary vector. The triad of high fever, severe myalgia, and headache is typical, but not specific. Although a self-limited disease in most cases, severe complications may occur. PCR techniques have been developed that allow the diagnosis to be established from the first day of symptoms. Ribavirin may merit consideration in the appropriate clinical setting.
[Mh] Termos MeSH primário: Febre do Carrapato do Colorado
[Mh] Termos MeSH secundário: Febre do Carrapato do Colorado/complicações
Febre do Carrapato do Colorado/diagnóstico
Febre do Carrapato do Colorado/epidemiologia
Vírus da Febre do Carrapato do Colorado/genética
Vírus da Febre do Carrapato do Colorado/isolamento & purificação
DNA Viral/sangue
Seres Humanos
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:0205
[Cu] Atualização por classe:051116
[Lr] Data última revisão:
051116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:020502
[St] Status:MEDLINE



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