Base de dados : MEDLINE
Pesquisa : B04.820.850.054.586 [Categoria DeCS]
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  1 / 5 MEDLINE  
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[PMID]:28719301
[Au] Autor:Waggoner J; Heath CJ; Ndenga B; Mutuku F; Sahoo MK; Mohamed-Hadley A; Vulule J; Mukoko D; Desiree LaBeaud A; Pinsky BA
[Ad] Endereço:Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
[Ti] Título:Development of a Real-Time Reverse Transcription Polymerase Chain Reaction for O'nyong-nyong Virus and Evaluation with Clinical and Mosquito Specimens from Kenya.
[So] Source:Am J Trop Med Hyg;97(1):121-124, 2017 Jul.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:O'nyong-nyong virus (ONNV), an alphavirus closely related to chikungunya virus (CHIKV), has been the documented cause of two large outbreaks in east Africa; however, little is known about the contribution of ONNV to cases of acute febrile illness during interepidemic periods. An ONNV real-time reverse transcription polymerase chain reaction (rRT-PCR) was developed and evaluated using clinical and mosquito pool samples. The ONNV rRT-PCR linear range extended from 8.0 to 2.0 log copies/µL, and the lower limit of 95% detection was 22.4 copies/µL. No cases of ONNV infection were identified in serum from 385 Kenyan children who presented with an acute febrile illness. Additionally, ONNV was not detected in 120 mosquito pools collected in coastal and western Kenya. The ONNV rRT-PCR demonstrated good analytical sensitivity when performed in monoplex or as a component of an ONNV-CHIKV duplex assay. This assay should provide a useful diagnostic for the detection of ONNV in surveillance studies.
[Mh] Termos MeSH primário: Infecções por Alphavirus/genética
Anopheles/virologia
Vírus O´nyong-nyong/genética
Vírus O´nyong-nyong/isolamento & purificação
Convulsões Febris/virologia
[Mh] Termos MeSH secundário: Adolescente
África Oriental
Infecções por Alphavirus/virologia
Animais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0027


  2 / 5 MEDLINE  
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[PMID]:27296554
[Au] Autor:Rios-González CM
[Ad] Endereço:Tte. Fariña y Vice Pte. Sánchez #392, Cnel. Oviedo, Paraguay. Electronic address: carlosmigue_rios@live.com.
[Ti] Título:Bibliometric study of international scientific production in O'nyong-Nyong virus during the years 1962-2016.
[So] Source:J Infect Public Health;10(1):137-138, 2017 Jan - Feb.
[Is] ISSN:1876-035X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Alphavirus/epidemiologia
Infecções por Alphavirus/virologia
Bibliometria
Vírus O´nyong-nyong/isolamento & purificação
Vírus O´nyong-nyong/patogenicidade
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170610
[Lr] Data última revisão:
170610
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


  3 / 5 MEDLINE  
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[PMID]:25658762
[Au] Autor:LaBeaud AD; Banda T; Brichard J; Muchiri EM; Mungai PL; Mutuku FM; Borland E; Gildengorin G; Pfeil S; Teng CY; Long K; Heise M; Powers AM; Kitron U; King CH
[Ad] Endereço:Children's Hospital Oakland Research Institute, Oakland, California, United States of America; Case Western Reserve University, Cleveland, Ohio, United States of America.
[Ti] Título:High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya.
[So] Source:PLoS Negl Trop Dis;9(2):e0003436, 2015 Feb.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chikungunya virus (CHIKV) and o'nyong nyong virus (ONNV) are mosquito-borne alphaviruses endemic in East Africa that cause acute febrile illness and arthritis. The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographics and other risk factors. METHODOLOGY: Demographic and exposure questionnaires were administered to 1,848 participants recruited from two village clusters (Milalani-Nganja and Vuga) in 2009. Sera were tested for alphavirus exposure using standardized CHIKV IgG ELISA protocols and confirmed with plaque reduction neutralization tests (PRNT). Logistic regression models were used to determine the variables associated with seropositivity. Weighted K test for global clustering of houses with alphavirus positive participants was performed for distance ranges of 50-1,000 meters, and G* statistic and kernel density mapping were used to identify locations of higher seroprevalence. PRINCIPAL FINDINGS: 486 (26%) participants were seropositive by IgG ELISA. Of 443 PRNT confirmed positives, 25 samples (6%) were CHIKV+, 250 samples (56%) were ONNV+, and 168 samples (38%) had high titers for both. Age was significantly associated with seropositivity (OR 1.01 per year, 95% C.I. 1.00-1.01); however, younger adults were more likely to be seropositive than older adults. Males were less likely to be seropositive (p<0.05; OR 0.79, 95% C.I. 0.64-0.97). Adults who owned a bicycle (p<0.05; OR 1.37, 95% C.I. 1.00-1.85) or motor vehicle (p<0.05; OR 4.64, 95% C.I. 1.19-18.05) were more likely to be seropositive. Spatial analysis demonstrated hotspots of transmission within each village and clustering among local households in Milalani-Nganja, peaking at the 200-500m range. CONCLUSIONS/SIGNIFICANCE: Alphavirus exposure, particularly ONNV exposure, is common in coastal Kenya with ongoing interepidemic transmission of both ONNV and CHIKV. Women and adults were more likely to be seropositive. Household location may be a defining factor for the ecology of alphaviral transmission in this region.
[Mh] Termos MeSH primário: Infecções por Alphavirus/epidemiologia
Febre de Chikungunya/epidemiologia
Vírus Chikungunya/imunologia
Vírus O´nyong-nyong/imunologia
[Mh] Termos MeSH secundário: Adulto
África Oriental
Idoso
Infecções por Alphavirus/transmissão
Animais
Febre de Chikungunya/transmissão
Criança
Feminino
Seres Humanos
Insetos Vetores/virologia
Quênia/epidemiologia
Masculino
Meia-Idade
Testes de Neutralização
Estudos Soroepidemiológicos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0003436


  4 / 5 MEDLINE  
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[PMID]:25548172
[Au] Autor:Carissimo G; Pondeville E; McFarlane M; Dietrich I; Mitri C; Bischoff E; Antoniewski C; Bourgouin C; Failloux AB; Kohl A; Vernick KD
[Ad] Endereço:Unit of Genetics and Genomics of Insect Vectors, Department of Parasites and Insect Vectors and CNRS Unit of Hosts, Vectors, and Pathogens, Unité de Recherche Associée 3012, Paris, France; Graduate School of Life Sciences ED515, Sorbonne Universités UPMC Paris VI, 75252 Paris, France.
[Ti] Título:Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota.
[So] Source:Proc Natl Acad Sci U S A;112(2):E176-85, 2015 Jan 13.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Arboviruses are transmitted by mosquitoes and other arthropods to humans and animals. The risk associated with these viruses is increasing worldwide, including new emergence in Europe and the Americas. Anopheline mosquitoes are vectors of human malaria but are believed to transmit one known arbovirus, o'nyong-nyong virus, whereas Aedes mosquitoes transmit many. Anopheles interactions with viruses have been little studied, and the initial antiviral response in the midgut has not been examined. Here, we determine the antiviral immune pathways of the Anopheles gambiae midgut, the initial site of viral infection after an infective blood meal. We compare them with the responses of the post-midgut systemic compartment, which is the site of the subsequent disseminated viral infection. Normal viral infection of the midgut requires bacterial flora and is inhibited by the activities of immune deficiency (Imd), JAK/STAT, and Leu-rich repeat immune factors. We show that the exogenous siRNA pathway, thought of as the canonical mosquito antiviral pathway, plays no detectable role in antiviral defense in the midgut but only protects later in the systemic compartment. These results alter the prevailing antiviral paradigm by describing distinct protective mechanisms in different body compartments and infection stages. Importantly, the presence of the midgut bacterial flora is required for full viral infectivity to Anopheles, in contrast to malaria infection, where the presence of the midgut bacterial flora is required for protection against infection. Thus, the enteric flora controls a reciprocal protection tradeoff in the vector for resistance to different human pathogens.
[Mh] Termos MeSH primário: Anopheles/imunologia
Anopheles/virologia
Arbovirus/imunologia
Arbovirus/patogenicidade
[Mh] Termos MeSH secundário: Infecções por Alphavirus/imunologia
Infecções por Alphavirus/transmissão
Animais
Anopheles/genética
Infecções por Arbovirus/imunologia
Infecções por Arbovirus/transmissão
Arbovirus/genética
Sistema Digestório/imunologia
Sistema Digestório/microbiologia
Sistema Digestório/virologia
Feminino
Interações Hospedeiro-Patógeno/genética
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Insetos Vetores/genética
Insetos Vetores/imunologia
Insetos Vetores/virologia
Janus Quinases/imunologia
Microbiota
Vírus O'nyong-nyong/genética
Vírus O'nyong-nyong/imunologia
Vírus O'nyong-nyong/patogenicidade
Plasmodium falciparum/imunologia
Plasmodium falciparum/patogenicidade
Interferência de RNA
RNA Interferente Pequeno/genética
Fatores de Transcrição STAT/imunologia
Transdução de Sinais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Small Interfering); 0 (STAT Transcription Factors); EC 2.7.10.2 (Janus Kinases)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141231
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1412984112


  5 / 5 MEDLINE  
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[PMID]:25271361
[Au] Autor:Tappe D; Kapaun A; Emmerich P; Campos Rde M; Cadar D; Günther S; Schmidt-Chanasit J
[Ti] Título:O'nyong-nyong virus infection imported to Europe from Kenya by a traveler.
[So] Source:Emerg Infect Dis;20(10):1766-7, 2014 Oct.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Alphavirus/epidemiologia
Infecções por Alphavirus/virologia
Vírus O´nyong-nyong/isolamento & purificação
[Mh] Termos MeSH secundário: Feminino
Alemanha/epidemiologia
Seres Humanos
Quênia/epidemiologia
Meia-Idade
Viagem
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1506
[Cu] Atualização por classe:151029
[Lr] Data última revisão:
151029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141002
[St] Status:MEDLINE
[do] DOI:10.3201/eid2010.140823



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