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[PMID]:28654563
[Au] Autor:Södermark L; Sigurdsson V; Näs W; Wall P; Trollfors B
[Ad] Endereço:From the *Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; †Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; and ‡Department of Medicine, Karlstad Hospital, Karlstad, Sweden.
[Ti] Título:Neuroborreliosis in Swedish Children: A Population-based Study on Incidence and Clinical Characteristics.
[So] Source:Pediatr Infect Dis J;36(11):1052-1056, 2017 Nov.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Borrelia burgdorferi is a common cause of bacterial meningitis, but there are very few studies on incidence in Europe. The aim of this study was to report the incidence and symptoms of neuroborreliosis in Swedish children. METHODS: Medical records of children (< 15 years) treated for neuroborreliosis 2002-2014 were studied retrospectively. The patients were identified in the computerized registers of discharge diagnoses at the Departments of Pediatrics and Infectious Diseases in Gothenburg, Borås, Trollhättan and Halmstad using International Classification of Diseases 10 diagnosis codes G51.0, G01.9 and/or A69.1. Of those, patients with symptoms compatible with neuroborreliosis and a white blood cell count in cerebrospinal fluid ≥ 7 cells/mm with ≥ 80% mononuclear cells were included. Only children living in the city of Gothenburg and 10 surrounding municipalities were included. RESULTS: Five hundred forty-eight children were included. The median age was 7 (1-14) years. The total incidence for the 13-year-period was 2.8/10,000 and remained unchanged during the period. The incidence was significantly higher in rural (4.0/10,000) than in urban municipalities (2.1/10,000). The most common presenting symptoms were headache (n = 335), fatigue (n = 330) and cranial nerve palsies (n = 329). The median duration of symptoms before admittance was 4.0 days for facial palsy and 14.0 days for other symptoms (P < 0.001). The median white blood cell count in cerebrospinal fluid was 129 (7-1069) cells/mm. CONCLUSIONS: This study is the largest so far in a pediatric population. The incidence of neuroborreliosis was higher than in previous European reports. This might be explained by increased Borrelia awareness, the distribution of tick population in Sweden, and the possibility that Swedish children more frequently play outdoors.
[Mh] Termos MeSH primário: Borrelia burgdorferi
Neuroborreliose de Lyme/epidemiologia
Meningites Bacterianas/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Paralisia Facial
Feminino
Cefaleia
Seres Humanos
Incidência
Lactente
Neuroborreliose de Lyme/microbiologia
Masculino
Meningites Bacterianas/microbiologia
Estudos Retrospectivos
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001653


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[PMID]:28651265
[Au] Autor:Örgel A; Hauser TK; Nägele T; Horger M
[Ti] Título:[Imaging in Cranial Nerve Neuritis by Lyme-Neuroborreliosis].
[Ti] Título:Neuritis bei Lyme-Neuroborreliose..
[So] Source:Rofo;189(7):599-602, 2017 07.
[Is] ISSN:1438-9010
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Borrelia
Doenças dos Nervos Cranianos/diagnóstico por imagem
Neuroborreliose de Lyme/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Neurite (Inflamação)/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Medicina Baseada em Evidências
Seres Humanos
Aumento da Imagem/métodos
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-104535


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[PMID]:28480854
[Au] Autor:Beridze M; Khizanishvili N; Mdivani M; Samushia O; Gogokhia N
[Ad] Endereço:Tbilisi State Medical University, Neurological Department of the First University Clinic, Georgia.
[Ti] Título:UNUSUAL MANIFESTATION OF NEUROBORELIOSIS (CASE REPORT).
[So] Source:Georgian Med News;(264):72-75, 2017 Mar.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:The paper reported the verified case of neuroboreliosis with unusual clinical presentation of Parkinsonism. Study aimed at establishing the significance of a precise differential diagnosis with substantial analysis of the symptoms of several diseases to avoid the false diagnosis and to conduct the opportune and adequate therapeutic management. We described the case of the diagnosed neuroboreliosis with clinical expression of Multiple Sclerosis (MS) and Parkinsonism. A 44 years old man was diagnosed as MS according to the McDonald's Criteria, who within two years developed typical clinical signs of Parkinsonism. Patient investigated neurologically, Brain contrast MRI (1.5 Tesla) was performed; Cerebrospinal fluid was researched for oligoclonal bands. Blood IgM and IgG were researched against Chlamidia pneumonie, Micoplasma pneumonie, Borrelia Burgdorferi, Herpes simplex 1/2, Cytomegalovirus by ELISA method. Clinically the patient expressed amimic face, oligobradikinesia, extrapiramidal rigidity in all limbs, resting tremor in upper limb fingers, horizontal nystagmus. Brain MRI showed multiple gadolinium enhanced demyelization lesions in periventricular and sub-cortical white matter. CSF oligoclonal bands were positive without dysfunction of blood-brain barrier. Blood IgM, IgG detected to be negative against Chlamidia pneumonie, Micoplasma pneumonie, cytomegalovirus, Herpes simplex ½, while the blood IgG was strongly positive against Borrelia burgdorferi, confirmed by followed Western blot test. Patient was stabilized by puls-therapy with 1 gr/intravenous Solumedrol (5 days) along with Rocephin treatment (2 gr /iv) for 21 days followed by long term treatment with Antiparkin (Carbidopa 250 mg, Levodopa 25 mg). MS and even Parkinsonism in suspicious cases should thoroughly be investigated for differentiation from chronic Neuroboreliosis.
[Mh] Termos MeSH primário: Neuroborreliose de Lyme/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Diagnóstico Diferencial
Seres Humanos
Masculino
Esclerose Múltipla/diagnóstico
Doença de Parkinson/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


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[PMID]:28378969
[Au] Autor:Oczko-Grzesik B; Kepa L; Puszcz-Matlinska M; Pudlo R; Zurek A; Badura-Glabik T
[Ad] Endereço:Clinical Department of Infectious Diseases, Bytom, Medical University of Silesia, Katowice, Poland.
[Ti] Título:Estimation of cognitive and affective disorders occurrence in patients with Lyme borreliosis.
[So] Source:Ann Agric Environ Med;24(1):33-38, 2017 Mar 01.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION AND OBJECTIVE: Lyme borreliosis (LB) is a disease caused by the bacteria Borrelia burgdorferi. The most common symptoms are related to the skin, musculo-scelatal system, central and peripheral nervous system, rarely to the heart muscle and the eye, and may occur in the multistage course of the disease. LB may additionally be accompanied by psychopathological symptoms. The aim of the study is estimation of the cognitive and affective disorders occurence in patients with LB. MATERIAL AND METHODS: The study was carried out in the group of 121 patients (61 females, 60 males) aged 18-65; mean age 46 years. All patients were diagnosed with late-stage of LB: 46 patients (38%) with Lyme arthritis and 75 patients (62%) with neuroborreliosis. Evaluation of the cognitive and affective functioning of patients was performed on the basis of a standardized interview and test methods: the Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT) and the Beck Depression Inventory (BDI). RESULTS: Cognitive disorders occurred statistically significantly more often in patients with neuroborreliosis (14.7%) than in patients with Lyme arthritis (4.3%). A group of females with neuroborreliosis and a group of males with the same diagnosis demonstrated cognitive deficits significantly more often (23.3% and 8.9%, respectively), compared to groups of patients with Lyme arthritis (6.5% in females and no cognitive deficits in males). A significantly higher percentage of depressive disorders was also noted in the group of males and females with neuroborreliosis (50.7%), compared to the group of patients with Lyme arthritis (39.1%). The symptoms of depression were particularly frequent in the females with neuroborreliosis (60%). The severity of depression measured by BDI was mild or moderate in most cases. In the examined groups, more patients with neuroborreliosis (44%), both in females (36.7%) and males (48.9%), demonstrated anxiety disorders. The obtained results showed a higher frequency of affective disorders compared to cognitive deficits, both in patients with Lyme arthritis and neuroborreliosis. CONCLUSIONS: An increased frequency of depressive and neurotic disorders was observed in patients with LB, particularly in patients with neuroborreliosis. Neurotic disorders, mainly adaptive, were most common in males with LB, while depressive disorders were more frequent in females. An increased frequency of cognitive deficits was observed in patients with neuroborreliosis, particularly in females.
[Mh] Termos MeSH primário: Disfunção Cognitiva/microbiologia
Doença de Lyme/psicologia
Transtornos do Humor/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Transtornos de Ansiedade/complicações
Transtornos de Ansiedade/epidemiologia
Transtornos de Ansiedade/microbiologia
Disfunção Cognitiva/complicações
Disfunção Cognitiva/epidemiologia
Feminino
Seres Humanos
Doença de Lyme/complicações
Neuroborreliose de Lyme/complicações
Neuroborreliose de Lyme/epidemiologia
Neuroborreliose de Lyme/microbiologia
Masculino
Meia-Idade
Transtornos do Humor/complicações
Transtornos do Humor/epidemiologia
Polônia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.5604/12321966.1229002


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[PMID]:28202084
[Au] Autor:Martinez AN; Burmeister AR; Ramesh G; Doyle-Meyers L; Marriott I; Philipp MT
[Ad] Endereço:Division of Bacteriology and Parasitology, Tulane National Primate Research Center, 18703 Three Rivers Rd., Covington, LA, 70433, USA.
[Ti] Título:Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis.
[So] Source:J Neuroinflammation;14(1):37, 2017 Feb 15.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Substance P (SP) is produced at high levels in the central nervous system (CNS), and its target receptor, neurokinin 1 receptor (NK-1R), is expressed by glia and leukocytes. This tachykinin functions to exacerbate inflammatory responses at peripheral sites. Moreover, SP/NK-1R interactions have recently been associated with severe neuroinflammation and neuronal damage. We have previously demonstrated that NK-1R antagonists can limit neuroinflammatory damage in a mouse model of bacterial meningitis. Furthermore, we have since shown that these agents can attenuate Borrelia burgdorferi-induced neuronal and glial inflammatory mediator production in non-human primate brain explants and isolated neuronal cells. METHODS: In the present study, we have assessed the role played by endogenous SP/NK-1R interactions in damaging CNS inflammation in an established rhesus macaque model that faithfully reproduces the key clinical features of Lyme neuroborreliosis, using the specific NK-1R antagonist, aprepitant. We have utilized multiplex ELISA to quantify immune mediator levels in cerebrospinal fluid, and RT-PCR and immunoblot analyses to quantify cytokine and NK-1R expression, respectively, in brain cortex, dorsal root ganglia, and spinal cord tissues. In addition, we have assessed astrocyte number/activation status in brain cortical tissue by immunofluorescence staining and confocal microscopy. RESULTS: We demonstrate that aprepitant treatment attenuates B. burgdorferi-induced elevations in CCL2, CXCL13, IL-17A, and IL-6 gene expression in dorsal root ganglia, spinal cord, and/or cerebrospinal fluid of rhesus macaques at 2 to 4 weeks following intrathecal infection. In addition, we demonstrate that this selective NK-1R antagonist also prevents increases in total cortical brain NK-1R expression and decreases in the expression of the astrocyte marker, glial fibrillary acidic protein, associated with B. burgdorferi infection. CONCLUSIONS: The ability of a centrally acting NK-1R inhibitor to attenuate B. burgdorferi-associated neuroinflammatory responses and sequelae raises the intriguing possibility that such FDA-approved agents could be repurposed for use as an adjunctive therapy for the treatment of bacterial CNS infections.
[Mh] Termos MeSH primário: Encefalite/tratamento farmacológico
Encefalite/etiologia
Neuroborreliose de Lyme/complicações
Morfolinas/uso terapêutico
Antagonistas do Receptor de Neuroquinina-1/uso terapêutico
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Astrócitos/efeitos dos fármacos
Astrócitos/metabolismo
Astrócitos/microbiologia
Astrócitos/patologia
Borrelia burgdorferi/fisiologia
Quimiocina CCL2/líquido cefalorraquidiano
Quimiocina CXCL13/genética
Quimiocina CXCL13/metabolismo
Citocinas/genética
Citocinas/metabolismo
Modelos Animais de Doenças
Encefalite/patologia
Feminino
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/metabolismo
Proteína Glial Fibrilar Ácida/metabolismo
Macaca mulatta
Masculino
RNA Mensageiro/metabolismo
Receptores da Neurocinina-1/genética
Receptores da Neurocinina-1/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokine CCL2); 0 (Chemokine CXCL13); 0 (Cytokines); 0 (Glial Fibrillary Acidic Protein); 0 (Morpholines); 0 (Neurokinin-1 Receptor Antagonists); 0 (RNA, Messenger); 0 (Receptors, Neurokinin-1); 1NF15YR6UY (aprepitant)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0813-x


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[PMID]:28175945
[Au] Autor:Dersch R; Rauer S
[Ad] Endereço:Abteilung für Neurologie und Neurophysiologie, Universitätsklinikum Freiburg, Breisacher Str. 64, 79106, Freiburg, Deutschland. rick.dersch@uniklinik-freiburg.de.
[Ti] Título:[Neuroborreliosis - Diagnostics, treatment and course].
[Ti] Título:Neuroborreliose ­ Diagnostik, Therapie und Verlauf..
[So] Source:Nervenarzt;88(4):419-431, 2017 Apr.
[Is] ISSN:1433-0407
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Lyme neuroborreliosis is a tick-borne infectious disease caused by the spirochete bacterium Borrelia burgdorferi sensu lato. Clinical manifestations are classified as early and late Lyme neuroborreliosis. Early manifestations are much more common than late manifestations. Serological testing should only be performed when typical neurological symptoms are present because false positive results are common due to a high seroprevalence in the population. Cerebrospinal fluid (CSF) analysis should be performed if Lyme neuroborreliosis is suspected. A systematic review found similar effects of beta-lactam antibiotics and doxycycline regarding the outcome of neurological symptoms and adverse effects. The prognosis after antibiotic treatment is usually favorable and residual symptoms can rarely persist. Impairments in quality of life, fatigue, depression and cognitive impairment are not more frequent in patients after treatment of Lyme neuroborreliosis than in the normal healthy population.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Borrelia/isolamento & purificação
Líquido Cefalorraquidiano/microbiologia
Doxiciclina/administração & dosagem
Neuroborreliose de Lyme/diagnóstico
Neuroborreliose de Lyme/terapia
beta-Lactamas/administração & dosagem
[Mh] Termos MeSH secundário: Borrelia/efeitos dos fármacos
Diagnóstico Diferencial
Relação Dose-Resposta a Droga
Medicina Baseada em Evidências
Seres Humanos
Neuroborreliose de Lyme/microbiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (beta-Lactams); N12000U13O (Doxycycline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1007/s00115-016-0263-1


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[PMID]:28127071
[Au] Autor:Roaldsnes E; Eikeland R; Berild D
[Ad] Endereço:Oslo universitetssykehus, Ullevål og Det medisinske fakultet Universitetet i Oslo.
[Ti] Título:Lyme neuroborreliosis in cases of non-specific neurological symptoms.
[Ti] Título:Lyme-nevroborreliose ved uspesifikke nevrologiske symptomer..
[So] Source:Tidsskr Nor Laegeforen;137(2):101-104, 2017 Jan.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Mh] Termos MeSH primário: Neuroborreliose de Lyme
[Mh] Termos MeSH secundário: Anticorpos Antibacterianos/sangue
Borrelia burgdorferi/imunologia
Borrelia burgdorferi/isolamento & purificação
Doenças dos Nervos Cranianos/etiologia
Seres Humanos
Neuroborreliose de Lyme/líquido cefalorraquidiano
Neuroborreliose de Lyme/complicações
Neuroborreliose de Lyme/diagnóstico
Registros Médicos
Mialgia/etiologia
Parestesia/etiologia
Radiculopatia/etiologia
Punção Espinal
Cefaleia do Tipo Tensional/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.15.1115


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[PMID]:28127063
[Au] Autor:Mygland Å
[Ti] Título:Could it be Lyme neuroborreliosis?
[Ti] Título:Kan det være Lyme-nevroborreliose?.
[So] Source:Tidsskr Nor Laegeforen;137(2):86, 2017 Jan.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/sangue
Neuroborreliose de Lyme/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Neuroborreliose de Lyme/líquido cefalorraquidiano
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.16.1032


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[PMID]:28109263
[Au] Autor:Schwenkenbecher P; Pul R; Wurster U; Conzen J; Pars K; Hartmann H; Sühs KW; Sedlacek L; Stangel M; Trebst C; Skripuletz T
[Ad] Endereço:Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
[Ti] Título:Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization.
[So] Source:BMC Infect Dis;17(1):90, 2017 Jan 21.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neuroborreliosis represents a relevant infectious disease and can cause a variety of neurological manifestations. Different stages and syndromes are described and atypical symptoms can result in diagnostic delay or misdiagnosis. The aim of this retrospective study was to define the pivotal neurological deficits in patients with neuroborreliosis that were the reason for admission in a hospital. METHODS: We retrospectively evaluated data of patients with neuroborreliosis. Only patients who fulfilled the diagnostic criteria of an intrathecal antibody production against Borrelia burgdorferi were included in the study. RESULTS: Sixty-eight patients were identified with neuroborreliosis. Cranial nerve palsy was the most frequent deficit (50%) which caused admission to a hospital followed by painful radiculitis (25%), encephalitis (12%), myelitis (7%), and meningitis/headache (6%). In patients with a combination of deficits, back pain was the first symptom, followed by headache, and finally by cranial nerve palsy. Indeed, signs of meningitis were often found in patients with neuroborreliosis, but usually did not cause admission to a hospital. Unusual cases included patients with sudden onset paresis that were initially misdiagnosed as stroke and one patient with acute delirium. Cerebrospinal fluid (CSF) analysis revealed typical changes including elevated CSF cell count in all but one patient, a blood-CSF barrier dysfunction (87%), CSF oligoclonal bands (90%), and quantitative intrathecal synthesis of immunoglobulins (IgM in 74%, IgG in 47%, and IgA in 32% patients). Importantly, 6% of patients did not show Borrelia specific antibodies in the blood. CONCLUSION: In conclusion, the majority of patients presented with typical neurological deficits. However, unusual cases such as acute delirium indicate that neuroborreliosis has to be considered in a wide spectrum of neurological diseases. CSF analysis is essential for a reliable diagnosis of neuroborreliosis.
[Mh] Termos MeSH primário: Doenças dos Nervos Cranianos/etiologia
Encefalite/etiologia
Cefaleia/etiologia
Hospitalização
Neuroborreliose de Lyme/complicações
Meningite/etiologia
Mielite/etiologia
Radiculopatia/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antibacterianos/líquido cefalorraquidiano
Formação de Anticorpos
Barreira Hematoencefálica
Borrelia burgdorferi/imunologia
Criança
Pré-Escolar
Diagnóstico Tardio
Feminino
Seres Humanos
Imunoglobulina A/líquido cefalorraquidiano
Imunoglobulina G/líquido cefalorraquidiano
Imunoglobulina M/líquido cefalorraquidiano
Neuroborreliose de Lyme/líquido cefalorraquidiano
Neuroborreliose de Lyme/diagnóstico
Masculino
Meia-Idade
Bandas Oligoclonais/líquido cefalorraquidiano
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Immunoglobulin M); 0 (Oligoclonal Bands)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-016-2112-z


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[PMID]:28040562
[Au] Autor:Jahfari S; Krawczyk A; Coipan EC; Fonville M; Hovius JW; Sprong H; Takumi K
[Ad] Endereço:Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
[Ti] Título:Enzootic origins for clinical manifestations of Lyme borreliosis.
[So] Source:Infect Genet Evol;49:48-54, 2017 Apr.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Both early localized and late disseminated forms of Lyme borreliosis are caused by Borrelia burgdorferi senso lato. Differentiating between the spirochetes that only cause localized skin infection from those that cause disseminated infection, and tracing the group of medically-important spirochetes to a specific vertebrate host species, are two critical issues in disease risk assessment and management. Borrelia burgdorferi senso lato isolates from Lyme borreliosis cases with distinct clinical manifestations (erythema migrans, neuroborreliosis, acrodermatitis chronica atrophicans, and Lyme arthritis) and isolates from Ixodes ricinus ticks feeding on rodents, birds and hedgehogs were typed to the genospecies level by sequencing part of the intergenic spacer region. In-depth molecular typing was performed by sequencing eight additional loci with different characteristics (plasmid-bound, regulatory, and housekeeping genes). The most abundant genospecies and genotypes in the clinical isolates were identified by using odds ratio as a measure of dominance. Borrelia afzelii was the most common genospecies in acrodermatitis patients and engorged ticks from rodents. Borrelia burgdorferi senso stricto was widespread in erythema migrans patients. Borrelia bavariensis was widespread in neuroborreliosis patients and in ticks from hedgehogs, but rare in erythema migrans patients. Borrelia garinii was the dominant genospecies in ticks feeding on birds. Spirochetes in ticks feeding on hedgehogs were overrepresented in genotypes of the plasmid gene ospC from spirochetes in erythema migrans patients. Spirochetes in ticks feeding on hedgehogs were overrepresented in genotypes of ospA from spirochetes in acrodermatitis patients. Spirochetes from ticks feeding on birds were overrepresented in genotypes of the plasmid and regulatory genes dbpA, rpoN and rpoS from spirochetes in neuroborreliosis patients. Overall, the analyses of our datasets support the existence of at least three transmission pathways from an enzootic cycle to a clinical manifestation of Lyme borreliosis. Based on the observations with these nine loci, it seems to be justified to consider the population structure of B. burgdorferi senso lato as being predominantly clonal.
[Mh] Termos MeSH primário: Vetores Aracnídeos/microbiologia
Borrelia burgdorferi/genética
DNA Bacteriano/genética
Genótipo
Ixodes/microbiologia
Filogenia
[Mh] Termos MeSH secundário: Animais
Técnicas de Tipagem Bacteriana
Aves/microbiologia
Borrelia burgdorferi/classificação
Borrelia burgdorferi/isolamento & purificação
Células Clonais
DNA Intergênico/genética
Eritema Migrans Crônico/microbiologia
Eritema Migrans Crônico/patologia
Ouriços-Cacheiros/microbiologia
Especificidade de Hospedeiro
Seres Humanos
Neuroborreliose de Lyme/microbiologia
Neuroborreliose de Lyme/patologia
Plasmídeos/química
Plasmídeos/metabolismo
Roedores/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (DNA, Intergenic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE



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