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  1 / 1885 MEDLINE  
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[PMID]:29381995
[Au] Autor:Yan Y; Wang J; Qu B; Zhang Y; Wei Y; Liu H; Wu C
[Ad] Endereço:Department of Neurology.
[Ti] Título:CXCL13 and TH1/Th2 cytokines in the serum and cerebrospinal fluid of neurosyphilis patients.
[So] Source:Medicine (Baltimore);96(47):e8850, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurosyphilis is a chronic infectious disease with involvement of central nervous system infection by Treponema pallidum. This study was to investigate the contents of B lymphocyte chemokine 1 (BLC-1/chemokine [C-X-C motif] ligand 13), Th1 cytokines (Interleukin [IL]-2, IL-12, and Interferon [IFN]-γ), and Th2 cytokines (IL-6 and IL-10) in serum and cerebrospinal fluid (CSF) of HIV-negative patients with neurosyphilis before and after treatment, aiming to elucidate roles of CXCL13 and Th1/Th2 cytokines in immune response to and pathogenesis of neurosyphilis.Enzyme-linked immunosorbent assay was employed to detect the contents of CXCL13, IL-2, IL-12, IFN-γ, IL-6, and IL-10 in serum and CSF of 47 HIV-negative patients with neurosyphilis, 36 syphilis patients without neurological involvement and 23 controls (noninfectious intracranial disease) before, 3 and 12 months after treatment with high dose penicillin.Results showed that there was no significant difference in blood CXCL13 content among 3 groups (P > .05); CSF CXCL13 content in neurosyphilis patients was significantly higher than in other 2 groups (P < .001), and positively related to leucocyte count, protein concentration, and IgG index. IL-6 and IL-10 contents of the serum and CSF in neurosyphilis patients were markedly higher than in other 2 groups (P < .05 or .01), but IL-2, IL-12, and IFN-γ of the serum and CSF were significantly lower than in other 2 groups (P < .05 or .01). The IL-6, IL-10, IL-2, IL-12, and IFN-γ contents of the serum and CSF were comparable between control group and syphilis group (P > .05). CSF CXCL13 content was positively related with IL-6 and IL-10 content, while negatively related to IL-12 content in neurosyphilis patients. CSF IL-6 content was negatively related with IL-12 content. In neurosyphilis patients, the CSF CXCL13 content reduced significantly at 3 and 12 months (P < .001), the CSF IL-2 and IL-12 contents increased significantly at 12 months, and CSF IL-6 contents reduced significantly at 12 months after treatment (P < .05 or .01).It is concluded that neurosyphilis patients did not have normal immune function. CXCL13 and Th1/Th2 cytokines are involved in the immune response of neurosyphilis patients. CSF CXCL13 and Th1/Th2 cytokines contents may be used for the diagnosis and evaluation of therapeutic efficacy of neurosyphilis.
[Mh] Termos MeSH primário: Quimiocina CXCL13/análise
Citocinas/análise
Neurossífilis/sangue
Neurossífilis/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/uso terapêutico
Estudos de Casos e Controles
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Interferon gama/análise
Interleucina-10/análise
Interleucina-12/análise
Interleucina-2/análise
Interleucina-6/análise
Masculino
Meia-Idade
Neurossífilis/tratamento farmacológico
Penicilinas/uso terapêutico
Sífilis/sangue
Sífilis/líquido cefalorraquidiano
Sífilis/tratamento farmacológico
Equilíbrio Th1-Th2/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (CXCL13 protein, human); 0 (Chemokine CXCL13); 0 (Cytokines); 0 (IL10 protein, human); 0 (IL2 protein, human); 0 (IL6 protein, human); 0 (Interleukin-2); 0 (Interleukin-6); 0 (Penicillins); 130068-27-8 (Interleukin-10); 187348-17-0 (Interleukin-12); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008850


  2 / 1885 MEDLINE  
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[PMID]:28931218
[Au] Autor:Yu Q; Cheng Y; Wang Y; Wang C; Lu H; Guan Z; Huang J; Gong W; Shi M; Ni L; Wu J; Peng R; Zhou P
[Ad] Endereço:Shanghai Skin Disease Hospital, Clinical School of Anhui Medical University.
[Ti] Título:Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid.
[So] Source:J Infect Dis;216(5):534-544, 2017 Sep 01.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Previous studies documented that humoral immune responses participated in neurological damage in neurosyphilis patients. However, the mechanisms that trigger and maintain humoral immunity involved in neurosyphilis remain unknown. Methods: Using flow cytometry, expression of B cells was measured in neurosyphilis and non-neurosyphilis. Expression of immunoglobulin indices and chemokine ligand CXCL13 was detected by enzyme-linked immunosorbent assay. The migration and inhibition assays were evaluated by modified chamber assays. The presence of CXCL13+ cells, cluster of differentiation (CD)20+ B cells, CD3+ T cells, CD138+ plasma cells and CD35+ follicular dendritic cells was studied by immunohistochemistry. Results: Enrichment of B cells was observed and activated in the cerebrospinal fluid (CSF) of neurosyphilis patients. Immunoglobulin indices were increased and associated with the progress to neurosyphilis. High expression of CSF CXCL13 mediated B cell migration both in vitro and in vivo. There was a positive correlation among the CSF B cells, immunoglobulin indices, and CSF CXCL13 levels. Ectopic germinal centers (EGCs), important structures for humoral immunity, were observed in the intracranial syphilitic gumma. Conclusions: CXCL13/CXCR5 mediated the aggregation of B cells, that directed the aberrant humoral immune responses via the formation of EGCs, which suggests a molecular mechanism of neurological damage in neurosyphilis.
[Mh] Termos MeSH primário: Linfócitos B/metabolismo
Quimiocina CXCL13/líquido cefalorraquidiano
Imunidade Humoral
Neurossífilis/líquido cefalorraquidiano
Receptores CXCR5/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Formação de Anticorpos
Biomarcadores/líquido cefalorraquidiano
Estudos de Casos e Controles
Diferenciação Celular
Feminino
Citometria de Fluxo
Seguimentos
Seres Humanos
Imunoglobulina A/sangue
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Masculino
Meia-Idade
Neurossífilis/diagnóstico
Plasmócitos/metabolismo
Linfócitos T/metabolismo
Treponema pallidum
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (CXCL13 protein, human); 0 (CXCR5 protein, human); 0 (Chemokine CXCL13); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Immunoglobulin M); 0 (Receptors, CXCR5)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix233


  3 / 1885 MEDLINE  
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[PMID]:28859081
[Au] Autor:Marks M; Jarvis JN; Howlett W; Mabey DCW
[Ad] Endereço:Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
[Ti] Título:Neurosyphilis in Africa: A systematic review.
[So] Source:PLoS Negl Trop Dis;11(8):e0005880, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Therefore it might be expected that neurosyphilis would be an important and not uncommon manifestation of syphilis in Africa and frequently occur in association with HIV co-infection; yet few data are available on neurosyphilis in Africa. The aim of this study is to review data on neurosyphilis in Africa since the onset of the HIV epidemic. METHODS: We searched the literature for references on neurosyphilis in Africa for studies published between the 1st of January 1990 and 15th February 2017. We included case reports, case series, and retrospective and prospective cohort and case-control studies. We did not limit inclusion based on the diagnostic criteria used for neurosyphilis. For retrospective and prospective cohorts, we calculated the proportion of study participants who were diagnosed with neurosyphilis according to the individual study criteria. Depending on the study, we assessed the proportion of patients with syphilis found to have neurosyphilis, and the proportion of patients with neurological syndromes who had neurosyphilis. Due to heterogeneity of data no formal pooling of the data or meta-analysis was undertaken. RESULTS: Amongst patients presenting with a neurological syndrome, three studies of patients with meningitis were identified; neurosyphilis was consistently reported to cause approximately 3% of all cases. Three studies on stroke reported mixed findings but were limited due to the small number of patients undergoing CSF examination, whilst neurosyphilis continued to be reported as a common cause of dementia in studies from North Africa. Ten studies reported on cases of neurosyphilis amongst patients known to have syphilis. Studies from both North and Southern Africa continue to report cases of late stage syphilis, including tabes dorsalis and neurosyphilis, in association with ocular disease. DISCUSSION: This is the first systematic review of the literature on neurosyphilis in Africa since the beginning of the HIV epidemic. Neurosyphilis continues to be reported as a manifestation of both early and late syphilis, but the methodological quality of the majority of the included studies was poor. Future well-designed prospective studies are needed to better delineate the incidence and clinical spectrum of neurosyphilis in Africa and to better define interactions with HIV in this setting.
[Mh] Termos MeSH primário: Coinfecção/epidemiologia
Infecções por HIV/epidemiologia
Neurossífilis/epidemiologia
[Mh] Termos MeSH secundário: África/epidemiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005880


  4 / 1885 MEDLINE  
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[PMID]:28739848
[Au] Autor:Budhram A; Silverman M; Burneo JG
[Ad] Endereço:Departments of Clinical Neurological Sciences (Budhram, Burneo) and Medicine (Silverman), Schulich School of Medicine, Western University, London, Ont., Canada adrian.budhram@medportal.ca.
[Ti] Título:Neurosyphilis mimicking autoimmune encephalitis in a 52-year-old man.
[So] Source:CMAJ;189(29):E962-E965, 2017 07 24.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Encefalite/diagnóstico
Doença de Hashimoto/diagnóstico
Neurossífilis/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Eletroencefalografia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170190


  5 / 1885 MEDLINE  
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[PMID]:28446129
[Au] Autor:Xiao Y; Tong ML; Liu LL; Lin LR; Chen MJ; Zhang HL; Zheng WH; Li SL; Lin HL; Lin ZF; Xing HQ; Niu JJ; Yang TC
[Ad] Endereço:Zhongshan Hospital, Medical College of Xiamen University, Xiamen, 361004, China.
[Ti] Título:Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study.
[So] Source:BMC Infect Dis;17(1):310, 2017 Apr 26.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS). METHODS: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients. Clinical and laboratory characteristics of S-NS were compared with N-NS to identify factors predictive of S-NS. Serum rapid plasma reagin (RPR), Treponema pallidum particle agglutination (TPPA), and their parallel testing format for screening S-NS were evaluated. RESULTS: The likelihood of S-NS was positively associated with the serum RPR and TPPA titers. The serum TPPA titers performed better than the serum RPR titers in screening S-NS. The optimal cut-off points to recognize S-NS were serum RPR titer ≥1:4 and serum TPPA titer ≥1:2560 respectively. A parallel testing format of a serum RPR titer ≥1:2 and serum TPPA titer ≥1:1280 screened out 95.8% of S-NS and all confirmed cases of neurosyphilis. S-NS was independently associated with male sex, serum RPR titer ≥1:4, serum TPPA titer ≥1:2560, and elevated serum creatine kinase. Concurrence of these factors increased the likelihood of S-NS. CONCLUSIONS: Quantitation of serum TPPA is worthwhile and performs better than serum RPR in screening S-NS. Serum RPR, serum TPPA, male sex, and serum creatine kinase can predict S-NS. Moreover, patients with both a serum RPR titer <1:2 and a serum TPPA titer <1:1280 have a low probability of S-NS, suggesting that it is reasonable to reduce lumbar punctures in such individuals.
[Mh] Termos MeSH primário: Neurossífilis/diagnóstico
Neurossífilis/etiologia
[Mh] Termos MeSH secundário: Testes de Aglutinação/métodos
Feminino
Soropositividade para HIV
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Fatores de Risco
Punção Espinal
Sífilis/complicações
Sorodiagnóstico da Sífilis
Treponema pallidum/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2339-3


  6 / 1885 MEDLINE  
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[PMID]:28291299
[Au] Autor:Akinci E; Öncü F; Topçular B
[Ti] Título:[Neurosyphilis in Psychiatric Settings: Three Case Reports].
[Ti] Título:Psikiyatri Kliniginde Nörosifiliz: Üç Olgu Bildirimi..
[So] Source:Turk Psikiyatri Derg;28(1):61-66, 2017.
[Is] ISSN:1300-2163
[Cp] País de publicação:Turkey
[La] Idioma:tur
[Ab] Resumo:Syphilis is a generally sexually transmitted and multisystem disease caused by the spirochete Treponema pallidum. All of the organs of the body may be involved during the course of the disease. Neurosyphilis is a clinical form of syphilis with the central nervous system (CNS) involvement. While primarily meningeal and vascular structures are involved in early neurosyphilis, a parenchymal affection of the brain and spinal cord emerges at later stages of neurosyphilis. It presents with symptoms of meningitis, meningovasculitis and parenchymal neurosyphilis (presenting as tabes dorsalis and general paresis). Clinically, it can mimic a variety of psychiatric disorders such as depression, psychosis, mania, delirium, personality changes and dementia. During its progression making presentations similar to many systemic or neuropsychiatric diseases, syphilis is defined as "great imitator". Nowadays, neurosyphilis is a rare disease as a result of the widespread use of antibiotics that must be kept in mind in the differential diagnosis of neurological and psychiatric disorders. In this article, three neurosyphilis cases with different psychiatric presentations are reported and literature relevant to syphilis are reviewed.
[Mh] Termos MeSH primário: Neurossífilis/diagnóstico
Transtornos Psicóticos/etiologia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Neuroimagem
Neurossífilis/complicações
Neurossífilis/diagnóstico por imagem
Neurossífilis/psicologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


  7 / 1885 MEDLINE  
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[PMID]:28288165
[Au] Autor:Peng RR; Wu J; Zhao W; Qi T; Shi M; Guan Z; Lu H; Long F; Gao Z; Zhang S; Zhou P
[Ad] Endereço:Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Shanghai, People's Republic of China.
[Ti] Título:Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?
[So] Source:PLoS Negl Trop Dis;11(3):e0005456, 2017 Mar.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when treating other diseases. This study aimed to investigate the incidence, presentation, management and prognosis of benzylpenicillin-induced neutropenia in treating neurosyphilis based on a large sample of syphilis patients in Shanghai. METHODOLOGY/PRINCIPAL FINDINGS: Between 1st January 2013 and 31st December 2015, 1367 patients with neurosyphilis were treated with benzylpenicillin, 578 of whom were eligible for recruitment to this study. Among patients without medical co-morbidities, the total incidence of benzylpenicillin-induced neutropenia and severe neutropenia was 2.42% (95% CI: 1.38-4.13%) and 0.35% (95% CI: 0.06-1.39%), respectively. The treatment duration before onset of neutropenia ranged from 10 to 14 days, with a total cumulative dose of between 240 and 324 megaunits of benzylpenicillin. Neutropenia was accompanied by symptoms of chills and fever (5 patients), fatigue (2 patients), cough (1 patient), sore throat (1 patient), diarrhea (1 patient) and erythematous rash (1 patient). The severity of neutropenia was not associated with age, gender or type of neurosyphilis (p>0.05). Neutropenia, even when severe, was often tolerated and normalized within one week. A more serious neutropenia did not occur when reinstituting benzylpenicillin in patients with mild or moderate neutropenia nor when ceftriaxone was used three months after patients had previously experienced severe neutropenia. CONCLUSIONS/SIGNIFICANCE: Benzylpenicillin-induced neutropenia was uncommon in our cohort of patients. Continuation of therapy was possible with intensive surveillance for those with mild or moderate neutropenia. For severe neutropenia, it is not essential to aggressively use hematopoietic growth factors or broad-spectrum antibiotics for patients in good physical condition after withdrawing anti-neurosyphilis regimen. We did not see an exacerbation of neutropenia in patients with the readministration of benzylpenicillin.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Neurossífilis/complicações
Neurossífilis/tratamento farmacológico
Neutropenia/induzido quimicamente
Neutropenia/epidemiologia
Penicilina G/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/administração & dosagem
China/epidemiologia
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Neutropenia/patologia
Penicilina G/administração & dosagem
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005456


  8 / 1885 MEDLINE  
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[PMID]:28258131
[Au] Autor:Pekic S; Popovic V
[Ad] Endereço:School of MedicineUniversity of Belgrade, Belgrade, Serbia.
[Ti] Título:DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism.
[So] Source:Eur J Endocrinol;176(6):R269-R282, 2017 Jun.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism in several other conditions such as other massess in the sellar and parasellar region, brain damage caused by radiation and by traumatic brain injury, vascular lesions, infiltrative/immunological/inflammatory diseases (lymphocytic hypophysitis, sarcoidosis and hemochromatosis), infectious diseases and genetic disorders. Hypopituitarism may be permanent and progressive with sequential pattern of hormone deficiencies (radiation-induced hypopituitarism) or transient after traumatic brain injury with possible recovery occurring years from the initial event. In recent years, there is increased reporting of less common and less reported causes of hypopituitarism with its delayed diagnosis. The aim of this review is to summarize the published data and to allow earlier identification of populations at risk of hypopituitarism as optimal hormonal replacement may significantly improve their quality of life and life expectancy.
[Mh] Termos MeSH primário: Adenoma/diagnóstico
Irradiação Craniana/efeitos adversos
Hipofisite/diagnóstico
Hipopituitarismo/diagnóstico
Neoplasias Hipofisárias/diagnóstico
[Mh] Termos MeSH secundário: Adenoma/complicações
Abscesso Encefálico/complicações
Abscesso Encefálico/diagnóstico
Lesões Encefálicas Traumáticas/complicações
Infecções do Sistema Nervoso Central/complicações
Infecções do Sistema Nervoso Central/diagnóstico
Diagnóstico Diferencial
Diagnóstico Precoce
Intervenção Médica Precoce
Doença de Erdheim-Chester/complicações
Doença de Erdheim-Chester/diagnóstico
Tumor Glômico/complicações
Tumor Glômico/diagnóstico
Granulomatose com Poliangiite/complicações
Granulomatose com Poliangiite/diagnóstico
Hemocromatose/complicações
Hemocromatose/diagnóstico
Hemossiderose/complicações
Hemossiderose/diagnóstico
Histiocitose de Células de Langerhans/complicações
Histiocitose de Células de Langerhans/diagnóstico
Terapia de Reposição Hormonal
Seres Humanos
Hipofisite/complicações
Hipopituitarismo/tratamento farmacológico
Hipopituitarismo/etiologia
Aneurisma Intracraniano/complicações
Aneurisma Intracraniano/diagnóstico
Linfoma/complicações
Linfoma/diagnóstico
Neurossífilis/complicações
Neurossífilis/diagnóstico
Apoplexia Hipofisária/complicações
Apoplexia Hipofisária/diagnóstico
Neoplasias Hipofisárias/complicações
Neoplasias Hipofisárias/secundário
Plasmocitoma/complicações
Plasmocitoma/diagnóstico
Transtornos Puerperais/diagnóstico
Sarcoidose/complicações
Sarcoidose/diagnóstico
Sela Túrcica
Hemorragia Subaracnóidea/complicações
Hemorragia Subaracnóidea/diagnóstico
Tuberculose do Sistema Nervoso Central/complicações
Tuberculose do Sistema Nervoso Central/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-16-1065


  9 / 1885 MEDLINE  
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[PMID]:28192580
[Au] Autor:Triemstra J; Reno K; Chohlas-Wood R; Nash C
[Ti] Título:A Brief Resolved Unexplained Event and Congenital Neurosyphilis.
[So] Source:Pediatr Ann;46(2):e61-e64, 2017 Feb 01.
[Is] ISSN:1938-2359
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brief resolved unexplained event (BRUE) is a common pediatric problem that presents to ambulatory and emergency settings. Infants presenting with a BRUE can be separated into low- and high-risk groups per recent guidelines. Most low-risk infants who present with a BRUE can be discharged home with anticipatory guidance and education provided to the caregivers; however, high-risk infants should undergo further testing and observation to determine the cause of their event. Congenital neurosyphilis can be a rare cause of a BRUE. Therefore, high-risk infants with a BRUE should have evaluations focused on potential diagnosis supported by the patient's history and physical examination. [Pediatr Ann. 2017;46(2):e61-e64.].
[Mh] Termos MeSH primário: Sintomas Inexplicáveis
Neurossífilis/congênito
Neurossífilis/diagnóstico
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Diagnóstico Diferencial
Seres Humanos
Lactente
Recém-Nascido
Infusões Intravenosas
Masculino
Neurossífilis/tratamento farmacológico
Penicilina G/administração & dosagem
Fatores de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.3928/19382359-20170118-02


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Texto completo
[PMID]:28093716
[Au] Autor:Metzger YC; Miodovnik M; Epshteyn S
[Ad] Endereço:Department of Dermatology, The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
[Ti] Título:Syphilitic chancre and condylomata lata possibly coexisting with neurosyphilis.
[So] Source:Int J Dermatol;56(3):312-313, 2017 Mar.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cancro/complicações
Neurossífilis/complicações
Doenças do Pênis/microbiologia
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Seres Humanos
Masculino
Penicilina G/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13462



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