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  1 / 1405 MEDLINE  
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[PMID]:28457353
[Au] Autor:Ismail N; McBride JW
[Ad] Endereço:Departments of Pathology and Immunology, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall, Room 739, Pittsburgh, PA 15217, USA. Electronic address: ismailn@upmc.edu.
[Ti] Título:Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis.
[So] Source:Clin Lab Med;37(2):317-340, 2017 Jun.
[Is] ISSN:1557-9832
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively. The threat to public health is increasing with newly emerging ehrlichial and anaplasma agents, yet vaccines for human ehrlichioses and anaplasmosis are not available, and therapeutic options are limited. This article reviews recent advances in the understanding of HME and HGA.
[Mh] Termos MeSH primário: Anaplasma phagocytophilum
Anaplasmose
Ehrlichia
Ehrlichiose
Carrapatos/microbiologia
[Mh] Termos MeSH secundário: Anaplasmose/complicações
Anaplasmose/diagnóstico
Anaplasmose/epidemiologia
Animais
Ehrlichiose/complicações
Ehrlichiose/diagnóstico
Ehrlichiose/epidemiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  2 / 1405 MEDLINE  
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[PMID]:28829732
[Au] Autor:Kim CM; Kim SW; Kim DM; Yoon NR; Jha P; Jang SJ; Ahn YJ; Lim D; Lee SH; Hwang SD; Lee YS
[Ad] Endereço:Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.
[Ti] Título:Case Report: Polymerase Chain Reaction Testing of Tick Bite Site Samples for the Diagnosis of Human Granulocytic Anaplasmosis.
[So] Source:Am J Trop Med Hyg;97(2):403-406, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by , an obligate intracellular bacterium. Until now, the utility of tick-bite site samples for HGA diagnosis has not been reported. Using a patient's buffy coat and tick-bite site crust samples, we performed polymerase chain reaction (PCR) testing using - or -specific primers. PCR with buffy coat and crust samples obtained before doxycycline administration was positive. Six days after doxycycline administration, PCR with the buffy coat sample was negative but PCR with a crust tissue sample from the tick-bite site remained positive. This is the first case to suggest that crust tissue at the tick-bite site may be useful for early HGA diagnosis in patients who have already been treated with antibiotics such as doxycycline.
[Mh] Termos MeSH primário: Anaplasmose/sangue
Anaplasmose/microbiologia
Picadas de Carrapatos/sangue
Picadas de Carrapatos/microbiologia
Doenças Transmitidas por Carrapatos/sangue
Doenças Transmitidas por Carrapatos/microbiologia
[Mh] Termos MeSH secundário: Idoso
Anaplasma phagocytophilum
Anaplasmose/diagnóstico
Diagnóstico Precoce
Seres Humanos
Masculino
Reação em Cadeia da Polimerase
República da Coreia
Doenças Transmitidas por Carrapatos/diagnóstico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0570


  3 / 1405 MEDLINE  
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[PMID]:28738085
[Au] Autor:Liu Y; Watson SC; Gettings JR; Lund RB; Nordone SK; Yabsley MJ; McMahan CS
[Ad] Endereço:Department of Mathematical Sciences, Clemson University, Clemson, SC, United States of America.
[Ti] Título:A Bayesian spatio-temporal model for forecasting Anaplasma species seroprevalence in domestic dogs within the contiguous United States.
[So] Source:PLoS One;12(7):e0182028, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper forecasts the 2016 canine Anaplasma spp. seroprevalence in the United States from eight climate, geographic and societal factors. The forecast's construction and an assessment of its performance are described. The forecast is based on a spatial-temporal conditional autoregressive model fitted to over 11 million Anaplasma spp. seroprevalence test results for dogs conducted in the 48 contiguous United States during 2011-2015. The forecast uses county-level data on eight predictive factors, including annual temperature, precipitation, relative humidity, county elevation, forestation coverage, surface water coverage, population density and median household income. Non-static factors are extrapolated into the forthcoming year with various statistical methods. The fitted model and factor extrapolations are used to estimate next year's regional prevalence. The correlation between the observed and model-estimated county-by-county Anaplasma spp. seroprevalence for the five-year period 2011-2015 is 0.902, demonstrating reasonable model accuracy. The weighted correlation (accounting for different sample sizes) between 2015 observed and forecasted county-by-county Anaplasma spp. seroprevalence is 0.987, exhibiting that the proposed approach can be used to accurately forecast Anaplasma spp. seroprevalence. The forecast presented herein can a priori alert veterinarians to areas expected to see Anaplasma spp. seroprevalence beyond the accepted endemic range. The proposed methods may prove useful for forecasting other diseases.
[Mh] Termos MeSH primário: Anaplasma/imunologia
Anaplasmose/sangue
Anaplasmose/imunologia
Anticorpos Antibacterianos/sangue
Doenças do Cão/sangue
Doenças do Cão/imunologia
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Clima
Cães
Previsões/métodos
Densidade Demográfica
Prevalência
Estudos Soroepidemiológicos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182028


  4 / 1405 MEDLINE  
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[PMID]:28722620
[Au] Autor:Nitzan O; Blum A; Marva E; Katz A; Tzadok BS; Nachum-Biala Y; Baneth G; Peretz A
[Ad] Endereço:Faculty of Medicine in the Galilee, Bar Ilan University, Ramat Gan, Israel.
[Ti] Título:Case Report: Infectious Diseases in Pilgrims Visiting the Holy Land.
[So] Source:Am J Trop Med Hyg;97(2):611-614, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Every year Christian pilgrims from around the world visit the holy sites located around the Sea of Galilee. Some become ill during their stay with infectious diseases that were acquired in their country of origin, and are hospitalized at Poriya Medical Center. They pose a diagnostic challenge due to language barriers, the rarity of these infections in Israel, and the fact that diagnostic tests are not readily available. All patient records from 2015 of Holy Land tourists hospitalized at Poriya Medical Center were screened for the diagnosis of imported zoonotic diseases that are not commonly diagnosed in Israel. Three patients who were on a Holy Land tour were hospitalized during 2015 with laboratory-confirmed diagnostically challenging zoonotic infectious diseases: a 91-year-old priest from Ethiopia diagnosed with relapsing fever due to , an 85-year-old retired mountaineer from New Hampshire diagnosed with human granulocytic anaplasmosis, and a 57-year-old farmer from central Brazil diagnosed with leptospirosis. These case reports emphasize the importance of considering imported zoonotic infectious diseases and obtaining appropriate diagnostic tests when treating Holy Land travelers to Israel.
[Mh] Termos MeSH primário: Anaplasmose
Doenças Transmissíveis
Leptospirose
Febre Recorrente
Viagem/estatística & dados numéricos
Zoonoses
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Animais
Etiópia
Seres Humanos
Israel
Masculino
Meia-Idade
New Hampshire
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0097


  5 / 1405 MEDLINE  
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[PMID]:28678004
[Au] Autor:Ochirkhuu N; Konnai S; Odbileg R; Murata S; Ohashi K
[Ad] Endereço:1 Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University , Sapporo, Japan .
[Ti] Título:Molecular Epidemiological Survey and Genetic Characterization of Anaplasma Species in Mongolian Livestock.
[So] Source:Vector Borne Zoonotic Dis;17(8):539-549, 2017 Aug.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anaplasma species are obligate intracellular rickettsial pathogens that cause great economic loss to the animal industry. Few studies on Anaplasma infections in Mongolian livestock have been conducted. This study examined the prevalence of Anaplasma marginale, Anaplasma ovis, Anaplasma phagocytophilum, and Anaplasma bovis by polymerase chain reaction assay in 928 blood samples collected from native cattle and dairy cattle (Bos taurus), yaks (Bos grunniens), sheep (Ovis aries), and goats (Capra aegagrus hircus) in four provinces of Ulaanbaatar city in Mongolia. We genetically characterized positive samples through sequencing analysis based on the heat-shock protein groEL, major surface protein 4 (msp4), and 16S rRNA genes. Only A. ovis was detected in Mongolian livestock (cattle, yaks, sheep, and goats), with 413 animals (44.5%) positive for groEL and 308 animals (33.2%) positive for msp4 genes. In the phylogenetic tree, we separated A. ovis sequences into two distinct clusters based on the groEL gene. One cluster comprised sequences derived mainly from sheep and goats, which was similar to that in A. ovis isolates from other countries. The other divergent cluster comprised sequences derived from cattle and yaks and appeared to be newly branched from that in previously published single isolates in Mongolian cattle. In addition, the msp4 gene of A. ovis using same and different samples with groEL gene of the pathogen demonstrated that all sequences derived from all animal species, except for three sequences derived from cattle and yak, were clustered together, and were identical or similar to those in isolates from other countries. We used 16S rRNA gene sequences to investigate the genetically divergent A. ovis and identified high homology of 99.3-100%. However, the sequences derived from cattle did not match those derived from sheep and goats. The results of this study on the prevalence and molecular characterization of A. ovis in Mongolian livestock can facilitate the control of infectious diseases in livestock.
[Mh] Termos MeSH primário: Anaplasma/isolamento & purificação
Anaplasmose/microbiologia
Gado/microbiologia
Epidemiologia Molecular
[Mh] Termos MeSH secundário: Anaplasma/genética
Anaplasmose/epidemiologia
Animais
Chaperonina 60/genética
Chaperonina 60/metabolismo
DNA Bacteriano/genética
Regulação Bacteriana da Expressão Gênica
Mongólia/epidemiologia
Filogenia
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chaperonin 60); 0 (DNA, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2017.2111


  6 / 1405 MEDLINE  
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[PMID]:28628633
[Au] Autor:Schotthoefer AM; Schrodi SJ; Meece JK; Fritsche TR; Shukla SK
[Ad] Endereço:Marshfield Clinic Research Institute, Marshfield Clinic, Marshfield, Wisconsin, United States of America.
[Ti] Título:Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis.
[So] Source:PLoS One;12(6):e0179655, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human anaplasmosis (HA) is an emerging tick-borne disease that may present as a mild flu-like illness or a life threatening, sepsis-like condition. Although disease severity is hypothesized to relate to immunopathology and immune dysfunction in humans, studies to directly measure immune responses in infected humans have been very limited. We quantified cytokines in 80 confirmed HA patients using a multiplex chemiluminescence immunoassay system and compared similarly measured responses in 1000 control subjects. Pro-inflammatory cytokines were significantly elevated in HA patients (all seven p<0.0001). Interferon gamma (IFN-γ) concentrations were particularly high, with average concentrations 7.8 times higher in the HA patients than the controls. A subset of cytokines consisting of IL-1ß, IL-8, IL-6, TNF-α, and IL-10 was also coordinately high and significantly associated with severity of thrombocytopenia in HA patients. Patients with infections in the very acute stage (≤ 4 days ill) tended to have the highest IFN-γ, IL-12p70, and IL-2 levels. Higher concentrations of IL-13 and IL-5 were associated with diarrhea and vomiting. Our findings support a pathophysiological role for a pro-inflammatory response in HA, especially with regard to the modulation of hematopoiesis and subsequent hematopoietic complications.
[Mh] Termos MeSH primário: Anaplasmose/patologia
Citocinas/análise
Imunoensaio
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anaplasmose/complicações
Anaplasmose/imunologia
Anaplasmose/metabolismo
Estudos de Casos e Controles
Criança
Pré-Escolar
Diarreia/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Contagem de Plaquetas
Índice de Gravidade de Doença
Células Th1/citologia
Células Th1/metabolismo
Células Th2/citologia
Células Th2/metabolismo
Vômito/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179655


  7 / 1405 MEDLINE  
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[PMID]:28476972
[Au] Autor:SadguruPrasad LT; Madhusudhan B; Kodihalli B P; Ghosh PC
[Ad] Endereço:Research Center for Nanoscience and Technology, Department of Biochemistry and Food Technology, Davangere University, Davangere 577002, Karnataka, India.
[Ti] Título:Development and evaluation of oxytetracycline-loaded PMMA nanoparticles for oral delivery against anaplasmosis.
[So] Source:IET Nanobiotechnol;11(1):119-126, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Poly-methyl methacrylate (PMMA) polymer with remarkable properties and merits are being preferred in various biomedical applications due to its biocompatibility, non-toxicity and cost effectiveness. In this investigation, oxytetracycline-loaded PMMA nanoparticles were prepared using nano-precipitation method for the treatment of anaplasmosis. The prepared nanoparticles were characterised using dynamic light scattering (DLS), atomic force microscopy (AFM), differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) spectroscopy. The mean average diameter of the nanoparticles ranged between 190-240 nm and zeta potential was found to be -19 mV. The drug loading capacity and entrapment efficiency of nanoparticles was found varied between 33.7-62.2% and 40.5-60.0%. The drug release profile exhibited a biphasic phenomenon indicating controlled drug release. The uptake of coumarin-6(C-6)-loaded PMMA nanoparticles in ( 3D7) culture model was studied. The preferential uptake of C-6-loaded nanoparticles by the Plasmodium infected erythrocytes in comparison with the uninfected erythrocytes was observed under fluorescence microscopy. These findings suggest that oxytetracycline-loaded PMMA nanoparticles were found to be an effective oral delivery vehicle and an alternative pharmaceutical formulation in anaplasmosis treatment, too.
[Mh] Termos MeSH primário: Anaplasmose/tratamento farmacológico
Preparações de Ação Retardada/administração & dosagem
Nanocápsulas/administração & dosagem
Nanocápsulas/química
Oxitetraciclina/administração & dosagem
Polimetil Metacrilato/química
[Mh] Termos MeSH secundário: Absorção Fisico-Química
Administração Oral
Antibacterianos/administração & dosagem
Antibacterianos/química
Células Cultivadas
Preparações de Ação Retardada/síntese química
Difusão
Eritrócitos/química
Eritrócitos/microbiologia
Seres Humanos
Nanocápsulas/ultraestrutura
Oxitetraciclina/química
Tamanho da Partícula
Plasmodium falciparum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Delayed-Action Preparations); 0 (Nanocapsules); 9011-14-7 (Polymethyl Methacrylate); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0061


  8 / 1405 MEDLINE  
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[PMID]:28438088
[Au] Autor:Pennisi MG; Hofmann-Lehmann R; Radford AD; Tasker S; Belák S; Addie DD; Boucraut-Baralon C; Egberink H; Frymus T; Gruffydd-Jones T; Hartmann K; Horzinek MC; Hosie MJ; Lloret A; Lutz H; Marsilio F; Thiry E; Truyen U; Möstl K
[Ti] Título:Anaplasma, Ehrlichia and Rickettsia species infections in cats: European guidelines from the ABCD on prevention and management
[So] Source:J Feline Med Surg;19(5):542-548, 2017 05.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OVERVIEW: Anaplasma species, Ehrlichia species and Rickettsia species are vector-borne pathogens infecting a wide variety of mammals, but causing disease in very few of them. Infection in cats: Anaplasma phagocytophilum is the most important feline pathogen among these rickettsial organisms, and coinfections are possible. Little information is available on the pathogenesis of these agents in cats. Clinical signs are usually reported soon after tick infestation. They are mostly non-specific, consisting of fever, anorexia and lethargy. Joint pain may occur. Infection in humans: Some rickettsial species ( A phagocytophilum, Ehrlichia chaffeensis, Ehrlichia ewingii, Rickettsia conorii, Rickettsia rickettsii, Rickettsia felis, Rickettsia typhi and Candidatus Neoehrlichia mikurensis) are of zoonotic concern. Direct contact with cat saliva should be avoided because of potential contamination by R felis. Infected cats are 'sentinels' of the presence of rickettsial pathogens in ticks and fleas in a given geographical area, and they signal a risk for people exposed to vectors.
[Mh] Termos MeSH primário: Anaplasmose
Doenças do Gato
Ehrlichiose/veterinária
Infecções por Rickettsia/veterinária
[Mh] Termos MeSH secundário: Anaplasma/fisiologia
Anaplasmose/diagnóstico
Anaplasmose/tratamento farmacológico
Anaplasmose/microbiologia
Anaplasmose/prevenção & controle
Animais
Doenças do Gato/diagnóstico
Doenças do Gato/tratamento farmacológico
Doenças do Gato/microbiologia
Doenças do Gato/prevenção & controle
Gatos
Ehrlichia/fisiologia
Ehrlichiose/diagnóstico
Ehrlichiose/microbiologia
Ehrlichiose/terapia
Seres Humanos
Rickettsia/fisiologia
Infecções por Rickettsia/diagnóstico
Infecções por Rickettsia/microbiologia
Infecções por Rickettsia/terapia
[Pt] Tipo de publicação:GUIDELINE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X17706462


  9 / 1405 MEDLINE  
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[PMID]:28410950
[Au] Autor:Elhamiani Khatat S; Khallaayoune K; Errafyk N; Van Gool F; Duchateau L; Daminet S; Kachani M; El Amri H; Azrib R; Sahibi H
[Ad] Endereço:Institut Agronomique et Vétérinaire Hassan II, Madinat Al Irfane, BP 6202, Rabat-Instituts, 10101, Morocco; Faculty of Veterinary Medicine of Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium. Electronic address: elhamianis@yahoo.fr.
[Ti] Título:Detection of Anaplasma spp. and Ehrlichia spp. anibodies, and Dirofilaria immitis antigens in dogs from seven locations of Morocco.
[So] Source:Vet Parasitol;239:86-89, 2017 May 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In Morocco no data has been published on canine exposure to Anaplasma spp., Borrrelia burgdorferi, and Ehrlichia spp., and only one report is available on the occurrence of Dirofilaria immitis in dogs. Therefore, the aim of this study was to collect current data on the canine exposure to these vector-borne pathogens (VBPs) in Morocco. A total of 217 urban (n=57), rural (n=110) and military (n=50) dogs from seven Moroccan locations were screened for Anaplasma spp., B. burgdorferi and Ehrlichia spp. antibodies and for D. immitis antigens using a commercial in-clinic ELISA test. Of these dogs, 182 (83.9%) tested positive for at least one pathogen and positivity to two or three pathogens was found in 14.3% and 2.3% of the dogs, respectively. Ehrlichia spp. antibodies (34.6%) were the most frequently detected followed by Anaplasma spp. antibodies (16.6%) and D. immitis antigens (16.1%). None of the dogs was tested seropositive to B. burgdorferi. Statistically significant differences in seropositivity rates were found for Ehrlichia spp. and D. immitis in rural dogs especially those from the north central region (p<0.001) but not for Anaplasma spp. No significant difference was found according to the health status of the dog. This study demonstrates that Moroccan dogs are at high risk of acquiring a vector-borne infection.
[Mh] Termos MeSH primário: Anaplasma/imunologia
Anaplasmose/imunologia
Dirofilaria immitis/imunologia
Dirofilariose/imunologia
Doenças do Cão/parasitologia
Ehrlichia/imunologia
[Mh] Termos MeSH secundário: Anaplasmose/epidemiologia
Animais
Anticorpos Antibacterianos/sangue
Antígenos de Helmintos/sangue
Dirofilariose/epidemiologia
Doenças do Cão/epidemiologia
Cães
Ehrlichiose/epidemiologia
Ehrlichiose/imunologia
Ehrlichiose/veterinária
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antigens, Helminth)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


  10 / 1405 MEDLINE  
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[PMID]:28331130
[Au] Autor:Marko D; Perry AM; Ponnampalam A; Nasr MR
[Ad] Endereço:Department of Pathology, University of Manitoba.
[Ti] Título:Cytopenias and clonal expansion of gamma/delta T-cells in a patient with anaplasmosis: a potential diagnostic pitfall.
[So] Source:J Clin Exp Hematop;56(3):160-164, 2017.
[Is] ISSN:1880-9952
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Human granulocytic anaplasmosis is a rare, tick-borne infectious disease caused by Anaplasma phagocytophilum. Herein, we report a rare case of human granulocytic anaplasmosis associated with cytopenias and clonal expansion of gamma/delta T-cells in the bone marrow. A 77-year old man presented multiple times to the emergency department complaining of muscle weakness. Complete blood count detected cytopenias and peripheral blood smear showed pseudo Pelger-Huet neutrophils. These findings prompted bone marrow evaluation with ancillary studies including flow cytometry, karyotyping and T-cell rearrangement studies. Careful examination of peripheral blood smear revealed very rare neutrophils with intracytoplasmic inclusions, suggestive of ehrlichiosis/anaplasmosis. Bone marrow evaluation showed dyserythropoiesis, dysmegakaryopoiesis and prominence of hemophagocytic histiocytes. Furthermore, an increased number of T-cells was seen in the bone marrow and flow cytometry showed excess of gamma/delta T-cells, while T-cell rearrangement studies detected a T-cell clone. Serologic evaluation confirmed the diagnosis of anaplasmosis. This case nicely illustrates hematologic sequelae of infection with Anaplasma and potential diagnostic pitfalls, such as myelodysplastic syndrome and T-cell lymphoproliferative disorder. To our knowledge, this is the first reported case of clonal expansion of gamma/delta T-cells associated with anaplasmosis. Pathologists should be careful and vigilant when screening peripheral blood smears, as they are often the first to raise the suspicion of anaplasmosis.
[Mh] Termos MeSH primário: Anaplasmose/diagnóstico
Pancitopenia
Receptores de Antígenos de Linfócitos T gama-delta/análise
[Mh] Termos MeSH secundário: Idoso
Proliferação Celular
Células Clonais/patologia
Diagnóstico Diferencial
Seres Humanos
Masculino
Linfócitos T/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Antigen, T-Cell, gamma-delta)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.3960/jslrt.56.160



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