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  1 / 2427 MEDLINE  
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[PMID]:28257448
[Au] Autor:Mootien S; Kaplan PM
[Ad] Endereço:L2 Diagnostics LLC, New Haven, Connecticut, United States of America.
[Ti] Título:Monoclonal antibodies specific for Bacteroides fragilis enterotoxins BFT1 and BFT2 and their use in immunoassays.
[So] Source:PLoS One;12(3):e0173128, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have developed 22 mouse IgG1 monoclonal antibodies (mAbs) against Bacteroides fragilis zinc metalloprotease toxins 1 and 2 (BFT1 and BFT2). Mice were immunized with recombinant BFT1 or BFT2 proteins with metalloprotease activity. Eight of the mAbs bind specifically to BFT1. One mAb, 2H6, binds specifically to BFT2. The remaining 13 mAbs bind to both BFT1 and BFT2. The eight BFT1-specific mAbs recognize at least five different epitopes on the toxin. Four of the BFT1-specific mAbs neutralized rBFT1 metalloprotease activity. Only one of these four mAbs, 1D9, neutralizes the cytotoxic effect of BFT1. Here, we describe the development of enzyme-linked immunosorbent assays (ELISAs) to detect BFT1 or BFT2 toxin in an isotype-specific manner. The sandwich ELISAs have a detection limit of 20 to 40 ng/ml when purified recombinant BFT protein is diluted into PBS. The sandwich ELISA can be used to distinguish and quantify levels of rBFT1 and rBFT2 in stool. This ELISA can be an important tool to investigate the association between BFT expression by enterotoxigenic B. fragilis and diseases such as diarrhea, inflammatory bowel disease and colorectal cancer.
[Mh] Termos MeSH primário: Infecções por Bacteroides/microbiologia
Diarreia/microbiologia
Enterotoxinas/isolamento & purificação
Metaloendopeptidases/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/imunologia
Especificidade de Anticorpos
Infecções por Bacteroides/diagnóstico
Infecções por Bacteroides/imunologia
Bacteroides fragilis/imunologia
Bacteroides fragilis/isolamento & purificação
Bacteroides fragilis/patogenicidade
Diarreia/diagnóstico
Diarreia/imunologia
Enterotoxinas/imunologia
Ensaio de Imunoadsorção Enzimática
Epitopos/imunologia
Fezes/microbiologia
Seres Humanos
Metaloendopeptidases/imunologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Enterotoxins); 0 (Epitopes); EC 3.4.24.- (Metalloendopeptidases); EC 3.4.24.74 (fragilysin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173128


  2 / 2427 MEDLINE  
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[PMID]:28151975
[Au] Autor:Purcell RV; Pearson J; Aitchison A; Dixon L; Frizelle FA; Keenan JI
[Ad] Endereço:Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand.
[Ti] Título:Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia.
[So] Source:PLoS One;12(2):e0171602, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Enterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes. Here, we aim to examine the association of colonic mucosal colonization with ETBF and the presence of a range of lesions on the colonic neoplastic spectrum. METHODS: Mucosal tissue from up to four different colonic sites was obtained from a consecutive series of 150 patients referred for colonoscopy. The presence and relative abundance of the B. fragilis toxin gene (bft) in each tissue sample was determined using quantitative PCR, and associations with clinicopathological characteristics were analysed. FINDINGS: We found a high concordance of ETBF between different colonic sites (86%). Univariate analysis showed statistically significant associations between ETBF positivity and the presence of low-grade dysplasia (LGD), tubular adenomas (TA), and serrated polyps (P-values of 0.007, 0.027, and 0.007, respectively). A higher relative abundance of ETBF was significantly associated with LGD and TA (P-values of < 0.0001 and 0.025, respectively). Increased ETBF positivity and abundance was also associated with left-sided biopsies, compared to those from the right side of the colon. CONCLUSION: Our results showing association of ETBF positivity and increased abundance with early-stage carcinogenic lesions underlines its importance in the development of colorectal cancer, and we suggest that detection of ETBF may be a potential marker of early colorectal carcinogenesis.
[Mh] Termos MeSH primário: Infecções por Bacteroides/complicações
Bacteroides fragilis
Neoplasias Colorretais/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Toxinas Bacterianas/análise
Colo/química
Colo/microbiologia
Neoplasias Colorretais/microbiologia
Feminino
Seres Humanos
Mucosa Intestinal/química
Mucosa Intestinal/microbiologia
Masculino
Metaloendopeptidases/análise
Meia-Idade
Reação em Cadeia da Polimerase
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins); EC 3.4.24.- (Bacteroides fragilis toxin); EC 3.4.24.- (Metalloendopeptidases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171602


  3 / 2427 MEDLINE  
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[PMID]:28108390
[Au] Autor:Nakamura I; Aoki K; Miura Y; Yamaguchi T; Matsumoto T
[Ad] Endereço:Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan. Electronic address: task300@tokyo-med.ac.jp.
[Ti] Título:Fatal sepsis caused by multidrug-resistant Bacteroides fragilis, harboring a cfiA gene and an upstream insertion sequence element, in Japan.
[So] Source:Anaerobe;44:36-39, 2017 Apr.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Here, we report a case of fatal sepsis resulting from an intra-abdominal infection caused by a Bacteroides fragilis strain containing a CfiA4 metallo-ß-lactamase and an upstream insertion sequence (IS) element. Meropenem was used as empiric therapy for septic shock as a result of the intra-abdominal infection, although two rounds of carbapenem treatment had been administered previously. B. fragilis was isolated from two anaerobic blood culture bottles 4 days after the onset of septic shock. Susceptibility testing revealed that the isolate was non-susceptible to all tested agents except metronidazole and tigecycline. The isolate gave a positive result in ethylenediaminetetraacetic acid and carbapenem inactivation tests, but a negative result in a double-disk synergy test using sodium mercaptoacetate. Next-generation whole-genome sequencing indicated the presence of the cfiA4, emrG and emrF genes. PCR indicated the presence of an IS element upstream of the cifA4 gene. Although carbapenem-resistant B. fragilis isolates have previously been reported, clinical sepsis by this organism is considered rare. In Japan, as in most countries worldwide, routine susceptibility testing and the detection of metallo-ß-lactamases is not carried out in anaerobic organisms, including B. fragilis. The emergence of carbapenem resistance during therapy should be monitored, as B. fragilis strains containing the cfiA gene show decreased sensitivity during carbapenem therapy. Therefore, susceptibility testing and appropriate antibiotic stewardship are required in cases of anaerobic bacterial infections.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Infecções por Bacteroides/diagnóstico
Bacteroides fragilis/efeitos dos fármacos
Elementos de DNA Transponíveis
Farmacorresistência Bacteriana Múltipla
Sepse/diagnóstico
beta-Lactamases/genética
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Antibacterianos/farmacologia
Infecções por Bacteroides/microbiologia
Infecções por Bacteroides/patologia
Bacteroides fragilis/genética
Bacteroides fragilis/isolamento & purificação
Hemocultura
Evolução Fatal
Feminino
Genoma Bacteriano
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Infecções Intra-Abdominais/complicações
Japão
Testes de Sensibilidade Microbiana
Sepse/microbiologia
Sepse/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (DNA Transposable Elements); EC 3.5.2.6 (beta-Lactamases); EC 3.5.2.6 (carbapenemase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE


  4 / 2427 MEDLINE  
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[PMID]:28011371
[Au] Autor:Otte E; Nielsen HL; Hasman H; Fuglsang-Damgaard D
[Ad] Endereço:Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: erikotte@rm.dk.
[Ti] Título:First report of metronidazole resistant, nimD-positive, Bacteroides stercoris isolated from an abdominal abscess in a 70-year-old woman.
[So] Source:Anaerobe;43:91-93, 2017 Feb.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We here present the first case of a metronidazole resistant nimD positive Bacteroides stercoris. The isolate originated from a polymicrobial intra-abdominal abscess in a 70-year-old woman. The nimD gene was detected by use of whole-genome shotgun sequencing and the subsequent use of the ResFinder 2.1 web service.
[Mh] Termos MeSH primário: Abscesso Abdominal/diagnóstico
Antibacterianos/farmacologia
Proteínas de Bactérias/genética
Infecções por Bacteroides/diagnóstico
Bacteroides/isolamento & purificação
Farmacorresistência Bacteriana
Metronidazol/farmacologia
[Mh] Termos MeSH secundário: Abscesso Abdominal/tratamento farmacológico
Abscesso Abdominal/microbiologia
Idoso
Proteínas de Bactérias/metabolismo
Bacteroides/genética
Infecções por Bacteroides/tratamento farmacológico
Infecções por Bacteroides/microbiologia
DNA Bacteriano/genética
Feminino
Seres Humanos
Testes de Sensibilidade Microbiana
Análise de Sequência de DNA
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (DNA, Bacterial); 140QMO216E (Metronidazole)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


  5 / 2427 MEDLINE  
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[PMID]:27867083
[Au] Autor:Snydman DR; Jacobus NV; McDermott LA; Goldstein EJ; Harrell L; Jenkins SG; Newton D; Patel R; Hecht DW
[Ad] Endereço:Tufts Medical Center, Box 238, 800 Washington Street, Boston, MA, 02111, USA; Tufts University School of Medicine, Boston, MA, USA. Electronic address: dsnydman@tuftsmedicalcenter.org.
[Ti] Título:Trends in antimicrobial resistance among Bacteroides species and Parabacteroides species in the United States from 2010-2012 with comparison to 2008-2009.
[So] Source:Anaerobe;43:21-26, 2017 Feb.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The susceptibility trends for Bacteroides fragilis and related species against various antibiotics were determined using data from 3 years of surveillance (2010-2012) on 779 isolates referred by 7 medical centers. The antibiotic test panel included imipenem, ertapenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefoxitin, clindamycin, moxifloxacin, tigecycline, linezolid, chloramphenicol and . MICs were determined using the agar dilution CLSI reference method. Carbapenem resistance remained low (range 1.1%-2.5%) and unchanged from 2008 to 9 through 2010-2012. Resistance also remained low to the beta-lactam/beta-lactamase inhibitor combinations (1.1%-4.4%). While resistance to clindamycin and moxifloxacin remained high; rates were lower for B. fragilis in 2010-12 (24% and 19% respectively) compared to the earlier time frame of 2008-9 (29% and 35% respectively for the earlier time frame). There were notable species and resistance associations which have been demonstrated previously. No resistance to metronidazole or chloramphenicol resistance was seen. These data demonstrate the continued variability in resistance among Bacteroides and Parabacteroides species, but do demonstrate that carbapenems and beta-lactam/beta-lactamase inhibitor combinations remain very active throughout the United States.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Infecções por Bacteroides/tratamento farmacológico
Bacteroidetes/efeitos dos fármacos
Carbapenêmicos/farmacologia
Resistência Microbiana a Medicamentos
Inibidores de beta-Lactamases/farmacologia
[Mh] Termos MeSH secundário: Bacteroides/efeitos dos fármacos
Infecções por Bacteroides/microbiologia
Bacteroides fragilis/efeitos dos fármacos
Seres Humanos
Testes de Sensibilidade Microbiana
Ácido Penicilânico/análogos & derivados
Ácido Penicilânico/farmacologia
Piperacilina/farmacologia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Carbapenems); 0 (beta-Lactamase Inhibitors); 157044-21-8 (piperacillin, tazobactam drug combination); 87-53-6 (Penicillanic Acid); X00B0D5O0E (Piperacillin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


  6 / 2427 MEDLINE  
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[PMID]:27852672
[Au] Autor:Ho PL; Ho LY; Yau CY; Tong MK; Chow KH
[Ad] Endereço:Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China plho@hkucc.hku.hk.
[Ti] Título:A Novel Selective Medium for Isolation of Bacteroides fragilis from Clinical Specimens.
[So] Source:J Clin Microbiol;55(2):384-390, 2017 Feb.
[Is] ISSN:1098-660X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel Bacteroides fragilis selective (BFS) medium, consisting of a brain heart infusion agar base supplemented with yeast extract, cysteine hydrochloride, bile salts, vitamin K, hemin, glucose, esculin, ferric ammonium citrate, bromothymol blue, gentamicin, kanamycin, and novobiocin, was evaluated. When BFS agar was tested with a collection of 303 bacteria of different genera, it allowed the growth of B. fragilis as large yellow colonies, with blackening of the medium after 48 h of anaerobic incubation, while the growth of most other anaerobes, facultative anaerobes, and aerobes was inhibited. In a prospective comparison of BFS agar with a routinely used medium (neomycin blood agar) in 1,209 clinical specimens, 60 B. fragilis bacteria were detected on BFS agar while 46 were detected on the routine agar (McNemar's test, P = 0.008). In conclusion, this novel medium may be added to improve the recovery of B. fragilis in clinical specimens and to facilitate surveillance of antimicrobial-resistant strains.
[Mh] Termos MeSH primário: Técnicas Bacteriológicas/métodos
Infecções por Bacteroides/diagnóstico
Bacteroides fragilis/crescimento & desenvolvimento
Bacteroides fragilis/isolamento & purificação
Meios de Cultura/química
[Mh] Termos MeSH secundário: Anaerobiose
Infecções por Bacteroides/microbiologia
Seres Humanos
Seleção Genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1128/JCM.01988-16


  7 / 2427 MEDLINE  
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[PMID]:27713022
[Au] Autor:Goldstein EJ; Citron DM; Tyrrell KL; Leoncio ES; Merriam CV
[Ad] Endereço:R. M. Alden Research Laboratory, Culver City, CA 90230, USA; The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: ejcgmd@aol.com.
[Ti] Título:The underappreciated in vitro activity of tedizolid against Bacteroides fragilis species, including strains resistant to metronidazole and carbapenems.
[So] Source:Anaerobe;43:1-3, 2017 Feb.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Because Bacteroides fragilis has the ability to develop mechanisms of resistance to almost all antibiotics, we studied the comparative in vitro activity of tedizolid against 124 Bacteroides group species clinical isolates, including carbapenem, metronidazole and piperacillin-tazobactam resistant strains. Tedizolid had an MIC of 2 µg/ml (range, 0.5-4 µg/ml) and was 1-4 times more active than linezolid that had an MIC of 8 µg/ml (range, 2-16 µg/ml). It was also active (MICs 0.5-2 µg/ml) against the 27 ertapenem, 2 metronidazole and 12 piperacillin-tazobactam resistant strains tested. This suggests that tedizolid may be useful treating infections, including bacteremias, due to resistant B. fragilis group species, as well as, mixed skin and soft tissue infections such as diabetic foot infections caused by Gram-positive aerobes and B. fragilis group species.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Infecções por Bacteroides/tratamento farmacológico
Infecções por Bacteroides/microbiologia
Bacteroides fragilis/efeitos dos fármacos
Farmacorresistência Bacteriana Múltipla
Oxazolidinonas/farmacologia
Tetrazóis/farmacologia
[Mh] Termos MeSH secundário: Bacteroides fragilis/isolamento & purificação
Carbapenêmicos/farmacologia
Seres Humanos
Metronidazol/farmacologia
Testes de Sensibilidade Microbiana
Ácido Penicilânico/análogos & derivados
Ácido Penicilânico/farmacologia
Piperacilina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carbapenems); 0 (Oxazolidinones); 0 (Tetrazoles); 140QMO216E (Metronidazole); 157044-21-8 (piperacillin, tazobactam drug combination); 87-53-6 (Penicillanic Acid); 97HLQ82NGL (torezolid); X00B0D5O0E (Piperacillin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


  8 / 2427 MEDLINE  
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[PMID]:27301879
[Au] Autor:Thiele Orberg E; Fan H; Tam AJ; Dejea CM; Destefano Shields CE; Wu S; Chung L; Finard BB; Wu X; Fathi P; Ganguly S; Fu J; Pardoll DM; Sears CL; Housseau F
[Ad] Endereço:Oncology Department, Johns Hopkins University, Baltimore, Maryland, USA.
[Ti] Título:The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.
[So] Source:Mucosal Immunol;10(2):421-433, 2017 Mar.
[Is] ISSN:1935-3456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17 (IL-17)-dependent colon tumorigenesis in Min mice. We examined the role of IL-17 and ETBF on the differentiation of myeloid cells into myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages, which are known to promote tumorigenesis. The myeloid compartment associated with ETBF-induced colon tumorigenesis in Min mice was defined using flow cytometry and gene expression profiling. Cell-sorted immature myeloid cells were functionally assayed for inhibition of T-cell proliferation and inducible nitric oxide synthase expression to delineate MDSC populations. A comparison of ETBF infection with that of other oncogenic bacteria (Fusobacterium nucleatum or pks Escherichia coli) revealed a specific, ETBF-associated colonic immune infiltrate. ETBF-triggered colon tumorigenesis is associated with an IL-17-driven myeloid signature characterized by subversion of steady-state myelopoiesis in favor of the generation of protumoral monocytic-MDSCs (MO-MDSCs). Combined action of the B. fragilis enterotoxin BFT and IL-17 on colonic epithelial cells promoted the differentiation of MO-MDSCs, which selectively upregulated Arg1 and Nos2, produced NO, and suppressed T-cell proliferation. Evidence of a pathogenic inflammatory signature in humans colonized with ETBF may allow for the identification of populations at risk for developing colon cancer.
[Mh] Termos MeSH primário: Infecções por Bacteroides/imunologia
Bacteroides fragilis/imunologia
Colo/microbiologia
Neoplasias Colorretais/imunologia
Células Epiteliais/imunologia
Células Supressoras Mieloides/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Arginase/genética
Arginase/metabolismo
Toxinas Bacterianas/imunologia
Carcinogênese
Diferenciação Celular
Proliferação Celular
Células Cultivadas
Colo/imunologia
Colo/patologia
Neoplasias Colorretais/genética
Modelos Animais de Doenças
Genes APC
Seres Humanos
Tolerância Imunológica
Interleucina-17/metabolismo
Metaloendopeptidases/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Mutantes
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins); 0 (Interleukin-17); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 3.4.24.- (Bacteroides fragilis toxin); EC 3.4.24.- (Metalloendopeptidases); EC 3.5.3.1 (Arg1 protein, mouse); EC 3.5.3.1 (Arginase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.1038/mi.2016.53


  9 / 2427 MEDLINE  
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[PMID]:25648668
[Au] Autor:Ji DD; Huang IH; Lai CC; Wu FT; Jiang DD; Hsu BM; Lin WC
[Ad] Endereço:Department of Tropical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Research and Diagnostics, Centers for Disease Control, Department of Health, Taiwan, ROC.
[Ti] Título:Prevalence and characterization of enterotoxigenic Bacteroides fragilis and toxigenic Clostridium difficile in a Taipei emergency department.
[So] Source:J Microbiol Immunol Infect;50(1):83-89, 2017 Feb.
[Is] ISSN:1995-9133
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/PURPOSE: Enterotoxigenic Bacteroides fragilis (ETBF) and toxin-encoding Clostridium difficile (TXCD) are associated with gastroenteritis. Routine anaerobic blood culture for recovery of these anaerobic pathogens is not used for the detection of their toxins, especially for toxin-variant TXCD. The aim of this study was to investigate the prevalence and risk factors of the genotypes of these anaerobes in patients with acute diarrheal illnesses. METHODS: The data and samples of 513 patients with gastroenteritis were collected in a Taipei emergency department from March 1, 2006 to December 31, 2009. Nonenterotoxigenic B. fragilis (NTBF) and ETBF and the toxin genotypes of TXCD were detected by molecular methods. RESULTS: The prevalence rates of NTBF, ETBF, and TXCD infections were 33.14%, 1.56%, and 2.34%, respectively. ETBF infections often occurred in the elderly (average age = 67.13 years) and during the cold, dry winters. TXCD infections were widely distributed in age and often occurred in the warm, wet springs and summers. The symptoms of ETBF-infected patients were significantly more severe than those of NTBF-infected patients. CONCLUSION: This study identified and analyzed the prevalence, risk factors, and clinical presentations of these anaerobic infections. Future epidemiologic and clinical studies are needed to understand the role of ETBF and TXCD in human gastroenteritis.
[Mh] Termos MeSH primário: Toxinas Bacterianas/análise
Infecções por Bacteroides/epidemiologia
Bacteroides fragilis/isolamento & purificação
Infecções por Clostridium/epidemiologia
Clostridium difficile/isolamento & purificação
Diarreia/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Toxinas Bacterianas/genética
Infecções por Bacteroides/microbiologia
Bacteroides fragilis/metabolismo
Infecções por Clostridium/microbiologia
Clostridium difficile/metabolismo
Diarreia/microbiologia
Serviço Hospitalar de Emergência
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Estações do Ano
Taiwan/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150205
[St] Status:MEDLINE


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Fotocópia
[PMID]:27904124
[Au] Autor:Fukuchi T; Kawasaki S; Hayashi H; Koreeda D; Ashikawa T
[Ad] Endereço:Division of Internal Medicine, National Hospital Organization Minami-Wakayama Medical Center, Japan.
[Ti] Título:Mycotic Aneurysm Caused by Bacteroides fragilis in an Elderly Immunosuppressed Patient.
[So] Source:Intern Med;55(23):3535-3538, 2016.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:An 82-year-old Japanese man, who presented with a fever and abdominal pain, was admitted to our hospital. According to enhanced computed tomography images, the probable diagnosis was abdominal aortic mycotic aneurysm. Eight sets of blood cultures obtained from the patient were negative. Despite administering treatment with vancomycin and ceftriaxone, the aneurysm progressively enlarged. He underwent open debridement surgery and in situ replacement because of an aneurysmal rupture. Bacteroides fragilis was isolated from the tissue culture of the aortic wall. Metronidazole was administered and discontinued without any infection relapse. When faced with similar cases, rare pathogens should thus be considered as possible causes of mycotic aneurysms.
[Mh] Termos MeSH primário: Aneurisma Infectado/diagnóstico
Aneurisma da Aorta Abdominal/diagnóstico
Infecções por Bacteroides/diagnóstico
Bacteroides fragilis/isolamento & purificação
Hospedeiro Imunocomprometido
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Aneurisma Infectado/microbiologia
Aneurisma da Aorta Abdominal/microbiologia
Infecções por Bacteroides/microbiologia
Evolução Fatal
Seres Humanos
Masculino
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE



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