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  1 / 1158 MEDLINE  
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[PMID]:29073136
[Au] Autor:Harms A; Liesch M; Körner J; Québatte M; Engel P; Dehio C
[Ad] Endereço:Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland.
[Ti] Título:A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella.
[So] Source:PLoS Genet;13(10):e1007077, 2017 Oct.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Host-targeting type IV secretion systems (T4SS) evolved from conjugative T4SS machineries that mediate interbacterial plasmid transfer. However, the origins of effectors secreted by these virulence devices have remained largely elusive. Previous work showed that some effectors exhibit homology to toxins of bacterial toxin-antitoxin modules, but the evolutionary trajectories underlying these ties had not been resolved. We previously reported that FicT toxins of FicTA toxin-antitoxin modules disrupt cellular DNA topology via their enzymatic FIC (filamentation induced by cAMP) domain. Intriguingly, the FIC domain of the FicT toxin VbhT of Bartonella schoenbuchensis is fused to a type IV secretion signal-the BID (Bep intracellular delivery) domain-similar to the Bartonella effector proteins (Beps) that are secreted into eukaryotic host cells via the host-targeting VirB T4SS. In this study, we show that the VbhT toxin is an interbacterial effector protein secreted via the conjugative Vbh T4SS that is closely related to the VirB T4SS and encoded by plasmid pVbh of B. schoenbuchensis. We therefore propose that the Vbh T4SS together with its effector VbhT represent an evolutionary missing link on a path that leads from a regular conjugation system and FicTA toxin-antitoxin modules to the VirB T4SS and the Beps. Intriguingly, phylogenetic analyses revealed that the fusion of FIC and BID domains has probably occurred independently in VbhT and the common ancestor of the Beps, suggesting parallel evolutionary paths. Moreover, several other examples of TA module toxins that are bona fide substrates of conjugative T4SS indicate that their recruitment as interbacterial effectors is prevalent and serves yet unknown biological functions in the context of bacterial conjugation. We propose that the adaptation for interbacterial transfer favors the exaptation of FicT and other TA module toxins as inter-kingdom effectors and may thus constitute an important stepping stone in the evolution of host-targeted effector proteins.
[Mh] Termos MeSH primário: Antitoxinas/metabolismo
Sistemas de Secreção Bacterianos/genética
Sistemas de Secreção Bacterianos/metabolismo
Toxinas Bacterianas/metabolismo
Bartonella/genética
Bartonella/patogenicidade
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Antitoxinas/genética
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Toxinas Bacterianas/genética
Infecções por Bartonella/microbiologia
Conjugação Genética
Regulação Bacteriana da Expressão Gênica
Interações Hospedeiro-Patógeno
Plasmídeos
Homologia de Sequência
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitoxins); 0 (Bacterial Proteins); 0 (Bacterial Secretion Systems); 0 (Bacterial Toxins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007077


  2 / 1158 MEDLINE  
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[PMID]:28727827
[Au] Autor:McKee CD; Kosoy MY; Bai Y; Osikowicz LM; Franka R; Gilbert AT; Boonmar S; Rupprecht CE; Peruski LF
[Ad] Endereço:Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States of America.
[Ti] Título:Diversity and phylogenetic relationships among Bartonella strains from Thai bats.
[So] Source:PLoS One;12(7):e0181696, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bartonellae are phylogenetically diverse, intracellular bacteria commonly found in mammals. Previous studies have demonstrated that bats have a high prevalence and diversity of Bartonella infections globally. Isolates (n = 42) were obtained from five bat species in four provinces of Thailand and analyzed using sequences of the citrate synthase gene (gltA). Sequences clustered into seven distinct genogroups; four of these genogroups displayed similarity with Bartonella spp. sequences from other bats in Southeast Asia, Africa, and Eastern Europe. Thirty of the isolates representing these seven genogroups were further characterized by sequencing four additional loci (ftsZ, nuoG, rpoB, and ITS) to clarify their evolutionary relationships with other Bartonella species and to assess patterns of diversity among strains. Among the seven genogroups, there were differences in the number of sequence variants, ranging from 1-5, and the amount of nucleotide divergence, ranging from 0.035-3.9%. Overall, these seven genogroups meet the criteria for distinction as novel Bartonella species, with sequence divergence among genogroups ranging from 6.4-15.8%. Evidence of intra- and intercontinental phylogenetic relationships and instances of homologous recombination among Bartonella genogroups in related bat species were found in Thai bats.
[Mh] Termos MeSH primário: Infecções por Bartonella/veterinária
Bartonella/genética
Quirópteros/microbiologia
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Biodiversidade
Citrato (si)-Sintase/genética
Filogenia
Polimorfismo Genético
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); EC 2.3.3.1 (Citrate (si)-Synthase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181696


  3 / 1158 MEDLINE  
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[PMID]:28722567
[Au] Autor:Stuckey MJ; Chomel BB; Galvez-Romero G; Olave-Leyva JI; Obregón-Morales C; Moreno-Sandoval H; Aréchiga-Ceballos N; Salas-Rojas M; Aguilar-Setién A
[Ad] Endereço:Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California.
[Ti] Título: Infection in Hematophagous, Insectivorous, and Phytophagous Bat Populations of Central Mexico and the Yucatan Peninsula.
[So] Source:Am J Trop Med Hyg;97(2):413-422, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although emerging nonviral pathogens remain relatively understudied in bat populations, there is an increasing focus on identifying bat-associated bartonellae around the world. Many novel strains have been described from both bats and their arthropod ectoparasites, including , a zoonotic agent of human endocarditis. This cross-sectional study was designed to describe novel strains isolated from bats sampled in Mexico and evaluate factors potentially associated with infection. A total of 238 bats belonging to seven genera were captured in five states of Central Mexico and the Yucatan Peninsula. Animals were screened by bacterial culture from whole blood and/or polymerase chain reaction of DNA extracted from heart tissue or blood. spp. were isolated or detected in 54 (22.7%) bats, consisting of 41 (38%) hematophagous, 10 (16.4%) insectivorous, and three (4.3%) phytophagous individuals. This study also identified as another possible bat reservoir of . Univariate and multivariate logistic regression models suggested that infection was positively associated with blood-feeding diet and ectoparasite burden. Phylogenetic analysis identified a number of genetic variants across hematophagous, phytophagous, and insectivorous bats that are unique from described bat-borne species. However, these strains were closely related to those bartonellae previously identified in bat species from Latin America.
[Mh] Termos MeSH primário: Infecções por Bartonella/genética
Infecções por Bartonella/microbiologia
Bartonella/genética
Bartonella/isolamento & purificação
Quirópteros/microbiologia
[Mh] Termos MeSH secundário: Animais
Estudos Transversais
Variação Genética
México
Filogenia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0680


  4 / 1158 MEDLINE  
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[PMID]:28633264
[Au] Autor:Schnitzer K; Or Z; Sawaed S; Sharoni E; Bisharat N
[Ad] Endereço:Department of Medicine D, Emek Medical Center, Afula, Israel.
[Ti] Título:Rapidly Progressive Bioprosthetic Aortic Valve Stenosis Due to Bartonella Species Endocarditis.
[So] Source:Ann Thorac Surg;104(1):e57-e59, 2017 Jul.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Rapid progression of valvular stenosis in the setting of infective endocarditis is extremely rare. Here we describe a patient with Bartonella endocarditis on a bioprosthetic aortic valve that caused rapidly progressive aortic stenosis without regurgitation. At operation the bioprosthetic valve was severely fibrotic and calcified, with markedly thickened and distorted leaflets and circular partial detachment from the aortic ring. The patient underwent aortic root replacement with aortic bioprosthesis and aortic grafting with reimplantation of the coronary ostia.
[Mh] Termos MeSH primário: Estenose da Valva Aórtica/etiologia
Infecções por Bartonella/complicações
Bartonella/isolamento & purificação
Bioprótese/efeitos adversos
Endocardite Bacteriana/complicações
Infecções Relacionadas à Prótese/complicações
[Mh] Termos MeSH secundário: Idoso
Estenose da Valva Aórtica/diagnóstico
Estenose da Valva Aórtica/cirurgia
Infecções por Bartonella/diagnóstico
Infecções por Bartonella/microbiologia
Progressão da Doença
Ecocardiografia Transesofagiana
Endocardite Bacteriana/diagnóstico
Endocardite Bacteriana/microbiologia
Feminino
Seres Humanos
Infecções Relacionadas à Prótese/diagnóstico
Infecções Relacionadas à Prótese/microbiologia
Recidiva
Reoperação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE


  5 / 1158 MEDLINE  
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[PMID]:28628613
[Au] Autor:Pons MJ; Gomes C; Aguilar R; Barrios D; Aguilar-Luis MA; Ruiz J; Dobaño C; Del Valle-Mendoza J; Moncunill G
[Ad] Endereço:Centro de Investigación e Innovación de la Facultad de Ciencias de la Salud de la Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
[Ti] Título:Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru.
[So] Source:PLoS Negl Trop Dis;11(6):e0005684, 2017 Jun.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Analysis of immune responses in Bartonella bacilliformis carriers are needed to understand acquisition of immunity to Carrion's disease and may allow identifying biomarkers associated with bacterial infection and disease phases. Serum samples from 144 healthy subjects from 5 villages in the North of Peru collected in 2014 were analyzed. Four villages had a Carrion's disease outbreak in 2013, and the other is a traditionally endemic area. Thirty cytokines, chemokines and growth factors were determined in sera by fluorescent bead-based quantitative suspension array technology, and analyzed in relation to available data on bacteremia quantified by RT-PCR, and IgM and IgG levels measured by ELISA against B. bacilliformis lysates. The presence of bacteremia was associated with low concentrations of HGF (p = 0.005), IL-15 (p = 0.002), IL-6 (p = 0.05), IP-10 (p = 0.008), MIG (p = 0.03) and MIP-1α (p = 0.03). In multi-marker analysis, the same and further TH1-related and pro-inflammatory biomarkers were inversely associated with infection, whereas angiogenic chemokines and IL-10 were positively associated. Only EGF and eotaxin showed a moderate positive correlation with bacteremia. IgM seropositivity, which reflects a recent acute infection, was associated with lower levels of eotaxin (p = 0.05), IL-6 (p = 0.001), and VEGF (p = 0.03). Only GM-CSF and IL-10 concentrations were positively associated with higher levels of IgM (p = 0.01 and p = 0.007). Additionally, IgG seropositivity and levels were associated with high levels of angiogenic markers VEGF (p = 0.047) and eotaxin (p = 0.006), respectively. Our findings suggest that B. bacilliformis infection causes immunosuppression, led in part by overproduction of IL-10. This immunosuppression probably contributes to the chronicity of asymptomatic infections favoring B. bacilliformis persistence in the host, allowing the subsequent transmission to the vector. In addition, angiogenic markers associated with bacteremia and IgG levels may be related to the induction of endothelial cell proliferation in cutaneous lesions during chronic infections, being possible candidate biomarkers of asymptomatic infections.
[Mh] Termos MeSH primário: Infecções por Bartonella/imunologia
Infecções por Bartonella/patologia
Bartonella bacilliformis/imunologia
Portador Sadio/imunologia
Citocinas/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antibacterianos/sangue
Bacteriemia/imunologia
Bacteriemia/patologia
Criança
Pré-Escolar
DNA Bacteriano/análise
DNA Bacteriano/genética
Feminino
Seres Humanos
Imunoensaio
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Lactente
Recém-Nascido
Masculino
Meia-Idade
Peru
Reação em Cadeia da Polimerase em Tempo Real
População Rural
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Cytokines); 0 (DNA, Bacterial); 0 (Immunoglobulin G); 0 (Immunoglobulin M)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005684


  6 / 1158 MEDLINE  
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[PMID]:28541836
[Au] Autor:Alsarraf M; Mohallal EME; Mierzejewska EJ; Behnke-Borowczyk J; Welc-Faleciak R; Bednarska M; Dziewit L; Zalat S; Gilbert F; Behnke JM; Bajer A
[Ad] Endereço:1 Department of Parasitology, Faculty of Biology, Institute of Zoology, University of Warsaw , Warsaw, Poland .
[Ti] Título:Description of Candidatus Bartonella fadhilae n. sp. and Candidatus Bartonella sanaae n. sp. (Bartonellaceae) from Dipodillus dasyurus and Sekeetamys calurus (Gerbillinae) from the Sinai Massif (Egypt).
[So] Source:Vector Borne Zoonotic Dis;17(7):483-494, 2017 Jul.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bartonella spp. are parasites of mammalian erythrocytes and endothelial cells, transmitted by blood-feeding arthropod ectoparasites. Different species of rodents may constitute the main hosts of Bartonella, including several zoonotic species of Bartonella. The aim of this study was to identify and compare Bartonella species and genotypes isolated from rodent hosts from the South Sinai, Egypt. Prevalence of Bartonella infection was assessed in rodents (837 Acomys dimidiatus, 73 Acomys russatus, 111 Dipodillus dasyurus, and 65 Sekeetamys calurus) trapped in 2000, 2004, 2008, and 2012 in four dry montane wadis around St. Katherine town in the Sinai Mountains. Total DNA was extracted from blood samples, and PCR amplification and sequencing of the Bartonella-specific 860-bp gene fragment of rpoB and the 810-bp gene fragment of gltA were used for molecular and phylogenetic analyses. The overall prevalence of Bartonella in rodents was 7.2%. Prevalence differed between host species, being 30.6%, 10.8%, 9.6%, and 3.6% in D. dasyurus, S. calurus, A. russatus, and A. dimidiatus, respectively. The phylogenetic analyses of six samples of Bartonella (five from D. dasyurus and one from S. calurus) based on a fragment of the rpoB gene, revealed the existence of two distinct genetic groups (with 95-96% reciprocal sequence identity), clustering with several unidentified isolates obtained earlier from the same rodent species, and distant from species that have already been described (90-92% of sequence identity to the closest match from the GenBank reference database). Thus, molecular and phylogenetic analyses led to the description of two species: Candidatus Bartonella fadhilae n. sp. and Candidatus Bartonella sanaae n. sp. The identification of their vectors and the medical significance of these species need further investigation.
[Mh] Termos MeSH primário: Infecções por Bartonella/veterinária
Bartonella/classificação
Gerbillinae/microbiologia
[Mh] Termos MeSH secundário: Animais
Bartonella/genética
Bartonella/isolamento & purificação
Infecções por Bartonella/epidemiologia
Infecções por Bartonella/microbiologia
DNA Bacteriano
Egito/epidemiologia
Genótipo
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2016.2093


  7 / 1158 MEDLINE  
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[PMID]:28502279
[Au] Autor:Ikeda P; Seki MC; Carrasco AOT; Rudiak LV; Miranda JMD; Gonçalves SMM; Hoppe EGL; Albuquerque ACA; Teixeira MMG; Passos CE; Werther K; Machado RZ; André MR
[Ad] Endereço:Faculdade de Ciências Agrárias e Veterinárias,Universidade Estadual Paulista (Unesp),Jaboticabal, SP,Brazil.
[Ti] Título:Evidence and molecular characterization of Bartonella spp. and hemoplasmas in neotropical bats in Brazil.
[So] Source:Epidemiol Infect;145(10):2038-2052, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The order Chiroptera is considered the second largest group of mammals in the world, hosting important zoonotic virus and bacteria. Bartonella and hemotropic mycoplasmas are bacteria that parasite different mammals' species, including humans, causing different clinical manifestations. The present work aimed investigating the occurrence and assessing the phylogenetic positioning of Bartonella spp. and Mycoplasma spp. in neotropical bats sampled from Brazil. Between December 2015 and April 2016, 325 blood and/or tissues samples were collected from 162 bats comprising 19 different species sampled in five states of Brazil. Out of 322 bat samples collected, while 17 (5·28%) were positive to quantitative PCR for Bartonella spp. based on nuoG gene, 45 samples (13·97%) were positive to cPCR assays for hemoplasmas based on 16S rRNA gene. While seven sequences were obtained for Bartonella (nuoG) (n = 3), gltA (n = 2), rpoB (n = 1), ftsZ (n = 1), five 16S rRNA sequences were obtained for hemoplasmas. In the phylogenetic analysis, the Bartonella sequences clustered with Bartonella genotypes detected in bats sampled in Latin America countries. All five hemoplasmas sequences clustered together as a monophyletic group by Maximum Likelihood and Bayesian Inference analyses. The present work showed the first evidence of circulation of Bartonella spp. and hemoplasmas among bats in Brazil.
[Mh] Termos MeSH primário: Infecções por Bartonella/veterinária
Bartonella/genética
Quirópteros
Infecções por Mycoplasma/veterinária
Mycoplasma/genética
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Bartonella/isolamento & purificação
Infecções por Bartonella/epidemiologia
Infecções por Bartonella/microbiologia
Brasil/epidemiologia
DNA Bacteriano/genética
Mycoplasma/isolamento & purificação
Infecções por Mycoplasma/epidemiologia
Infecções por Mycoplasma/microbiologia
Filogenia
Análise de Sequência de DNA/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (DNA, Bacterial)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000966


  8 / 1158 MEDLINE  
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[PMID]:28490579
[Au] Autor:Okaro U; Addisu A; Casanas B; Anderson B
[Ad] Endereço:Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
[Ti] Título:Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis.
[So] Source:Clin Microbiol Rev;30(3):709-746, 2017 Jul.
[Is] ISSN:1098-6618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since the reclassification of the genus in 1993, the number of species has grown from 1 to 45 currently designated members. Likewise, the association of different species with human disease continues to grow, as does the range of clinical presentations associated with these bacteria. Among these, blood-culture-negative endocarditis stands out as a common, often undiagnosed, clinical presentation of infection with several different species. The limitations of laboratory tests resulting in this underdiagnosis of endocarditis are discussed. The varied clinical picture of infection and a review of clinical aspects of endocarditis caused by are presented. We also summarize the current knowledge of the molecular basis of pathogenesis, focusing on surface adhesins in the two species that most commonly cause endocarditis, and . We discuss evidence that surface adhesins are important factors for autoaggregation and biofilm formation by species. Finally, we propose that biofilm formation is a critical step in the formation of vegetative masses during -mediated endocarditis and represents a potential reservoir for persistence by these bacteria.
[Mh] Termos MeSH primário: Infecções por Bartonella/microbiologia
Bartonella/fisiologia
Endocardite/microbiologia
[Mh] Termos MeSH secundário: Infecções por Bartonella/sangue
Infecções por Bartonella/diagnóstico
Infecções por Bartonella/patologia
Endocardite/sangue
Endocardite/diagnóstico
Endocardite/patologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1128/CMR.00013-17


  9 / 1158 MEDLINE  
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[PMID]:28418306
[Au] Autor:Papineni P; Carroll A; Radvan J; Hemsley C; Chambers J; Cortes N; Harrison T; Klein JL
[Ti] Título:Management of Bartonella Prosthetic Valve Endocarditis without Cardiac Surgery.
[So] Source:Emerg Infect Dis;23(5):861-863, 2017 05.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two cases of Bartonella prosthetic valve endocarditis were cured when treated for 2 weeks with gentamicin and 3 months with doxycycline. Clinical cure correlated with decreased Bartonella antibody titers. This report suggests a strategy to monitor, treat, and cure Bartonella prosthetic valve endocarditis.
[Mh] Termos MeSH primário: Infecções por Bartonella/complicações
Infecções por Bartonella/microbiologia
Bartonella
Endocardite Bacteriana/etiologia
Endocardite Bacteriana/terapia
Próteses Valvulares Cardíacas/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/administração & dosagem
Antibacterianos/uso terapêutico
Bartonella/genética
Bartonella/imunologia
Infecções por Bartonella/diagnóstico
Gerenciamento Clínico
Endocardite Bacteriana/diagnóstico
Feminino
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.3201/eid2305.161238


  10 / 1158 MEDLINE  
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[PMID]:28399271
[Au] Autor:Palomar AM; Cevidanes A; Portillo A; Kalema-Zikusoka G; Chirife AD; Romero L; Muro J; Mugisha L; Oteo JA; Millán J
[Ad] Endereço:Center of Rickettsiosis and Arthropod-Borne Diseases, Hospital San Pedro-CIBIR, Logroño, Spain.
[Ti] Título:High Prevalence of Rickettsia spp. in Dog Fleas (Siphonaptera: Pulicidae) in Rural Uganda.
[So] Source:J Med Entomol;54(4):1076-1079, 2017 Jul 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fleas are known vectors of zoonotic agents. Thirty-five fleas, including 28 Ctenocephalides felis (Bouché), four Pulex irritans (L.), and three Echidnophaga gallinacea (Westwood) from 19 rural dogs from southwestern Uganda were analyzed for the presence of Rickettsia spp. (ompB, gltA, and 17 kDa fragment genes) and Bartonella spp. (rpoB and ITS genes) by PCR. Rickettsial DNA was detected in 27 out of 28 of Ct. felis and in two out of four P. irritans. None of the E. gallinacea specimens harbored Rickettsia DNA. Rickettsia felis was confirmed in 12 Ct. felis and in the two P. irritans specimens with positive PCR-results. In addition, the presence of Candidatus Rickettsia asemboensis was evidenced in 15 Ct. felis. Bartonella spp. was not amplified in any sample. Our survey indicates that R. felis, the agent of the flea-borne spotted fever, is present in the study area. Besides, this is the first description of Ca. R. asemboensis in Uganda.
[Mh] Termos MeSH primário: Infecções por Bartonella/veterinária
Doenças do Cão/epidemiologia
Infestações por Pulgas/veterinária
Infecções por Rickettsia/veterinária
Sifonápteros/microbiologia
[Mh] Termos MeSH secundário: Animais
Bartonella/isolamento & purificação
Infecções por Bartonella/epidemiologia
Infecções por Bartonella/microbiologia
DNA Bacteriano/genética
Doenças do Cão/microbiologia
Doenças do Cão/parasitologia
Cães
Infestações por Pulgas/epidemiologia
Infestações por Pulgas/parasitologia
Prevalência
Rickettsia/isolamento & purificação
Infecções por Rickettsia/epidemiologia
Infecções por Rickettsia/microbiologia
Análise de Sequência de DNA
Sifonápteros/classificação
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjx048



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