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[PMID]:29369209
[Au] Autor:Wang Y; Tang XY; Yuan J; Wu SQ; Chen G; Zhang MM; Wang MG; Zhang WY; He JQ
[Ad] Endereço:Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
[Ti] Título:Bone marrow granulomas in a high tuberculosis prevalence setting: A clinicopathological study of 110 cases.
[So] Source:Medicine (Baltimore);97(4):e9726, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Granulomas were reported in 0.3% to 3% of bone marrow biopsies. The aim of the study was to evaluate the incidence and etiology of bone marrow granulomas (BMGs) in the West China Hospital, which located at a high tuberculosis (TB) prevalence area in China.A retrospective case review was performed on 11,339 bone marrow biopsies at the West China Hospital of Sichuan University between January 2011 and December 2015. Cases with BMGs were retrieved and their clinical data and histopathological features were collected, examined, and analyzed.Out of 11,339, 110 cases showed granulomatous lesions in the bone marrow biopsies (0.97%). Etiologies were indentified in 80 cases (72.8%), with infections being the most common (64.5%), following by malignancies (4.5%) and autoimmune diseases (3.6%). Among infectious cases, 87.32% (62/71) cases were diagnosed as TB, a positive acid-fast stain or/and polymerase chain reaction (PCR) result for mycobacterium TB DNA fragment amplification was obtained for 35 cases. In 30 cases (27.27%), a definite diagnosis could not be established.In a TB high prevalence region in China, with a combined histological, clinical, serological, and molecular approach, we were able to clarify the cause in 72.73% of the bone marrow granulomatous cases. TB is the most common underlying etiologies. Therefore, acid-fast stain and quantitative PCR for mycobacterium TB DNA amplification are recommended as a routine for bone marrow biopsies in TB high prevalence regions.
[Mh] Termos MeSH primário: Doenças da Medula Óssea/etiologia
Granuloma/etiologia
Tuberculose Pulmonar/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Doenças da Medula Óssea/diagnóstico
Doenças da Medula Óssea/epidemiologia
Brucelose/diagnóstico
China/epidemiologia
Diagnóstico Diferencial
Feminino
Granuloma/diagnóstico
Granuloma/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Micoses/diagnóstico
Prevalência
Estudos Retrospectivos
Tuberculose Pulmonar/complicações
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009726


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[PMID]:29254496
[Au] Autor:Villalobos-Vindas JM; Amuy E; Barquero-Calvo E; Rojas N; Chacón-Díaz C; Chaves-Olarte E; Guzman-Verri C; Moreno E
[Ad] Endereço:Caja Costarricense de Seguro Social, San José, Costa Rica.
[Ti] Título:Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports.
[So] Source:J Med Case Rep;11(1):352, 2017 Dec 19.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified two brucellosis human cases caused by B. neotomae, demonstrating that this species has zoonotic potential. CASES PRESENTATION: Within almost 4 years of each other, a 64-year-old Costa Rican white Hispanic man and a 51-year-old Costa Rican white Hispanic man required medical care at public hospitals of Costa Rica. Their hematological and biochemical parameters were within normal limits. No adenopathies or visceral abnormalities were found. Both patients showed intermittent fever, disorientation, and general malaise and a positive Rose Bengal test compatible with Brucella infection. Blood and cerebrospinal fluid cultures rendered Gram-negative coccobacilli identified by genomic analysis as B. neotomae. After antibiotic treatment, the patients recovered with normal mental activities. CONCLUSIONS: This is the first report describing in detail the clinical disease caused by B. neotomae in two unrelated patients. In spite of previous claims, this bacterium keeps zoonotic potential. Proposals to generate vaccines by using B. neotomae as an immunogen must be reexamined and countries housing the natural reservoir must consider the zoonotic risk.
[Mh] Termos MeSH primário: Brucelose/diagnóstico
Infecções do Sistema Nervoso Central/diagnóstico
[Mh] Termos MeSH secundário: Brucella
Confusão/etiologia
Costa Rica
Febre/etiologia
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1496-8


  3 / 7569 MEDLINE  
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[PMID]:29255538
[Au] Autor:Ayoola MC; Akinseye VO; Cadmus E; Awosanya E; Popoola OA; Akinyemi OO; Perrett L; Taylor A; Stack J; Moriyon I; Cadmus SI
[Ad] Endereço:Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
[Ti] Título:Prevalence of bovine brucellosis in slaughtered cattle and barriers to better protection of abattoir workers in Ibadan, South-Western Nigeria.
[So] Source:Pan Afr Med J;28:68, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: Brucellosis is a neglected zoonosis of public health importance. This study was conducted to determine the prevalence and risk factors of brucellosis among slaughtered cattle as well as challenges to the protection of abattoir workers in Nigeria. Methods: A slaughterhouse study was conducted in a major abattoir in Ibadan from March to August, 2013. To diagnose brucellosis, serum samples from 1,241 slaughtered cattle were tested using Rose-Bengal test (RBT) and competitive enzyme-linked immunosorbent assay (cELISA); again, 57 milk samples were tested with milk ring test (MRT) and indirect ELISA (iELISA). Furthermore, a survey on the usage of personal protective equipment (PPE) and challenges to its use by abattoir workers was done. Data were analysed using Stata 12. Results: Seroprevalence by RBT was 7.8%; 77.3% (75/97) of these were corroborated by cELISA. Prevalence in milk samples by MRT and indirect ELISA were 33.3% and 3.5%, respectively. Sex (OR: 2.5; 95%CI:1.3-4.5) was the factor significantly associated with seropositivity. None of the abattoir workers used standard protective overalls; while, 99.6% of the meat handlers and 84.1% of the butchers worked barefoot. Most of the workers (75.7%) wore no protective gloves. The respondents agreed that provision of free PPE and sanctions against non-users would encourage its use. Conclusion: Our findings indicate moderate prevalence (7.8%) of bovine brucellosis with sex of cattle being a risk factor. A notable barrier to better protection of abattoir workers against brucellosis is perceived inconvenience arising from use of gloves. Therefore, preventive and control measures against brucellosis must include education and use of PPE among abattoir workers.
[Mh] Termos MeSH primário: Matadouros
Brucella/isolamento & purificação
Brucelose/epidemiologia
Doenças Profissionais/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Animais
Brucelose/prevenção & controle
Brucelose/veterinária
Bovinos
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Masculino
Nigéria/epidemiologia
Doenças Profissionais/microbiologia
Exposição Ocupacional/efeitos adversos
Prevalência
Roupa de Proteção/utilização
Fatores de Risco
Estudos Soroepidemiológicos
Fatores Sexuais
Zoonoses/microbiologia
Zoonoses/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.68.10925


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[PMID]:28457067
[Au] Autor:Tzur A; Sedaka Y; Fruchtman Y; Leibovitz E; Cavari Y; Noyman I; Ben-Shimol S; Shelef I; Lazar I
[Ad] Endereço:Pediatric Neurology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
[Ti] Título:Rapidly Progressing Fatal Neurobrucellosis in a Healthy Child in an Endemic Area in Southern Israel.
[So] Source:Isr Med Assoc J;19(2):125-127, 2017 Feb.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Encefalopatias
Brucella/isolamento & purificação
Brucelose
Meningites Bacterianas
[Mh] Termos MeSH secundário: Anticonvulsivantes/administração & dosagem
Árabes
Encéfalo/diagnóstico por imagem
Encefalopatias/diagnóstico
Encefalopatias/microbiologia
Encefalopatias/fisiopatologia
Encefalopatias/terapia
Brucelose/complicações
Brucelose/diagnóstico
Criança
Angiografia por Tomografia Computadorizada/métodos
Diagnóstico Diferencial
Eletroencefalografia/métodos
Evolução Fatal
Escala de Coma de Glasgow
Seres Humanos
Israel
Masculino
Meningites Bacterianas/diagnóstico
Meningites Bacterianas/microbiologia
Meningites Bacterianas/fisiopatologia
Meningites Bacterianas/terapia
Exame Neurológico/métodos
Respiração Artificial/métodos
Tempo para o Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anticonvulsants)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29049182
[Au] Autor:Zhang T; Ji D; Wang F
[Ad] Endereço:Department of Interventional Therapy, First Affiliated Hospital of Dalian Medical University, Dalian, China.
[Ti] Título:Endovascular treatment of Brucella-infected abdominal aortic aneurysm: A case report.
[So] Source:Medicine (Baltimore);96(42):e7666, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: In very rare cases, a primary infected abdominal aortic aneurysm (IAAA) is caused by a species of Brucella. In this report, we report such a case that was successfully treated with a novel approach. To the best of our knowledge, this was the first case occurring in China, in which an infection of the abdominal aortic aneurysm was caused by a Brucella species. PATIENT CONCERNS: The clinical findings included high fever, fatigue, and abdominal pain. DIAGNOSES: The diagnosis was confirmed by computed tomography angiography and by bacteriologic isolation from the patient's blood culture. INTERVENTIONS: The patient was given endovascular aneurysm repair (EVAR) and Brucella-sensitive antibiotics for 6 weeks. OUTCOMES: During the 10-month follow-up, the patient's clinical course remained uneventful. LESSONS: Our case study supports the premise that endovascular aneurysm repair is an appropriate alternative strategy to treat an infected abdominal aortic aneurysm. Compared with conventional surgical treatment, EVAR with long-term oral antibiotics is a simpler, less traumatic, and more efficient procedure. However, this needs to be further evaluated through long-term follow-up.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/terapia
Brucella/isolamento & purificação
Brucelose/complicações
Procedimentos Endovasculares/métodos
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Aneurisma da Aorta Abdominal/microbiologia
Brucelose/microbiologia
Brucelose/terapia
Terapia Combinada
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007666


  6 / 7569 MEDLINE  
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[PMID]:29023541
[Au] Autor:Mailybayeva A; Yespembetov B; Ryskeldinova S; Zinina N; Sansyzbay A; Renukaradhya GJ; Petrovsky N; Tabynov K
[Ad] Endereço:Laboratory of Infectious Disease Prevention, Research Institute for Biological Safety Problems, Zhambulskaya Oblast, Kordaiskiy Rayon, Gvardeiskiy, Republic of Kazakhstan.
[Ti] Título:Improved influenza viral vector based Brucella abortus vaccine induces robust B and T-cell responses and protection against Brucella melitensis infection in pregnant sheep and goats.
[So] Source:PLoS One;12(10):e0186484, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella Omp16 and L7/L12 proteins (Flu-BA). Our success in the Flu-BA vaccine trial in cattle and results of a pilot study in non-pregnant small ruminants prompted us in the current study to test its efficacy against B. melitensis infection in pregnant sheep and goats. In this study, we improved the Flu-BA vaccine formulation and immunization method to achieve maximum efficacy and safety. The Flu-BA vaccine formulation had two additional proteins Omp19 and SOD, and administered thrice with 20% Montanide Gel01 adjuvant, simultaneously by both subcutaneous and conjunctival routes at 21 days intervals in pregnant sheep and goats. At 42 days post-vaccination (DPV) we detected antigen-specific IgG antibodies predominantly of IgG2a isotype but also IgG1, and also detected a strong lymphocyte recall response with IFN-γ production. Importantly, our candidate vaccine prevented abortion in 66.7% and 77.8% of pregnant sheep and goats, respectively. Furthermore, complete protection (absence of live B. melitensis 16M) was observed in 55.6% and 66.7% of challenged sheep and goats, and 72.7% and 90.0% of their fetuses (lambs/yeanlings), respectively. The severity of B. melitensis 16M infection in vaccinated sheep and goats and their fetuses (index of infection and rates of Brucella colonization in tissues) was significantly lower than in control groups. None of the protection parameters after vaccination with Flu-BA vaccine were statistically inferior to protection seen with the commercial B. melitensis Rev.1 vaccine (protection against abortion and vaccination efficacy, alpha = 0.18-0.34, infection index, P = 0.37-0.77, Brucella colonization, P = 0.16 to P > 0.99). In conclusion, our improved Flu-BA vaccine formulation and delivery method were found safe and effective in protecting pregnant sheep and goats against adverse consequences of B. melitensis infection.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Vacina contra Brucelose/imunologia
Brucella melitensis/genética
Brucelose/prevenção & controle
Orthomyxoviridae/genética
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Aborto Espontâneo/prevenção & controle
Animais
Anticorpos/imunologia
Antígenos de Bactérias/genética
Antígenos de Bactérias/imunologia
Antígenos de Bactérias/metabolismo
Linfócitos B/citologia
Linfócitos B/metabolismo
Proteínas da Membrana Bacteriana Externa/genética
Proteínas da Membrana Bacteriana Externa/imunologia
Proteínas da Membrana Bacteriana Externa/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/imunologia
Proteínas de Bactérias/metabolismo
Vacina contra Brucelose/genética
Vacina contra Brucelose/metabolismo
Brucella melitensis/patogenicidade
Brucelose/imunologia
Feminino
Cabras
Hemaglutininas Virais/imunologia
Imunoglobulina G/imunologia
Interferon gama/metabolismo
Lipoproteínas/genética
Lipoproteínas/imunologia
Lipoproteínas/metabolismo
Gravidez
Ovinos
Superóxido Dismutase-1/genética
Superóxido Dismutase-1/imunologia
Superóxido Dismutase-1/metabolismo
Linfócitos T/citologia
Linfócitos T/metabolismo
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Antigens, Bacterial); 0 (Bacterial Outer Membrane Proteins); 0 (Bacterial Proteins); 0 (Brucella Vaccine); 0 (Hemagglutinins, Viral); 0 (Immunoglobulin G); 0 (Lipoproteins); 0 (OMP19 protein, Brucella abortus); 82115-62-6 (Interferon-gamma); EC 1.15.1.1 (Superoxide Dismutase-1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186484


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[PMID]:28873022
[Au] Autor:San-Miguel Ayanz JM; Garcia-Peña FJ; García-Lunar P; Ortega-Mora LM; Ruano MJ; Álvarez-García G; Collantes-Fernández E
[Ad] Endereço:1 ZOETIS , Madrid, Spain .
[Ti] Título:Seroprevalence of Leptospirosis, Brucellosis, and Q Fever in a Wild Red Deer (Cervus elaphus) Population Kept in a Fenced Reserve in Absence of Contact with Livestock.
[So] Source:Vector Borne Zoonotic Dis;17(10):692-697, 2017 Oct.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wildlife health is of interest for public and animal health because wild animals have been identified as important sentinels for the surveillance for zoonotic pathogens. This work investigated Brucella spp., Coxiella burnetii, and Leptospira spp. infection seroprevalence in a free-ranging red deer population. The study was conducted in a fenced reserve with controlled hunting activity in central Spain with animals that did not have any contact with livestock. Sampling was performed at two time points before and 5 years after the implementation of new management measures, including a reduction in the red deer population in the reserve. In addition, the presence of Leptospira DNA was tested in placental and fetal samples from seropositive pregnant animals. Antibodies against Brucella and Coxiella were not detected in any sample. The seroprevalence of Leptospira was 9.4% (13/137) in the first sampling for serovars Canicola and Panama. Five years later, the prevalence rose to 38.5% (97/252) with Pomona, the only serovar detected. Animals older than 2 years (50%; 70/140) were more likely to be Pomona seropositive than animals ≤2 years old (25.2%; 27/107; p < 0.001). Leptospira DNA was not detected in any sample tested. In conclusion, wild red deer in this area without contact with livestock seem not to play an important role in Brucella spp. and C. burnetii maintenance. The high seroprevalence of Leptospira spp. serogroup Pomona could indicate a risk for people with narrow contact with these animals, but the carrier status was not assessed. Consequently, it is unknown if red deer would represent a risk for human infection. Considering that wild boar could be the source of infection to red deer, the role of wild boar in the spread of leptospirosis and the risk for human infection should be investigated.
[Mh] Termos MeSH primário: Brucelose/veterinária
Cervos/microbiologia
Leptospirose/veterinária
Febre Q/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Brucelose/sangue
Conservação dos Recursos Naturais
Feminino
Leptospira/classificação
Leptospirose/sangue
Gado
Masculino
Prevalência
Febre Q/sangue
Fatores de Risco
Estudos Soroepidemiológicos
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2016.2105


  8 / 7569 MEDLINE  
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[PMID]:28817647
[Au] Autor:Rossetti CA; Arenas-Gamboa AM; Maurizio E
[Ad] Endereço:Instituto de Patobiología, CICVyA-CNIA, INTA. Nicolás Repetto y de Los Reseros s/n, Hurlingham, Buenos Aires, Argentina.
[Ti] Título:Caprine brucellosis: A historically neglected disease with significant impact on public health.
[So] Source:PLoS Negl Trop Dis;11(8):e0005692, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak offspring are the characteristic clinical signs of the disease that is associated with an extensive negative impact in a flock's productivity. B. melitensis is also the most virulent Brucella species for humans, responsible for a severely debilitating and disabling illness that results in high morbidity with intermittent fever, chills, sweats, weakness, myalgia, abortion, osteoarticular complications, endocarditis, depression, anorexia, and low mortality. Historical observations indicate that goats have been the hosts of B. melitensis for centuries; but around 1905, the Greek physician Themistokles Zammit was able to build the epidemiological link between "Malta fever" and the consumption of goat milk. While the disease has been successfully managed in most industrialized countries, it remains a significant burden on goat and human health in the Mediterranean region, the Middle East, Central and Southeast Asia (including India and China), sub-Saharan Africa, and certain areas in Latin America, where approximately 3.5 billion people live at risk. In this review, we describe a historical evolution of the disease, highlight the current worldwide distribution, and estimate (by simple formula) the approximate costs of brucellosis outbreaks to meat- and milk-producing farms and the economic losses associated with the disease in humans. Successful control leading to eradication of caprine brucellosis in the developing world will require a coordinated Global One Health approach involving active involvement of human and animal health efforts to enhance public health and improve livestock productivity.
[Mh] Termos MeSH primário: Brucella melitensis/isolamento & purificação
Brucelose/epidemiologia
Brucelose/veterinária
Doenças das Cabras/epidemiologia
Doenças Negligenciadas/epidemiologia
Doenças Negligenciadas/veterinária
Zoonoses/epidemiologia
[Mh] Termos MeSH secundário: Animais
Controle de Doenças Transmissíveis/métodos
Efeitos Psicossociais da Doença
Saúde Global
Doenças das Cabras/transmissão
Cabras
Seres Humanos
Prevalência
Saúde Pública
Zoonoses/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005692


  9 / 7569 MEDLINE  
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[PMID]:28808159
[Au] Autor:Machelart A; Khadrawi A; Demars A; Willemart K; De Trez C; Letesson JJ; Muraille E
[Ad] Endereço:Unité de Recherche en Biologie des Microorganismes, Laboratoire d'Immunologie et de Microbiologie, Université de Namur, Namur, Belgium.
[Ti] Título:Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen.
[So] Source:Infect Immun;85(11), 2017 Nov.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The spleen is known as an important filter for blood-borne pathogens that are trapped by specialized macrophages in the marginal zone (MZ): the CD209 MZ macrophages (MZMs) and the CD169 marginal metallophilic macrophages (MMMs). Acute systemic infection strongly impacts MZ populations and the location of T and B lymphocytes. This phenomenon has been linked to reduced chemokine secretion by stromal cells. spp. are the causative agent of brucellosis, a widespread zoonotic disease. Here, we used infection as a model to investigate the impact of chronic stealth infection on splenic MZ macrophage populations. During the late phase of infection, we observed a loss of both MZMs and MMMs, with a durable disappearance of MZMs, leading to a reduction of the ability of the spleen to take up soluble antigens, beads, and unrelated bacteria. This effect appears to be selective as every other lymphoid and myeloid population analyzed increased during infection, which was also observed following and infection. Comparison of wild-type and deficient mice suggested that MZ macrophage population loss is dependent on interferon gamma (IFN-γ) receptor but independent of T cells or tumor necrosis factor alpha receptor 1 (TNF-αR1) signaling pathways and is not correlated to an alteration of CCL19, CCL21, and CXCL13 chemokine mRNA expression. Our results suggest that MZ macrophage populations are particularly sensitive to persistent low-level IFN-γ-mediated inflammation and that infection could reduce the ability of the spleen to perform certain MZM- and MMM-dependent tasks, such as antigen delivery to lymphocytes and control of systemic infection.
[Mh] Termos MeSH primário: Brucelose/imunologia
Interações Hospedeiro-Patógeno
Interferon gama/imunologia
Macrófagos/imunologia
Receptores de Interferon/imunologia
Baço/imunologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Linfócitos B/imunologia
Linfócitos B/microbiologia
Brucella abortus/efeitos dos fármacos
Brucella abortus/imunologia
Brucella abortus/patogenicidade
Brucella melitensis/efeitos dos fármacos
Brucella melitensis/imunologia
Brucella melitensis/patogenicidade
Brucella suis/efeitos dos fármacos
Brucella suis/imunologia
Brucella suis/patogenicidade
Brucelose/tratamento farmacológico
Brucelose/genética
Brucelose/microbiologia
Quimiocina CCL19/genética
Quimiocina CCL19/imunologia
Quimiocina CCL21/genética
Quimiocina CCL21/imunologia
Quimiocina CXCL13/genética
Quimiocina CXCL13/imunologia
Doença Crônica
Regulação da Expressão Gênica
Interferon gama/genética
Macrófagos/microbiologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
RNA Mensageiro/genética
RNA Mensageiro/imunologia
Receptores de Interferon/deficiência
Receptores de Interferon/genética
Receptores Tipo I de Fatores de Necrose Tumoral/deficiência
Receptores Tipo I de Fatores de Necrose Tumoral/genética
Receptores Tipo I de Fatores de Necrose Tumoral/imunologia
Rifampina/farmacologia
Transdução de Sinais
Baço/microbiologia
Estreptomicina/farmacologia
Linfócitos T/imunologia
Linfócitos T/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Ccl19 protein, mouse); 0 (Chemokine CCL19); 0 (Chemokine CCL21); 0 (Chemokine CXCL13); 0 (Cxcl13 protein, mouse); 0 (RNA, Messenger); 0 (Receptors, Interferon); 0 (Receptors, Tumor Necrosis Factor, Type I); 0 (interferon gamma receptor); 82115-62-6 (Interferon-gamma); VJT6J7R4TR (Rifampin); Y45QSO73OB (Streptomycin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


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[PMID]:28793352
[Au] Autor:Hernández-Mora G; Bonilla-Montoya R; Barrantes-Granados O; Esquivel-Suárez A; Montero-Caballero D; González-Barrientos R; Fallas-Monge Z; Palacios-Alfaro JD; Baldi M; Campos E; Chanto G; Barquero-Calvo E; Chacón-Díaz C; Chaves-Olarte E; Guzmán Verri C; Romero-Zúñiga JJ; Moreno E
[Ad] Endereço:Servicio Nacional de Salud Animal (SENASA), Ministerio de Agricultura y Ganadería, Heredia, Costa Rica.
[Ti] Título:Brucellosis in mammals of Costa Rica: An epidemiological survey.
[So] Source:PLoS One;12(8):e0182644, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in the country. We have performed a brucellosis survey in these host mammal species, from 1999-2016. In addition, we have documented the number of human brucellosis reported cases, from 2003-2016. The brucellosis seroprevalence in goat and sheep herds was 0.98% and 0.7% respectively, with no Brucella isolation. Antibodies against Brucella were not detected in feral or domestic pigs. Likewise, brucellosis seroprevalence in horse and water buffalo farms was estimated in 6.5% and 21.7%, respectively, with no Brucella isolation. Six cetacean species showed positive reactions against Brucella antigens, and B. ceti was isolated in 70% (n = 29) of striped dolphins (Stenella coeruleoalba). A steady increase in the diagnosis of human brucellosis cases was observed. Taking into account the prevalence of brucellosis in the various host mammals of Costa Rica, different measures are recommended.
[Mh] Termos MeSH primário: Brucelose/veterinária
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Animais
Brucelose/epidemiologia
Búfalos/microbiologia
Criança
Costa Rica/epidemiologia
Golfinhos/microbiologia
Feminino
Doenças das Cabras/epidemiologia
Doenças das Cabras/microbiologia
Cabras/microbiologia
Doenças dos Cavalos/epidemiologia
Doenças dos Cavalos/microbiologia
Cavalos
Seres Humanos
Masculino
Meia-Idade
Estudos Soroepidemiológicos
Ovinos/microbiologia
Doenças dos Ovinos/epidemiologia
Doenças dos Ovinos/microbiologia
Suínos
Doenças dos Suínos/epidemiologia
Doenças dos Suínos/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182644



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