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Pesquisa : C01.252.400.170.400 [Categoria DeCS]
Referências encontradas : 226 [refinar]
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[PMID]:28507073
[Au] Autor:Zimmerman SM; Dyke JS; Jelesijevic TP; Michel F; Lafontaine ER; Hogan RJ
[Ad] Endereço:Department of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, Georgia, USA.
[Ti] Título:Antibodies against -Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei.
[So] Source:Infect Immun;85(8), 2017 Aug.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:, a facultative intracellular bacterium and tier 1 biothreat, causes the fatal zoonotic disease glanders. The organism possesses multiple genes encoding autotransporter proteins, which represent important virulence factors and targets for developing countermeasures in pathogenic Gram-negative bacteria. In the present study, we investigated one of these autotransporters, BatA, and demonstrate that it displays lipolytic activity, aids in intracellular survival, is expressed , elicits production of antibodies during infection, and contributes to pathogenicity in a mouse aerosol challenge model. A mutation in the gene of wild-type strain ATCC 23344 was found to be particularly attenuating, as BALB/c mice infected with the equivalent of 80 median lethal doses cleared the organism. This finding prompted us to test the hypothesis that vaccination with the mutant strain elicits protective immunity against subsequent infection with wild-type bacteria. We discovered that not only does vaccination provide high levels of protection against lethal aerosol challenge with ATCC 23344, it also protects against infection with multiple isolates of the closely related organism and causative agent of melioidosis, Passive-transfer experiments also revealed that the protective immunity afforded by vaccination with the mutant strain is predominantly mediated by IgG antibodies binding to antigens expressed exclusively Collectively, our data demonstrate that BatA is a target for developing medical countermeasures and that vaccination with a mutant lacking expression of the protein provides a platform to gain insights regarding mechanisms of protective immunity against and , including antigen discovery.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/imunologia
Burkholderia mallei/imunologia
Burkholderia pseudomallei/imunologia
Melioidose/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Burkholderia mallei/genética
Burkholderia mallei/crescimento & desenvolvimento
Burkholderia mallei/patogenicidade
Burkholderia pseudomallei/patogenicidade
Modelos Animais de Doenças
Mormo/imunologia
Mormo/microbiologia
Mormo/prevenção & controle
Imunoglobulina G/imunologia
Melioidose/imunologia
Melioidose/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Mutação
Vacinação
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Bacterial Proteins); 0 (Immunoglobulin G); 0 (Virulence Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE


  2 / 226 MEDLINE  
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[PMID]:28418830
[Au] Autor:Morris JL; Fane A; Sarovich DS; Price EP; Rush CM; Govan BL; Parker E; Mayo M; Currie BJ; Ketheesan N
[Ti] Título:Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-like Variation in the bimA Motility Gene, Australia.
[So] Source:Emerg Infect Dis;23(5), 2017 05.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
[Mh] Termos MeSH primário: Burkholderia pseudomallei/genética
Infecções Bacterianas do Sistema Nervoso Central/microbiologia
Variação Genética
Melioidose/microbiologia
Proteínas dos Microfilamentos/genética
[Mh] Termos MeSH secundário: Animais
Austrália
Burkholderia mallei/genética
Burkholderia pseudomallei/isolamento & purificação
Infecções Bacterianas do Sistema Nervoso Central/mortalidade
Infecções Bacterianas do Sistema Nervoso Central/patologia
Doenças Transmissíveis Emergentes/microbiologia
Doenças Transmissíveis Emergentes/mortalidade
Doenças Transmissíveis Emergentes/patologia
Modelos Animais de Doenças
Progressão da Doença
Mormo/microbiologia
Seres Humanos
Melioidose/mortalidade
Melioidose/patologia
Camundongos
Mucosa Nasal/microbiologia
Fagócitos/imunologia
Fagócitos/microbiologia
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BimA protein, Burkholderia pseudomallei); 0 (Microfilament Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.3201/eid2305.151417


  3 / 226 MEDLINE  
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[PMID]:27799332
[Au] Autor:Chua J; Senft JL; Lockett SJ; Brett PJ; Burtnick MN; DeShazer D; Friedlander AM
[Ad] Endereço:Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA Jennifer.Chua.ctr@mail.mil Arthur.M.Friedlander.civ@mail.mil.
[Ti] Título:pH Alkalinization by Chloroquine Suppresses Pathogenic Burkholderia Type 6 Secretion System 1 and Multinucleated Giant Cells.
[So] Source:Infect Immun;85(1), 2017 Jan.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Burkholderia mallei and B. pseudomallei cause glanders and melioidosis, respectively, in humans and animals. A hallmark of pathogenesis is the formation of granulomas containing multinucleated giant cells (MNGCs) and cell death. These processes depend on type 6 secretion system 1 (T6SS-1), which is required for virulence in animals. We examined the cell biology of MNGC formation and cell death. We found that chloroquine diphosphate (CLQ), an antimalarial drug, inhibits Burkholderia growth, phagosomal escape, and subsequent MNGC formation. This depends on CLQ's ability to neutralize the acid pH because other alkalinizing compounds similarly inhibit escape and MNGC formation. CLQ inhibits bacterial virulence protein expression because T6SS-1 and some effectors of type 3 secretion system 3 (T3SS-3), which is also required for virulence, are expressed at acid pH. We show that acid pH upregulates the expression of Hcp1 of T6SS-1 and TssM, a protein coregulated with T6SS-1. Finally, we demonstrate that CLQ treatment of Burkholderia-infected Madagascar hissing cockroaches (HCs) increases their survival. This study highlights the multiple mechanisms by which CLQ inhibits growth and virulence and suggests that CLQ be further tested and considered, in conjunction with antibiotic use, for the treatment of diseases caused by Burkholderia.
[Mh] Termos MeSH primário: Antiácidos/farmacologia
Burkholderia mallei/efeitos dos fármacos
Burkholderia pseudomallei/efeitos dos fármacos
Cloroquina/farmacologia
Células Gigantes/efeitos dos fármacos
Sistemas de Secreção Tipo VI/efeitos dos fármacos
Virulência/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/metabolismo
Burkholderia mallei/metabolismo
Burkholderia pseudomallei/metabolismo
Linhagem Celular
Mormo/tratamento farmacológico
Mormo/microbiologia
Concentração de Íons de Hidrogênio
Melioidose/tratamento farmacológico
Melioidose/microbiologia
Camundongos
Sistemas de Secreção Tipo III/efeitos dos fármacos
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antacids); 0 (Bacterial Proteins); 0 (Type III Secretion Systems); 0 (Type VI Secretion Systems); 0 (Virulence Factors); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE


  4 / 226 MEDLINE  
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[PMID]:27738703
[Au] Autor:Bernhards RC; Cote CK; Amemiya K; Waag DM; Klimko CP; Worsham PL; Welkos SL
[Ad] Endereço:Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD, 21702-5011, USA.
[Ti] Título:Characterization of in vitro phenotypes of Burkholderia pseudomallei and Burkholderia mallei strains potentially associated with persistent infection in mice.
[So] Source:Arch Microbiol;199(2):277-301, 2017 Mar.
[Is] ISSN:1432-072X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), the agents of melioidosis and glanders, respectively, are Tier 1 biothreats. They infect humans and animals, causing disease ranging from acute and fatal to protracted and chronic. Chronic infections are especially challenging to treat, and the identification of in vitro phenotypic markers which signal progression from acute to persistent infection would be extremely valuable. First, a phenotyping strategy was developed employing colony morphotyping, chemical sensitivity testing, macrophage infection, and lipopolysaccharide fingerprint analyses to distinguish Burkholderia strains. Then mouse spleen isolates collected 3-180 days after infection were characterized phenotypically. Isolates from long-term infections often exhibited increased colony morphology differences and altered patterns of antimicrobial sensitivity and macrophage infection. Some of the Bp and Bm persistent infection isolates clearly displayed enhanced virulence in mice. Future studies will evaluate the potential role and significance of these phenotypic markers in signaling the establishment of a chronic infection.
[Mh] Termos MeSH primário: Burkholderia mallei/isolamento & purificação
Burkholderia pseudomallei/isolamento & purificação
Mormo/microbiologia
Melioidose/microbiologia
[Mh] Termos MeSH secundário: Animais
Burkholderia mallei/patogenicidade
Burkholderia pseudomallei/patogenicidade
Linhagem Celular
Feminino
Lipopolissacarídeos/análise
Macrófagos/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Fenótipo
Baço/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1007/s00203-016-1303-8


  5 / 226 MEDLINE  
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[PMID]:27736903
[Au] Autor:Lowe CW; Satterfield BA; Nelson DB; Thiriot JD; Heder MJ; March JK; Drake DS; Lew CS; Bunnell AJ; Moore ES; O'Neill KL; Robison RA
[Ad] Endereço:Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, 84602, United States of America.
[Ti] Título:A Quadruplex Real-Time PCR Assay for the Rapid Detection and Differentiation of the Most Relevant Members of the B. pseudomallei Complex: B. mallei, B. pseudomallei, and B. thailandensis.
[So] Source:PLoS One;11(10):e0164006, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Burkholderia pseudomallei complex classically consisted of B. mallei, B. pseudomallei, and B. thailandensis, but has now expanded to include B. oklahomensis, B. humptydooensis, and three unassigned Burkholderia clades. Methods for detecting and differentiating the B. pseudomallei complex has been the topic of recent research due to phenotypic and genotypic similarities of these species. B. mallei and B. pseudomallei are recognized as CDC Tier 1 select agents, and are the causative agents of glanders and melioidosis, respectively. Although B. thailandensis and B. oklahomensis are generally avirulent, both display similar phenotypic characteristics to that of B. pseudomallei. B. humptydooensis and the Burkholderia clades are genetically similar to the B. pseudomallei complex, and are not associated with disease. Optimal identification of these species remains problematic, and PCR-based methods can resolve issues with B. pseudomallei complex detection and differentiation. Currently, no PCR assay is available that detects the major species of the B. pseudomallei complex. A real-time PCR assay in a multiplex single-tube format was developed to simultaneously detect and differentiate B. mallei, B. pseudomallei, and B. thailandensis, and a common sequence found in B. pseudomallei, B. mallei, B. thailandensis, and B. oklahomensis. A total of 309 Burkholderia isolates and 5 other bacterial species were evaluated. The assay was 100% sensitive and specific, demonstrated sensitivity beyond culture and GC methods for the isolates tested, and is completed in about an hour with a detection limit between 2.6pg and 48.9pg of gDNA. Bioinformatic analyses also showed the assay is likely 100% specific and sensitive for all 84 fully sequenced B. pseudomallei, B. mallei, B. thailandensis, and B. oklahomensis strains currently available in GenBank. For these reasons, this assay could be a rapid and sensitive tool in the detection and differentiation for those species of the B. pseudomallei complex with recognized clinical and practical significance.
[Mh] Termos MeSH primário: Infecções por Burkholderia/diagnóstico
Infecções por Burkholderia/microbiologia
Burkholderia/genética
[Mh] Termos MeSH secundário: Burkholderia/isolamento & purificação
Burkholderia mallei/genética
Burkholderia mallei/isolamento & purificação
Burkholderia pseudomallei/genética
Burkholderia pseudomallei/isolamento & purificação
DNA Bacteriano/isolamento & purificação
Mormo/microbiologia
Seres Humanos
Melioidose/microbiologia
Reação em Cadeia da Polimerase em Tempo Real/métodos
Sensibilidade e Especificidade
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164006


  6 / 226 MEDLINE  
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[PMID]:27339929
[Au] Autor:Jones BV
[Ad] Endereço:Ermin Way House, 34-36 Dollar Street, Cirencester GL7 2AN, e-mail: vivashbvj123@btinternet.com.
[Ti] Título:Glanders and history.
[So] Source:Vet Rec;178(26):664, 2016 06 25.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Mormo
[Mh] Termos MeSH secundário: Animais
Cavalos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE
[do] DOI:10.1136/vr.i3451


  7 / 226 MEDLINE  
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[PMID]:27313253
[Au] Autor:Malik P
[Ad] Endereço:CCS National Institute of Animal Health, Ministry of Agriculture and Farmers Welfare, Baghpat 250609, India e-mail: malikphisar@hotmail.com.
[Ti] Título:Harmonising diagnostic testing for glanders in equids.
[So] Source:Vet Rec;178(25):630-1, 2016 Jun 18.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Burkholderia mallei/isolamento & purificação
Testes Diagnósticos de Rotina/veterinária
Mormo/diagnóstico
[Mh] Termos MeSH secundário: Animais
Testes Diagnósticos de Rotina/métodos
Cavalos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.1136/vr.i3093


  8 / 226 MEDLINE  
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[PMID]:27288893
[Au] Autor:Kettle AN; Wernery U
[Ad] Endereço:Equine International Consultancy FZ LLE, Dubai, UAE.
[Ti] Título:Glanders and the risk for its introduction through the international movement of horses.
[So] Source:Equine Vet J;48(5):654-8, 2016 Sep.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glanders is the contagious zoonotic disease caused by infection with Burkholderia mallei. It affects primarily horses, donkeys and mules. The disease was eradicated from large areas of the Western world in the early 20th century, but, over the last 10-20 years, has emerged and re-emerged in areas in which it was previously unknown or had been eradicated. Although glanders was previously thought to manifest in only acute or chronic presentations, it now appears that B. mallei can produce latent infections similar to those caused by Burkholderia pseudomallei. These latent infections may or may not be detectable by current diagnostic tests. The diagnostic test currently recommended by the World Organisation for Animal Health (Office International des Epizooties [OIE]) for international trade in equids is the complement fixation test (CFT). This test has been shown to have varying sensitivities and specificities depending on the antigen and methodology used. False positives are problematic for the horse-owner and veterinary authority, whereas false negatives may allow the reintroduction of B. mallei into B. mallei-free areas. These gaps in knowledge of the epidemiology of glanders, and weaknesses in its diagnosis, coupled with the increased movement of equids, indicate that infection with B. mallei remains a major risk in the context of international movement of equids.
[Mh] Termos MeSH primário: Mormo/transmissão
Internacionalidade
Transportes
[Mh] Termos MeSH secundário: Animais
Cavalos
Fatores de Risco
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160612
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12599


  9 / 226 MEDLINE  
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[PMID]:27271739
[Au] Autor:Hatcher CL; Mott TM; Muruato LA; Sbrana E; Torres AG
[Ad] Endereço:Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
[Ti] Título:Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders.
[So] Source:Infect Immun;84(8):2345-54, 2016 Aug.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Burkholderia mallei is the causative agent of glanders, an incapacitating disease with high mortality rates in respiratory cases. Its endemicity and ineffective treatment options emphasize its public health threat and highlight the need for a vaccine. Live attenuated vaccines are considered the most viable vaccine strategy for Burkholderia, but single-gene-deletion mutants have not provided complete protection. In this study, we constructed the select-agent-excluded B. mallei ΔtonB Δhcp1 (CLH001) vaccine strain and investigated its ability to protect against acute respiratory glanders. Here we show that CLH001 is attenuated, safe, and effective at protecting against lethal B. mallei challenge. Intranasal administration of CLH001 to BALB/c and NOD SCID gamma (NSG) mice resulted in complete survival without detectable colonization or abnormal organ histopathology. Additionally, BALB/c mice intranasally immunized with CLH001 in a prime/boost regimen were fully protected against lethal challenge with the B. mallei lux (CSM001) wild-type strain.
[Mh] Termos MeSH primário: Vacinas Bacterianas/imunologia
Burkholderia mallei/imunologia
Mormo/imunologia
Vacinas Atenuadas/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/imunologia
Antígenos de Bactérias/genética
Antígenos de Bactérias/imunologia
Vacinas Bacterianas/genética
Burkholderia mallei/genética
Modelos Animais de Doenças
Feminino
Mormo/mortalidade
Mormo/prevenção & controle
Imunização
Imunização Secundária
Hospedeiro Imunocomprometido
Imunoglobulina G/imunologia
Camundongos
Mutação
Vacinas Atenuadas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antigens, Bacterial); 0 (Bacterial Vaccines); 0 (Immunoglobulin G); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1128/IAI.00328-16


  10 / 226 MEDLINE  
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[PMID]:27183720
[Au] Autor:Bondareva OS; Savchenko SS; Tkachenko GA; Ledeneva ML; Lemasova LV; Antonov VA
[Ti] Título:[GENOTYPING OF THE BURKHOLDERIA MALLEI STRAINS BASED ON DIFFERENT REGION ANALYSIS].
[So] Source:Mol Gen Mikrobiol Virusol;34(1):33-7, 2016.
[Is] ISSN:0208-0613
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Development of the genotyping methods of glanders agent is urgent due to its high pathogenicity, lack of effective preventive measures and threat of the use of Burkholderia mallei as a biological weapon. In this work we proposed a scheme for the typing of the B. mallei strains based on different region analysis (DFR). The choice of variable loci differentially presented in various strains of glanders agents was performed by analyzing annotated whole-genome sequences of the B. mallei strains. Primers and fluorescence probes were designed for 9 selected loci. The amplification conditions for different regions were optimized in two variants: with electrophoretic detection and hybridization-fluorescence detection in the strip format. The possibility of applying the DFR analysis to genetic characterization of strains was assessed in 14 B. mallei strains. The genetic profiles of the studied B. mallei strains revealed that the developed DFR-typing scheme was characterized by high discrimination power (Hunter-Gaston index value was 0.92), reproducibility, rapidity, easy interpretation, and applicability for epidemiological surveillance of glanders.
[Mh] Termos MeSH primário: Burkholderia mallei/genética
DNA Bacteriano/genética
Técnicas de Genotipagem
Mormo/genética
Reação em Cadeia da Polimerase
[Mh] Termos MeSH secundário: Animais
Burkholderia mallei/isolamento & purificação
Seres Humanos
Federação Russa
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160517
[Lr] Data última revisão:
160517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160518
[St] Status:MEDLINE



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