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[PMID]:29195496
[Au] Autor:de Curraize C; Amoureux L; Bador J; Chapuis A; Siebor E; Clément C; Sauge J; Aho-Glélé LS; Neuwirth C
[Ad] Endereço:Bacteriology Department, University Hospital Dijon and UMR 6249, PTB, BP 37013, 21070, Dijon Cedex, France.
[Ti] Título:"Does the Salmonella Genomic Island 1 (SGI1) confer invasiveness properties to human isolates?"
[So] Source:BMC Infect Dis;17(1):741, 2017 12 01.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the eighties, a multidrug resistant clone of Salmonella Typhimurium DT104 emerged in UK and disseminated worldwide. This clone harbored a Salmonella genomic island 1 (SGI1) that consists of a backbone and a multidrug resistant region encoding for penta-resistance (ampicillin, chloramphenicol/florfenicol, streptomycin/spectinomycin, sulphonamides and tetracycline (ACSSuT)). Several authors suggested that SGI1 might have a potential role in enhancement of virulence properties of Salmonella enterica. The aim of this study was to investigate whether nontyphoidal S. enterica isolates carrying SGI1 cause more severe illness than SGI1 free ones in humans. METHODS: From 2011 to 2016, all patients infected with nontyphoidal S. enterica in our hospital were retrospectively included. All nontyphoidal S. enterica isolates preserved in our University Hospital (Dijon, France) were screened for the presence of SGI1. Clinical and biological data of patients were retrospectively collected to evaluate illness severity. Statistical analysis of data was performed by Kruskal-Wallis test or Fisher's exact test for univariate analysis, and by logistic regression for multivariate analysis. RESULTS: A total of 100 isolates of S. enterica (22 serovars) were collected. Twelve isolates (12%) belonging to 4 serovars harbored SGI1: S. Typhimurium, S. Infantis, S. Kentucky, S. St Paul. The severity of the disease was age-related (for invasive infection, sepsis and inflammatory response) and was associated with immunosuppression (for invasive infection, sepsis and bacteremia) but not with the presence of SGI1 or with antimicrobial resistance. CONCLUSION: A rather high proportion (12%) of human clinical isolates belonging to various serovars (for the first time serovar St Paul) and harboring various antimicrobial resistance profile carried SGI1. Diseases due to SGI1-positive S. enterica or to antimicrobial resistant isolates were not more severe than the others. This first clinical observation should be confirmed by a multicenter and prospective study.
[Mh] Termos MeSH primário: Ilhas Genômicas/genética
Infecções por Salmonella/etiologia
Salmonella enterica/genética
Salmonella enterica/patogenicidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Antibacterianos/farmacologia
Criança
Farmacorresistência Bacteriana/efeitos dos fármacos
Farmacorresistência Bacteriana/genética
França
Seres Humanos
Testes de Sensibilidade Microbiana
Meia-Idade
Estudos Retrospectivos
Infecções por Salmonella/microbiologia
Salmonella enterica/efeitos dos fármacos
Salmonella enterica/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2847-1


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[PMID]:29208263
[Au] Autor:Chou DW; Yu CC
[Ad] Endereço:Department of Critical Care Medicine, Tainan Municipal Hospital, Tainan, Taiwan. Electronic address: choudw@gmail.com.
[Ti] Título:Nontyphoidal Salmonella Emphysematous Osteomyelitis.
[So] Source:Am J Med Sci;354(6):635-636, 2017 12.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteomielite/complicações
Osteomielite/diagnóstico por imagem
Infecções por Salmonella/complicações
Infecções por Salmonella/diagnóstico por imagem
[Mh] Termos MeSH secundário: Complicações do Diabetes/diagnóstico por imagem
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:29447692
[Au] Autor:Vázquez-Torres A
[Ad] Endereço:Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Veterans Affairs Eastern Colorado Health Care System, Denver, CO 80220, USA. Electronic address: andres.vazquez-torres@ucdenver.edu.
[Ti] Título:Less Is Best in the Convergent Evolution of Typhoidal Salmonella.
[So] Source:Cell Host Microbe;23(2):151-153, 2018 02 14.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Related works in this issue of Cell Host & Microbe (Bronner et al., 2018) and in a recent issue of Cell Reports (Hiyoshi et al., 2018) demonstrate how loss-of-function mutations in butyrate utilization and lipopolysaccharide O-antigen processing contribute to evasion of innate host defenses and the convergent evolution of distinct typhoidal Salmonella lineages.
[Mh] Termos MeSH primário: Infecções por Salmonella
Salmonella/genética
[Mh] Termos MeSH secundário: Lipopolissacarídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Lipopolysaccharides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:29175935
[Au] Autor:Williams D
[Ad] Endereço:Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
[Ti] Título:Reptile keeping and care.
[So] Source:Vet Rec;181(21):570-571, 2017 11 25.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Répteis
Infecções por Salmonella
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j5260


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[PMID]:29216183
[Au] Autor:MacLennan CA; Msefula CL; Gondwe EN; Gilchrist JJ; Pensulo P; Mandala WL; Mwimaniwa G; Banda M; Kenny J; Wilson LK; Phiri A; MacLennan JM; Molyneux EM; Molyneux ME; Graham SM
[Ad] Endereço:Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
[Ti] Título:Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study.
[So] Source:PLoS Negl Trop Dis;11(12):e0006027, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical syndrome. Drug resistance means that empirical antibiotic therapy is often ineffective and currently no vaccine is available. The study objective was to identify risk factors for mortality among children presenting to hospital with invasive Salmonella disease in Africa. We conducted a prospective study enrolling consecutive children with microbiologically-confirmed invasive Salmonella disease admitted to Queen Elizabeth Central Hospital, Blantyre, in 2006. Data on clinical presentation, co-morbidities and outcome were used to identify children at risk of inpatient mortality through logistic-regression modeling. Over one calendar year, 263 consecutive children presented with invasive Salmonella disease. Median age was 16 months (range 0-15 years) and 52/256 children (20%; 95%CI 15-25%) died. Nontyphoidal serovars caused 248/263 (94%) of cases. 211/259 (81%) of isolates were multi-drug resistant. 251/263 children presented with bacteremia, 6 with meningitis and 6 with both. Respiratory symptoms were present in 184/240 (77%; 95%CI 71-82%), 123/240 (51%; 95%CI 45-58%) had gastrointestinal symptoms and 101/240 (42%; 95%CI 36-49%) had an overlapping clinical syndrome. Presentation at <7 months (OR 10.0; 95%CI 2.8-35.1), dyspnea (OR 4.2; 95%CI 1.5-12.0) and HIV infection (OR 3.3; 95%CI 1.1-10.2) were independent risk factors for inpatient mortality. Invasive Salmonella disease in Malawi is characterized by high mortality and prevalence of multi-drug resistant isolates, along with non-specific presentation. Young infants, children with dyspnea and HIV-infected children bear a disproportionate burden of the Salmonella-associated mortality in Malawi. Strategies to improve prevention, diagnosis and management of invasive Salmonella disease should be targeted at these children.
[Mh] Termos MeSH primário: Bacteriemia/epidemiologia
Infecções por HIV/complicações
Meningites Bacterianas/epidemiologia
Infecções por Salmonella/epidemiologia
Salmonella/imunologia
[Mh] Termos MeSH secundário: Adolescente
Bacteriemia/etiologia
Bacteriemia/microbiologia
Bacteriemia/mortalidade
Criança
Pré-Escolar
Farmacorresistência Bacteriana Múltipla
Feminino
Seres Humanos
Lactente
Modelos Logísticos
Malaui/epidemiologia
Masculino
Meningites Bacterianas/etiologia
Meningites Bacterianas/microbiologia
Meningites Bacterianas/mortalidade
Prevalência
Estudos Prospectivos
Fatores de Risco
Salmonella/isolamento & purificação
Infecções por Salmonella/etiologia
Infecções por Salmonella/microbiologia
Infecções por Salmonella/mortalidade
Sorogrupo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006027


  6 / 10676 MEDLINE  
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[PMID]:29233795
[Au] Autor:Stephen DM; Barnett AG
[Ad] Endereço:Institute of Health and Biomedical Innovation, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland, Australia.
[Ti] Título:Using Microsimulation to Estimate the Future Health and Economic Costs of Salmonellosis under Climate Change in Central Queensland, Australia.
[So] Source:Environ Health Perspect;125(12):127001, 2017 Dec 11.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence of salmonellosis, a costly foodborne disease, is rising in Australia. Salmonellosis increases during high temperatures and rainfall, and future incidence is likely to rise under climate change. Allocating funding to preventative strategies would be best informed by accurate estimates of salmonellosis costs under climate change and by knowing which population subgroups will be most affected. OBJECTIVE: We used microsimulation models to estimate the health and economic costs of salmonellosis in Central Queensland under climate change between 2016 and 2036 to inform preventative strategies. METHODS: We projected the entire population of Central Queensland to 2036 by simulating births, deaths, and migration, and salmonellosis and two resultant conditions, reactive arthritis and postinfectious irritable bowel syndrome. We estimated salmonellosis risks and costs under baseline conditions and under projected climate conditions for Queensland under the A1FI emissions scenario using composite projections from 6 global climate models (warm with reduced rainfall). We estimated the resulting costs based on direct medical expenditures combined with the value of lost quality-adjusted life years (QALYs) based on willingness-to-pay. RESULTS: Estimated costs of salmonellosis between 2016 and 2036 increased from 456.0 QALYs (95% CI: 440.3, 473.1) and AUD29,900,000 million (95% CI: AUD28,900,000, AUD31,600,000), assuming no climate change, to 485.9 QALYs (95% CI: 469.6, 503.5) and AUD31,900,000 (95% CI: AUD30,800,000, AUD33,000,000) under the climate change scenario. CONCLUSION: We applied a microsimulation approach to estimate the costs of salmonellosis and its sequelae in Queensland during 2016-2036 under baseline conditions and according to climate change projections. This novel application of microsimulation models demonstrates the models' potential utility to researchers for examining complex interactions between weather and disease to estimate future costs. https://doi.org/10.1289/EHP1370.
[Mh] Termos MeSH primário: Mudança Climática
Infecções por Salmonella/economia
Infecções por Salmonella/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Artrite Reativa/economia
Artrite Reativa/epidemiologia
Criança
Pré-Escolar
Feminino
Serviços de Saúde/economia
Serviços de Saúde/utilização
Temperatura Alta
Seres Humanos
Lactente
Recém-Nascido
Síndrome do Intestino Irritável/economia
Síndrome do Intestino Irritável/epidemiologia
Masculino
Meia-Idade
Modelos Econométricos
Anos de Vida Ajustados por Qualidade de Vida
Queensland/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1289/EHP1370


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[PMID]:29342165
[Au] Autor:Mughini-Gras L; Schaapveld M; Kramers J; Mooij S; Neefjes-Borst EA; Pelt WV; Neefjes J
[Ad] Endereço:National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, Bilthoven, the Netherlands.
[Ti] Título:Increased colon cancer risk after severe Salmonella infection.
[So] Source:PLoS One;13(1):e0189721, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study examined whether severe Salmonella infection, usually acquired from contaminated food, is associated with increased colon cancer risk in humans. METHODS AND FINDINGS: We performed a nationwide registry-based study to assess colon cancer risk after diagnosed Salmonella infection. National infectious disease surveillance records (1999-2015) for Dutch residents aged ≥20 years when diagnosed with salmonellosis (n = 14,264) were linked to the Netherlands Cancer Registry. Salmonella-infected patients were laboratory-confirmed under medical consultation after 1-2 weeks of illness. These datasets also contained information on Salmonella serovar and type of infection. Colon cancer risk (overall and per colon subsite) among patients with a diagnosed Salmonella infection was compared with expected colon cancer risk in the general population. Data from the nationwide registry of histo- and cytopathology (PALGA) and Statistics Netherlands (CBS) allowed assessing potential effects of age, gender, latency, socioeconomic status, genetic predisposition, inflammatory bowel disease (IBD), and tumor features. We found that compared to the general population, colon cancer risk was significantly increased (standardized incidence ratio [SIR] 1.54; 95%CI 1.09-2.10) among patients with Salmonella infection diagnosed <60 years of age. Such increased risk concerned specifically the ascending/transverse colon (SIR 2.12; 95%CI 1.38-3.09) after S. Enteritidis infection (SIR 2.97; 95%CI 1.73-4.76). Salmonellosis occurred more frequently among colon cancer patients with pre-infectious IBD, a known risk factor for colon cancer. Colon tumors of patients with a history of Salmonella infection were mostly of low grade. CONCLUSIONS: Patients diagnosed with severe salmonellosis have an increased risk of developing cancer in the ascending/transverse parts of the colon. This risk concerns particularly S. Enteritidis infection, suggesting a contribution of this major foodborne pathogen to colon cancer development.
[Mh] Termos MeSH primário: Neoplasias do Colo/complicações
Infecções por Salmonella/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Neoplasias do Colo/patologia
Feminino
Seres Humanos
Masculino
Camundongos
Meia-Idade
Sistema de Registros
Estudos Retrospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189721


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[PMID]:29255088
[Au] Autor:Clark-Curtiss JE; Curtiss R
[Ad] Endereço:Division of Infectious Diseases and Global Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610.
[Ti] Título: Vaccines: Conduits for Protective Antigens.
[So] Source:J Immunol;200(1):39-48, 2018 01 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vaccines afford a better and more cost-effective approach to combatting infectious diseases than continued reliance on antibiotics or antiviral or antiparasite drugs in the current era of increasing incidences of diseases caused by drug-resistant pathogens. Recombinant attenuated vaccines (RASVs) have been significantly improved to exhibit the same or better attributes than wild-type parental strains to colonize internal lymphoid tissues and persist there to serve as factories to continuously synthesize and deliver rAgs. Encoded by codon-optimized pathogen genes, Ags are selected to induce protective immunity to infection by that pathogen. After immunization through a mucosal surface, the RASV attributes maximize their abilities to elicit mucosal and systemic Ab responses and cell-mediated immune responses. This article summarizes many of the numerous innovative technologies and discoveries that have resulted in RASV platforms that will enable development of safe efficacious RASVs to protect animals and humans against a diversity of infectious disease agents.
[Mh] Termos MeSH primário: Infecções por Salmonella/imunologia
Vacinas contra Salmonella/imunologia
Salmonella/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Bactérias/imunologia
Resistência a Medicamentos
Seres Humanos
Imunidade Inata
Vacinação em Massa
Vacinas Atenuadas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Salmonella Vaccines); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1600608


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[PMID]:28747347
[Au] Autor:Ye W; Hu MM; Lei CQ; Zhou Q; Lin H; Sun MS; Shu HB
[Ad] Endereço:College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China; and.
[Ti] Título:TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.
[So] Source:J Immunol;199(5):1856-1864, 2017 09 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:TLR-mediated signaling pathways play critical roles in host defense against microbials. However, dysregulation of innate immune and inflammatory responses triggered by TLRs would result in harmful damage to the host. Using a gene-knockout mouse model, we show that tripartite motif (TRIM) 8 negatively regulates TLR3- and TLR4-mediated innate immune and inflammatory responses. TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including , , , and , evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as infection-induced loss of body weight and septic shock. TRIM8 interacted with Toll/IL-1 receptor domain-containing adapter-inducing IFN-ß and mediated its K6- and K33-linked polyubiquitination, leading to disruption of the Toll/IL-1 receptor domain-containing adapter-inducing IFN-ß-TANK-binding kinase-1 association. Our findings uncover an additional mechanism on the termination of TLR3/4-mediated inflammatory and innate immune responses.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transporte Vesicular/metabolismo
Proteínas de Transporte/metabolismo
Inflamação/imunologia
Proteínas do Tecido Nervoso/metabolismo
Proteínas Serina-Treonina Quinases/metabolismo
Infecções por Salmonella/imunologia
Salmonella typhimurium/imunologia
Choque Séptico/imunologia
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte/genética
Citocinas/genética
Citocinas/metabolismo
Células HEK293
Seres Humanos
Imunidade Inata
Inflamação/microbiologia
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Proteínas do Tecido Nervoso/genética
Poli I-C/imunologia
Ligação Proteica
Transdução de Sinais
Receptor 3 Toll-Like/metabolismo
Receptor 4 Toll-Like/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adaptor Proteins, Vesicular Transport); 0 (Carrier Proteins); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Nerve Tissue Proteins); 0 (TICAM-1 protein, mouse); 0 (TLR3 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 3); 0 (Toll-Like Receptor 4); 0 (Trim8 protein, mouse); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (TBK1 protein, human); O84C90HH2L (Poly I-C)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601647


  10 / 10676 MEDLINE  
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[PMID]:28456552
[Au] Autor:Ziebell K; Chui L; King R; Johnson S; Boerlin P; Johnson RP
[Ad] Endereço:National Microbiology Laboratory at Guelph, PHAC, Guelph, ON, Canada.
[Ti] Título:Subtyping of Canadian isolates of Salmonella Enteritidis using Multiple Locus Variable Number Tandem Repeat Analysis (MLVA) alone and in combination with Pulsed-Field Gel Electrophoresis (PFGE) and phage typing.
[So] Source:J Microbiol Methods;139:29-36, 2017 08.
[Is] ISSN:1872-8359
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Salmonella enterica subspecies enterica serovar Enteritidis (SE) is one of the most common causes of human salmonellosis and in Canada currently accounts for over 40% of human cases. Reliable subtyping of isolates is required for outbreak detection and source attribution. However, Pulsed-Field Gel Electrophoresis (PFGE), the current standard subtyping method for Salmonella spp., is compromised by the high genetic homogeneity of SE. Multiple Locus Variable Number Tandem Repeat Analysis (MLVA) was introduced to supplement PFGE, although there is a lack of data on the ability of MLVA to subtype Canadian isolates of SE. Three subtyping methods, PFGE, MLVA and phage typing were compared for their discriminatory power when applied to three panels of Canadian SE isolates: Panel 1: 70 isolates representing the diversity of phage types (PTs) and PFGE subtypes within these PTs; Panel 2: 214 apparently unrelated SE isolates of the most common PTs; and Panel 3: 27 isolates from 10 groups of epidemiologically related strains. For Panel 2 isolates, four MLVA subtypes were shared among 74% of unrelated isolates and in Panel 3 isolates, one MLVA subtype accounted for 62% of the isolates. For all panels, combining results from PFGE, MLVA and PT gave the best discrimination, except in Panel 1, where the combination of PT and PFGE was equally as high, due to the selection criteria for this panel. However, none of these methods is sufficiently discriminatory alone for reliable outbreak detection or source attribution, and must be applied together to achieve sufficient discrimination for practical purposes. Even then, some large clusters were not differentiated adequately. More discriminatory methods are required for reliable subtyping of this genetically highly homogeneous serovar. This need will likely be met by whole genome sequence analysis given the recent promising reports and as more laboratories implement this tool for outbreak response and surveillance.
[Mh] Termos MeSH primário: Técnicas de Tipagem Bacteriana/métodos
Tipagem de Bacteriófagos
Eletroforese em Gel de Campo Pulsado
Repetições Minissatélites
Salmonella enteritidis/classificação
Salmonella enteritidis/genética
[Mh] Termos MeSH secundário: Animais
Canadá
DNA Bacteriano/genética
Surtos de Doenças
Seres Humanos
Laboratórios
Infecções por Salmonella/microbiologia
Salmonella enteritidis/isolamento & purificação
Sorogrupo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE



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