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[PMID]:29324228
[Au] Autor:Stecher B; Jung K
[Ad] Endereço:Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstr. 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site LMU Munich, Munich, Germany. Electronic address: stecher@mvp.uni-muenchen.de.
[Ti] Título:LACTATEing Salmonella: A Host-Derived Fermentation Product Fuels Pathogen Growth.
[So] Source:Cell Host Microbe;23(1):3-4, 2018 01 10.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infection by Salmonella enterica serovar Typhimurium is accompanied by dysbiosis and a decrease of microbiota-derived butyrate. In this issue of Cell Host & Microbe, Gillis et al. (2018) demonstrate that the lack of butyrate reprograms colonic epithelial metabolism toward lactate fermentation. Lactate is then used as a respiratory electron donor, supporting Salmonella growth and thus promoting infection.
[Mh] Termos MeSH primário: Fermentação
Salmonella typhimurium
[Mh] Termos MeSH secundário: Colo
Salmonelose Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  2 / 8096 MEDLINE  
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[PMID]:29328567
[Au] Autor:Bosnjak I; Zdravkovic N; Colovic S; Randelovic S; Galic N; Radojicic M; Sekler M; Aleksic-Kovacevic S; Krnjaic D
[Ti] Título:Neglected zoonosis: The prevalence of Salmonella spp. in pet reptiles in Serbia.
[So] Source:Vojnosanit Pregl;73(10):980-2, 2016 Oct.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Mh] Termos MeSH primário: Animais de Estimação/microbiologia
Répteis/microbiologia
Salmonelose Animal/transmissão
Salmonella/patogenicidade
Zoonoses/transmissão
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Fatores de Risco
Salmonelose Animal/diagnóstico
Salmonelose Animal/epidemiologia
Salmonelose Animal/microbiologia
Sérvia/epidemiologia
Zoonoses/diagnóstico
Zoonoses/epidemiologia
Zoonoses/microbiologia
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP160809222B


  3 / 8096 MEDLINE  
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[PMID]:28470335
[Au] Autor:Han GG; Song AA; Kim EB; Yoon SH; Bok JD; Cho CS; Kil DY; Kang SK; Choi YJ
[Ad] Endereço:Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
[Ti] Título:Improved antimicrobial activity of Pediococcus acidilactici against Salmonella Gallinarum by UV mutagenesis and genome shuffling.
[So] Source:Appl Microbiol Biotechnol;101(13):5353-5363, 2017 Jul.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pediococcus acidilactici is a widely used probiotic, and Salmonella enterica serovar Gallinarum (SG) is a significant pathogen in the poultry industry. In this study, we improved the antimicrobial activity of P. acidilactici against SG using UV mutation and genome shuffling (GS). To improve antimicrobial activity against SG, UV mutagenesis was performed against wild-type P. acidilactici (WT), and five mutants showed improved antimicrobial activity. To further improve antimicrobial activity, GS was performed on five UV mutants. Following GS, four mutants showed improved antimicrobial activity compared with the UV mutants and WT. The antimicrobial activity of GS1 was highest among the mutants; however, the activity was reduced when the culture supernatant was treated with proteinase K, suggesting that the improved antimicrobial activity is due to a proteinous substance such as bacteriocin. To validate the activity of GS1 in vivo, we designed multi-species probiotics and performed broiler feeding experiments. Groups consisted of no treatment (NC), avilamycin-treated (PC), probiotic group 1 containing WT (T1), and probiotic group 2 containing GS1 (T2). In broiler feeding experiments, coliform bacteria were significantly reduced in T2 compared with NC, PC, and T1. The cecal microbiota was modulated and pathogenic bacteria were reduced by GS1 oral administration. In this study, GS1 showed improved antimicrobial activity against SG in vitro and reduced pathogenic bacteria in a broiler feeding experiment. These results suggest that GS1 can serve as an efficient probiotic, as an alternative to antibiotics in the poultry industry.
[Mh] Termos MeSH primário: Antibiose
Embaralhamento de DNA
Mutagênese
Pediococcus acidilactici/genética
Pediococcus acidilactici/fisiologia
Probióticos
Salmonella/fisiologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Anti-Infecciosos
Bacteriocinas/biossíntese
Bacteriocinas/farmacologia
Ceco/microbiologia
Galinhas/microbiologia
Meios de Cultura/química
Endopeptidase K/metabolismo
Genoma Bacteriano
Pediococcus acidilactici/efeitos dos fármacos
Pediococcus acidilactici/efeitos da radiação
Doenças das Aves Domésticas/microbiologia
Doenças das Aves Domésticas/terapia
Probióticos/química
Salmonella/efeitos dos fármacos
Salmonelose Animal/microbiologia
Salmonelose Animal/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Bacteriocins); 0 (Culture Media); EC 3.4.21.64 (Endopeptidase K)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-017-8293-6


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[PMID]:28462509
[Au] Autor:Southwood LL; Lindborg S; Myers M; Aceto HW
[Ad] Endereço:Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania.
[Ti] Título:Influence of Salmonella status on the long-term outcome of horses after colic surgery.
[So] Source:Vet Surg;46(6):780-788, 2017 Aug.
[Is] ISSN:1532-950X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare long-term outcome of Salmonella-positive versus Salmonella-negative horses discharged from hospital after colic surgery. STUDY DESIGN: Retrospective case-control. ANIMALS: Horses discharged from the hospital after colic surgery. For each horse with positive culture for Salmonella enterica (SAL-POS, n = 59), at least 2 horses testing negative for S. enterica (SAL-NEG, n = 119) were enrolled. METHODS: Owners were interviewed via phone at least 12 months after surgery regarding: (1) complications after discharge from the hospital; (2) duration of survival; and (3) return to prior or intended use. Association between immediate postoperative clinical variables such as Salmonella status and long-term measures of outcome was tested via ratios (odds ratio [OR]) and 95% confidence intervals. Data were analyzed for survival using a Cox proportional hazards model and for return to use using multivariable logistic regression. RESULTS: SAL-POS horses had a higher OR of surgical site infection (2.7 [1.1-6.9] P = .027) and weight loss (6.8 [1.8-26.1] P = .002). At the time of follow-up, there were 53/56 (95%) SAL-POS and 99/118 (84%) SAL-NEG horses alive. The final multivariable model for nonsurvival included postoperative colic (hazard ratio 7.6 [2.8-19.2] P = .002) and the interaction between Salmonella status and duration of rectal temperature > 103°F postoperatively (SAL-POS 1.04 [1.01-1.07] and SAL-NEG 1.16 [1.06-1.25], P = .005). The majority of horses returned to their intended use regardless of their SAL-POS (38/50, 76%) or SAL-NEG (77/96, 80%, P = .498) status. CONCLUSION: Salmonella-positive horses that survive to discharge from the hospital after colic surgery have similar risks of long-term complications (colic/diarrhea), survival, and return to function than Salmonella-negative horses.
[Mh] Termos MeSH primário: Cólica/veterinária
Doenças dos Cavalos/cirurgia
Salmonelose Animal/epidemiologia
Salmonella/fisiologia
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Cólica/microbiologia
Cólica/cirurgia
Feminino
Doenças dos Cavalos/microbiologia
Cavalos
Modelos Logísticos
Masculino
Razão de Chances
Estudos Retrospectivos
Salmonelose Animal/microbiologia
Infecção da Ferida Cirúrgica/veterinária
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/vsu.12660


  5 / 8096 MEDLINE  
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[PMID]:28449706
[Au] Autor:Borton MA; Sabag-Daigle A; Wu J; Solden LM; O'Banion BS; Daly RA; Wolfe RA; Gonzalez JF; Wysocki VH; Ahmer BMM; Wrighton KC
[Ad] Endereço:Department of Microbiology, The Ohio State University, 484 W. 12th Avenue, 440 Biological Sciences Building, Columbus, OH, 43210, USA.
[Ti] Título:Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome.
[So] Source:Microbiome;5(1):47, 2017 04 27.
[Is] ISSN:2049-2618
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Salmonella is one of the most significant food-borne pathogens to affect humans and agriculture. While it is well documented that Salmonella infection triggers host inflammation, the impacts on the gut environment are largely unknown. A CBA/J mouse model was used to evaluate intestinal responses to Salmonella-induced inflammation. In parallel, we evaluated chemically induced inflammation by dextran sodium sulfate (DSS) and a non-inflammation control. We profiled gut microbial diversity by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from fecal and cecal samples. These data were correlated to the inflammation marker lipocalin-2 and short-chain fatty acid concentrations. RESULTS: We demonstrated that inflammation, chemically or biologically induced, restructures the chemical and microbial environment of the gut over a 16-day period. We observed that the ten mice within the Salmonella treatment group had a variable Salmonella relative abundance, with three high responding mice dominated by >46% Salmonella at later time points and the remaining seven mice denoted as low responders. These low- and high-responding Salmonella groups, along with the chemical DSS treatment, established an inflammation gradient with chemical and low levels of Salmonella having at least 3 log-fold lower lipocalin-2 concentration than the high-responding Salmonella mice. Total short-chain fatty acid and individual butyrate concentrations each negatively correlated with inflammation levels. Microbial communities were also structured along this inflammation gradient. Low levels of inflammation, regardless of chemical or biological induction, enriched for Akkermansia spp. in the Verrucomicrobiaceae and members of the Bacteroidetes family S24-7. Relative to the control or low inflammation groups, high levels of Salmonella drastically decreased the overall microbial diversity, specifically driven by the reduction of Alistipes and Lachnospiraceae in the Bacteroidetes and Firmicutes phyla, respectively. Conversely, members of the Enterobacteriaceae and Lactobacillus were positively correlated to high levels of Salmonella-induced inflammation. CONCLUSIONS: Our results show that enteropathogenic infection and intestinal inflammation are interrelated factors modulating gut homeostasis. These findings may prove informative with regard to prophylactic or therapeutic strategies to prevent disruption of microbial communities, or promote their restoration.
[Mh] Termos MeSH primário: Bactérias/classificação
Microbioma Gastrointestinal
Lipocalina-2/metabolismo
Salmonelose Animal/imunologia
Análise de Sequência de DNA/métodos
[Mh] Termos MeSH secundário: Animais
Bactérias/genética
Bactérias/isolamento & purificação
Ceco/microbiologia
DNA Bacteriano/genética
DNA Ribossômico/genética
Sulfato de Dextrana/efeitos adversos
Fezes/microbiologia
Camundongos
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Lipocalin-2); 0 (RNA, Ribosomal, 16S); 126469-30-5 (Lcn2 protein, mouse); 9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s40168-017-0264-8


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[PMID]:29040285
[Au] Autor:Yang HJ; Bogomolnaya L; McClelland M; Andrews-Polymenis H
[Ad] Endereço:Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M University System Health Science Center, Bryan, TX, United States of America.
[Ti] Título:De novo pyrimidine synthesis is necessary for intestinal colonization of Salmonella Typhimurium in chicks.
[So] Source:PLoS One;12(10):e0183751, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:pyrE (STM3733) encodes orotate phosphoribosyltransferase (OPRTase; EC 2.4.2.10), the fifth enzyme of the de novo pyrimidine biosynthetic pathway. We identified a ΔpyrE mutant as under selection in screening of a Salmonella mutant library in 4-day old chicks. Here, we confirm that a ΔpyrE mutant colonizes 4-day old chicks poorly in competitive infection with isogenic wild type, and that the ability of this mutant to colonize chicks could be restored by providing a copy of pyrE in trans. We further show that our ΔpyrE mutant grows poorly in nutrient poor conditions in vitro, and that the ability of this mutant to grow is restored, both in vitro and in chicks, when precursors to the pyrimidine salvage pathway were provided. This finding suggests that the environment in the chick intestine during our infections lacks sufficient precursors of the pyrimidine salvage pathway to support Salmonella growth. Finally, we show that the colonization defect of a ΔpyrE mutant during infection occurs in to chicks, but not in CBA/J mice or ligated ileal loops in calves. Our data suggest that de novo pyrimidine synthesis is necessary for colonization of Salmonella Typhimurium in the chick, and that the salvage pathway is not used in this niche.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Galinhas/microbiologia
Orotato Fosforribosiltransferase/genética
Doenças das Aves Domésticas/microbiologia
Pirimidinas/biossíntese
Salmonelose Animal/microbiologia
Salmonella typhimurium/genética
Fatores de Virulência/genética
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/metabolismo
Bovinos
Contagem de Colônia Microbiana
Deleção de Genes
Expressão Gênica
Biblioteca Gênica
Teste de Complementação Genética
Especificidade de Hospedeiro
Camundongos
Camundongos Endogâmicos CBA
Orotato Fosforribosiltransferase/deficiência
Doenças das Aves Domésticas/metabolismo
Doenças das Aves Domésticas/patologia
Salmonelose Animal/metabolismo
Salmonelose Animal/patologia
Salmonella typhimurium/metabolismo
Salmonella typhimurium/patogenicidade
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Pyrimidines); 0 (Virulence Factors); EC 2.4.2.10 (Orotate Phosphoribosyltransferase); K8CXK5Q32L (pyrimidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183751


  7 / 8096 MEDLINE  
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[PMID]:28961267
[Au] Autor:Vinod N; Noh HB; Oh S; Ji S; Park HJ; Lee KS; Kim SC; Park HO; Yang JS; Choi CW
[Ad] Endereço:Department of Biology & Medicinal Science, Pai Chai University, Daejeon, Korea.
[Ti] Título:A Salmonella typhimurium ghost vaccine induces cytokine expression in vitro and immune responses in vivo and protects rats against homologous and heterologous challenges.
[So] Source:PLoS One;12(9):e0185488, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salmonella enteritidis and Salmonella typhimurium are important food-borne bacterial pathogens, which are responsible for diarrhea and gastroenteritis in humans and animals. In this study, S. typhimurium bacterial ghost (STG) was generated based on minimum inhibitory concentration (MIC) of sodium hydroxide (NaOH). Experimental studies performed using in vitro and in vivo experimental model systems to characterize effects of STG as a vaccine candidate. When compared with murine macrophages (RAW 264.7) exposed to PBS buffer (98.1%), the macrophages exposed to formalin-killed inactivated cells (FKC), live wild-type bacterial cells and NaOH-induced STG at 1 × 108 CFU/mL showed 85.6%, 66.5% and 84.6% cell viability, respectively. It suggests that STG significantly reduces the cytotoxic effect of wild-type bacterial cells. Furthermore, STG is an excellent inducer for mRNAs of pro-inflammatory cytokine (TNF-α, IL-1ß) and factor (iNOS), anti-inflammatory cytokine (IL-10) and dual activities (IL-6) in the stimulated macrophage cells. In vivo, STG vaccine induced humoral and cellular immune responses and protection against homologous and heterologous challenges in rats. Furthermore, the immunogenicity and protective efficacy of STG vaccine were compared with those of FKC and non-vaccinated PBS control groups. The vaccinated rats from STG group exhibited higher levels of serum IgG antibody responses, serum bactericidal antibodies, and CD4+ and CD8+ T-cell populations than those of the FKC and PBS control groups. Most importantly, after challenge with homologous and heterologous strains, the bacterial loads in the STG group were markedly lower than the FKC and PBS control groups. In conclusion, these findings suggest that the STG vaccine induces protective immunity against homologous and heterologous challenges.
[Mh] Termos MeSH primário: Vacinas Bacterianas/administração & dosagem
Citocinas/metabolismo
Salmonelose Animal/prevenção & controle
Salmonella typhimurium/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/biossíntese
Anticorpos Antibacterianos/sangue
Vacinas Bacterianas/imunologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Linhagem Celular
Citocinas/genética
Mediadores da Inflamação/metabolismo
Camundongos
RNA Mensageiro/genética
Ratos
Salmonelose Animal/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Bacterial Vaccines); 0 (Cytokines); 0 (Inflammation Mediators); 0 (RNA, Messenger)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185488


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[PMID]:28922030
[Au] Autor:Chaney WE; Agga GE; Nguyen SV; Arthur TM; Bosilevac JM; Dreyling E; Rishi A; Brichta-Harhay D
[Ad] Endereço:1 Roka Bioscience, Inc., 10398 Pacific Center Court, San Diego, California 92121.
[Ti] Título:Rapid Detection and Classification of Salmonella enterica Shedding in Feedlot Cattle Utilizing the Roka Bioscience Atlas Salmonella Detection Assay for the Analysis of Rectoanal Mucosal Swabs.
[So] Source:J Food Prot;80(10):1760-1767, 2017 Oct.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With an increasing focus on preharvest food safety, rapid methods are required for the detection and quantification of foodborne pathogens such as Salmonella enterica in beef cattle. We validated the Atlas Salmonella Detection Assay (SEN), a nucleic acid amplification technology that targets Salmonella rRNA, for the qualitative detection of S. enterica with sample enrichment using immunomagnetic separation as a reference test, and we further evaluated its accuracy to predict pathogen load using SEN signal-to-cutoff (SCO) values from unenriched samples to classify animals as high or nonhigh shedders. Rectoanal mucosal swabs (RAMS) were collected from 238 beef cattle from five cohorts located in the Midwest or southern High Plains of the United States between July 2015 and April 2016. Unenriched RAMS samples were used for the enumeration and SEN SCO analyses. Enriched samples were tested using SEN and immunomagnetic separation methods for the detection of Salmonella. The SEN method was 100% sensitive and specific for the detection of Salmonella from the enriched RAMS samples. A SEN SCO value of 8, with a sensitivity of 93.5% and specificity of 94.3%, was found to be an optimum cutoff value for classifying animals as high or nonhigh shedders from the unenriched RAMS samples. The SEN assay is a rapid and reliable method for the qualitative detection and categorization of the shedding load of Salmonella from RAMS in feedlot cattle.
[Mh] Termos MeSH primário: Doenças dos Bovinos/microbiologia
Salmonelose Animal/microbiologia
Salmonella enterica/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/diagnóstico
Fezes/microbiologia
Masculino
Membrana Mucosa
Salmonella
Salmonelose Animal/diagnóstico
Salmonella enterica/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-17-124


  9 / 8096 MEDLINE  
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[PMID]:28864509
[Au] Autor:Arsevska E; Singleton D; Sánchez-Vizcaíno F; Williams N; Jones PH; Smyth S; Heayns B; Wardeh M; Radford AD; Dawson S; Noble PJM; Davies RH
[Ad] Endereço:Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, UK.
[Ti] Título:Small animal disease surveillance: GI disease and salmonellosis.
[So] Source:Vet Rec;181(9):228-232, 2017 Sep 02.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Presentation for gastrointestinal (GI) disease comprised 2.2 per cent of cat, 3.2 per cent of dog and 2.2 per cent of rabbit consultations between April 1, 2016 and March 31, 2017Diarrhoea and vomiting without blood were the most frequently reported GI disease clinical signs (34.4 and 38.9 per cent in cats and 42.8 and 37.3 per cent in dogs, respectively)The mean percentage of samples testing positive for in dogs was double that in cats (0.82 per cent and 0.41 per cent, respectively) from January 1, 2011 to December 31, 2016In dogs, autumn was associated with a greater proportion of -positive sample submissions; no clear suggestion of seasonal variation in cats was observedIn both cats and dogs, isolates belonging to group B serotypes were the most common (68.9 per cent in cats and 55.0 per cent in dogs).
[Mh] Termos MeSH primário: Doenças do Gato/epidemiologia
Doenças do Cão/epidemiologia
Gastroenteropatias/veterinária
Salmonelose Animal/epidemiologia
Vigilância de Evento Sentinela/veterinária
[Mh] Termos MeSH secundário: Animais
Gatos
Cães
Gastroenteropatias/epidemiologia
Coelhos
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j3642


  10 / 8096 MEDLINE  
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[PMID]:28821568
[Au] Autor:Liu W; Liu X; Li Y; Zhao J; Liu Z; Hu Z; Wang Y; Yao Y; Miller AW; Su B; Cookson MR; Li X; Kang Z
[Ad] Endereço:Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Título:LRRK2 promotes the activation of NLRC4 inflammasome during Typhimurium infection.
[So] Source:J Exp Med;214(10):3051-3066, 2017 Oct 02.
[Is] ISSN:1540-9538
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although genetic polymorphisms in the gene are associated with a variety of diseases, the physiological function of LRRK2 remains poorly understood. In this study, we report a crucial role for LRRK2 in the activation of the NLRC4 inflammasome during host defense against serovar Typhimurium infection. deficiency reduced caspase-1 activation and IL-1ß secretion in response to NLRC4 inflammasome activators in macrophages. mice exhibited impaired clearance of pathogens after acute Typhimurium infection. Mechanistically, LRRK2 formed a complex with NLRC4 in the macrophages, and the formation of the LRRK2-NLRC4 complex led to the phosphorylation of NLRC4 at Ser533. Importantly, the kinase activity of LRRK2 is required for optimal NLRC4 inflammasome activation. Collectively, our study reveals an important role for LRRK2 in the host defense by promoting NLRC4 inflammasome activation.
[Mh] Termos MeSH primário: Proteínas Reguladoras de Apoptose/fisiologia
Proteínas de Ligação ao Cálcio/fisiologia
Inflamassomos/imunologia
Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/fisiologia
Salmonelose Animal/imunologia
Salmonella typhimurium/imunologia
[Mh] Termos MeSH secundário: Animais
Caspase 1/fisiologia
Inflamassomos/fisiologia
Interleucina-1beta/fisiologia
Macrófagos/fisiologia
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fosforilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins); 0 (Calcium-Binding Proteins); 0 (Inflammasomes); 0 (Interleukin-1beta); 0 (Ipaf protein, mouse); EC 2.7.11.1 (Leucine-Rich Repeat Serine-Threonine Protein Kinase-2); EC 2.7.11.1 (Lrrk2 protein, mouse); EC 3.4.22.36 (Caspase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1084/jem.20170014



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