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[PMID]:29385373
[Au] Autor:Bann M; Kaul DR; Haider MZ; Saint S; Goldberger ZD
[Ad] Endereço:From the Department of Medicine (M.B., M.Z.H., Z.D.G.) and the Divisions of General Internal Medicine (M.B., M.Z.H.) and Cardiology (Z.D.G.), University of Washington School of Medicine, Harborview Medical Center, Seattle; and the Department of Internal Medicine (D.R.K., S.S.) and Division of Infect
[Ti] Título:Home Sweet Home.
[So] Source:N Engl J Med;378(5):461-466, 2018 Feb 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Salmonella typhi/isolamento & purificação
Viagem
Febre Tifoide/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Febre/etiologia
Bactérias Gram-Negativas/isolamento & purificação
Seres Humanos
Mialgia/etiologia
Sudorese
Febre Tifoide/complicações
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcps1704731


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[PMID]:29216496
[Au] Autor:Russell K; Addiman S; Grynszpan D; Freedman J; Lopez Bernal J; Yin Z; Rawlings C; Balasegaram S
[Ad] Endereço:Emerging Infections and Zoonoses, National Infection Service, Public Health England, 61 Colindale Avenue, London, NW9 5EQ, UK. Electronic address: Katherine.russell@phe.gov.uk.
[Ti] Título:The impact of new national guidance for the public health management of enteric fever in England.
[So] Source:Public Health;154:79-86, 2018 Jan.
[Is] ISSN:1476-5616
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: New guidance was published in England in February 2012 to support the public health management of enteric fever and reduce the risks of secondary transmission. The new guidance was evaluated to assess: STUDY DESIGN: Quantitative and qualitative evaluation of the implementation of new public health guidance. METHODS: A qualitative review of all non-travel-related cases from February 2010 to January 2014 to compare the risk of secondary transmission before and after the guidance introduction; an audit of clearance sampling for each case and their contacts reported in London from February 2012-January 2015 to compare with a previous London audit; and an online user survey in November 2014. RESULTS: The proportions of non-travel cases reported before and after the introduction of the new guidance were similar, 6% in 2010-2012 compared to 7% in 2012-2014 (P = 0.33). There was a 32% reduction in the number of clearance samples required for cases and the estimated period of exclusion from work or school was reduced from 54 days to 16 days. Compliance in case clearance improved from 53% to 90% and contact screening compliance improved from 42% to 80%. The targeted screening of contacts led to a significantly higher positive yield (3.6% from 1.5%, P = 0.003). All symptomatic co-travellers presented to a healthcare professional, suggesting that screening could be restricted to those in risk groups for transmission. Feedback from users highlighted additional areas, such as management of large organised groups of co-travellers and those diagnosed abroad, which has informed the update of the national guidance. CONCLUSIONS: The new guidance has not led to an increase in secondary transmission of enteric fever in England and findings have been used to inform an update of the guidance. The new guidance also represents a reduced burden of investigation and thus a likely reduced cost to patients, healthcare professionals, laboratories and environmental health officers.
[Mh] Termos MeSH primário: Guias como Assunto
Administração em Saúde Pública
Febre Tifoide/prevenção & controle
[Mh] Termos MeSH secundário: Inglaterra/epidemiologia
Seres Humanos
Pesquisa Qualitativa
Doença Relacionada a Viagens
Febre Tifoide/epidemiologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:29303231
[Ti] Título:Immunization and Vaccine-related Implementation Research Advisory Committee (IVIR-AC): summary of conclusions and recommendations, 20­22 September 2017.
[Ti] Título:Comité consultatif sur la vaccination et la recherché sur la mise en oeuvre des vaccins (IVIR-AC): résumé des conclusions et recommandations, 20-22 septembre 2017..
[So] Source:Wkly Epidemiol Rec;93(1):1-7, 2018 Jan 05.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Comitês Consultivos
Programas de Imunização/normas
Vacinas Antimaláricas/administração & dosagem
Malária/prevenção & controle
Vacinas Virais/administração & dosagem
Viroses/prevenção & controle
[Mh] Termos MeSH secundário: Fatores Etários
Mortalidade da Criança
Pré-Escolar
Cólera/epidemiologia
Cólera/prevenção & controle
Seres Humanos
Esquemas de Imunização
Lactente
Infecções por Papillomavirus/prevenção & controle
Vacinas contra Papillomavirus/administração & dosagem
Raiva/prevenção & controle
Vacinas Antirrábicas/administração & dosagem
Infecções por Rotavirus/prevenção & controle
Vacinas contra Rotavirus/administração & dosagem
Febre Tifoide/prevenção & controle
Vacinas Tíficas-Paratíficas/administração & dosagem
[Pt] Tipo de publicação:GUIDELINE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Malaria Vaccines); 0 (Papillomavirus Vaccines); 0 (Rabies Vaccines); 0 (Rotavirus Vaccines); 0 (Typhoid-Paratyphoid Vaccines); 0 (Viral Vaccines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE


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[PMID]:29184606
[Au] Autor:Nahimana MR; Ngoc CT; Olu O; Nyamusore J; Isiaka A; Ndahindwa V; Dassanayake L; Rusanganwa A
[Ad] Endereço:WHO Country Office, Ebenezer House, Boulevard of Umuganda, Kigali, Rwanda.
[Ti] Título:Knowledge, attitude and practice of hygiene and sanitation in a Burundian refugee camp: implications for control of a Salmonella typhi outbreak.
[So] Source:Pan Afr Med J;28:54, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: A outbreak was reported in a Burundian refugee camp in Rwanda in October 2015. Transmission persisted despite increased hygiene promotion activities and hand-washing facilities instituted to prevent and control the outbreak. A knowledge, attitude and practice (KAP) study was carried out to assess the effectiveness of ongoing typhoid fever preventive interventions. Methods: A cross-sectional survey was conducted in Mahama Refugee Camp of Kirehe District, Rwanda from January to February 2016. Data were obtained through administration of a structured KAP questionnaire. Descriptive, bivariate and multivariate analysis was performed using STATA software. Results: A total of 671 respondents comprising 264 (39.3%) males and 407 (60.7%) females were enrolled in the study. A comparison of hand washing practices before and after institution of prevention and control measures showed a 37% increase in the proportion of respondents who washed their hands before eating and after using the toilet (p < 0.001). About 52.8% of participants reported having heard about typhoid fever, however 25.9% had received health education. Only 34.6% and 38.6% of the respondents respectively knew how typhoid fever spreads and is prevented. Most respondents (98.2%) used pit latrines for disposal of feces. Long duration of stay in the camp, age over 35 years and being unemployed were statistically associated with poor hand washing practices. Conclusion: The findings of this study underline the need for bolstering up health education and hygiene promotion activities in Mahama and other refugee camp settings.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Higiene/normas
Saneamento/normas
Febre Tifoide/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Burundi/etnologia
Estudos Transversais
Surtos de Doenças/prevenção & controle
Feminino
Desinfecção das Mãos/normas
Educação em Saúde/métodos
Seres Humanos
Masculino
Meia-Idade
Campos de Refugiados
Ruanda/epidemiologia
Salmonella typhi/isolamento & purificação
Sanitários Públicos/normas
Febre Tifoide/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.54.12265


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[PMID]:29176850
[Au] Autor:Zellweger RM; Basnyat B; Shrestha P; Prajapati KG; Dongol S; Sharma PK; Koirala S; Darton TC; Dolecek C; Thompson CN; Thwaites GE; Baker SG; Karkey A
[Ad] Endereço:The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
[Ti] Título:A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital.
[So] Source:PLoS Negl Trop Dis;11(11):e0006051, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since the early 1990s. Susceptibility against commonly used antimicrobials for treating enteric fever has gradually changed throughout South Asia since this time, posing serious treatment challenges. Here, we aimed to longitudinally describe trends in the isolation of Salmonella enterica and assess changes in their antimicrobial susceptibility in Kathmandu over a 23-year period. METHODS: We conducted a retrospective analysis of standardised microbiological data from April 1992 to December 2014 at a single healthcare facility in Kathmandu, examining time trends of Salmonella-associated bacteraemia and the corresponding antimicrobial susceptibility profiles of the isolated organisms. RESULTS: Over 23 years there were 30,353 positive blood cultures. Salmonella enterica accounted for 65.4% (19,857/30,353) of all the bacteria positive blood cultures. S. Typhi and S. Paratyphi A were the dominant serovars, constituting 68.5% (13,592/19,857) and 30.5% (6,057/19,857) of all isolated Salmonellae. We observed (i) a peak in the number of Salmonella-positive cultures in 2002, a year of heavy rainfall and flooding in the Kathmandu Valley, followed by a decline toward pre-flood baseline by 2014, (ii) an increase in the proportion of S. Paratyphi in all Salmonella-positive cultures between 1992 and 2014, (iii) a decrease in the prevalence of MDR for both S. Typhi and S. Paratyphi, and (iv) a recent increase in fluoroquinolone non-susceptibility in both S. Typhi and S. Paratyphi isolates. CONCLUSIONS: Our work describes significant changes in the epidemiology of Salmonella enterica in the Kathmandu Valley during the last quarter of a century. We highlight the need to examine current treatment protocols for enteric fever and suggest a change from fluoroquinolone monotherapy to combination therapies of macrolides or cephalosporins along with older first-line antimicrobials that have regained their efficacy.
[Mh] Termos MeSH primário: Farmacorresistência Bacteriana Múltipla
Febre Paratifoide/epidemiologia
Salmonella paratyphi A/efeitos dos fármacos
Salmonella typhi/efeitos dos fármacos
Febre Tifoide/epidemiologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bacteriemia/microbiologia
Fluoroquinolonas/farmacologia
Seres Humanos
Modelos Lineares
Testes de Sensibilidade Microbiana
Nepal/epidemiologia
Febre Paratifoide/tratamento farmacológico
Estudos Retrospectivos
Salmonella paratyphi A/isolamento & purificação
Salmonella typhi/isolamento & purificação
Centros de Atenção Terciária
Febre Tifoide/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006051


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[PMID]:28742135
[Au] Autor:Hannemann S; Galán JE
[Ad] Endereço:Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America.
[Ti] Título:Salmonella enterica serovar-specific transcriptional reprogramming of infected cells.
[So] Source:PLoS Pathog;13(7):e1006532, 2017 Jul.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite their high degree of genomic similarity, different Salmonella enterica serovars are often associated with very different clinical presentations. In humans, for example, the typhoidal S. enterica serovar Typhi causes typhoid fever, a life-threatening systemic disease. In contrast, the non-typhoidal S. enterica serovar Typhimurium causes self-limiting gastroenteritis. The molecular bases for these different clinical presentations are incompletely understood. The ability to re-program gene expression in host cells is an essential virulence factor for typhoidal and non-typhoidal S. enterica serovars. Here, we have compared the transcriptional profile of cultured epithelial cells infected with S. Typhimurium or S. Typhi. We found that both serovars stimulated distinct transcriptional responses in infected cells that are associated with the stimulation of specific signal transduction pathways. These specific responses were associated with the presence of a distinct repertoire of type III secretion effector proteins. These observations provide major insight into the molecular bases for potential differences in the pathogenic mechanisms of typhoidal and non-typhoidal S. enterica serovars.
[Mh] Termos MeSH primário: Gastroenterite/microbiologia
Salmonella enterica/genética
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Seres Humanos
Salmonella typhi/genética
Salmonella typhi/metabolismo
Sorogrupo
Transcrição Genética
Febre Tifoide/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006532


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[PMID]:29081828
[Au] Autor:Tilahun GT; Makinde OD; Malonza D
[Ad] Endereço:Pan African University Institute of Basic Sciences Technology and Innovation, Nairobi, Kenya.
[Ti] Título:Modelling and Optimal Control of Typhoid Fever Disease with Cost-Effective Strategies.
[So] Source:Comput Math Methods Med;2017:2324518, 2017.
[Is] ISSN:1748-6718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We propose and analyze a compartmental nonlinear deterministic mathematical model for the typhoid fever outbreak and optimal control strategies in a community with varying population. The model is studied qualitatively using stability theory of differential equations and the basic reproductive number that represents the epidemic indicator is obtained from the largest eigenvalue of the next-generation matrix. Both local and global asymptotic stability conditions for disease-free and endemic equilibria are determined. The model exhibits a forward transcritical bifurcation and the sensitivity analysis is performed. The optimal control problem is designed by applying Pontryagin maximum principle with three control strategies, namely, the prevention strategy through sanitation, proper hygiene, and vaccination; the treatment strategy through application of appropriate medicine; and the screening of the carriers. The cost functional accounts for the cost involved in prevention, screening, and treatment together with the total number of the infected persons averted. Numerical results for the typhoid outbreak dynamics and its optimal control revealed that a combination of prevention and treatment is the best cost-effective strategy to eradicate the disease.
[Mh] Termos MeSH primário: Surtos de Doenças/prevenção & controle
Modelos Biológicos
Febre Tifoide/epidemiologia
Febre Tifoide/prevenção & controle
[Mh] Termos MeSH secundário: Biologia Computacional
Simulação por Computador
Análise Custo-Benefício
Surtos de Doenças/economia
Seres Humanos
Programas de Rastreamento
Conceitos Matemáticos
Dinâmica não Linear
Febre Tifoide/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171031
[St] Status:MEDLINE
[do] DOI:10.1155/2017/2324518


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[PMID]:29073137
[Au] Autor:Saha S; Islam M; Uddin MJ; Saha S; Das RC; Baqui AH; Santosham M; Black RE; Luby SP; Saha SK
[Ad] Endereço:Child Health Research Foundation, Department of Microbiology, Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh.
[Ti] Título:Integration of enteric fever surveillance into the WHO-coordinated Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) platform: A low cost approach to track an increasingly important disease.
[So] Source:PLoS Negl Trop Dis;11(10):e0005999, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lack of surveillance systems and accurate data impede evidence-based decisions on treatment and prevention of enteric fever, caused by Salmonella Typhi/Paratyphi. The WHO coordinates a global Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) surveillance network but does not monitor enteric fever. We evaluated the feasibility and sustainability of integrating enteric fever surveillance into the ongoing IB-VPD platform. METHODOLOGIES: The IB-VPD surveillance system uses WHO definitions to enroll 2-59 month children hospitalized with possible pneumonia, sepsis or meningitis. We expanded this surveillance system to additionally capture suspect enteric fever cases during 2012-2016, in two WHO sentinel hospitals of Bangladesh, by adding inclusion criteria of fever ≥102°F for ≥3 days, irrespective of other manifestations. Culture-positive enteric fever cases from in-patient departments (IPD) detected in the hospital laboratories but missed by the expanded surveillance, were also enrolled to assess completion. Costs for this integration were calculated for the additional personnel and resources required. PRINCIPAL FINDINGS: In the IB-VPD surveillance, 5,185 cases were enrolled; 3% (N = 171/5185) were positive for microbiological growth, of which 55% (94/171) were culture-confirmed cases of enteric fever (85 Typhi and 9 Paratyphi A). The added inclusion criteria for enteric fever enrolled an additional 1,699 cases; 22% (358/1699) were positive, of which 85% (349/358) were enteric fever cases (305 Typhi and 44 Paratyphi A). Laboratory surveillance of in-patients of all ages enrolled 311 additional enteric fever cases (263 Typhi and 48 Paratyphi A); 9% (28/311) were 2-59 m and 91% (283/311) >59 m. Altogether, 754 (94+349+311) culture-confirmed enteric fever cases were found, of which 471 were 2-59 m. Of these 471 cases, 94% (443/471) were identified through the hospital surveillances and 6% (28/471) through laboratory results. Twenty-three percent (170/754) of all cases were children <2 years. Additional cost for the integration was USD 44,974/year, a 27% increase to the IB-VPD annual expenditure. CONCLUSION: In a setting where enteric disease is a substantial public health problem, we could integrate enteric fever surveillance into the standard IB-VPD surveillance platform at a modest cost.
[Mh] Termos MeSH primário: Vigilância em Saúde Pública/métodos
Febre Tifoide/epidemiologia
[Mh] Termos MeSH secundário: Bangladesh/epidemiologia
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Febre Paratifoide/economia
Febre Paratifoide/epidemiologia
Febre Paratifoide/prevenção & controle
Salmonella paratyphi A/isolamento & purificação
Salmonella typhi/isolamento & purificação
Febre Tifoide/economia
Febre Tifoide/prevenção & controle
Vacinas Tíficas-Paratíficas/administração & dosagem
Vacinação
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Typhoid-Paratyphoid Vaccines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005999


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[PMID]:28931025
[Au] Autor:Kuijpers LMF; Phe T; Veng CH; Lim K; Ieng S; Kham C; Fawal N; Fabre L; Le Hello S; Vlieghe E; Weill FX; Jacobs J; Peetermans WE
[Ad] Endereço:Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
[Ti] Título:The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.
[So] Source:PLoS Negl Trop Dis;11(9):e0005964, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Enteric fever remains a major public health problem in low resource settings and antibiotic resistance is increasing. In Asia, an increasing proportion of infections is caused by Salmonella enterica serovar Paratyphi A, which for a long time was assumed to cause a milder clinical syndrome compared to Salmonella enterica serovar Typhi. METHODOLOGY: A retrospective chart review study was conducted of 254 unique cases of blood culture confirmed enteric fever who presented at a referral adult hospital in Phnom Penh, Cambodia between 2008 and 2015. Demographic, clinical and laboratory data were collected from clinical charts and antibiotic susceptibility testing was performed. Whole genome sequence analysis was performed on a subset of 121 isolates. RESULTS: One-hundred-and-ninety unique patients were diagnosed with Salmonella Paratyphi A and 64 with Salmonella Typhi. In the period 2008-2012, Salmonella Paratyphi A comprised 25.5% of 47 enteric fever cases compared to 86.0% of 207 cases during 2013-2015. Presenting symptoms were identical for both serovars but higher median leukocyte counts (6.8 x 109/L vs. 6.3 x 109/L; p = 0.035) and C-reactive protein (CRP) values (47.0 mg/L vs. 36 mg/L; p = 0.034) were observed for Salmonella Typhi infections. All but one of the Salmonella Typhi isolates belonged to haplotype H58 associated with multidrug resistance (MDR) (i.e. resistance to ampicillin, chloramphenicol and co-trimoxazole).;42.9% actually displayed MDR compared to none of the Salmonella Paratyphi A isolates. Decreased ciprofloxacin susceptibility (DCS) was observed in 96.9% (62/64) of Salmonella Typhi isolates versus 11.5% (21/183) of Salmonella Paratyphi A isolates (all but one from 2015). All isolates were susceptible to azithromycin and ceftriaxone. CONCLUSIONS: In Phnom Penh, Cambodia, Salmonella Paratyphi A now causes the majority of enteric fever cases and decreased susceptibility against ciprofloxacin is increasing. Overall, Salmonella Typhi was significantly more associated with MDR and DCS compared to Salmonella Paratyphi A.
[Mh] Termos MeSH primário: Febre Tifoide/microbiologia
Febre Tifoide/patologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Camboja/epidemiologia
Farmacorresistência Bacteriana
Feminino
Seres Humanos
Masculino
Febre Paratifoide/epidemiologia
Febre Paratifoide/microbiologia
Febre Paratifoide/patologia
Estudos Retrospectivos
Salmonella paratyphi A/classificação
Salmonella paratyphi A/isolamento & purificação
Salmonella typhi/classificação
Salmonella typhi/efeitos dos fármacos
Salmonella typhi/isolamento & purificação
Febre Tifoide/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005964


  10 / 6544 MEDLINE  
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[PMID]:28749963
[Au] Autor:de Jong HK; Garcia-Laorden MI; Hoogendijk AJ; Parry CM; Maude RR; Dondorp AM; Faiz MA; van der Poll T; Wiersinga WJ
[Ad] Endereço:Department of Internal Medicine, Division of Infectious Diseases and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands.
[Ti] Título:Expression of intra- and extracellular granzymes in patients with typhoid fever.
[So] Source:PLoS Negl Trop Dis;11(7):e0005823, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Typhoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide. Granzymes are serine proteases promoting cytotoxic lymphocytes mediated eradication of intracellular pathogens via the induction of cell death and which can also play a role in inflammation. We aimed to characterize the expression of extracellular and intracellular granzymes in patients with typhoid fever and whether the extracellular levels of granzyme correlated with IFN-γ release. METHODS AND PRINCIPAL FINDINGS: We analyzed soluble protein levels of extracellular granzyme A and B in healthy volunteers and patients with confirmed S. Typhi infection on admission and day of discharge, and investigated whether this correlated with interferon (IFN)-γ release, a cytokine significantly expressed in typhoid fever. The intracellular expression of granzyme A, B and K in subsets of lymphocytic cells was determined using flow cytometry. Patients demonstrated a marked increase of extracellular granzyme A and B in acute phase plasma and a correlation of both granzymes with IFN-γ release. In patients, lower plasma levels of granzyme B, but not granzyme A, were found at day of discharge compared to admission, indicating an association of granzyme B with stage of disease. Peripheral blood mononuclear cells of typhoid fever patients had a higher percentage of lymphocytic cells expressing intracellular granzyme A and granzyme B, but not granzyme K, compared to controls. CONCLUSION: The marked increase observed in extra- and intracellular levels of granzyme expression in patients with typhoid fever, and the correlation with stage of disease, suggests a role for granzymes in the host response to this disease.
[Mh] Termos MeSH primário: Granzimas/sangue
Interferon gama/sangue
Febre Tifoide/sangue
[Mh] Termos MeSH secundário: Adulto
Bangladesh
Estudos de Casos e Controles
Feminino
Citometria de Fluxo
Seres Humanos
Células Matadoras Naturais/imunologia
Contagem de Linfócitos
Masculino
Meia-Idade
Estudos Prospectivos
Salmonella typhi/isolamento & purificação
Linfócitos T/imunologia
Febre Tifoide/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
82115-62-6 (Interferon-gamma); EC 3.4.21.- (GZMB protein, human); EC 3.4.21.- (Granzymes); EC 3.4.21.78 (GZMA protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005823



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