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[PMID]:29369556
[Au] Autor:Afanas'ev MV; Balakhonov SV; Tokmakova EG; Polovinkina VS; Sidorova EA; Sinkov VV
[Ti] Título:[Analysis of complete sequence of cryptic plasmid pTP33 from Yersinia pestis isolated in Tuva natural focus of plague].
[So] Source:Genetika;52(9):1012-20, 2016 Sep.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This paper studies a full nucleotide sequence of cryptic plasmid pTP33, which was isolated from the typical plague strain of the Tuvinian natural focus, Yersinia pestis I-2638. Sequencing was carried out using the 454 GS Junior platform (Roche). In analysis using the software package GS De Novo Assembler v. 2.7 (Roche) and the algorithm Newbler v. 2.7, 1855 nucleotide reads, which contained 1101246 nucleotides, were assembled to a contig of 33 978 bp. The GC content of the obtained nucleotide sequence was 50.25%. During annotation, we found 56 open reading frames. Homologs of the predicted reading frames were sought in the BLAST databases. We detected 22 reading frames coding hypothetical proteins, 23 frames coding phagerelated proteins, and 11 frames coding proteins with known functions, including toxin­antitoxin system YefM-YoeB, nucleic acids and polysaccharides metabolism proteins (exopolysaccharide production protein ExoZ, exodeoxyribonuclease VIII), and replication proteins (ParA). Some predicted pTP33 proteins were found to be homologs (from 45 to 75%) with sequences of phage-related proteins of certain microorganisms­endosymbionts of insects (Sodalis glossinidius) and endosymbionts of entomopathogenic nematodes (Photorhabdus luminescens, P. asymbiotica, Xenorhabdus bovienii).
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Peste/genética
Plasmídeos/genética
Yersinia pestis/genética
[Mh] Termos MeSH secundário: Sibéria
Yersinia pestis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 3924 MEDLINE  
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[PMID]:29300731
[Au] Autor:Bonds MH; Ouenzar MA; Garchitorena A; Cordier LF; McCarty MG; Rich ML; Andriamihaja B; Haruna J; Farmer PE
[Ad] Endereço:Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
[Ti] Título:Madagascar can build stronger health systems to fight plague and prevent the next epidemic.
[So] Source:PLoS Negl Trop Dis;12(1):e0006131, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Epidemias/prevenção & controle
Peste/epidemiologia
Peste/prevenção & controle
[Mh] Termos MeSH secundário: Programas Governamentais
Seres Humanos
Madagáscar/epidemiologia
Saúde Pública/métodos
Yersinia pestis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006131


  3 / 3924 MEDLINE  
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[PMID]:29261403
[Au] Autor:Mead PS
[Ad] Endereço:From the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Fort Collins, CO.
[Ti] Título:Plague in Madagascar - A Tragic Opportunity for Improving Public Health.
[So] Source:N Engl J Med;378(2):106-108, 2018 Jan 11.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Controle de Doenças Transmissíveis
Surtos de Doenças
Peste/epidemiologia
Yersinia pestis
[Mh] Termos MeSH secundário: Surtos de Doenças/prevenção & controle
Seres Humanos
Madagáscar/epidemiologia
Peste/prevenção & controle
Peste/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1713881


  4 / 3924 MEDLINE  
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[PMID]:29227994
[Au] Autor:Mitchell CL; Andrianaivoarimanana V; Colman RE; Busch J; Hornstra-O'Neill H; Keim PS; Wagner DM; Rajerison M; Birdsell DN
[Ad] Endereço:The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.
[Ti] Título:Low cost, low tech SNP genotyping tools for resource-limited areas: Plague in Madagascar as a model.
[So] Source:PLoS Negl Trop Dis;11(12):e0006077, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Genetic analysis of pathogenic organisms is a useful tool for linking human cases together and/or to potential environmental sources. The resulting data can also provide information on evolutionary patterns within a targeted species and phenotypic traits. However, the instruments often used to generate genotyping data, such as single nucleotide polymorphisms (SNPs), can be expensive and sometimes require advanced technologies to implement. This places many genotyping tools out of reach for laboratories that do not specialize in genetic studies and/or lack the requisite financial and technological resources. To address this issue, we developed a low cost and low tech genotyping system, termed agarose-MAMA, which combines traditional PCR and agarose gel electrophoresis to target phylogenetically informative SNPs. METHODOLOGY/PRINCIPAL FINDINGS: To demonstrate the utility of this approach for generating genotype data in a resource-constrained area (Madagascar), we designed an agarose-MAMA system targeting previously characterized SNPs within Yersinia pestis, the causative agent of plague. We then used this system to genetically type pathogenic strains of Y. pestis in a Malagasy laboratory not specialized in genetic studies, the Institut Pasteur de Madagascar (IPM). We conducted rigorous assay performance validations to assess potential variation introduced by differing research facilities, reagents, and personnel and found no difference in SNP genotyping results. These agarose-MAMA PCR assays are currently employed as an investigative tool at IPM, providing Malagasy researchers a means to improve the value of their plague epidemiological investigations by linking outbreaks to potential sources through genetic characterization of isolates and to improve understanding of disease ecology that may contribute to a long-term control effort. CONCLUSIONS: The success of our study demonstrates that the SNP-based genotyping capacity of laboratories in developing countries can be expanded with manageable financial cost for resource constraint laboratories. This is a practical formula that reduces resource-driven limitations to genetic research and promises to advance global collective knowledge of infectious diseases emanating from resource limited regions of the world.
[Mh] Termos MeSH primário: Técnicas de Genotipagem/instrumentação
Peste/diagnóstico
Polimorfismo de Nucleotídeo Único
Yersinia pestis/genética
[Mh] Termos MeSH secundário: Custos e Análise de Custo
Eletroforese em Gel de Ágar
Técnicas de Genotipagem/economia
Recursos em Saúde
Seres Humanos
Madagáscar
Reação em Cadeia da Polimerase
Yersinia pestis/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006077


  5 / 3924 MEDLINE  
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[PMID]:28455335
[Au] Autor:Benavides-Montaño JA; Vadyvaloo V
[Ad] Endereço:Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA.
[Ti] Título:Yersinia pestis Resists Predation by Acanthamoeba castellanii and Exhibits Prolonged Intracellular Survival.
[So] Source:Appl Environ Microbiol;83(13), 2017 Jul 01.
[Is] ISSN:1098-5336
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plague is a flea-borne rodent-associated zoonotic disease caused by The disease is characterized by epizootics with high rodent mortalities, punctuated by interepizootic periods when the bacterium persists in an unknown reservoir. This study investigates the interaction between and the ubiquitous soil free-living amoeba (FLA) to assess if the bacterium can survive within soil amoebae and whether intracellular mechanisms are conserved between infection of mammalian macrophages and soil amoebae. The results demonstrate that during coculture with amoebae, representative strains of epidemic biovars Medievalis, Orientalis, and Antiqua are phagocytized and able to survive within amoebae for at least 5 days. Key determinants of the intracellular interaction of and phagocytic macrophages, PhoP and the type three secretion system (T3SS), were then tested for their roles in the -amoeba interaction. Consistent with a requirement for the PhoP transcriptional activator in the intracellular survival of in macrophages, a PhoP mutant is unable to survive when cocultured with amoebae. Additionally, induction of the T3SS blocks phagocytic uptake of by amoebae, similar to that which occurs during macrophage infection. Electron microscopy revealed that in , resides intact within spacious vacuoles which were characterized using lysosomal trackers as being separated from the lysosomal compartment. This evidence for prolonged survival and subversion of intracellular digestion of within FLA suggests that protozoa may serve as a protective soil reservoir for is a reemerging flea-borne zoonotic disease. Sylvatic plague cycles are characterized by an epizootic period during which the disease spreads rapidly, causing high rodent mortality, and an interepizootic period when the bacterium quiescently persists in an unknown reservoir. An understanding of the ecology of in the context of its persistence in the environment and its reactivation to initiate a new epizootic cycle is key to implementing novel surveillance strategies to more effectively predict and prevent new disease outbreaks. Here, we demonstrate prolonged survival and subversion of intracellular digestion of within a soil free-living amoeba. This suggests the potential role for protozoa as a protective soil reservoir for , which may help explain the recrudescence of plague epizootics.
[Mh] Termos MeSH primário: Acanthamoeba castellanii/microbiologia
Viabilidade Microbiana
Yersinia pestis/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Acanthamoeba castellanii/fisiologia
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Seres Humanos
Peste/microbiologia
Sistemas de Secreção Tipo III/genética
Sistemas de Secreção Tipo III/metabolismo
Yersinia pestis/genética
Yersinia pestis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Type III Secretion Systems)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  6 / 3924 MEDLINE  
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[PMID]:29227777
[Au] Autor:Kontopoulos DG; Kontopoulou T; Ho HC; García-Carreras B
[Ad] Endereço:Imperial College London, Silwood Park Campus, Ascot, Berkshire, United Kingdom d.kontopoulos13@imperial.ac.uk.
[Ti] Título:Towards a theoretically informed policy against a rakghoul plague outbreak.
[So] Source:Med J Aust;207(11):490-494, 2017 Dec 11.
[Is] ISSN:1326-5377
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:A long time ago in a galaxy far, far away, the Sith Lord Karness Muur engineered the rakghoul plague, a disease that transformed infected humans into near-mindless predatory rakghouls. At its peak, the disease infected millions of individuals, giving rise to armies of rakghouls on a number of planets. Whether rakghoul populations have persisted until this day is not known, making a rakghoul invasion on Earth not completely improbable. Further, a strategy for defence against an outbreak of the disease on Earth has not yet been proposed. To fill this glaring gap, we developed the first mathematical model of the population dynamics of humans and rakghouls during a rakghoul plague outbreak. Using New South Wales as a model site, we then obtained ensembles of model predictions for the outcome of the rakghoul plague in two different disease control strategy scenarios (population evacuation and military intervention), and in the absence thereof. Finally, based on these predictions, we propose a set of policy guidelines for successfully controlling and eliminating outbreaks of the rakghoul plague in Australian states.
[Mh] Termos MeSH primário: Planejamento em Desastres
Surtos de Doenças
Modelos Teóricos
Dinâmica Populacional
[Mh] Termos MeSH secundário: Algoritmos
Animais
Bioterrorismo
Carnivoridade
Controle de Doenças Transmissíveis
Doenças Transmissíveis/transmissão
Planejamento em Desastres/legislação & jurisprudência
Planejamento em Desastres/métodos
Surtos de Doenças/prevenção & controle
Surtos de Doenças/estatística & dados numéricos
Seres Humanos
Militares
Filmes Cinematográficos
New South Wales
Peste
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  7 / 3924 MEDLINE  
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[PMID]:28934426
[Au] Autor:Pachulec E; Abdelwahed Bagga RB; Chevallier L; O'Donnell H; Guillas C; Jaubert J; Montagutelli X; Carniel E; Demeure CE
[Ad] Endereço:Yersinia Research Unit, Microbiology Department, Institut Pasteur.
[Ti] Título:Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague.
[So] Source:J Infect Dis;216(6):761-770, 2017 Sep 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Susceptibility to infection is in part genetically driven, and C57BL/6 mice resist various pathogens through the proinflammatory response of their M1 macrophages (MPs). However, they are susceptible to plague. It has been reported elsewhere that Mus spretus SEG mice resist plague and develop an immune response characterized by a strong recruitment of MPs. Methods: The responses of C57BL/6 and SEG MPs exposed to Yersinia pestis in vitro were examined. Results: SEG MPs exhibit a stronger bactericidal activity with higher nitric oxide production, a more proinflammatory polarized cytokine response, and a higher resistance to Y. pestis-induced apoptosis. This response was not specific to Y. pestis and involved a reduced sensitivity to M2 polarization/signal transducer and activator of transcription 6 activation and inhibition of caspase 8. The enhanced M1 profile was inducible in C57BL/6 MPs in vitro, and when transferred to susceptible C57BL/6 mice, these MPs significantly increased survival of bubonic plague. Conclusions: MPs can develop an enhanced functional profile beyond the prototypic M1, characterized by an even more potent proinflammatory response coordinated with resistance to killing. This programming plays a key role in the plague-resistance phenotype and may be similarly significant in other highly lethal infections, suggesting that orienting the MP response may represent a new therapeutic approach.
[Mh] Termos MeSH primário: Apoptose
Macrófagos/imunologia
Peste/imunologia
Yersinia pestis
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Citocinas/sangue
Feminino
Macrófagos/microbiologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos
Óxido Nítrico/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix348


  8 / 3924 MEDLINE  
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[PMID]:28873412
[Au] Autor:Vogler AJ; Andrianaivoarimanana V; Telfer S; Hall CM; Sahl JW; Hepp CM; Centner H; Andersen G; Birdsell DN; Rahalison L; Nottingham R; Keim P; Wagner DM; Rajerison M
[Ad] Endereço:The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.
[Ti] Título:Temporal phylogeography of Yersinia pestis in Madagascar: Insights into the long-term maintenance of plague.
[So] Source:PLoS Negl Trop Dis;11(9):e0005887, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Yersinia pestis appears to be maintained in multiple, geographically separate, and phylogenetically distinct subpopulations within the highlands of Madagascar. However, the dynamics of these locally differentiated subpopulations through time are mostly unknown. To address that gap and further inform our understanding of plague epidemiology, we investigated the phylogeography of Y. pestis in Madagascar over an 18 year period. METHODOLOGY/PRINCIPAL FINDINGS: We generated whole genome sequences for 31 strains and discovered new SNPs that we used in conjunction with previously identified SNPs and variable-number tandem repeats (VNTRs) to genotype 773 Malagasy Y. pestis samples from 1995 to 2012. We mapped the locations where samples were obtained on a fine geographic scale to examine phylogeographic patterns through time. We identified 18 geographically separate and phylogenetically distinct subpopulations that display spatial and temporal stability, persisting in the same locations over a period of almost two decades. We found that geographic areas with higher levels of topographical relief are associated with greater levels of phylogenetic diversity and that sampling frequency can vary considerably among subpopulations and from year to year. We also found evidence of various Y. pestis dispersal events, including over long distances, but no evidence that any dispersal events resulted in successful establishment of a transferred genotype in a new location during the examined time period. CONCLUSIONS/SIGNIFICANCE: Our analysis suggests that persistent endemic cycles of Y. pestis transmission within local areas are responsible for the long term maintenance of plague in Madagascar, rather than repeated episodes of wide scale epidemic spread. Landscape likely plays a role in maintaining Y. pestis subpopulations in Madagascar, with increased topographical relief associated with increased levels of localized differentiation. Local ecological factors likely affect the dynamics of individual subpopulations and the associated likelihood of observing human plague cases in a given year in a particular location.
[Mh] Termos MeSH primário: Filogeografia
Peste/epidemiologia
Peste/microbiologia
Yersinia pestis/classificação
Yersinia pestis/isolamento & purificação
[Mh] Termos MeSH secundário: Doenças Endêmicas
Genoma Bacteriano
Genótipo
Seres Humanos
Madagáscar/epidemiologia
Polimorfismo de Nucleotídeo Único
Análise de Sequência de DNA
Análise Espaço-Temporal
Yersinia pestis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005887


  9 / 3924 MEDLINE  
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[PMID]:28854255
[Au] Autor:Merkley ED; Sego LH; Lin A; Leiser OP; Kaiser BLD; Adkins JN; Keim PS; Wagner DM; Kreuzer HW
[Ad] Endereço:Chemical and Biological Signature Sciences, Pacific Northwest National Laboratory, Richland, Washington, United States of America.
[Ti] Título:Protein abundances can distinguish between naturally-occurring and laboratory strains of Yersinia pestis, the causative agent of plague.
[So] Source:PLoS One;12(8):e0183478, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The rapid pace of bacterial evolution enables organisms to adapt to the laboratory environment with repeated passage and thus diverge from naturally-occurring environmental ("wild") strains. Distinguishing wild and laboratory strains is clearly important for biodefense and bioforensics; however, DNA sequence data alone has thus far not provided a clear signature, perhaps due to lack of understanding of how diverse genome changes lead to convergent phenotypes, difficulty in detecting certain types of mutations, or perhaps because some adaptive modifications are epigenetic. Monitoring protein abundance, a molecular measure of phenotype, can overcome some of these difficulties. We have assembled a collection of Yersinia pestis proteomics datasets from our own published and unpublished work, and from a proteomics data archive, and demonstrated that protein abundance data can clearly distinguish laboratory-adapted from wild. We developed a lasso logistic regression classifier that uses binary (presence/absence) or quantitative protein abundance measures to predict whether a sample is laboratory-adapted or wild that proved to be ~98% accurate, as judged by replicated 10-fold cross-validation. Protein features selected by the classifier accord well with our previous study of laboratory adaptation in Y. pestis. The input data was derived from a variety of unrelated experiments and contained significant confounding variables. We show that the classifier is robust with respect to these variables. The methodology is able to discover signatures for laboratory facility and culture medium that are largely independent of the signature of laboratory adaptation. Going beyond our previous laboratory evolution study, this work suggests that proteomic differences between laboratory-adapted and wild Y. pestis are general, potentially pointing to a process that could apply to other species as well. Additionally, we show that proteomics datasets (even archived data collected for different purposes) contain the information necessary to distinguish wild and laboratory samples. This work has clear applications in biomarker detection as well as biodefense.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Proteínas de Bactérias/metabolismo
Peste/microbiologia
Yersinia pestis/metabolismo
[Mh] Termos MeSH secundário: Técnicas Bacteriológicas
Microbiologia Ambiental
Seres Humanos
Modelos Logísticos
Fenótipo
Peste/diagnóstico
Proteoma/metabolismo
Proteômica/métodos
Especificidade da Espécie
Yersinia pestis/classificação
Yersinia pestis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Proteome)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183478


  10 / 3924 MEDLINE  
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[PMID]:28847850
[Au] Autor:Dhariwala MO; Olson RM; Anderson DM
[Ad] Endereço:Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, Missouri, USA.
[Ti] Título:Induction of Type I Interferon through a Noncanonical Toll-Like Receptor 7 Pathway during Yersinia pestis Infection.
[So] Source:Infect Immun;85(11), 2017 Nov.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals, including humans. Plague develops as a consequence of bacterial neutralization of the host's innate immune response, which permits uncontrolled growth and causes the systemic hyperactivation of the inflammatory response. We previously found that host type I interferon (IFN) signaling is induced during infection and contributes to neutrophil depletion and disease. In this work, we show that type I IFN expression is derived from the recognition of intracellular by host Toll-like receptor 7 (TLR7). Type I IFN expression proceeded independent of myeloid differentiation factor 88 (MyD88), which is the only known signaling adaptor for TLR7, suggesting that a noncanonical mechanism occurs in -infected macrophages. In the murine plague model, TLR7 was a significant contributor to the expression of serum IFN-ß, whereas MyD88 was not. Furthermore, like the type I IFN response, TLR7 contributed to the lethality of septicemic plague and was associated with the suppression of neutrophilic inflammation. In contrast, TLR7 was important for defense against disease in the lungs. Together, these data demonstrate that an atypical TLR7 signaling pathway contributes to type I IFN expression during infection and suggest that the TLR7-driven type I IFN response plays an important role in determining the outcome of plague.
[Mh] Termos MeSH primário: Interações Hospedeiro-Patógeno
Interferon beta/imunologia
Glicoproteínas de Membrana/imunologia
Fator 88 de Diferenciação Mieloide/imunologia
Peste/imunologia
Receptor 7 Toll-Like/imunologia
Yersinia pestis/patogenicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Regulação da Expressão Gênica
Imunidade Inata
Interferon beta/genética
Pulmão/imunologia
Pulmão/microbiologia
Macrófagos/imunologia
Macrófagos/microbiologia
Glicoproteínas de Membrana/deficiência
Glicoproteínas de Membrana/genética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fator 88 de Diferenciação Mieloide/genética
Neutrófilos/imunologia
Neutrófilos/microbiologia
Peste/genética
Peste/microbiologia
Peste/mortalidade
Transdução de Sinais
Análise de Sobrevida
Receptor 7 Toll-Like/deficiência
Receptor 7 Toll-Like/genética
Virulência
Yersinia pestis/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Glycoproteins); 0 (Myd88 protein, mouse); 0 (Myeloid Differentiation Factor 88); 0 (Tlr7 protein, mouse); 0 (Toll-Like Receptor 7); 77238-31-4 (Interferon-beta)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde