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  1 / 1212 MEDLINE  
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[PMID]:29016688
[Au] Autor:Jia YP; Wang K; Zhang ZJ; Tong YN; Han D; Hu CY; Li Q; Xiang Y; Mao XH; Tang B
[Ad] Endereço:Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China.
[Ti] Título:TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation caused by Fusobacterium nucleatum in vivo.
[So] Source:PLoS One;12(10):e0186179, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Toll-like receptors (TLRs) 2 and 4 play critical roles in intestinal inflammation caused by Fusobacterium nucleatum (F. nucleatum) infection, but the role of TLR2/TLR4 in regulation of proinflammatory cytokines remains unknown. In this study, through microarray analysis and qRT-PCR, we showed that TLR2/TLR4 are involved in the F. nucleatum-induced inflammatory signaling pathway in Caco-2 cells, C57BL/6 mice and human clinical specimens. In TLR2-/- and TLR4-/- mice, F. nucleatum infection resulted in increased colonization of the bacteria and production of the proinflammatory cytokines IL-8, IL-1ß and TNF-α. In addition, the ratio of Foxp3+ CD4+ T cells in the total CD4+ T cells in TLR2-/- and TLR4-/- mice was less than that in wild-type mice, and the ratio in hybrid mice was more than that in knockout mice, which suggested that TLR2/TLR4 mediated the number of Tregs. Furthermore, it was observed that inflammatory cytokine levels were reduced in TLR2-/- mice after Treg transfer. Thus, these data indicate that TLR2/TLR4 regulate F. nucleatum-induced inflammatory cytokines through Tregs in vivo.
[Mh] Termos MeSH primário: Infecções por Fusobacterium/imunologia
Inflamação/imunologia
Receptor 2 Toll-Like/genética
Receptor 4 Toll-Like/genética
[Mh] Termos MeSH secundário: Adulto
Animais
Células CACO-2
Feminino
Infecções por Fusobacterium/microbiologia
Infecções por Fusobacterium/patologia
Fusobacterium nucleatum/imunologia
Fusobacterium nucleatum/patogenicidade
Seres Humanos
Inflamação/genética
Inflamação/microbiologia
Intestinos/microbiologia
Intestinos/patologia
Masculino
Camundongos
Camundongos Knockout
Análise em Microsséries
Meia-Idade
Transdução de Sinais
Linfócitos T Reguladores/imunologia
Receptor 2 Toll-Like/imunologia
Receptor 4 Toll-Like/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tlr2 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 2); 0 (Toll-Like Receptor 4)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186179


  2 / 1212 MEDLINE  
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[PMID]:28652481
[Au] Autor:Yu J; Elsayed S; Sun D
[Ad] Endereço:Department of Medicine (Yu, Elsayed, Sun); Department of Pathology and Laboratory Medicine (Elsayed), Schulich School of Medicine and Dentistry, Western University, London, Ont. jeffrey.yu@lhsc.on.ca.
[Ti] Título:A 44-year-old man with acute asymmetric polyarthritis and fever.
[So] Source:CMAJ;189(25):E861-E864, 2017 06 26.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Artralgia/microbiologia
Artrite Psoriásica/microbiologia
Infecções por Fusobacterium/tratamento farmacológico
Infecções por Fusobacterium/microbiologia
Streptobacillus/isolamento & purificação
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Antibacterianos/uso terapêutico
Artralgia/tratamento farmacológico
Artrite Psoriásica/tratamento farmacológico
Diagnóstico Diferencial
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170093


  3 / 1212 MEDLINE  
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[PMID]:28633639
[Au] Autor:Jayasimhan D; Wu L; Huggan P
[Ad] Endereço:Department of Medicine, Waikato Hospital, Level 2 Waiora Waikato Building, Pembroke Street, Hamilton, 3204, New Zealand. d.jayasimhan@gmail.com.
[Ti] Título:Fusobacterial liver abscess: a case report and review of the literature.
[So] Source:BMC Infect Dis;17(1):440, 2017 Jun 20.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fusobacteriae are facultative anaerobic gram-negative bacilli which cause a range of invasive infections, amongst which pyogenic liver abscesses are rare. We describe a case of Fusobacterium nucleatum liver abscess and review the relevant literature. CASE PRESENTATION: A 51-year-old lady presented with a 4-day history of abdominal pain, diarrhoea, fever, rigors, and lethargy. Imaging revealed an abscess which was drained. Cultures of the blood and abscess aspirate grew Fusobacterium nucleatum and Prevotella pleuritidis respectively. She achieved full recovery following treatment. A MEDLINE search was undertaken using free-text and Medical Subject Headings (MeSH), keywords "Fusobacterium" and "Liver abscess". Non-English language reports and cases without confirmed growth of Fusobacterium species were excluded. Additional cases were identified by surveying the references of each report and by using the same keywords in a web-based search. Forty-eight cases were identified, 41 in men. The median age was 42.5, with an interquartile range of 33. F. nucleatum and F. necrophorum were in involved in 22 cases each, and 4 cases were not further speciated. Among cases of F. nucleatum liver abscess, nine were attributed to periodontal disease, four to lower gastrointestinal tract disease, one to Lemierre's Syndrome, and eight were considered cryptogenic. All patients treated made a full recovery. Antimicrobial treatment duration ranged from 2 weeks to 6 months with a median of 6 weeks. CONCLUSION: Fusobacterium nucleatum is an uncommon cause of liver abscess generally associated with good clinical outcomes with contemporary medical and surgical care.
[Mh] Termos MeSH primário: Infecções por Fusobacterium/etiologia
Fusobacterium nucleatum/patogenicidade
Abscesso Hepático Piogênico/microbiologia
[Mh] Termos MeSH secundário: Infecções por Bacteroidaceae/etiologia
Drenagem
Feminino
Infecções por Fusobacterium/tratamento farmacológico
Infecções por Fusobacterium/microbiologia
Seres Humanos
Abscesso Hepático Piogênico/tratamento farmacológico
Abscesso Hepático Piogênico/etiologia
Masculino
Meia-Idade
Doenças Periodontais/microbiologia
Prevotella/patogenicidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2548-9


  4 / 1212 MEDLINE  
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[PMID]:28628741
[Au] Autor:Jiang YS; Stacy A; Whiteley M; Ellington AD; Bhadra S
[Ad] Endereço:Department of Molecular Biosciences, College of Natural Sciences, The University of Texas, Austin, TX, 78712, USA.
[Ti] Título:Amplicon Competition Enables End-Point Quantitation of Nucleic Acids Following Isothermal Amplification.
[So] Source:Chembiochem;18(17):1692-1695, 2017 Sep 05.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:It is inherently difficult to quantitate nucleic acid analytes with most isothermal amplification assays. We developed loop-mediated isothermal amplification (LAMP) reactions in which competition between defined numbers of "false" and "true" amplicons leads to order of magnitude quantitation by a single endpoint determination. These thresholded LAMP reactions were successfully used to directly and quantitatively estimate the numbers of nucleic acids in complex biospecimens, including directly from cells and in sewage, with the values obtained closely correlating with qPCR quantitations. Thresholded LAMP reactions are amenable to endpoint readout by cell phone, unlike other methods that require continuous monitoring, and should therefore prove extremely useful in developing one-pot reactions for point-of-care diagnostics without needing sophisticated material or informatics infrastructure.
[Mh] Termos MeSH primário: Técnicas de Amplificação de Ácido Nucleico
Ácidos Nucleicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Infecções por Fusobacterium/diagnóstico
Fusobacterium nucleatum/genética
Camundongos
Neuropilina-2/genética
Neuropilina-2/metabolismo
Ácidos Nucleicos/genética
Sistemas Automatizados de Assistência Junto ao Leito
Proteínas Proto-Oncogênicas B-raf/genética
Proteínas Proto-Oncogênicas B-raf/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Neuropilin-2); 0 (Nucleic Acids); 0 (RNA, Messenger); EC 2.7.11.1 (Braf protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700317


  5 / 1212 MEDLINE  
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[PMID]:28579042
[Au] Autor:Van Metre DC
[Ad] Endereço:Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W. Drake Road, Fort Collins, CO 80523-1678, USA. Electronic address: dcvanm@colostate.edu.
[Ti] Título:Pathogenesis and Treatment of Bovine Foot Rot.
[So] Source:Vet Clin North Am Food Anim Pract;33(2):183-194, 2017 Jul.
[Is] ISSN:1558-4240
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bovine foot rot (BFR) is an infectious disease of the interdigital skin and subcutaneous tissues of beef and dairy cattle that occurs under a variety of management and environmental settings. The anaerobic, gram-negative bacteria Fusobacterium necrophorum, Porphyromonas levii, and Prevotella intermedia are commonly isolated from lesions. A multitude of host, agent, and environmental factors contribute to the development of BFR. Initiation of systemic antimicrobial therapy early in the course of disease commonly leads to resolution. Delays in treatment may result in extension of infection into deeper bone, synovial structures, or ligamentous structures, and the prognosis for recovery is reduced.
[Mh] Termos MeSH primário: Doenças dos Bovinos
Pododermatite Necrótica dos Ovinos
Coxeadura Animal
[Mh] Termos MeSH secundário: Animais
Infecções por Bacteroidaceae/tratamento farmacológico
Infecções por Bacteroidaceae/microbiologia
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Doenças dos Bovinos/microbiologia
Pododermatite Necrótica dos Ovinos/tratamento farmacológico
Pododermatite Necrótica dos Ovinos/microbiologia
Infecções por Fusobacterium/tratamento farmacológico
Infecções por Fusobacterium/microbiologia
Fusobacterium necrophorum/fisiologia
Coxeadura Animal/tratamento farmacológico
Coxeadura Animal/microbiologia
Porphyromonas/fisiologia
Prevotella intermedia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


  6 / 1212 MEDLINE  
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[PMID]:28576541
[Au] Autor:Benadjaoud Y; Klopp-Dutote N; Choquet M; Brunel E; Guiheneuf R; Page C
[Ad] Endereço:Department of Paediatrics, University Hospital, Amiens, France.
[Ti] Título:A case of acute clival osteomyelitis in a 7-year-old boy secondary to infection of a Thornwaldt cyst.
[So] Source:Int J Pediatr Otorhinolaryngol;95:87-90, 2017 Apr.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Clival osteomyelitis is a potentially life-threatening infection that can occur in healthy children. It can be related to congenital anomalies. We report the case of a 7-year-old boy with Streptococcus intermedius and Fusobacterium clival osteomyelitis arising from a Thornwaldt cyst situated in a fossa navicularis magna of the occipital bone. Multidisciplinary management is necessary to ensure rapid improvement and complete healing.
[Mh] Termos MeSH primário: Fossa Craniana Posterior/patologia
Cistos/complicações
Infecções por Fusobacterium/complicações
Nasofaringe/patologia
Osso Occipital/patologia
Osteomielite/etiologia
Infecções Estreptocócicas/complicações
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Criança
Fusobacterium/isolamento & purificação
Infecções por Fusobacterium/tratamento farmacológico
Seres Humanos
Masculino
Infecções Estreptocócicas/tratamento farmacológico
Streptococcus intermedius/isolamento & purificação
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


  7 / 1212 MEDLINE  
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[PMID]:28445341
[Au] Autor:Broadley M; Schweon SJ
[Ad] Endereço:Marissa Broadley is an infection prevention practitioner at Saratoga Hospital in Saratoga Springs, N.Y. Steven J. Schweon is an infection prevention consultant in Saylorsburg, Pa.
[Ti] Título:Get the facts about Fusobacterium.
[So] Source:Nursing;47(5):64-65, 2017 05.
[Is] ISSN:1538-8689
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Fusobacterium/epidemiologia
Infecções por Fusobacterium/terapia
Fusobacterium/patogenicidade
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Carcinogênese
Infecções por Fusobacterium/enfermagem
Seres Humanos
Masculino
Meia-Idade
Avaliação em Enfermagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1097/01.NURSE.0000515524.23032.d5


  8 / 1212 MEDLINE  
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[PMID]:28390644
[Au] Autor:Mourad MR; Siwoski OM; Brownback KR
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City, KS.
[Ti] Título:A 19-Year-Old College Student With Headache, Photophobia, and Flulike Illness.
[So] Source:Chest;151(4):e95-e98, 2017 Apr.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE PRESENTATION: A 19-year-old previously healthy man presented, minimally responsive, in respiratory distress to an ED after a 2-week history of headache, photophobia, and neck stiffness. Associated symptoms included low-grade fevers, malaise, and dark urine. He had no recent travel, ill contacts, consumption of undercooked meat, new sexual contacts, or illicit drug use. The patient resided in a campus dormitory and did not consume alcohol or tobacco.
[Mh] Termos MeSH primário: Enterite/microbiologia
Infecções por Fusobacterium/microbiologia
Fusobacterium necrophorum/isolamento & purificação
Linfo-Histiocitose Hemofagocítica/microbiologia
[Mh] Termos MeSH secundário: Dexametasona/uso terapêutico
Diagnóstico Diferencial
Enterite/tratamento farmacológico
Infecções por Fusobacterium/tratamento farmacológico
Glucocorticoides/uso terapêutico
Cefaleia
Seres Humanos
Linfo-Histiocitose Hemofagocítica/tratamento farmacológico
Masculino
Fotofobia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


  9 / 1212 MEDLINE  
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[PMID]:28260599
[Au] Autor:Klug TE
[Ad] Endereço:tejsehlersklug@hotmail.com.
[Ti] Título:Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
[So] Source:Dan Med J;64(3), 2017 Mar.
[Is] ISSN:2245-1919
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:PTA is a collection of pus located between the tonsillar capsule and the pharyngeal constrictor muscle. It is considered a complication of acute tonsillitis and is the most prevalent deep neck infection (approximately 2000 cases annually in Denmark) and cause of acute admission to Danish ENT departments. Teenagers and young adults are most commonly affected and males may predominate over females. However, no studies of age- and gender-stratified incidence rates have previously been published. Furthermore, smoking may be associated with increased risk of peritonsillar abscess (PTA) development, although the magnitude of the association has not been estimated. Complications are relatively rare. They include parapharyngeal abscess (PPA), upper airway obstruction, Lemierre´s syndrome, necrotizing fasciitis, mediastinitis, erosion of the internal carotid artery, brain abscess, and streptococcal toxic shock syndrome. The treatment consists of abscess drainage and antimicrobial therapy. There are three accepted methods of surgical intervension: needle aspiration, incision and drainage (ID), and acute tonsillectomy (á chaud). Internationally, there is a strong trend towards less invasive surgical approach to PTA treatment with avoidance of acute tonsillectomy, needle aspiration instead of ID, and in some cases even antibiotic treatment without surgical drainage. The preferred antibiotic regimen varies greatly between countries and centers. Group A streptococcus (GAS) is the only established pathogen in PTA. However, GAS is only recovered from approximately 20% of PTA patients. The pathogens in the remaining 80% are unknown. Culturing of PTA pus aspirates often yields a polymicrobial mixture of aerobes and anaerobes. As the tonsils of healthy individuals are already heavily and diversely colonized, the identification of significant pathogens is challenging. In addition, when studying PTA microbiology, one must consider diagnostic precision, collection, handling, and transportation of appropriate specimens, choice of methodology for detection and quantification of microorganisms, current or recent antibiotic treatment of patients, potential shift in significant pathogens during the course of infection, and factors associated with increased risk of PTA development.  The trend towards de-escalated surgical intervention and increasing reliance on antibiotic treatment, require studies defining the significant pathogens in PTA in order to determine optimal antibiotic regimens. Complications secondary to PTA may be avoided or better controlled with improved knowledge concerning the significant pathogens in PTA. Furthermore, identification of pathogens other than GAS, may lead the way for earlier bacterial diagnosis and timely intervention before abscess formation in sore throat patients. The identification and quantification of risk factors for PTA development constitutes another approach to reduce the incidence of PTA. As clinicians, we noticed that FN was recovered from PTA patients with increasing frequency and that patients infected with Fusobacterium necrophorum (FN) seemed to be more severely affected than patients infected with other bacteria. Furthermore, we occationally observed concomitant PPA in addition to a PTA, which made us hypothesize that PPA and PTA is often closely related and may share significant pathogens. Hence, our aims were: 1. To explore the microbiology of PTA with a special attention to Fusobacterium necrophorum (FN). 2. To elucidate whether smoking, age, gender, and seasons are risk factors for the development of PTA. 3. To characterize patients with PPA, explore the relationship between PPA and PTA, identify the pathogens associated with PPA, and review our management of PPA. In a retrospective study on all 847 PTA patients admitted to the ENT department at Aarhus University Hospital (AUH) from 2001 to 2006, we found that FN was the most prevalent (23%) bacterial strain in pus specimens. FN-positive patients displayed significantly higher infection markers (CRP and neutrophil counts) than patients infected with other bacteria (P = 0.01 and P < 0.001, respectively). In a subsequent prospective and comparative study on 36 PTA patients and 80 patients undergoing elective tonsillectomy (controls), we recovered FN from 58% of PTA aspirates. Furthermore, FN was detected significantly more frequently in the tonsillar cores of PTA patients (56%) compared to the tonsillar cores of the controls (24%) (P = 0.001). We also analysed sera taken acutely and at least two weeks after surgery for the presence of anti-FN antibodies. We found increasing levels (at least two-fold) of anti-FN antibodies in eight of 11 FN-positive (in the tonsillar cultures) PTA patients, which was significantly more frequent compared to none of four FN-negative PTA patients and nine of 47 electively tonsillectomized controls (P = 0.026 and P < 0.001, respectively). Blood cultures obtained during acute tonsillectomy mirrored the bacterial findings in the tonsillar specimens with 22% of patients having bacteremia with FN. However, bacteremia during elective tonsillectomy was at least as prevalent as bacteremia during quinsy tonsillectomy, which challenges the distinction made by the European Society of Cardiology between quinsy and elective tonsillectomy, namely that antibiotic prophylaxis is only recommended to patients undergoing procedures to treat an established infection (i.e. PTA). Using PCR analysis for the presence of herpes simplex 1 and 2, adenovirus, influenza A and B, Epstein-Barr virus (EBV), and respiratory syncytial virus A and B, we explored a possible role of viruses in PTA. However, our results did not indicate that any of these viruses are involved in the development of PTA. Privious studies have documented an association between EBV and PTA in approximately 4% of PTA cases. In addition to the involvement of GAS, the following findings suggest a pathogenic role for FN in PTA: 1. Repeated high isolation rates of FN in PTA pus aspirates. 2. Higher isolation rates in PTA patients compared to electively tonsillectomised controls. 3. Development of anti-FN antibodies in FN-positive patients with PTA. 4. Significantly higher inflammatory markers in FN-positive patients compared to PTA patients infected with other bacteria. We studied the smoking habits among the same 847 PTA patients admitted to the ENT department, AUH from 2001 to 2006. We found that smoking was associated with increased risk of PTA for both genders and across all age groups. The increased risk of PTA among smokers was not related to specific bacteria. Conclusions on causality cannot be drawn from this retrospective study, but the pathophysiology behind the increased risk of PTA in smokers may be related to, previously shown, alterations in the tonsillar, bacterial flora or the local and systemical inflammatory and immunological milieu. Studying all 1,620 patients with PTA in Aarhus County from 2001 to 2006 and using population data for Aarhus County for the same six years, age- and gender-stratified mean annual incidence rates of PTA were calculated. The incidence of PTA was highly related to age and gender. The seasonal variation of PTA was insignificant. However, the microbiology of PTA fluctuated with seasons: GAS-positive PTA cases were significantly more prevalent in the winter and spring compared to the summer, while FN-positive PTA patients exhibited a more even distribution over the year, but with a trend towards higher prevalence in the summer than in the winter. In a series of 63 patients with PPA, we found that 33 (52%) patients had concomitant PTA. This association between PPA and PTA was much higher than previously documented. We therefore suggest that combined tonsillectomy and intrapharyngeal incision in cases where PTA is present or suspected. The results of our routine cultures could not support a frequent role of FN in PPA. Based on our findings suggesting that FN is a frequent pathogen in PTA, we recommend clindamycin instead of a macrolide in penicillin-allergic patients with PTA. Furthermore, cultures made from PTA aspirates should include a selective FN-agar plate in order to identify growth of this bacterium. Recent studies of sore throat patients document an association between recovery of FN and acute tonsillitis. Studying the bacterial flora of both tonsils in study II, we found almost perfect concordance between the bacterial findings of the tonsillar core at the side of the abscess and contralaterally. This finding suggests that FN is not a subsequent overgrowth phenomenon after abscess development, but that FN can act as pathogen in severe acute tonsillitis. Future studies of patients with FN-positive acute tonsillitis focusing on the optimal methods (clinical characteristics, culture, polymerase chain reaction, or other) for diagnosis and whether antibiotics (and which) can reduce symptoms and avoid complications are warranted. Until further studies are undertaken, we recommend clinicians to have increased focus on acute tonsillitis patients aged 15-24 years with regards to symptoms and findings suggestive of incipient peritonsillar involvement. We have conducted a number of studies with novel findings: 1. FN is a significant and prevalent pathogen in PTA. 2. Bacteremia during abscess tonsillectomy is no more prevalent than during elective tonsillectomy. 3. The development of anti-FN antibodies in FN-positive PTA patients. We have used novel approaches as principles to suggest pathogenic significance of candidate microorganisms: 1. Comparative microbiology between PTA patients and "normal tonsils". 2. Measurements indicating larger inflammatory response compared to clinically equivalent infection.
[Mh] Termos MeSH primário: Infecções por Fusobacterium/diagnóstico
Abscesso Peritonsilar
Infecções Estreptocócicas/diagnóstico
[Mh] Termos MeSH secundário: Abscesso/etiologia
Adolescente
Adulto
Fatores Etários
Criança
Feminino
Infecções por Fusobacterium/terapia
Fusobacterium necrophorum/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Tonsila Palatina/anatomia & histologia
Abscesso Peritonsilar/diagnóstico
Abscesso Peritonsilar/microbiologia
Abscesso Peritonsilar/fisiopatologia
Abscesso Peritonsilar/cirurgia
Doenças Faríngeas/etiologia
Fatores de Risco
Estações do Ano
Fatores Sexuais
Fumar/efeitos adversos
Infecções Estreptocócicas/terapia
Streptococcus pyogenes/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


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[PMID]:28122872
[Au] Autor:Van TT; Cox LM; Cox ME; Dien Bard J
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
[Ti] Título:Prevalence of Fusobacterium necrophorum in Children Presenting with Pharyngitis.
[So] Source:J Clin Microbiol;55(4):1147-1153, 2017 Apr.
[Is] ISSN:1098-660X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:, an obligate anaerobic bacterium, was recently reported to be an important cause of bacterial pharyngitis with a prevalence as high as that of group A (GAS) in adolescents and young adults. Importantly, is the primary causative agent of the life-threatening Lemierre's syndrome, and screening of pharyngeal samples may be warranted for its early detection and prevention. The aim of this study was to determine the prevalences of and groups A and C/G streptococci as agents of bacterial pharyngitis in children. Pharyngeal samples ( = 300) were collected from pediatric patients presenting to the emergency department with signs and symptoms of pharyngitis. Overall, 10 (3.3%), 79 (26.3%), and 4 (1.3%) patients were PCR positive for , GAS, and group C/G streptococci, respectively. The prevalence of was significantly higher in patients between the ages of 14 and 20 years at 13.5% than in patients aged 14 years and younger (1.9%, < 0.001). All positive patients presented with signs and symptoms similar to GAS pharyngitis. Our data demonstrated a potential role for as a pathogen of pharyngitis among young adults, but suggests that the prevalence of is low in preadolescent patients.
[Mh] Termos MeSH primário: Infecções por Fusobacterium/epidemiologia
Infecções por Fusobacterium/microbiologia
Fusobacterium necrophorum/isolamento & purificação
Faringite/epidemiologia
Faringite/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Reação em Cadeia da Polimerase
Prevalência
Estudos Prospectivos
Infecções Estreptocócicas/epidemiologia
Infecções Estreptocócicas/microbiologia
Streptococcus/classificação
Streptococcus/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1128/JCM.02174-16



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