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[PMID]:27959596
[Au] Autor:Osman C; Clark TW
[Ad] Endereço:University of Southampton, Southampton, United Kingdom chinar.osman@uhs.nhs.uk.
[Ti] Título:Tabes Dorsalis and Argyll Robertson Pupils.
[So] Source:N Engl J Med;375(20):e40, 2016 Nov 17.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Tabes Dorsal/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Distúrbios Pupilares/etiologia
Tabes Dorsal/complicações
Treponema pallidum/isolamento & purificação
Carga Viral
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


  2 / 390 MEDLINE  
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[PMID]:27937025
[Au] Autor:Ellis H
[Ad] Endereço:Emeritus Professor of Surgery, Guy's, King's and St Thomas' School of Biomedical Sciences, London SE1 1UL.
[Ti] Título:Sir William Gull: distinguished physician.
[So] Source:Br J Hosp Med (Lond);77(12):717, 2016 Dec 02.
[Is] ISSN:1750-8460
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: História da Medicina
[Mh] Termos MeSH secundário: Anorexia Nervosa/história
História do Século XIX
Mixedema
Tabes Dorsal/história
Reino Unido
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Gull W
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  3 / 390 MEDLINE  
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[PMID]:27434214
[Au] Autor:Bogousslavsky J; Tatu L
[Ad] Endereço:Swiss Medical Network Neurocentre, Genolier-Glion/Montreux-Lausanne-Geneva-Lugano-Fribourg-Neuchatel-Basel-Zurich, Clinique Valmont, Glion sur Montreux, Switzerland.
[Ti] Título:Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb.
[So] Source:Eur Neurol;76(1-2):75-84, 2016.
[Is] ISSN:1421-9913
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Édouard Manet (1832-1883) is considered the 'father' of Impressionism and even of XXth century modern art. Manet's genius involved getting away from the classical narrative or historical topics and replacing them by the banality of daily life. Technically, he erased volumes into flat two-dimensional coloured planes, and distorted conventional perspective with often gross brushstrokes intentionally giving an 'unfinished' aspect to the work. It is little known that Manet had a very painful second part of his life, due to excruciating limb and chest pains, which developed in parallel with proprioceptive ataxia and gait imbalance. Manet always remained discreet about his private life, and we mainly know that his future wife was his family piano teacher, with whom he had a liaison already at age 17. Later, the great but platonic passion of his life was the painter Berthe Morisot (1841-1895), who got married to Manet's brother Eugène. In fact, we do not know whether he had any mistress at all, although he had several elegant 'flirts' in the mundane and artistic milieu. Thus, while Manet's progressive painful ataxia from age 40 yields little doubt on its tabetic origin, how he contracted syphilis at least 15-20 years before will probably remain a mystery. It is fascinating that Manet's daily struggle against pain and poor coordination may have led his art to become one of the most significant of modern times, opening the way to XXth century avant-gardes, along with another victim of syphilis, Paul Gauguin (1848-1903). Manet never showed any sign of General Paresis, and like his contemporary the writer Alphonse Daudet, his clinical picture remained dominated by paroxysmal pain and walking impairment. Difficult hand coordination made him quit watercolor painting, and during the last 2 years of his life, he had to focus on small format oil works, whose subject was nearly limited to modest bunches of fresh flowers, now often considered to be his maturity masterpieces. Having become bedridden, he had to be amputated of one leg, which was developing gangrene probably associated with ergot overuse. While he died shortly thereafter, we have some witness anecdotes suggesting that he experienced a phantom limb: when Claude Monet (1840-1926) visited him and sat down on his bed, Manet violently shouted at him that he was just sitting on his (absent) leg, which provoked terrible pains. With its facts and mysteries, the subtle interaction between Manet's illness and his work output remains one of the most intriguing stories in neurology of art.
[Mh] Termos MeSH primário: Ataxia/história
Pinturas/história
Membro Fantasma/história
Tabes Dorsal/história
[Mh] Termos MeSH secundário: Pessoas Famosas
França
História do Século XIX
Seres Humanos
Masculino
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Manet E
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1159/000447260


  4 / 390 MEDLINE  
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[PMID]:26875733
[Au] Autor:Adedara IA; Abolaji AO; Rocha JB; Farombi EO
[Ad] Endereço:Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. dedac2001@yahoo.co.uk.
[Ti] Título:Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity.
[So] Source:Neurochem Res;41(6):1430-8, 2016 Jun.
[Is] ISSN:1573-6903
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several experimental and epidemiological reports have associated manganese exposure with induction of oxidative stress and locomotor dysfunctions. Diphenyl diselenide (DPDS) is widely reported to exhibit antioxidant, anti-inflammatory and neuroprotective effects in in vitro and in vivo studies via multiple biochemical mechanisms. The present study investigated the protective effect of DPDS on manganese-induced toxicity in Drosophila melanogaster. The flies were exposed, in a dietary regimen, to manganese alone (30 mmol per kg) or in combination with DPDS (10 and 20 µmol per kg) for 7 consecutive days. Exposure to manganese significantly (p < 0.05) increased flies mortality, whereas the survivors exhibited significant locomotor deficits with increased acetylcholinesterase (AChE) activity. However, dietary supplementation with DPDS caused a significant decrease in mortality, improvement in locomotor activity and restoration of AChE activity in manganese-exposed flies. Additionally, the significant decreases in the total thiol level, activities of catalase and glutathione-S-transferase were accompanied with significant increases in the generation of reactive oxygen and nitrogen species and thiobarbituric acid reactive substances in flies exposed to manganese alone. Dietary supplementation with DPDS significantly augmented the antioxidant status and prevented manganese-induced oxidative stress in the treated flies. Collectively, the present data highlight that DPDS may be a promising chemopreventive drug candidate against neurotoxicity resulting from acute manganese exposure.
[Mh] Termos MeSH primário: Derivados de Benzeno/farmacologia
Modelos Animais de Doenças
Manganês/toxicidade
Fármacos Neuroprotetores/farmacologia
Compostos Organosselênicos/farmacologia
Tabes Dorsal/metabolismo
Tabes Dorsal/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Derivados de Benzeno/uso terapêutico
Drosophila melanogaster
Mortalidade/tendências
Fármacos Neuroprotetores/uso terapêutico
Síndromes Neurotóxicas/metabolismo
Síndromes Neurotóxicas/mortalidade
Síndromes Neurotóxicas/prevenção & controle
Compostos Organosselênicos/uso terapêutico
Espécies Reativas de Oxigênio/antagonistas & inibidores
Espécies Reativas de Oxigênio/metabolismo
Tabes Dorsal/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzene Derivatives); 0 (Neuroprotective Agents); 0 (Organoselenium Compounds); 0 (Reactive Oxygen Species); 1666-13-3 (diphenyldiselenide); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160216
[St] Status:MEDLINE
[do] DOI:10.1007/s11064-016-1852-x


  5 / 390 MEDLINE  
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[PMID]:25697346
[Au] Autor:Silver JR; Weiner MF
[Ti] Título:Nerve-stretching in the 19th century.
[So] Source:J Med Biogr;24(4):537-545, 2016 Nov.
[Is] ISSN:1758-1087
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Operative nerve-stretching was first described in 1872 to relieve incurable pain from sciatica and tabes dorsalis. It became popular for 20 years and numerous articles were published on the subject. It had many complications but relief was only transient and, consequently, it fell into disuse. This paper analyses the literature, contemporary views on the benefits of nerve stretching and its influence on more recent neurological practice.
[Mh] Termos MeSH primário: Neurologistas/história
Neurocirurgia/história
Manejo da Dor/história
Ciática/história
Tabes Dorsal/história
[Mh] Termos MeSH secundário: Europa (Continente)
História do Século XIX
Seres Humanos
Neurocirurgia/métodos
América do Norte
Manejo da Dor/métodos
Ciática/terapia
Tabes Dorsal/terapia
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:150221
[St] Status:MEDLINE


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[PMID]:25321411
[Au] Autor:Zhang YQ; Huang M; Jia XY; Zou YF; Chen D
[Ad] Endereço:From the Dept. of Neurology, Xiamen ChangGung Hospital, Xiamen, China.
[Ti] Título:A clinical study of new cases of parenchymal neurosyphilis: has tabes dorsalis disappeared or been missed?
[So] Source:J Neuropsychiatry Clin Neurosci;27(1):e17-21, 2015.
[Is] ISSN:1545-7222
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tabes dorsalis (TD) was documented as the most common parenchymal neurosyphilis, but its incidence dramatically declined in the antibiotic era. Syphilis has resurged on the China mainland since the 1980s. In recent years, physicians have been reporting parenchymal neurosyphilis, and the overwhelming majority was general paresis, but this was not the case in the authors' hospital. To make clear the real situation of parenchymal neurosyphilis in the authors' hospital, a retrospective review was carried out of the records of patients during 2009-2012. Overrepresented clinical new cases of tabetic and paretic parenchymal neurosyphilis were collected. Clinical characteristics, neuroimaging, laboratory data, and responses to penicillin were analyzed in two groups. The efficiency of two current criteria based on CSF antibodies tests was inspected. In the 43 cases with positive serum rapid plasma reagin (RPR) and TPPA tests, 18 patients met the criteria of this study: 11 presented with symptoms of general paresis, and seven had typical presentations of TD. There were statistical differences in serum RPR titers, CSF RPR, white blood cell count, and TP between the paretic and tabetic groups. The response to penicillin was relatively poor in TD. The efficiency of two current criteria was lower in the diagnosis of TD. TD was not uncommon in our area. Its clinical features remained typical, but underdiagnosis with CSF-based criteria and a decreased response to penicillin were prominent issues.
[Mh] Termos MeSH primário: Tabes Dorsal/diagnóstico
Tabes Dorsal/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/uso terapêutico
Proteínas Sanguíneas/metabolismo
China
Feminino
Seres Humanos
Masculino
Meia-Idade
Neuroimagem
Penicilinas/uso terapêutico
Estudos Retrospectivos
Tabes Dorsal/líquido cefalorraquidiano
Tabes Dorsal/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Blood Proteins); 0 (Penicillins)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150226
[Lr] Data última revisão:
150226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141017
[St] Status:MEDLINE
[do] DOI:10.1176/appi.neuropsych.13100303


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[PMID]:25419325
[Au] Autor:Lakjiri S; Mernissi FZ
[Ad] Endereço:Department of Dermatology, CHU Hassan II, Fez, Morocco.
[Ti] Título:Tabetic arthropathy revealing neurosyphilis: a new observation.
[So] Source:Pan Afr Med J;18:198, 2014.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Mh] Termos MeSH primário: Artropatia Neurogênica/etiologia
Hidrartrose/etiologia
Deformidades Articulares Adquiridas/etiologia
Articulação do Joelho/patologia
Tabes Dorsal/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Diagnóstico Tardio
Seres Humanos
Masculino
Penicilina G/uso terapêutico
Tabes Dorsal/complicações
Tabes Dorsal/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141124
[Lr] Data última revisão:
141124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141125
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2014.18.198.4893


  8 / 390 MEDLINE  
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[PMID]:25415801
[Au] Autor:Liu JT; Li XF; Xu KL; Zhang ZG; Ma QH; Liu GH; Yu ZH; Tang DZ; Jiang H
[Ti] Título:Bilateral total knee arthroplasty for Charcot knees associated with tabes dorsalis.
[So] Source:Pain Physician;17(6):E796-9, 2014 Nov-Dec.
[Is] ISSN:2150-1149
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Artroplastia do Joelho/métodos
Doenças Ósseas/etiologia
Doenças Ósseas/cirurgia
Joelho/patologia
Tabes Dorsal/complicações
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Joelho/cirurgia
Masculino
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1509
[Cu] Atualização por classe:141122
[Lr] Data última revisão:
141122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141122
[St] Status:MEDLINE


  9 / 390 MEDLINE  
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[PMID]:25228352
[Au] Autor:Weiner MF; Silver JR
[Ad] Endereço:MA History of Medicine, Oxford Brookes University, Oxford, UK.
[Ti] Título:Historical review: suspension therapy for the treatment of tabes dorsalis.
[So] Source:Eur Neurol;72(3-4):163-72, 2014.
[Is] ISSN:1421-9913
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Suspension therapy was developed by a Russian doctor, A. Motschutkovsky and at the end of the 19th century it was a popular treatment for tabes dorsalis. It was endorsed by Jean-Martin Charcot in France and Weir Mitchell in the United States; but after 10 years, it was abandoned because it proved to be useless and some patients developed paralysis. SUMMARY: The effect of suspension upon a spinal cord affected by tabes dorsalis and a healthy spinal cord has been analyzed in the light of current knowledge. The benefits of suspension were thought to be due to an improvement in the blood supply to the spinal cord and due to the suggestibility or the placebo effect. Key Message: Analysis of the contemporary literature in the light of current research shows that suspension therapy was a powerful weapon that could cause impairment to the conductivity of the spinal cord and this has important implications for current therapy such as the use of Harrington rods.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Musculoesqueléticos
Aparelhos Ortopédicos/história
Tabes Dorsal/história
Tabes Dorsal/terapia
[Mh] Termos MeSH secundário: História do Século XIX
História do Século XX
Seres Humanos
Medicina na Literatura
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1506
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140918
[St] Status:MEDLINE
[do] DOI:10.1159/000360620


  10 / 390 MEDLINE  
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[PMID]:24781221
[Au] Autor:Shishov AS; Savrasova NM; Titova TA; Kupriianova LV; Rudometov IuP
[Ti] Título:[Brain and spine cord lesions caused by syphilis].
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;114(3):14-23, 2014.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:OBJECTIVE: To analyze clinical features of the nervous system damage in syphilis taking into account the changes in the content of cerebrospinal fluid and clinical/anatomical brain damages of the brain. METHODS: The study was based on the analysis of 47 case histories of patients hospitalized in 1995-2001. The group included 47 patients, aged from 17 to 60 years. RESULTS: Syphilitic meningitis, syphilitic meningoneuritis, syphilitic menongoencephalitis, syphilitic meningovasculitis, cerebral gummas, syphilitic meningomyelitis and mental changes caused by syphilis are reviewed. CONCLUSIONS: The pathogenesis of different clinical forms of syphilitic damages of the brain and terminological issues are discussed.
[Mh] Termos MeSH primário: Neurossífilis/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meningites Bacterianas/diagnóstico
Meningites Bacterianas/etiologia
Meningoencefalite/diagnóstico
Meningoencefalite/microbiologia
Transtornos Mentais/diagnóstico
Transtornos Mentais/microbiologia
Meia-Idade
Neurossífilis/classificação
Neurossífilis/complicações
Tabes Dorsal/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1405
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140501
[St] Status:MEDLINE



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