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  1 / 1890 MEDLINE  
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[PMID]:29300774
[Au] Autor:Bryan LK; Alexander ER; Lawhon SD; Cohen ND
[Ad] Endereço:Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America.
[Ti] Título:Detection of vapN in Rhodococcus equi isolates cultured from humans.
[So] Source:PLoS One;13(1):e0190829, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhodococcus equi can cause severe infections in people, particularly in immunocompromised individuals. The R. equi virulence plasmids (vap) encoding vapA and vapB are linked to development of infections in domestic animals. Recently, a novel virulence plasmid, vapN, was identified in isolates cultured from cattle, but its prevalence or significance in human R. equi infections has not been extensively studied. To determine the prevalence of vapN in a diverse collection of human-derived isolates from different countries, 65 R. equi isolates collected by various institutions from 1984 to 2002 were screened for the presence of vapN and other virulence plasmids through polymerase chain reaction (PCR) using redesigned primer sets. Of the isolates that carried plasmids, 43% (16/37) were vapN-positive and fewer were vapB or vapA-positive (30 and 16%, respectively). This is the first report of vapN carriage in R. equi isolated from human infections. One isolate (H-30) carried vapN but did not amplify the conjugal plasmid transfer gene traA associated with carriage of vap, which could be explained by sequence variation within the traA gene. Another isolate (H-55) amplified traA, but did not amplify vapA, B, or N (traA+ vapABN-) with previously described primer sets or those developed for this study. The H-55 traA sequence had 98% identity to traA sequences in vapA plasmids, which suggests that it may carry a variant of previously characterized virulence plasmids or a novel virulence plasmid. Carriage of vapN in R. equi isolates derived from people is not uncommon and more research is needed to determine its significance in the epidemiology and pathogenesis of human R. equi infections.
[Mh] Termos MeSH primário: Infecções por Actinomycetales/microbiologia
Plasmídeos/genética
Rhodococcus equi/genética
Rhodococcus equi/patogenicidade
Virulência/genética
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Sequência de Bases
Primers do DNA/genética
DNA Bacteriano/genética
Proteínas de Ligação a DNA/genética
Genes Bacterianos
Variação Genética
Seres Humanos
Glicoproteínas de Membrana/genética
Infecções Oportunistas/microbiologia
Plasmídeos/isolamento & purificação
Reação em Cadeia da Polimerase
Rhodococcus equi/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (DNA Primers); 0 (DNA, Bacterial); 0 (DNA-Binding Proteins); 0 (Membrane Glycoproteins); 0 (VapA protein, Rhodococcus equi); 147571-32-2 (VapB protein, Bacteria)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190829


  2 / 1890 MEDLINE  
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[PMID]:28688759
[Au] Autor:Eschapasse E; Hussenet C; Bergeron A; Lebeaux D
[Ad] Endereço:Service de pneumologie, institut du thorax, hôpital G.-et-R.-Laënnec, CHU de Nantes, 44093 Nantes, France.
[Ti] Título:[Respiratory infections caused by slow-growing bacteria: Nocardia, Actinomyces, Rhodococcus].
[Ti] Título:Infections respiratoires à bactéries à croissance lente : Nocardia, Actinomyces, Rhodococcus..
[So] Source:Rev Mal Respir;34(6):661-671, 2017 Jun.
[Is] ISSN:1776-2588
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Pneumonia caused by slow-growing bacteria is rare but sometimes severe. STATE OF THE ART: These infections share many similarities such as several differential diagnoses, difficulties to identify the pathogen, the importance of involving the microbiologist in the diagnostic investigation and the need for prolonged antibiotic treatment. However, major differences distinguish them: Nocardia and Rhodococcus infect mainly immunocompromised patients while actinomycosis also concerns immunocompetent patients; the severity of nocardioses is related to their hematogenous spread while locoregional extension by contiguity makes the gravity of actinomycosis. PROSPECTIVE: For these diseases, molecular diagnostic tools are essential, either to obtain a species identification and guide treatment in the case of nocardiosis or to confirm the diagnosis from a biological sample. Treatment of these infections is complex due to: (1) the limited data in the literature; (2) the need for prolonged treatment of several months; (3) the management of toxicities and drug interactions for the treatment of Nocardia and Rhodococcus. CONCLUSION: Close cooperation between pneumonologists, infectious disease specialists and microbiologists is essential for the management of these patients.
[Mh] Termos MeSH primário: Actinomyces
Nocardia
Infecções Respiratórias/microbiologia
Rhodococcus
[Mh] Termos MeSH secundário: Actinomyces/crescimento & desenvolvimento
Actinomyces/isolamento & purificação
Infecções por Actinomycetales/diagnóstico
Infecções por Actinomycetales/microbiologia
Infecções por Actinomycetales/terapia
Actinomicose/diagnóstico
Actinomicose/microbiologia
Actinomicose/terapia
Bactérias/crescimento & desenvolvimento
Bactérias/isolamento & purificação
Diagnóstico Diferencial
Seres Humanos
Hospedeiro Imunocomprometido
Nocardia/crescimento & desenvolvimento
Nocardia/isolamento & purificação
Nocardiose/diagnóstico
Nocardiose/microbiologia
Nocardiose/terapia
Pneumonia/diagnóstico
Pneumonia/microbiologia
Pneumonia/terapia
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/patologia
Infecções Respiratórias/terapia
Rhodococcus/crescimento & desenvolvimento
Rhodococcus/isolamento & purificação
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


  3 / 1890 MEDLINE  
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[PMID]:28670986
[Au] Autor:Sallai I; Péterfy N; Sanatkhani M; Bejek Z; Antal I; Prinz G; Kristóf K; Skaliczki G
[Ad] Endereço:Ortopédiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Ülloi út 78/B II. emelet, 1082.
[Ti] Título:[Periprosthetic joint infection caused by Rhodococcus equi. Case report].
[Ti] Título:Rhodococcus equi által okozott nagyízületi endoprotézis körül kialakult fertozés..
[So] Source:Orv Hetil;158(27):1071-1074, 2017 Jul.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:Rhodococcus equi is a rare pathogen in humans causing infections mostly in immunocompromised hosts. We present the first case of periprosthetic joint infection caused by Rhodococcus equi. An 88-year-old male patient was referred to our clinic with a history of fever and right hip pain. The patient had multiple hip surgeries including total joint arthroplasty and revision for aseptic loosening on the right side. He was immunocompetent, but his additional medical history was remarkable for diabetes mellitus, diabetic nephropathy and stroke with hemiplegia resulting in immobilization. Radiography showed stable components, joint aspirate yielded Rhodococcus equi. Irrigation and debridement was proposed, but the patient refused any surgical intervention. Therefore antibiotic therapy was administered. At the last follow-up the patient is free of complaints but the C-reactive protein level is still elevated. This case illustrates the possible role of Rhodococcus equi in medical device-associated infections. Orv Hetil. 2017; 158(27): 1071-1074.
[Mh] Termos MeSH primário: Infecções por Actinomycetales/tratamento farmacológico
Infecções por Actinomycetales/microbiologia
Artroplastia de Quadril/efeitos adversos
Infecções Relacionadas à Prótese/tratamento farmacológico
Infecções Relacionadas à Prótese/microbiologia
[Mh] Termos MeSH secundário: Infecções por Actinomycetales/diagnóstico
Idoso de 80 Anos ou mais
Antibacterianos/uso terapêutico
Proteína C-Reativa
Seres Humanos
Masculino
Rhodococcus equi/isolamento & purificação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30794


  4 / 1890 MEDLINE  
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[PMID]:28628338
[Au] Autor:Yang L; Cao Y; Dan Z; Wang Z; Wang X
[Ad] Endereço:a Institute of Tuberculosis , 309 Hospital, Beijing , China.
[Ti] Título:Community-acquired Tsukamurella pneumonia in a young immunocompetent adult: a case misdiagnosed as pulmonary tuberculosis and literature review.
[So] Source:Postgrad Med;129(6):563-566, 2017 Aug.
[Is] ISSN:1941-9260
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This report describes a case of Tsukamurella pneumonia in a 24-year-old immunocompetent woman. The patient was diagnosed as having pulmonary tuberculosis and was treated for nearly 9 months. The correct diagnosis was suspected only when the results of mycobacteria nucleic acid amplification tests on cultural colonies were negative. Tsukamurella was identified from the patient's sputum and bronchoalveolar lavage fluid by using 16S rRNA sequence analysis. Here, the clinical presentation, diagnosis, and treatment strategies of Tsukamurella pneumonia are discussed, along with a literature review. Tsukamurella pneumonia may be highly underdiagnosed owing to its similarity with pulmonary tuberculosis and the habitual thinking of doctors in countries with a high tuberculosis burden. Tsukamurella should be carefully considered in the etiology of tuberculosis-like lung diseases.
[Mh] Termos MeSH primário: Infecções por Actinomycetales/diagnóstico
Infecções por Actinomycetales/microbiologia
Actinomycetales/isolamento & purificação
Infecções Comunitárias Adquiridas/diagnóstico
Infecções Comunitárias Adquiridas/microbiologia
Tuberculose Pulmonar/microbiologia
[Mh] Termos MeSH secundário: Líquido da Lavagem Broncoalveolar/microbiologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Testes de Sensibilidade Microbiana
RNA Ribossômico 16S
Escarro/microbiologia
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1080/00325481.2017.1344513


  5 / 1890 MEDLINE  
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[PMID]:28606064
[Au] Autor:Ding X; Yu Y; Chen M; Wang C; Kang Y; Li H; Lou J
[Ad] Endereço:Department of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
[Ti] Título:Bacteremia due to Gordonia polyisoprenivorans: case report and review of literature.
[So] Source:BMC Infect Dis;17(1):419, 2017 Jun 12.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gordonia polyisoprenivorans is a ubiquitous aerobic actinomycetes bacterium that rarely cause infections in humans. Here, we report a case of G. polyisoprenivorans catheter-related bacteremia in an AIDS patient. CASE PRESENTATION: A 37-year-old man with a past medical history of AIDS-related lymphoma suffered bacteremia caused by a Gram-positive corynebacterium. The strain was identified as a Gordonia species by matrix-assisted laser desorption ionization-time of flight mass spectrometry and confirmed to G. polyisoprenivorans by 16S rRNA combined with gyrB gene sequencing analyses. The patient was treated with imipenem and had a good outcome. CONCLUSIONS: The findings from our case and previously reported cases indicate that malignant hematologic disease, immunosuppression, and indwelling catheter heighten the risk for G. polyisoprenivorans infection. Molecular methods should be employed for proper identification of G. polyisoprenivorans to the species level.
[Mh] Termos MeSH primário: Infecções Oportunistas Relacionadas com a AIDS/microbiologia
Infecções por Actinomycetales/microbiologia
Bacteriemia/microbiologia
[Mh] Termos MeSH secundário: Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico
Infecções por Actinomycetales/tratamento farmacológico
Adulto
Bacteriemia/tratamento farmacológico
Infecções Relacionadas a Cateter/tratamento farmacológico
Infecções Relacionadas a Cateter/microbiologia
Cateteres de Demora
Gordonia (Bactéria)/genética
Gordonia (Bactéria)/patogenicidade
Seres Humanos
Masculino
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2523-5


  6 / 1890 MEDLINE  
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[PMID]:28421633
[Au] Autor:Rutenberg D; Venner M; Giguère S
[Ad] Endereço:Equine Clinic, School of Veterinary Medicine, Hanover, Germany.
[Ti] Título:Efficacy of Tulathromycin for the Treatment of Foals with Mild to Moderate Bronchopneumonia.
[So] Source:J Vet Intern Med;31(3):901-906, 2017 May.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is conflicting data regarding the efficacy of tulathromycin for the treatment of foals with bronchopneumonia. HYPOTHESES: Tulathromycin is effective for the treatment of bronchopneumonia in foals and noninferior to the combination of azithromycin and rifampin. ANIMALS: A total of 240 foals on a farm endemic for infections caused by Rhodococcus equi. METHODS: In a controlled, randomized, and double-blinded clinical trial, foals with ultrasonographic pulmonary lesions (abscess score 10-15 cm) were allocated to 3 groups: 1-tulathromycin IM q 7 days (n = 80); 2-azithromycin-rifampin, orally q24h (n = 80); or 3-untreated controls (n = 80). Physical examination and thoracic ultrasonography were performed by individuals unaware of treatment group assignment. Foals that worsened were considered treatment failures and removed from the study. RESULTS: The proportion of foals that recovered was significantly higher for foals treated with tulathromycin (70 of 79) or azithromycin-rifampin (76 of 80) compared to that of control foals (22 of 80). The difference in the percentage of efficacy of azithromycin-rifampin versus tulathromycin was 6.4% (90% CI = -0.72-13.5%). Given that the confidence interval crossed the predetermined noninferiority limit of 10%, the null hypothesis that the response rate in the azithromycin-rifampin group is superior to that of the tulathromycin group could not be rejected. Resolution of ultrasonographic lesions occurred faster in foals treated with azithromycin-rifampin than in foals treated with tulathromycin. CONCLUSION AND CLINICAL IMPORTANCE: Tulathromycin was effective for the treatment of bronchopneumonia in foals at this farm but not as effective as the combination of azithromycin-rifampin.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Broncopneumonia/veterinária
Dissacarídeos/uso terapêutico
Compostos Heterocíclicos/uso terapêutico
Doenças dos Cavalos/tratamento farmacológico
[Mh] Termos MeSH secundário: Infecções por Actinomycetales/tratamento farmacológico
Infecções por Actinomycetales/veterinária
Animais
Azitromicina/administração & dosagem
Azitromicina/uso terapêutico
Broncopneumonia/tratamento farmacológico
Broncopneumonia/microbiologia
Método Duplo-Cego
Quimioterapia Combinada/veterinária
Feminino
Cavalos
Masculino
Rhodococcus equi/efeitos dos fármacos
Rifampina/administração & dosagem
Rifampina/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Disaccharides); 0 (Heterocyclic Compounds); 83905-01-5 (Azithromycin); Q839I13422 (tulathromycin); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.14717


  7 / 1890 MEDLINE  
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[PMID]:28369330
[Au] Autor:MacArthur I; Anastasi E; Alvarez S; Scortti M; Vázquez-Boland JA
[Ad] Endereço:Division of Infection and Immunity, The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
[Ti] Título:Comparative Genomics of Rhodococcus equi Virulence Plasmids Indicates Host-Driven Evolution of the vap Pathogenicity Island.
[So] Source:Genome Biol Evol;9(5):1241-1247, 2017 May 01.
[Is] ISSN:1759-6653
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The conjugative virulence plasmid is a key component of the Rhodococcus equi accessory genome essential for pathogenesis. Three host-associated virulence plasmid types have been identified the equine pVAPA and porcine pVAPB circular variants, and the linear pVAPN found in bovine (ruminant) isolates. We recently characterized the R. equi pangenome (Anastasi E, et al. 2016. Pangenome and phylogenomic analysis of the pathogenic actinobacterium Rhodococcus equi. Genome Biol Evol. 8:3140-3148.) and we report here the comparative analysis of the virulence plasmid genomes. Plasmids within each host-associated type were highly similar despite their diverse origins. Variation was accounted for by scattered single nucleotide polymorphisms and short nucleotide indels, while larger indels-mostly in the plasticity region near the vap pathogencity island (PAI)-defined plasmid genomic subtypes. Only one of the plasmids analyzed, of pVAPN type, was exceptionally divergent due to accumulation of indels in the housekeeping backbone. Each host-associated plasmid type carried a unique PAI differing in vap gene complement, suggesting animal host-specific evolution of the vap multigene family. Complete conservation of the vap PAI was observed within each host-associated plasmid type. Both diversity of host-associated plasmid types and clonality of specific chromosomal-plasmid genomic type combinations were observed within the same R. equi phylogenomic subclade. Our data indicate that the overall strong conservation of the R. equi host-associated virulence plasmids is the combined result of host-driven selection, lateral transfer between strains, and geographical spread due to international livestock exchanges.
[Mh] Termos MeSH primário: Evolução Molecular
Ilhas Genômicas
Rhodococcus equi/genética
[Mh] Termos MeSH secundário: Infecções por Actinomycetales/microbiologia
Infecções por Actinomycetales/veterinária
Animais
Bovinos
Interações Hospedeiro-Patógeno
Filogenia
Plasmídeos
Rhodococcus equi/isolamento & purificação
Rhodococcus equi/patogenicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1093/gbe/evx057


  8 / 1890 MEDLINE  
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[PMID]:28245799
[Au] Autor:Hou C; Yang Y; Li Z
[Ad] Endereço:Department of Clinical Laboratory, The Shanxi Dayi Hospital, 99 Longcheng Road, Taiyuan, 030032, Shanxi, China. houchenrui835@126.com.
[Ti] Título:A Chinese patient with peritoneal dialysis-related peritonitis caused by Gordonia terrae: a case report.
[So] Source:BMC Infect Dis;17(1):179, 2017 Feb 28.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gordonia terrae is a rare cause of clinical infections, with only 23 reported cases. We report the first case of peritoneal dialysis-related peritonitis caused by Gordonia terrae in mainland China. CASE PRESENTATION: A 52-year-old man developed peritoneal dialysis-related peritonitis and received preliminary antibiotic treatment. After claiming that his symptoms had been resolved, the patient insisted on being discharged (despite our recommendations) and did not receive continued treatment after leaving the hospital. A telephone follow-up with the patient's relatives revealed that the patient died 3 months later. Routine testing did not identify the bacterial strain responsible for the infection, although matrix-assisted laser desorption/ionization time-of-flight mass spectrometry identified the strain as Gordonia rubropertincta. However, a 16S rRNA sequence analysis using an isolate from the peritoneal fluid culture revealed that the responsible strain was actually Gordonia terrae. Similar to this case, all previously reported cases have involved a delayed diagnosis and initial treatment failure, and the definitive diagnosis required a 16S rRNA sequence analysis. Changes from an inappropriate antibiotic therapy to an appropriate one have relied on microbiological testing and were performed 7-32 days after the initial treatment. CONCLUSIONS: The findings from our case and the previously reported cases indicate that peritoneal dialysis-related peritonitis caused by Gordonia terrae can be difficult to identify and treat. It may be especially challenging to diagnose these cases in countries with limited diagnostic resources.
[Mh] Termos MeSH primário: Infecções por Actinomycetales/diagnóstico
Gordonia (Bactéria)/isolamento & purificação
Diálise Peritoneal/efeitos adversos
Peritonite/diagnóstico
[Mh] Termos MeSH secundário: Infecções por Actinomycetales/etiologia
China
Seres Humanos
Masculino
Meia-Idade
Peritonite/etiologia
Peritonite/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2283-2


  9 / 1890 MEDLINE  
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[PMID]:28161038
[Au] Autor:Giguère S
[Ad] Endereço:Department of Large Animal Medicine, Veterinary Medical Center, University of Georgia, Athens GA 30605. Electronic address: gigueres@uga.edu.
[Ti] Título:Treatment of Infections Caused by Rhodococcus equi.
[So] Source:Vet Clin North Am Equine Pract;33(1):67-85, 2017 Apr.
[Is] ISSN:1558-4224
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pneumonia caused by Rhodococcus equi remains an important cause of disease and death in foals. The combination of a macrolide (erythromycin, azithromycin, or clarithromycin) with rifampin remains the recommended therapy for foals with clinical signs of infection caused by R equi. Most foals with small, subclinical ultrasonographic pulmonary lesions associated with R equi recover without therapy, and administration of antimicrobial agents to these subclinically affected foals does not hasten lesion resolution relative to administration of a placebo. Resistance to macrolides and rifampin in isolates of R equi is increasing.
[Mh] Termos MeSH primário: Infecções por Actinomycetales/veterinária
Antibacterianos/uso terapêutico
Doenças dos Cavalos/tratamento farmacológico
Doenças dos Cavalos/microbiologia
Pneumonia Bacteriana/veterinária
Rhodococcus equi/isolamento & purificação
[Mh] Termos MeSH secundário: Infecções por Actinomycetales/tratamento farmacológico
Animais
Azitromicina/uso terapêutico
Claritromicina/farmacologia
Farmacorresistência Bacteriana Múltipla
Eritromicina/uso terapêutico
Cavalos
Pneumonia Bacteriana/tratamento farmacológico
Pneumonia Bacteriana/microbiologia
Rifampina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 63937KV33D (Erythromycin); 83905-01-5 (Azithromycin); H1250JIK0A (Clarithromycin); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


  10 / 1890 MEDLINE  
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[PMID]:28144921
[Au] Autor:Zhao K; Li W; Huang T; Song X; Zhang X; Yue B
[Ad] Endereço:Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, 610064, Chengdu, People's Republic of China.
[Ti] Título:Comparative transcriptome analysis of Trueperella pyogenes reveals a novel antimicrobial strategy.
[So] Source:Arch Microbiol;199(5):649-655, 2017 Jul.
[Is] ISSN:1432-072X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Trueperella pyogenes is a prevalent opportunistic bacterium that normally causes diverse suppurative lesions, endometritis and pneumonia in various economically important animals. Although the genomic information of this species has been announced, little is known about its functional profiles. In this study, by performing a comparative transcriptome analysis between the highly and moderately virulent T. pyogenes isolates, we found the expression of a LuxR-type DNA-binding response regulator, PloR, was significantly up-regulated in the highly virulent T. pyogenes. Protein crystal structure prediction and primary functional assessment suggested that, the quorum-sensing signal molecules of Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli could significantly inhibit the growth, biofilm production and hemolysis of T. pyogenes by binding to the upstream sensor histidine kinase, PloS. Therefore, the PloS/PlosR two-component regulatory system might dominate the virulence of T. pyogenes. Our findings provide a major advance in understanding the pathogenesis of T. pyogenes, and may shed new light on the development of novel therapeutic strategies to control T. pyogenes infection.
[Mh] Termos MeSH primário: Actinomycetaceae/genética
Actinomycetaceae/patogenicidade
Infecções por Actinomycetales/patologia
Proteínas de Ligação a DNA/biossíntese
Perfilação da Expressão Gênica
Histidina Quinase/metabolismo
[Mh] Termos MeSH secundário: Actinomycetaceae/crescimento & desenvolvimento
Infecções por Actinomycetales/microbiologia
Animais
Anti-Infecciosos
Biofilmes/crescimento & desenvolvimento
Escherichia coli/metabolismo
Feminino
Histidina Quinase/genética
Pseudomonas aeruginosa/metabolismo
Percepção de Quorum
Virulência/genética
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (DNA-Binding Proteins); 0 (Virulence Factors); EC 2.7.13.1 (Histidine Kinase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1007/s00203-017-1338-5



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