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  1 / 1701 MEDLINE  
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[PMID]:28622620
[Au] Autor:Armstrong N; Richez M; Raoult D; Chabriere E
[Ad] Endereço:IHU Mediterranee Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. Electronic address: Nicholas.armstrong@univ-amu.fr.
[Ti] Título:Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1060:166-172, 2017 Aug 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A fast UHPLC-UV method was developed for the simultaneous analysis of Hydroxychloroquine, Minocycline and Doxycycline drugs from 100µL of human serum samples. Serum samples were extracted by liquid-liquid extraction and injected into a phenyl hexyl reverse phase column. Compounds were separated using a mobile phase linear gradient and monitored by UV detection at 343nm. Chloroquine and Oxytetracycline were used as internal standards. Lower and upper limits of quantifications, as well as the other levels of calibration, were validated with acceptable accuracy (<15% deviation) and precision (<15% coefficient of variation) according to the European Medicines Agency guidelines. This new method enables cost and time reduction and was considered suitable for the clinical laboratory. It is the first published assay for the therapeutic drug monitoring of patients diagnosed with Q fever or Whipple's disease.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Doxiciclina/sangue
Monitoramento de Medicamentos/métodos
Hidroxicloroquina/sangue
Minociclina/sangue
Febre Q/tratamento farmacológico
Doença de Whipple/tratamento farmacológico
[Mh] Termos MeSH secundário: Antibacterianos/sangue
Antibacterianos/farmacocinética
Antibacterianos/uso terapêutico
Doxiciclina/química
Doxiciclina/farmacocinética
Doxiciclina/uso terapêutico
Estabilidade de Medicamentos
Seres Humanos
Hidroxicloroquina/química
Hidroxicloroquina/farmacocinética
Hidroxicloroquina/uso terapêutico
Limite de Detecção
Modelos Lineares
Minociclina/farmacocinética
Minociclina/uso terapêutico
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 4QWG6N8QKH (Hydroxychloroquine); FYY3R43WGO (Minocycline); N12000U13O (Doxycycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE


  2 / 1701 MEDLINE  
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[PMID]:28559404
[Au] Autor:Trotta L; Weigt K; Schinnerling K; Geelhaar-Karsch A; Oelkers G; Biagi F; Corazza GR; Allers K; Schneider T; Erben U; Moos V
[Ad] Endereço:First Department of Internal Medicine, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy.
[Ti] Título:Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease.
[So] Source:Infect Immun;85(8), 2017 Aug.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from was previously identified as a B-cell antigen. We tested the capacity of Hsp70 and GrpE to elicit specific proinflammatory T-cell responses. Peripheral mononuclear cells from CWD patients and healthy donors were stimulated with lysate or recombinant GrpE or Hsp70 before levels of CD40L, CD69, perforin, granzyme B, CD107a, and gamma interferon (IFN-γ) were determined in T cells by flow cytometry. Upon stimulation with total bacterial lysate or recombinant GrpE or Hsp70 of , the proportions of activated effector CD4 T cells, determined as CD40L IFN-γ , were significantly lower in patients with CWD than in healthy controls; CD8 T cells of untreated CWD patients revealed an enhanced activation toward unspecific stimulation and -specific degranulation, although CD69 IFN-γ CD8 T cells were reduced upon stimulation with lysate and recombinant -derived proteins. Hsp70 and its cofactor GrpE are immunogenic in healthy individuals, eliciting effective responses against to control bacterial spreading. The lack of specific T-cell responses against these -derived proteins may contribute to the pathogenesis of CWD.
[Mh] Termos MeSH primário: Proteínas de Bactérias/imunologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Proteínas de Choque Térmico HSP70/imunologia
Proteínas de Choque Térmico/imunologia
Tropheryma/imunologia
Doença de Whipple/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Antígenos CD/genética
Linfócitos B/patologia
Duodeno/imunologia
Feminino
Citometria de Fluxo
Seres Humanos
Interferon gama/genética
Mucosa Intestinal/imunologia
Leucócitos Mononucleares/efeitos dos fármacos
Ativação Linfocitária
Masculino
Meia-Idade
Tropheryma/química
Tropheryma/genética
Doença de Whipple/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Bacterial Proteins); 0 (GrpE protein, Bacteria); 0 (HSP70 Heat-Shock Proteins); 0 (Heat-Shock Proteins); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


  3 / 1701 MEDLINE  
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[PMID]:28385924
[Au] Autor:Rollin DC; Paddock CD; Pritt BS; Cunningham SA; Denison AM
[Ad] Endereço:Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
[Ti] Título:Genotypic analysis of from patients with Whipple disease in the Americas.
[So] Source:J Clin Pathol;70(10):891-895, 2017 Oct.
[Is] ISSN:1472-4146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:, the agent of Whipple disease, causes a rare bacterial disease that may be fatal if not treated. The classical form of the disease includes diarrhoea, weight loss, arthritis, endocarditis and neurological manifestations. Genotyping studies done in Europe, Africa and Asia showed high genetic diversity with no correlation between genotypes and clinical features, but contributed to a better understanding of the epidemiology of the disease. More than 70 genotypes have been described. No similar assessment of in the USA and the Caribbean has been performed. In this study, we describe genetic analysis of DNA from histopathological samples obtained from 30 patients from the Americas with Whipple disease and compare the genotypes with those previously identified. Complete genotypes were obtained from 18 patients (60%). Only 4 genotypes were previously described, and 14 were newly reported, confirming the diversity of strains.
[Mh] Termos MeSH primário: Tropheryma/genética
Doença de Whipple/microbiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Américas
DNA Bacteriano/análise
Feminino
Genótipo
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1136/jclinpath-2017-204382


  4 / 1701 MEDLINE  
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[PMID]:28325722
[Au] Autor:Papakonstantinou D; Riste MJ; Langman G; Moran E
[Ad] Endereço:Department of Infectious Diseases and Tropical Medicine, Birmingham Heartlands Hospital, Heart of England NHS Hospital Trust, Birmingham, UK.
[Ti] Título:Misdiagnosing Whipple's disease in the young.
[So] Source:BMJ Case Rep;2017, 2017 Mar 21.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Whipple's disease is considered an infection of middle-aged white men of European ancestry. Cases are rare and disproportionately associated with occupational exposure to soil or animals. We report the case of a man aged 22 years with no risk factors, erroneously diagnosed with, and treated for, toxoplasmosis on the basis of consistent lymph node histology. The correct diagnosis was delayed by the dramatic symptomatic improvement resulting from this therapy. Whipple's disease should be considered in cases of granulomatous lymphadenopathy of unknown cause, even if the age of the patient does not fit the classic presentation of the disease.
[Mh] Termos MeSH primário: Erros de Diagnóstico
Linfonodos/patologia
Doença de Whipple/diagnóstico
Doença de Whipple/patologia
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Ceftriaxona/uso terapêutico
Diagnóstico Diferencial
Duodeno/patologia
Seres Humanos
Masculino
Toxoplasmose/diagnóstico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Doença de Whipple/tratamento farmacológico
Doença de Whipple/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 75J73V1629 (Ceftriaxone); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  5 / 1701 MEDLINE  
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[PMID]:28298472
[Au] Autor:Dolmans RA; Boel CH; Lacle MM; Kusters JG
[Ad] Endereço:Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
[Ti] Título:Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections.
[So] Source:Clin Microbiol Rev;30(2):529-555, 2017 Apr.
[Is] ISSN:1098-6618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Whipple's disease is a rare infectious disease that can be fatal if left untreated. The disease is caused by infection with , a bacterium that may be more common than was initially assumed. Most patients present with nonspecific symptoms, and as routine cultivation of the bacterium is not feasible, it is difficult to diagnose this infection. On the other hand, due to the generic symptoms, infection with this bacterium is actually quite often in the differential diagnosis. The gold standard for diagnosis used to be periodic acid-Schiff (PAS) staining of duodenal biopsy specimens, but PAS staining has a poor specificity and sensitivity. The development of molecular techniques has resulted in more convenient methods for detecting infections, and this has greatly improved the diagnosis of this often missed infection. In addition, the molecular detection of has resulted in an increase in knowledge about its pathogenicity, and this review gives an overview of the new insights in epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of infections.
[Mh] Termos MeSH primário: Doença de Whipple
[Mh] Termos MeSH secundário: Antibacterianos
Seres Humanos
Tropheryma/fisiologia
Doença de Whipple/diagnóstico
Doença de Whipple/epidemiologia
Doença de Whipple/patologia
Doença de Whipple/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1128/CMR.00033-16


  6 / 1701 MEDLINE  
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[PMID]:28281520
[Au] Autor:Krums LM; Bodunova NA; Sabel'nikova EA; Khomeriki SG; Mirzoev KM; Sokolova MS; Parfenov AI
[Ad] Endereço:Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.
[Ti] Título:[Whipple's disease: A clinical case report].
[Ti] Título:Bolezn' Uippla: opisanie klinicheskogo sluchaya..
[So] Source:Ter Arkh;89(2):103-104, 2017.
[Is] ISSN:0040-3660
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The paper describes a 56-year-old female patient who in December 2015 lost her appetite and 20 kg of weight, had diarrhea, rapidly increasing weakness, dizziness, joint pains, fever, swelling of the feet, and convulsions. Blood tests revealed anemia, elevated erythrocyte sedimentation rate, and hypoproteinemia. Computed tomography showed enlarged mesenteric and retroperitoneal lymph nodes. The doctor suspected lymphoma and referred her to the Moscow Clinical Research Center. The diagnosis of Whipple's disease was established by carrying out a small intestinal (duodenal) mucosal biopsy with the PAS reaction. A fat-free diet and antibiotic therapy with co-trimoxazole 2.0 g/day and ciprolen 0.3 g/day were prescribed for the patient. Fever and diarrhea disappeared, appetite appeared, weight gained, and blood counts normalized over 1 month of treatment. The patient was discharged with a recommendation to continue antibiotic treatment until the histopathological signs of the disease ceased.
[Mh] Termos MeSH primário: Doença de Whipple/diagnóstico
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Dieta com Restrição de Gorduras
Feminino
Seres Humanos
Meia-Idade
Doença de Whipple/dietoterapia
Doença de Whipple/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.17116/terarkh2017892103-104


  7 / 1701 MEDLINE  
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[PMID]:28262041
[Au] Autor:Lagier JC; Fenollar F; Raoult D
[Ad] Endereço:Aix Marseille Université, URMITE, IHU Méditerranée-Infection, UM63, CNRS 7278, IRD 198, INSERM 1095, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
[Ti] Título:Acute infections caused by Tropheryma whipplei.
[So] Source:Future Microbiol;12:247-254, 2017 Mar.
[Is] ISSN:1746-0921
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tropheryma whipplei is the causative bacterium of Whipple's disease. Its first culture has led to an enlargement of the field of the caused infections. Here, we comprehensively review acute T. whipplei infections. In a cohort study featuring 4000 children, T. whipplei was significantly more common in patients with diarrhea (4%) than in those without (1.7%). A case-controlled study highlighted 58 patients suffering from pneumonia with the detection of T. whipplei in their bronchoalveolar fluids. Finally, a recent study detected T. whipplei in the blood of 36 febrile patients experiencing pulmonary symptoms in a rural area of Senegal. T. whipplei is definitively an agent of acute gastroenteritis, a cause of nonmalarial fever in Africa, and probably a cause of pulmonary infections.
[Mh] Termos MeSH primário: Tropheryma/fisiologia
Doença de Whipple/microbiologia
[Mh] Termos MeSH secundário: Doença Aguda
Gastroenterite/microbiologia
Seres Humanos
Tropheryma/genética
Tropheryma/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.2217/fmb-2017-0178


  8 / 1701 MEDLINE  
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[PMID]:28098596
[Au] Autor:Liersch J; Carlotti A; Theunis A; Leonard A; Barrett M; Carlson JA; Schaller J
[Ad] Endereço:*Dermatopathology Duisburg, Duisburg, Germany; †Department of Pathology, APHP Cochin Hospital, University Paris-Descartes, Paris, France; ‡Department of Dermatology, Saint Pierre-Brugmann and Children's University Hospitals, UniversiteLibre de Bruxelles, Brussels, Belgium; and §Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, Albany, NY.
[Ti] Título:Erythema Nodosum Leprosum-Like Lesions Are a Histopathologic Pattern in Whipple's Disease and a Sign of the Immune Reconstitution Inflammatory Syndrome: A Case Series and Review of the Literature.
[So] Source:Am J Dermatopathol;39(4):259-266, 2017 Apr.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory and subcutaneous nodules can arise in treated and untreated cases of Whipple disease (WD). The inflammatory immune reconstitution syndrome describes paradoxical clinical inflammatory worsening of a preexisting condition because of a return of immune function. Clinicopathologic examination of 4 patients with WD who presented with erythema nodosum leprosum (ENL)-like lesions and the findings of a systematic review of this phenomenon revealed that ENL-like lesions occurred in predominantly middle-aged male patients who suffered from WD, mostly on the legs. Patients showed a nonvasculitic, mostly septal panniculits with neutrophils, macrophages, and lymphocytes. Numerous bacteria-laden periodic acid-Schiff + macrophages and free bacilli were detected in the dermis, as well as subcutaneous septae and adipose lobules. These lesions occurred in both untreated and treated patients as part of inflammatory immune reconstitution syndrome. In conclusion, ENL-like lesions represent a characteristic histopathologic pattern associated with WD, which can occur in different contexts whenever there is a change in the immunological status of the patient. This change can be triggered by antimicrobial treatment, immunomodulatory and immunosuppressant therapy, or occur spontaneously, rarely.
[Mh] Termos MeSH primário: Eritema Nodoso/microbiologia
Síndrome Inflamatória da Reconstituição Imune/patologia
Doença de Whipple/patologia
[Mh] Termos MeSH secundário: Eritema Nodoso/patologia
Seres Humanos
Imunossupressores/efeitos adversos
Masculino
Meia-Idade
Doença de Whipple/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000641


  9 / 1701 MEDLINE  
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[PMID]:27924649
[Au] Autor:Biagi F; Biagi GL; Corazza GR
[Ad] Endereço:a First Department of Internal Medicine , Fondazione IRCCS Policlinico San Matteo, University of Pavia , Pavia , Italy.
[Ti] Título:What is the best therapy for Whipple's disease? Our point of view.
[So] Source:Scand J Gastroenterol;52(4):465-466, 2017 Apr.
[Is] ISSN:1502-7708
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although Whipple's disease (WD) has been treated with antibiotics since the early 50s, the best antibiotics and the duration of the therapy have not yet been established. We consider here the pro and cons of the two most commonly used therapies, ceftriaxone followed by trimethoprim-sulfamethoxazole (TMP-SMZ) and hydroxychloroquine in combination with doxycycline. The therapy based on ceftriaxone and TMP-SMZ is efficient in the vast majority of patients for the first few years. However, since reinfections or reactivations can occur, a life-long prophylaxis is necessary and doxycycline is nowadays the best option. We thus propose a therapy based on merging these to therapies together, ceftriaxone, and TMP-SMZ for the first year(s) and then life-long prophylaxis with doxycycline.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Ceftriaxona/uso terapêutico
Doxiciclina/uso terapêutico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Doença de Whipple/tratamento farmacológico
[Mh] Termos MeSH secundário: Quimioterapia Combinada
Fezes/microbiologia
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Tropheryma/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 75J73V1629 (Ceftriaxone); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); N12000U13O (Doxycycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1080/00365521.2016.1264009


  10 / 1701 MEDLINE  
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[PMID]:27398638
[Au] Autor:Lehmann P; Ehrenstein B; Hartung W; Dragonas C; Reischl U; Fleck M
[Ad] Endereço:a Department of Rheumatology and Clinical Immunology , Asklepios Medical Centre , Bad Abbach , Germany.
[Ti] Título:PCR analysis is superior to histology for diagnosis of Whipple's disease mimicking seronegative rheumatic diseases.
[So] Source:Scand J Rheumatol;46(2):138-142, 2017 Mar.
[Is] ISSN:1502-7732
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The diagnosis of Whipple's disease (WD) is commonly confirmed by histology demonstrating Periodic Acid Schiff (PAS)-positive macrophages in the duodenal mucosa. Analysis of intestinal tissue or other specimens using polymerase chain reaction (PCR) is a more sensitive method. However, the relevance of positive PCR findings is still controversial. Therefore, we evaluated the relevance of histology and PCR findings to establishing the diagnosis of WD in a series of WD patients initially presenting with suspected rheumatic diseases. METHOD: Between 2006 and 2014, 20 patients with seronegative rheumatic diseases tested positive for Tropheryma whipplei (Tw) by PCR and/or histology and were enrolled in a retrospective analysis of the diagnostic value of both procedures. RESULTS: Seven of the 20 cases (35%) were diagnosed with 'classic' WD as indicated by PAS-positive macrophages. In the remaining 13 patients, the presence of Tw was detected by intestinal (n = 10) or synovial PCR analysis (n = 3). Two of the 20 patients (10%) with evidence of Tw did not respond to antibiotic therapy. They were not considered to suffer from WD. Therefore, relying only on histological findings of intestinal biopsies would have missed 11 (61%) of the 18 patients with WD in our cohort. In comparison, PCR of intestinal biopsies detected Tw-DNA in 14 (93%) of the 15 WD patients evaluated. Patients with a positive histology did not differ from PCR-positive patients with regard to sex, age, or duration of disease, but more often presented with gastrointestinal symptoms. CONCLUSIONS: A substantial number of WD patients present without typical intestinal histology findings. Additional PCR analysis of intestinal tissue or synovial fluid increased the sensitivity of the diagnostic evaluation and should be considered particularly in patients presenting with atypical seronegative rheumatic diseases and a high-risk profile for WD.
[Mh] Termos MeSH primário: Reação em Cadeia da Polimerase/métodos
Doenças Reumáticas/diagnóstico
Doença de Whipple/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/uso terapêutico
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Doença de Whipple/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE
[do] DOI:10.1080/03009742.2016.1183038



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