Base de dados : MEDLINE
Pesquisa : C01.539.375 [Categoria DeCS]
Referências encontradas : 913 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 92 ir para página                         

  1 / 913 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28847716
[Au] Autor:Jia C; Zhang F; Zhu Y; Qi X; Wang Y
[Ad] Endereço:Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.
[Ti] Título:Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.
[So] Source:Gene;632:43-49, 2017 Oct 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Matrix-remodeling associated 7 (MXRA7) gene was first reported in 2002 and named so for its co-expression with several genes known to relate with matrix-remodeling. However, not any studies had been intentionally performed to characterize this gene. We started defining the functions of MXRA7 by integrating bioinformatics analysis and experimental study. Data mining of MXRA7 expression in BioGPS, Gene Expression Omnibus and EurExpress platforms highlighted high level expression of Mxra7 in murine ocular tissues. Real-time PCR was employed to measure Mxra7 mRNA in tissues of adult C57BL/6 mice and demonstrated that Mxra7 was preferentially expressed at higher level in retina, corneas and lens than in other tissues. Then the inflammatory corneal neovascularization (CorNV) model and fungal corneal infections were induced in Balb/c mice, and mRNA levels of Mxra7 as well as several matrix-remodeling related genes (Mmp3, Mmp13, Ecm1, Timp1) were monitored with RT-PCR. The results demonstrated a time-dependent Mxra7 under-expression pattern (U-shape curve along timeline), while all other matrix-remodeling related genes manifested an opposite changes pattern (dome-shape curve). When limited data from BioGPS concerning human MXRA7 gene expression in human tissues were looked at, it was found that ocular tissue was also the one expressing highest level of MXRA7. To conclude, integrative assay of MXRA7 gene expression in public databank as well as domestic animal models revealed a selective high expression MXRA7 in murine and human ocular tissues, and its change patterns in two corneal disease models implied that MXRA7 might play a role in pathological processes or diseases involving injury, neovascularization and would healing.
[Mh] Termos MeSH primário: Córnea/metabolismo
Doenças da Córnea/metabolismo
Infecções Oculares/metabolismo
Neovascularização Patológica/metabolismo
Proteínas/metabolismo
[Mh] Termos MeSH secundário: Animais
Córnea/irrigação sanguínea
Proteínas da Matriz Extracelular/genética
Proteínas da Matriz Extracelular/metabolismo
Seres Humanos
Metaloproteinase 13 da Matriz/genética
Metaloproteinase 13 da Matriz/metabolismo
Metaloproteinase 3 da Matriz/genética
Metaloproteinase 3 da Matriz/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Proteínas/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Inibidor Tecidual de Metaloproteinase-1/genética
Inibidor Tecidual de Metaloproteinase-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Ecm1 protein, mouse); 0 (Extracellular Matrix Proteins); 0 (Mxra7 protein, mouse); 0 (Proteins); 0 (RNA, Messenger); 0 (Timp1 protein, mouse); 0 (Tissue Inhibitor of Metalloproteinase-1); EC 3.4.24.- (Matrix Metalloproteinase 13); EC 3.4.24.- (Mmp13 protein, mouse); EC 3.4.24.17 (Matrix Metalloproteinase 3); EC 3.4.24.17 (Mmp3 protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  2 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
[PMID]:28838031
[Au] Autor:Anshu A; Tan D; Chee SP; Mehta JS; Htoon HM
[Ad] Endereço:Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore, 168751.
[Ti] Título:Interventions for the management of CMV-associated anterior segment inflammation.
[So] Source:Cochrane Database Syst Rev;8:CD011908, 2017 08 24.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cytomegalovirus (CMV) is a virus that usually affects people with reduced immunity. In recent years, this virus has been thought to cause repeated inflammation in the eye, in otherwise healthy people. This form of inflammation can cause damage to the cornea (the outer layer of the eye) or to the optic nerve by causing secondary glaucoma, or to both, leading to visual loss. OBJECTIVES: Our primary objective was to assess the effects of drug therapies for the treatment of CMV-associated anterior segment inflammation.Our secondary objective was to determine the optimal dose and duration of treatment with respect to recurrence and adverse effects. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 2), MEDLINE Ovid (1946 to 21 March 2017), Embase Ovid (1947 to 21 March 2017), the ISRCTN registry (www.isrctn.com/editAdvancedSearch); searched 21 March 2017, ClinicalTrials.gov (www.clinicaltrials.gov); searched 21 March 2017, and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en); searched 21 March 2017. We did not use any date or language restrictions in the electronic searches for trials. Two review authors independently reviewed the titles and abstracts. SELECTION CRITERIA: We searched for randomised controlled trials (RCTs) on the management of CMV-associated anterior segment inflammation. DATA COLLECTION AND ANALYSIS: We planned to have two review authors independently extract data from reports of included studies and analyse data based on methods expected by Cochrane. MAIN RESULTS: We did not identify any RCTs that met our inclusion criteria. AUTHORS' CONCLUSIONS: There is currently no good-quality evidence on the management of CMV-associated anterior segment inflammation. Ideally, a well-designed RCT is needed to evaluate the effectiveness of different anti-CMV medications as well as the optimal dose and duration.
[Mh] Termos MeSH primário: Segmento Anterior do Olho
Antivirais/uso terapêutico
Infecções por Citomegalovirus/tratamento farmacológico
Infecções Oculares/tratamento farmacológico
Infecções Oculares/virologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD011908.pub2


  3 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28817556
[Au] Autor:Cope JR; Collier SA; Nethercut H; Jones JM; Yates K; Yoder JS
[Ad] Endereço:Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC.
[Ti] Título:Risk Behaviors for Contact Lens-Related Eye Infections Among Adults and Adolescents - United States, 2016.
[So] Source:MMWR Morb Mortal Wkly Rep;66(32):841-845, 2017 Aug 18.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contact lens-related eye infections, which can lead to serious outcomes, including blindness, are associated with several risk factors, including sleeping in lenses, exposing lenses to water, not adhering to replacement schedules, and reusing disinfecting solution (1). In some studies, adolescent and young adult contact lens wearers have been reported to be more likely than older adult contact lens wearers to develop eye infections (2,3) and more likely to have poor contact lens hygiene practices (2). In 2015, CDC reported the number and demographics of adult contact lens wearers in the United States to define the population at risk for contact lens-related eye infections (4); however, this estimate did not include adolescents. To better understand this group of younger contact lens wearers and guide prevention efforts, a population-based survey was used to assess contact lens wear, care behaviors, risk factors, and demographics among persons aged 12-17 years (referred to as adolescents in this report), young adults aged 18-24 years, and older adults aged ≥25 years in the United States. In 2016, an estimated 3.6 million adolescents (14.5%) wore contact lenses. Of the adolescents who wore contact lenses, 85% reported at least one behavior that put them at risk for a contact lens-related eye infection, compared with 81% of young adults, and 88% of older adults. These findings can inform the creation of age-specific targeted prevention messages aimed at contact lens wearers and establish a baseline for evaluating trends in contact lens wear, care habits, and contact lens-related risk behaviors.
[Mh] Termos MeSH primário: Lentes de Contato/efeitos adversos
Lentes de Contato/psicologia
Infecções Oculares/epidemiologia
Assunção de Riscos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Seres Humanos
Masculino
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6632a2


  4 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28752698
[Au] Autor:Sheu SJ
[Ad] Endereço:Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
[Ti] Título:Endophthalmitis.
[So] Source:Korean J Ophthalmol;31(4):283-289, 2017 Aug.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Endophthalmitis is a rare but severe form of ocular inflammation due to infection of the intraocular cavity that can lead to irreversible visual loss if not treated properly and timely. It can be classified as exogenous or endogenous based on the transmission route of the infectious source. Exogenous endophthalmitis occurs when infecting organisms gain entry into the eye via direct inoculation, while endogenous endophthalmitis occurs when infectious agents hematogenously spread into the eye from a distant focus of infection. The diagnosis of endophthalmitis depends mostly on the clinical findings on ophthalmological examination. Delayed diagnosis of endogenous endophthalmitis can lead to not only visual loss, but also increased risk of mortality. Since ocular and systemic symptoms of endophthalmitis are usually non-specific, early diagnosis relies on the alertness of clinicians. Early diagnosis and proper treatment are keys to saving the eye. Following advances in vitreoretinal pharmacotherapy and surgical technology, early surgical intervention is the current trend in the management of endophthalmitis.
[Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico
Endoftalmite
Infecções Oculares
[Mh] Termos MeSH secundário: Endoftalmite/diagnóstico
Endoftalmite/tratamento farmacológico
Endoftalmite/epidemiologia
Infecções Oculares/diagnóstico
Infecções Oculares/tratamento farmacológico
Infecções Oculares/epidemiologia
Saúde Global
Seres Humanos
Incidência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2017.0036


  5 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28715589
[Au] Autor:Lescrauwaet B; Miserocchi E; Thurau S; Bodaghi B; Duchateau L; Verstraeten T; Srivastava S
[Ad] Endereço:Xintera Ltd, Cambridge, United Kingdom.
[Ti] Título:Association Between Visual Function Response and Reduction of Inflammation in Noninfectious Uveitis of the Posterior Segment.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3555-3562, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To examine the association between visual function response (VFR) and inflammation reduction in active noninfectious uveitis of the posterior segment (NIU-PS). Methods: Phase 3 SAKURA Study 1 randomized 347 subjects in a double-masked fashion to receive injections of intravitreal sirolimus 44 µg (n = 117); 440 µg (n = 114); or 880 µg (n = 116) every other month. Vitreous haze (VH) response, a measure of inflammation reduction, was defined as a VH score of 0 or 0.5+ at month 5 based on the modified Standardized Uveitis Nomenclature Scale. Visual function was assessed with best-corrected visual acuity (BCVA) and the National Eye Institute (NEI) Visual Function Questionnaire-25 (VFQ-25). In this post-hoc analysis, principal component analysis was used to reduce the information in the multidimensional visual function outcome to a restricted number of independently relevant VFR measures. Minimal clinically important differences (MCID) for the VFQ-25-derived components were based on the standard error of measurements. Overall VFR was defined as either a BCVA improvement of ≥2 lines, or an improvement exceeding the MCID in the VFQ-25 based visual function measures. Results: The VFQ-25 composite score (VFQCS) and mental health subscale score (VFQMHS) were retained as relevant VFRs, with MCIDs of 4.3 and 11.7 points, respectively. A vitreous haze response was significantly associated with each VFR measure: VFQCS (odds ratio [OR] = 2.23; P = 0.0004); VFQMHS (OR = 2.84; P < 0.0001); BCVA (OR = 2.60; P = 0.0009), and overall VFR (OR = 2.65; P < 0.0001). Conclusions: Inflammation reduction to a VH score of 0 or 0.5+ was significantly associated with improved visual function. Achieving a VH response of 0 or 0.5+ is a patient-relevant outcome.
[Mh] Termos MeSH primário: Imunossupressores/uso terapêutico
Inflamação/tratamento farmacológico
Sirolimo/uso terapêutico
Uveíte Posterior/tratamento farmacológico
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Método Duplo-Cego
Infecções Oculares/fisiopatologia
Feminino
Seres Humanos
Imunossupressores/administração & dosagem
Inflamação/fisiopatologia
Injeções Intravítreas
Masculino
Meia-Idade
Medidas de Resultados Relatados pelo Paciente
Perfil de Impacto da Doença
Sirolimo/administração & dosagem
Inquéritos e Questionários
Uveíte Posterior/fisiopatologia
Corpo Vítreo/patologia
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Immunosuppressive Agents); W36ZG6FT64 (Sirolimus)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22049


  6 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28709803
[Au] Autor:St Leger AJ; Desai JV; Drummond RA; Kugadas A; Almaghrabi F; Silver P; Raychaudhuri K; Gadjeva M; Iwakura Y; Lionakis MS; Caspi RR
[Ad] Endereço:Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA.
[Ti] Título:An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.
[So] Source:Immunity;47(1):148-158.e5, 2017 Jul 18.
[Is] ISSN:1097-4180
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have associated commensal flora. The surface of the eye is also a mucosal site, but proof of a living, resident ocular microbiome remains elusive. Here, we used a mouse model of ocular surface disease to reveal that commensals were present in the ocular mucosa and had functional immunological consequences. We isolated one such candidate commensal, Corynebacterium mastitidis, and showed that this organism elicited a commensal-specific interleukin-17 response from γδ T cells in the ocular mucosa that was central to local immunity. The commensal-specific response drove neutrophil recruitment and the release of antimicrobials into the tears and protected the eye from pathogenic Candida albicans or Pseudomonas aeruginosa infection. Our findings provide direct evidence that a resident commensal microbiome exists on the ocular surface and identify the cellular mechanisms underlying its effects on ocular immune homeostasis and host defense.
[Mh] Termos MeSH primário: Candida albicans/imunologia
Candidíase/imunologia
Córnea/imunologia
Infecções por Corynebacterium/imunologia
Corynebacterium/imunologia
Infecções Oculares/imunologia
Imunidade nas Mucosas
Interleucina-17/metabolismo
Microbiota/imunologia
Neutrófilos/imunologia
Infecções por Pseudomonas/imunologia
Pseudomonas aeruginosa/imunologia
Linfócitos T/imunologia
Lágrimas/imunologia
[Mh] Termos MeSH secundário: Animais
Candidíase/microbiologia
Córnea/microbiologia
Infecções por Corynebacterium/microbiologia
Modelos Animais de Doenças
Infecções Oculares/microbiologia
Interações Hospedeiro-Patógeno
Seres Humanos
Interleucina-17/genética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Infiltração de Neutrófilos
Neutrófilos/microbiologia
Infecções por Pseudomonas/microbiologia
Receptores de Antígenos de Linfócitos T gama-delta/genética
Receptores de Antígenos de Linfócitos T gama-delta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-17); 0 (Receptors, Antigen, T-Cell, gamma-delta)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


  7 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28546688
[Au] Autor:Garg P; Das S; Roy A
[Ad] Endereço:Tej Kohli Cornea Institute, KAR Campus, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
[Ti] Título:Collagen Cross-linking for Microbial Keratitis.
[So] Source:Middle East Afr J Ophthalmol;24(1):18-23, 2017 Jan-Mar.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. The treatment also induces formation of inter- and intra-fibrillar bonds, thereby making the corneal collagen resistant to the action of proteases arresting stromal melt. Both properties are well documented in experiments. The antimicrobial action is seen against bacteria, fungi, and parasites. The animal experiments have documented its efficacy against bacterial and fungal keratitis models. The literature on its application in human corneal infection is highly variable and comprises case reports, case series, and comparative nonrandomized and randomized trials. The treatment has been used as primary treatment, adjunctive treatment along with antibiotics, as the first line of treatment as well as for failed medical treatment cases. Even the cases included are of variable severity caused by a variety of microorganisms including culture-negative cases. Furthermore, the treatment protocols are also variable. While most reports show beneficial effects for bacterial corneal ulcer cases, especially those with superficial infiltrate, the effect has been mixed for fungal and parasitic keratitis. In view of these characteristics, we infer that the level of evidence for its use in corneal ulcer is at most weak. We need well-characterized, high-quality, clinical trials of sufficient power to assess its true value.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Colágeno/uso terapêutico
Reagentes para Ligações Cruzadas/uso terapêutico
Infecções Oculares/tratamento farmacológico
Ceratite/tratamento farmacológico
[Mh] Termos MeSH secundário: Progressão da Doença
Quimioterapia Combinada
Seres Humanos
Fármacos Fotossensibilizantes/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_305_16


  8 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28546686
[Au] Autor:Majumder PD; Ghosh A; Biswas J
[Ad] Endereço:Department of Uvea, Sankara Nethralaya, Chennai, Tamil Nadu, India.
[Ti] Título:Infectious uveitis: An enigma.
[So] Source:Middle East Afr J Ophthalmol;24(1):2-10, 2017 Jan-Mar.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Infectious uveitis accounts for majority of the cases of uveitis in developing countries. It also encompasses an array of various microorganisms and their clinical presentations. Some of these infectious uveitic entities are familiar, while others are newly emerging in the global ophthalmic world. Many of these entities are also a major cause of morbidity and mortality, and appropriate, timely management is required to save not the eye, but life of the patient. This review highlights the ocular manifestations of various infectious uveitic entities, relevant to the ophthalmologist.
[Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico
Técnicas de Diagnóstico Oftalmológico
Gerenciamento Clínico
Infecções Oculares
Uveíte
[Mh] Termos MeSH secundário: Infecções Oculares/epidemiologia
Infecções Oculares/etiologia
Infecções Oculares/terapia
Saúde Global
Seres Humanos
Morbidade/tendências
Uveíte/epidemiologia
Uveíte/etiologia
Uveíte/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_252_16


  9 / 913 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28404853
[Au] Autor:Edwards RG; Longnecker R
[Ad] Endereço:Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
[Ti] Título:Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye.
[So] Source:J Virol;91(13), 2017 Jul 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As its name suggests, the host receptor herpesvirus entry mediator (HVEM) facilitates herpes simplex virus (HSV) entry through interactions with a viral envelope glycoprotein. HVEM also bridges several signaling networks, binding ligands from both tumor necrosis factor (TNF) and immunoglobulin (Ig) superfamilies with diverse, and often opposing, outcomes. While HVEM was first identified as a viral entry receptor for HSV, it is only recently that HVEM has emerged as an important host factor in immunopathogenesis of ocular HSV type 1 (HSV-1) infection. Surprisingly, HVEM exacerbates disease development in the eye independently of entry. HVEM signaling has been shown to play a variety of roles in modulating immune responses to HSV and other pathogens, and there is increasing evidence that these effects are responsible for HVEM-mediated pathogenesis in the eye. Here, we review the dual branches of HVEM function during HSV infection: entry and immunomodulation. HVEM is broadly expressed; intersects two important immunologic signaling networks; and impacts autoimmunity, infection, and inflammation. We hope that by understanding the complex range of effects mediated by this receptor, we can offer insights applicable to a wide variety of disease states.
[Mh] Termos MeSH primário: Infecções Oculares/patologia
Infecções por Herpesviridae/patologia
Herpesviridae/fisiologia
Interações Hospedeiro-Patógeno
Membro 14 de Receptores do Fator de Necrose Tumoral/metabolismo
Receptores Virais/metabolismo
Internalização do Vírus
[Mh] Termos MeSH secundário: Animais
Infecções Oculares/virologia
Infecções por Herpesviridae/virologia
Seres Humanos
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Receptors, Tumor Necrosis Factor, Member 14); 0 (Receptors, Virus)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  10 / 913 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28371196
[Au] Autor:Smedowski A; Tarnawska D; Orski M; Wroblewska-Czajka E; Kaarniranta K; Aragona P; Wylegala E
[Ad] Endereço:Department of Ophthalmology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
[Ti] Título:Cytoarchitecture of epithelial inflammatory infiltration indicates the aetiology of infectious keratitis.
[So] Source:Acta Ophthalmol;95(4):405-413, 2017 Jun.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To analyse cytological features of corneal epithelium in infectious keratitis. METHODS: One hundred and eighteen patients (53 males and 65 females) diagnosed with acute stage of infectious keratitis (45 viral, 40 bacterial, 23 fungal, 10 Acanthamoeba keratitis) were included in study. We performed retrospective analysis of bright and blue-light slit-lamp photographs and in vivo corneal confocal microscopy scans of the corneal epithelium from five corneal regions (superior, inferior, temporal, nasal and central). Density, morphology of inflammatory cells and their relation to epithelial structures, as well as density of nerve fibres, were evaluated in relation to the keratitis aetiology. RESULTS: We characterized five morphological types of inflammatory cells forming infiltration. Cell and nerve fibre densities showed significant differences between groups, and the most intense inflammatory infiltration was associated with fungal then bacterial, viral and Acanthamoeba keratitis. Additionally, differences in aetiology-specific ratio of round/non-round inflammatory cells were observed. CONCLUSION: Confocal microscopy analysis in infectious keratitis of various aetiologies revealed quantitative and qualitative differences in inflammatory cell infiltration expressed in different ratio of round/non-round inflammatory cells. In vivo microscopic analysis of both the corneal epithelial layer cytopathology and the cytology of inflammatory infiltration provides a fast and specific differentiation of keratitis aetiology that may increase the accuracy in the selection of the initial treatment.
[Mh] Termos MeSH primário: Epitélio Anterior/patologia
Infecções Oculares/patologia
Ceratite/diagnóstico
Microscopia Confocal/métodos
[Mh] Termos MeSH secundário: Adulto
Infecções Oculares/etiologia
Feminino
Seguimentos
Seres Humanos
Ceratite/etiologia
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13363



página 1 de 92 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde