Base de dados : MEDLINE
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  1 / 373 MEDLINE  
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[PMID]:29022861
[Au] Autor:Kocjan BJ; Hosnjak L; Racnik J; Zadravec M; Bakovnik N; Cigler B; Ummelen M; Hopman AHN; Gale N; Svara T; Gombac M; Poljak M
[Ad] Endereço:1​Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
[Ti] Título:Molecular characterization, prevalence and clinical relevance of Phodopus sungorus papillomavirus type 1 (PsuPV1) naturally infecting Siberian hamsters (Phodopus sungorus).
[So] Source:J Gen Virol;98(11):2799-2809, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phodopus sungorus papillomavirus type 1 (PsuPV1), naturally infecting Siberian hamsters (Phodopus sungorus) and clustering in the genus Pipapillomavirus (Pi-PV), is only the second PV type isolated from the subfamily of hamsters. In silico analysis of three independent complete viral genomes obtained from cervical adenocarcinoma, oral squamous cell carcinoma and normal oral mucosa revealed that PsuPV1 encodes characteristic viral proteins (E1, E2, E4, E6, E7, L1 and L2) with conserved functional domains and a highly conserved non-coding region. The overall high prevalence (102/114; 89.5 %) of PsuPV1 infection in normal oral and anogenital mucosa suggests that asymptomatic infection with PsuPV1 is very frequent in healthy Siberian hamsters from an early age onward, and that the virus is often transmitted between both anatomical sites. Using type-specific real-time PCR and chromogenic in situ hybridization, the presence of PsuPV1 was additionally detected in several investigated tumours (cervical adenocarcinoma, cervical adenomyoma, vaginal carcinoma in situ, ovarian granulosa cell tumour, mammary ductal carcinoma, oral fibrosarcoma, hibernoma and squamous cell papilloma) and normal tissues of adult animals. In the tissue sample of the oral squamous cell carcinoma individual, punctuated PsuPV1-specific in situ hybridization spots were detected within the nuclei of infected animal cells, suggesting viral integration into the host genome and a potential etiological association of PsuPV1 with sporadic cases of this neoplasm.
[Mh] Termos MeSH primário: Variação Genética
Papillomaviridae/classificação
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/veterinária
Phodopus
[Mh] Termos MeSH secundário: Canal Anal/virologia
Animais
Doenças Assintomáticas
Genoma Viral
Boca/virologia
Neoplasias/veterinária
Neoplasias/virologia
Papillomaviridae/genética
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Prevalência
Infecções do Sistema Genital/veterinária
Infecções do Sistema Genital/virologia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000943


  2 / 373 MEDLINE  
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[PMID]:28801359
[Au] Autor:Li LX; Labuda JC; Imai DM; Griffey SM; McSorley SJ
[Ad] Endereço:Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; lxli@uams.edu.
[Ti] Título:CCR7 Deficiency Allows Accelerated Clearance of from the Female Reproductive Tract.
[So] Source:J Immunol;199(7):2547-2554, 2017 Oct 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Immune mechanisms responsible for pathogen clearance from the female reproductive tract (FRT) are incompletely defined; in particular, the contribution of lymphocyte trafficking to this process is unclear. CCR7-deficient mice have profoundly altered lymphocyte recirculation and display ectopic formation of lymphocyte aggregates within mucosal nonlymphoid tissues, including the FRT. In this study, we investigated how altered lymphocyte distribution in CCR7-deficient mice would affect host responses to within the reproductive tract. As expected, CCR7-deficient mice exhibited reduced lymphocyte trafficking to lymph nodes and a corresponding increase in T cell populations within the FRT. After intravaginal infection with , CCR7-deficient mice displayed markedly reduced Ag-specific CD4 T cell responses within the local draining iliac lymph nodes, yet robust Th1 and Th17 responses were prominent in the FRT. In addition, -specific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexpected increase in the systemic IgA responses. Importantly, prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT while reducing tissue-associated inflammation and pathology. Thus, increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology.
[Mh] Termos MeSH primário: Infecções por Chlamydia/imunologia
Infecções por Chlamydia/microbiologia
Chlamydia muridarum/imunologia
Receptores CCR7/imunologia
Infecções do Sistema Genital/imunologia
Infecções do Sistema Genital/microbiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/biossíntese
Anticorpos Antibacterianos/sangue
Linfócitos T CD4-Positivos/imunologia
Movimento Celular
Chlamydia muridarum/isolamento & purificação
Feminino
Imunoglobulina A/sangue
Inflamação/microbiologia
Linfonodos/imunologia
Camundongos
Camundongos Knockout
Receptores CCR7/deficiência
Receptores CCR7/genética
Células Th1/imunologia
Células Th17/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Ccr7 protein, mouse); 0 (Immunoglobulin A); 0 (Receptors, CCR7)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601314


  3 / 373 MEDLINE  
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[PMID]:28797102
[Au] Autor:Zhang Y; Shao L; Li X; Zhong G
[Ad] Endereço:Department of Obstetrics and Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, PR China.
[Ti] Título:Uterotubal junction prevents chlamydial ascension via innate immunity.
[So] Source:PLoS One;12(8):e0183189, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ascension to the oviduct is necessary for Chlamydia to induce tubal infertility. Using the Chlamydia muridarum induction of hydrosalpinx mouse model, we have demonstrated a significant role of the uterotubal junction in preventing chlamydial ascending infection. First, delivery of C. muridarum to either side of the uterotubal junction resulted in significant reduction in live organisms from the tissues on the opposite sides. However, the recovery yields remained similar among different sections of the uterine horn. These observations suggest that the uterotubal junction may function as a barrier between the uterine horn and oviduct. Second, deficiency in innate immunity signaling pathways mediated by either MyD88 or STING significantly compromised the uterotubal junction barrier function, permitting C. muridarum to spread freely between uterine horn and oviduct. Finally, transcervical inoculation of C. muridarum led to significantly higher incidence of bilateral hydrosalpinges in the STING-deficient mice while the same inoculation mainly induced unilateral hydrosalpinx in the wild type mice, suggesting that the STING pathway-dependent uterotubal junction plays a significant role in preventing tubal pathology. Thus, we have demonstrated for the first time that the uterotubal junction is a functional barrier for preventing tubal infection by a sexually transmitted agent, providing the first in vivo evidence for detecting chlamydial infection by the STING pathway.
[Mh] Termos MeSH primário: Infecções por Chlamydia/patologia
Chlamydia muridarum/imunologia
Tubas Uterinas/patologia
Imunidade Inata
Oviductos/patologia
Infecções do Sistema Genital/patologia
Útero/patologia
[Mh] Termos MeSH secundário: Animais
Infecções por Chlamydia/imunologia
Infecções por Chlamydia/microbiologia
Modelos Animais de Doenças
Tubas Uterinas/imunologia
Tubas Uterinas/microbiologia
Feminino
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Oviductos/imunologia
Oviductos/microbiologia
Infecções do Sistema Genital/imunologia
Infecções do Sistema Genital/microbiologia
Salpingite/imunologia
Salpingite/microbiologia
Salpingite/patologia
Útero/imunologia
Útero/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183189


  4 / 373 MEDLINE  
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[PMID]:28760882
[Au] Autor:Marlin R; Nugeyre MT; Tchitchek N; Parenti M; Hocini H; Benjelloun F; Cannou C; Dereuddre-Bosquet N; Levy Y; Barré-Sinoussi F; Scarlatti G; Le Grand R; Menu E
[Ad] Endereço:Immunologie des Infections Virales et des Maladies Auto-immunes (ImVA)/Infrastructure Nationale pour la Modélisation des Maladies Infectieuses Humaines et les Thérapies Innovantes (IDMIT)/Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA)/Direction de la Recherche Fondamentale (DRF
[Ti] Título:Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry.
[So] Source:J Immunol;199(5):1923-1932, 2017 Sep 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The female reproductive tract (FRT) is one of the major mucosal invasion sites for HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the FRT after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized specific immune responses in all compartments of the FRT of nonhuman primates after systemic vaccination. Memory T cells were preferentially found in the lower tract (vagina and cervix), whereas APCs and innate lymphoid cells were mainly located in the upper tract (uterus and fallopian tubes). This compartmentalization of immune cells in the FRT was supported by transcriptomic analyses and a correlation network. Polyfunctional MVA-specific CD8 T cells were detected in the blood, lymph nodes, vagina, cervix, uterus, and fallopian tubes. Anti-MVA IgG and IgA were detected in cervicovaginal fluid after a second vaccine dose. Thus, systemic vaccination with an MVA vector elicits cellular and Ab responses in the FRT.
[Mh] Termos MeSH primário: Células Apresentadoras de Antígenos/imunologia
Genitália Feminina/imunologia
HIV-1/patogenicidade
Infecções do Sistema Genital/imunologia
Linfócitos T/imunologia
Vírus Vaccinia/imunologia
Vaccinia/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Vacinas contra a AIDS/imunologia
Animais
Anticorpos Antivirais/metabolismo
Antígenos Virais/imunologia
Células Cultivadas
Transmissão de Doença Infecciosa
Feminino
Vetores Genéticos/genética
Genitália Feminina/virologia
Seres Humanos
Imunidade Celular
Imunidade Humoral
Imunoglobulina A/metabolismo
Imunoglobulina G/metabolismo
Memória Imunológica
Primatas
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AIDS Vaccines); 0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Viral Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700320


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[PMID]:28711899
[Au] Autor:Smiianov VA; Vygovskaya LA
[Ad] Endereço:Sumy State University, Sumy, Ukraine.
[Ti] Título:Intrauterine infections - challenges in the perinatal period (literature review).
[So] Source:Wiad Lek;70(3 pt 1):512-515, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The purpose of the study is to summarize the literature data on the state of intrauterine infections that cause antenatal fetal abnormalities. MATERIALS AND METHODS: This article presents the assessment of 25 world literature sources from 2000 to 2016, which discuss the etiology of infectious agents acting on the fetus and causing a variety of pathological conditions. RESULTS: During gestation many researchers refer to the infection as one of the causes of antenatal fetal abnormalities. The etiology of intrauterine infection is diverse and differs between countries with different economic conditions. Detection of an infectious agent makes it possible to promptly carry out preventive measures, to improve hygiene standards in order to reduce the rate of infection transmission from mother to fetus. CONCLUSION: Timely detection of the etiology of intrauterine infections promotes the identification of high-risk groups giving a possibility to provide treatment in order to prevent the transmission of an infectious agent having direct economic benefits, especially in resource-poor countries with low and middle income.
[Mh] Termos MeSH primário: Complicações Infecciosas na Gravidez/etiologia
Infecções do Sistema Genital/etiologia
Doenças Uterinas/microbiologia
[Mh] Termos MeSH secundário: Feminino
Feto/anormalidades
Seres Humanos
Gravidez
Complicações Infecciosas na Gravidez/microbiologia
Complicações Infecciosas na Gravidez/virologia
Complicações Parasitárias na Gravidez/etiologia
Infecções do Sistema Genital/complicações
Infecções do Sistema Genital/microbiologia
Infecções do Sistema Genital/virologia
Natimorto
Doenças Uterinas/parasitologia
Doenças Uterinas/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


  6 / 373 MEDLINE  
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[PMID]:28652307
[Au] Autor:Gangaiah D; Raterman EL; Wu H; Fortney KR; Gao H; Liu Y; Jerse AE; Spinola SM
[Ad] Endereço:Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
[Ti] Título:Both MisR (CpxR) and MisS (CpxA) Are Required for Neisseria gonorrhoeae Infection in a Murine Model of Lower Genital Tract Infection.
[So] Source:Infect Immun;85(9), 2017 Sep.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During infection, senses and responds to stress; such responses may be modulated by MisRS (NGO0177 and NGO0176), a two-component system that is a homolog of CpxRA. In , CpxRA senses and responds to envelope stress; CpxA is a sensor kinase/phosphatase for CpxR, a response regulator. When a mutant is grown in medium containing glucose, CpxR is phosphorylated by acetyl phosphate but cannot be dephosphorylated, resulting in constitutive activation. Kandler and coworkers (J. L. Kandler, C. L. Holley, J. L. Reimche, V. Dhulipala, J. T. Balthazar, A. Muszynski, R. W. Carlson, and W. M. Shafer, Antimicrob Agents Chemother 60:4690-4700, 2016, https://doi.org/10.1128/AAC.00823-16) showed that MisR (CpxR) is required for the maintenance of membrane integrity and resistance to antimicrobial peptides, suggesting a role in gonococcal survival Here, we evaluated the contributions of MisR and MisS (CpxA) to gonococcal infection in a murine model of cervicovaginal colonization and identified MisR-regulated genes using RNA sequencing (RNA-Seq). The deletion of or severely reduced the capacity of to colonize mice or maintain infection over a 7-day period and reduced microbial fitness after exposure to heat shock. Compared to the wild type (WT), the inactivation of identified 157 differentially regulated genes, most of which encoded putative envelope proteins. The inactivation of identified 17 differentially regulated genes compared to the WT and 139 differentially regulated genes compared to the mutant, 111 of which overlapped those differentially expressed in the comparison of the WT versus the mutant. These data indicate that an intact MisRS system is required for gonococcal infection of mice. Provided the MisR is constitutively phosphorylated in the mutant, the data suggest that controlled but not constitutive activation is required for gonococcal infection in mice.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Gonorreia/microbiologia
Neisseria gonorrhoeae/patogenicidade
Proteínas Quinases/metabolismo
Infecções do Sistema Genital/microbiologia
Fatores de Virulência/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Colo do Útero/microbiologia
Modelos Animais de Doenças
Feminino
Deleção de Genes
Perfilação da Expressão Gênica
Regulação Bacteriana da Expressão Gênica
Camundongos Endogâmicos BALB C
Proteínas Quinases/genética
Regulon
Análise de Sequência de RNA
Transdução de Sinais
Vagina/microbiologia
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Virulence Factors); 153554-07-5 (CpxR protein, Bacteria); EC 2.7.- (Protein Kinases); EC 2.7.3.- (CpxA protein, bacteria)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


  7 / 373 MEDLINE  
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[PMID]:28584162
[Au] Autor:Shao L; Zhang T; Liu Q; Wang J; Zhong G
[Ad] Endereço:Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
[Ti] Título:Chlamydia muridarum with Mutations in Chromosomal Genes and/or Is Deficient in Colonizing the Mouse Gastrointestinal Tract.
[So] Source:Infect Immun;85(8), 2017 Aug.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chlamydiae colonize the gastrointestinal tracts of both animals and humans. However, their medical significance remains unknown. We have previously shown that wild-type spreads to and establishes stable colonization of the gastrointestinal tract following intravaginal inoculation. In the present study, we found that with mutations in chromosomal genes and/or was defective in spreading to the mouse gastrointestinal tract, which correlated with its attenuated pathogenicity in the upper genital tract. This correlation was more consistent than that of chlamydial pathogenicity with ascending infection in the genital tract, since attenuated spread significantly less to the gastrointestinal tract but maintained robust ascending infection of the upper genital tract. Transcervical inoculation further confirmed the correlation between spreading to the gastrointestinal tract and its pathogenicity in the upper genital tract. Finally, defective spreading of mutants was due to their inability to colonize the gastrointestinal tract since intragastric inoculation did not rescue the mutants' colonization. Thus, promoting colonization of the gastrointestinal tract may represent a primary function of the TC0237 and TC0668 proteins. Correlation of chlamydial colonization of the gastrointestinal tract with chlamydial pathogenicity in the upper genital tract suggests a potential role for gastrointestinal chlamydiae in genital tract pathogenicity.
[Mh] Termos MeSH primário: Infecções por Chlamydia/microbiologia
Chlamydia muridarum/genética
Chlamydia muridarum/patogenicidade
Cromossomos Bacterianos/genética
Trato Gastrointestinal/microbiologia
Mutação
[Mh] Termos MeSH secundário: Animais
Chlamydia muridarum/crescimento & desenvolvimento
Chlamydia muridarum/fisiologia
Modelos Animais de Doenças
Feminino
Camundongos
Infecções do Sistema Genital/microbiologia
Vagina/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE


  8 / 373 MEDLINE  
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[PMID]:28531212
[Au] Autor:Zhang D; Li T; Chen L; Zhang X; Zhao G; Liu Z
[Ad] Endereço:Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing China.
[Ti] Título:Epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in Beijing, China.
[So] Source:PLoS One;12(5):e0178033, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence of lower genital tract infections in China has been increasing in recent years. The link between high-risk human papillomavirus (HR-HPV) and other sexually transmitted diseases (STDs) remains unclear. METHODS: From March to October 2014, gynecological examinations and questionnaires were conducted on 1218 married women. Cervical secretions and vaginal swab specimens were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Ureaplasma urealyticum (UU), yeast, clue cells and HR-HPV. RESULTS: Laboratory results were available for 1195 of 1218 married women. HR-HPV was detected in 7.0% of participants. Forty-seven percent of women had lower genital tract infections (LGTIs). UU was the most common infection (35.5%), followed by bacterial vaginosis (BV) (10.5%), yeast infection (3.7%), CT (2.2%), and Trichomonas vaginalis (1.7%). BV was associated with an increased risk of HR- HPV (P < 0.0001; odds ratio, 3.0 [95% CI, 1.7-5.4]). There was a strong correlation between abnormal cervical cytology and HR-HPV infection (P < 0.0001). CONCLUSIONS: The prevalence of LGTIs in Beijing is at a high level. It is clinically important to screen for the simultaneous presence of pathogens that cause co-infections with HR-HPV.
[Mh] Termos MeSH primário: Infecções por Papillomavirus/epidemiologia
Infecções do Sistema Genital/epidemiologia
Infecções do Sistema Genital/microbiologia
Vagina/microbiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Alphapapillomavirus/isolamento & purificação
China/epidemiologia
Chlamydia trachomatis/isolamento & purificação
Estudos Transversais
Feminino
Seres Humanos
Meia-Idade
Neisseria gonorrhoeae/isolamento & purificação
Prevalência
Inquéritos e Questionários
Ureaplasma urealyticum/isolamento & purificação
Leveduras/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178033


  9 / 373 MEDLINE  
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[PMID]:28364266
[Au] Autor:Khalafalla AI; Al Eknah MM; Abdelaziz M; Ghoneim IM
[Ad] Endereço:Camel Research Centre, King Faisal University, Al Ahsa, 31982, Saudi Arabia. abdokhlf@yahoo.co.uk.
[Ti] Título:A study on some reproductive disorders in dromedary camel herds in Saudi Arabia with special references to uterine infections and abortion.
[So] Source:Trop Anim Health Prod;49(5):967-974, 2017 Jun.
[Is] ISSN:1573-7438
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dromedary camels complaining from conception failure or abortion were investigated and their herders interviewed in Al Ahsa province, Kingdom of Saudi Arabia (KSA) during 2013 and 2015. The most important reproductive disorder according to the responders is uterine infection (60.2%) followed by obesity (22.3%) then physiological conditions (hormonal disturbances; 7.8%), adhesions (3.9%) and repeat breeders (2.9%). Of the camel herders, 78.6% reported previous occurrence of abortion in their herds and 46% reported abortion cases in the last season (2015/2016), while 21.4% reported no history of abortion. Most of the responders (97.1%) do not call a veterinarian for cases of abortion in their herds and 53.4% do not discard aborted materials. The majority of the herders (76.7%) deny that handling aborted materials or touching vaginal fluids can result in human infection, or replied they do not know. Uterine swab samples were collected and tested by PCR for seven potential pathogens and sera tested for antibodies against bovine viral diarrhea virus (BVDV) and Brucella. Five pathogens were identified in infected uterine samples, namely Coxiella burnetii (36%), Campylobacter spp. (27%), Brucella spp. (17%), Salmonella spp. (13%), and Chlamydia spp. (7%). Sero-prevalence of Brucella and BVDV was 8.2 and 29.1% in overall sera, respectively, and varies with regard to the region. The findings of the present study demonstrate that reproductive disorders dominated by uterine infections and abortions are widespread in dromedary camels in KSA.
[Mh] Termos MeSH primário: Aborto Animal/epidemiologia
Camelus
Infecções do Sistema Genital/veterinária
Doenças Uterinas/veterinária
[Mh] Termos MeSH secundário: Aborto Animal/microbiologia
Animais
Feminino
Incidência
Prevalência
Infecções do Sistema Genital/epidemiologia
Infecções do Sistema Genital/microbiologia
Arábia Saudita/epidemiologia
Doenças Uterinas/epidemiologia
Doenças Uterinas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1007/s11250-017-1284-x


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[PMID]:28303813
[Au] Autor:Rawre J; Juyal D; Dhawan B
[Ad] Endereço:Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Título:Molecular typing of : An overview.
[So] Source:Indian J Med Microbiol;35(1):17-26, 2017 Jan-Mar.
[Is] ISSN:1998-3646
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Urogenital infection due to Chlamydia trachomatis (CT) is one of the most common bacterial sexually transmitted infections (STIs) and is a major public health problem worldwide. Molecular characterisation of CT is important for understanding the pathophysiological mechanisms of chlamydial disease and its transmission dynamics in sexual networks. Traditionally, strain typing of CT was based on serotyping methods characterising the major outer membrane protein (MOMP). With the advent of polymerase chain reaction and sequencing the era of molecular typing began. Molecular characterization of CT strains is based on sequence analysis of ompA gene encoding MOMP. However, in due course of time, improvements were made to enhance the discriminatory power of sequencing and quality of epidemiological information. New high-resolution genotyping methods using multiple loci such as multilocus sequence typing (MLST) and multiple loci variable number of tandem repeats (MLVA) were developed but were unable to differentiate mixed infections (MIs). The development of DNA-hybridisation methods emerged as a major breakthrough in detecting MIs. Although MLST and MLVA are more discriminative than other genotyping methods, they are laborious and expensive. DNA microarray technique is an affordable alternative for genotyping. Since recombination is widespread in the CT genome, ompA is not a reliable marker for phylogenetic studies; hence, whole genome sequencing may provide maximum phylogenetic resolution of CT strains. A descriptive review is provided of the various molecular CT typing methods. The vital information gained can be used for formulating screening programmes, targeted prevention and optimising therapeutic measures aiming to reduce disease transmission.
[Mh] Termos MeSH primário: Infecções por Chlamydia/microbiologia
Chlamydia trachomatis/classificação
Chlamydia trachomatis/genética
Técnicas de Genotipagem/métodos
Tipagem Molecular/métodos
Infecções do Sistema Genital/microbiologia
[Mh] Termos MeSH secundário: Infecções por Chlamydia/epidemiologia
Chlamydia trachomatis/isolamento & purificação
Genótipo
Seres Humanos
Epidemiologia Molecular/métodos
Infecções do Sistema Genital/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.4103/ijmm.IJMM_16_341



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