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[PMID]:29377913
[Au] Autor:Zhang SF; Tuo JL; Huang XB; Zhu X; Zhang DM; Zhou K; Yuan L; Luo HJ; Zheng BJ; Yuen KY; Li MF; Cao KY; Xu L
[Ad] Endereço:Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
[Ti] Título:Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou.
[So] Source:PLoS One;13(1):e0191789, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human coronavirus (HCoV) is one of the most common causes of respiratory tract infection throughout the world. To investigate the epidemiological and genetic variation of HCoV in Guangzhou, south China, we collected totally 13048 throat and nasal swab specimens from adults and children with fever and acute upper respiratory infection symptoms in Gunazhou, south China between July 2010 and June 2015, and the epidemiological features of HCoV and its species were studied. Specimens were screened for HCoV by real-time RT-PCR, and 7 other common respiratory viruses were tested simultaneously by PCR or real-time PCR. HCoV was detected in 294 cases (2.25%) of the 13048 samples, with most of them inpatients (251 cases, 85.4% of HCoV positive cases) and young children not in nursery (53.06%, 156 out of 294 HCoV positive cases). Four HCoVs, as OC43, 229E, NL63 and HKU1 were detected prevalent during 2010-2015 in Guangzhou, and among the HCoV positive cases, 60.20% were OC43, 16.67% were 229E, 14.97% were NL63 and 7.82% were HKU1. The month distribution showed that totally HCoV was prevalent in winter, but differences existed in different species. The 5 year distribution of HCoV showed a peak-valley distribution trend, with the detection rate higher in 2011 and 2013 whereas lower in 2010, 2012 and 2014. The age distribution revealed that children (especially those <3 years old) and old people (>50 years) were both high risk groups to be infected by HCoV. Of the 294 HCoV positive patients, 34.69% (101 cases) were co-infected by other common respiratory viruses, and influenza virus was the most common co-infecting virus (30/101, 29.70%). Fifteen HCoV-OC43 positive samples of 2013-2014 were selected for S gene sequencing and phylogenetic analysis, and the results showed that the 15 strains could be divided into 2 clusters in the phylogenetic tree, 12 strains of which formed a separate cluster that was closer to genotype G found in Malaysia. It was revealed for the first time that genotype B and genotype G of HCoV-OC43 co-circulated and the newly defined genotype G was epidemic as a dominant genotype during 2013-2014 in Guanzhou, south China.
[Mh] Termos MeSH primário: Coronavirus/isolamento & purificação
Filogenia
Infecções Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: China/epidemiologia
Coronavirus/classificação
Coronavirus/patogenicidade
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191789


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[PMID]:29458556
[Au] Autor:Abdel-Moneim AS; Soliman MS; Kamel MM; El-Kholy AA
[Ad] Endereço:1​Microbiology Department, College of Medicine, Taif University, Al-Taif 21944, Saudi Arabia.
[Ti] Título:Sequence analysis of the G gene of hRSVA ON1 genotype from Egyptian children with acute respiratory tract infections.
[So] Source:J Med Microbiol;67(3):387-391, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human respiratory syncytial virus causes severe lower respiratory tract infection in neonates and children. Genotype ON1, with duplication of 72-nt in the G gene, was first detected in Canada and then recorded in other countries. In the current study, we describe the first detection of the ON1 genotype among children in Egypt in 2014/2015. Sequence analysis of the full-attachment G gene revealed that the majority of the strains examined were related to the ON1 genotype and only one sample related to N1 genotype. The Egyptian ON1 strains showed unique non-silent mutations in addition to variable mutations near the antigenic sites in comparison to the original ON1 ancestor strain. Continuous surveillance of hRSV regionally and globally is needed to understand the evolutionary mechanisms and strategies adopted by hRSV and their inducers for better adaption to the host.
[Mh] Termos MeSH primário: Infecções por Vírus Respiratório Sincicial/virologia
Vírus Sincicial Respiratório Humano/genética
Infecções Respiratórias/virologia
Proteínas Virais de Fusão/genética
[Mh] Termos MeSH secundário: Canadá/epidemiologia
Pré-Escolar
Egito/epidemiologia
Evolução Molecular
Feminino
Genótipo
Seres Humanos
Lactente
Masculino
Mutação
Nasofaringe/virologia
Filogenia
Infecções por Vírus Respiratório Sincicial/epidemiologia
Vírus Sincicial Respiratório Humano/isolamento & purificação
Infecções Respiratórias/epidemiologia
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (G glycoprotein, Respiratory syncytial virus); 0 (Viral Fusion Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000699


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[PMID]:29237521
[Au] Autor:Zhang PF; Feng XQ; Wu CL; Zhang YM
[Ad] Endereço:Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yumingzhang1966@hotmail.com.
[Ti] Título:[Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1234-1238, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To examine the clinical features of children with acute lymphoblastic leukemia (ALL) complicated by pulmonary infection after chemotherapy. METHODS: The clinical data of 108 ALL children (115 case-times) with post-chemotherapy pulmonary infection were retrospectively reviewed. The risk factors for pulmonary infection and the relationship between pathogens and chest CT findings were evaluated. RESULTS: The highest incidence (77.4% ) of pulmonary infection occurred during remission induction, peaking at 31-60 days after chemotherapy. Patients with neutropenia had the highest incidence rate of pulmonary infection (67.0%). Bacteria (36%) and fungi (41%) were the two most common pathogens in the 41 patients who were etiologically suspected of or diagnosed with pulmonary infection. There was no significant difference in chest CT findings between patients with bacterial and fungal infections. CONCLUSIONS: The children with ALL are most susceptible to pulmonary infection during remission induction, especially when they are neutropenic. Bacteria and fungi are the main pathogens of pulmonary infections in these patients. However, the changes in chest CT images are poor indicators of the nature of pulmonary infection.
[Mh] Termos MeSH primário: Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
Infecções Respiratórias/etiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações
Infecções Respiratórias/diagnóstico por imagem
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/microbiologia
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:28459437
[Au] Autor:Toussaint M; Jackson DJ; Swieboda D; Guedán A; Tsourouktsoglou TD; Ching YM; Radermecker C; Makrinioti H; Aniscenko J; Bartlett NW; Edwards MR; Solari R; Farnir F; Papayannopoulos V; Bureau F; Marichal T; Johnston SL
[Ad] Endereço:Airway Disease Infection Section, National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
[Ti] Título:Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
[So] Source:Nat Med;23(6):681-691, 2017 06.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
[Mh] Termos MeSH primário: Asma/imunologia
Citocinas/imunologia
DNA/imunologia
Armadilhas Extracelulares/imunologia
Infecções por Picornaviridae/imunologia
Hipersensibilidade Respiratória/imunologia
Infecções Respiratórias/imunologia
Células Th2/imunologia
[Mh] Termos MeSH secundário: Adulto
Animais
Estudos de Casos e Controles
Dermatophagoides farinae/imunologia
Modelos Animais de Doenças
Feminino
Seres Humanos
Interferon gama/imunologia
Interleucina-13/imunologia
Interleucina-4/imunologia
Interleucina-5/imunologia
Masculino
Camundongos
Meia-Idade
Rhinovirus
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Interleukin-13); 0 (Interleukin-5); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4332


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[PMID]:29260224
[Au] Autor:Gerber JS; Ross RK; Bryan M; Localio AR; Szymczak JE; Wasserman R; Barkman D; Odeniyi F; Conaboy K; Bell L; Zaoutis TE; Fiks AG
[Ad] Endereço:Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
[Ti] Título:Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections.
[So] Source:JAMA;318(23):2325-2336, 2017 12 19.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Acute respiratory tract infections account for the majority of antibiotic exposure in children, and broad-spectrum antibiotic prescribing for acute respiratory tract infections is increasing. It is not clear whether broad-spectrum treatment is associated with improved outcomes compared with narrow-spectrum treatment. Objective: To compare the effectiveness of broad-spectrum and narrow-spectrum antibiotic treatment for acute respiratory tract infections in children. Design, Setting, and Participants: A retrospective cohort study assessing clinical outcomes and a prospective cohort study assessing patient-centered outcomes of children between the ages of 6 months and 12 years diagnosed with an acute respiratory tract infection and prescribed an oral antibiotic between January 2015 and April 2016 in a network of 31 pediatric primary care practices in Pennsylvania and New Jersey. Stratified and propensity score-matched analyses to account for confounding by clinician and by patient-level characteristics, respectively, were implemented for both cohorts. Exposures: Broad-spectrum antibiotics vs narrow-spectrum antibiotics. Main Outcomes and Measures: In the retrospective cohort, the primary outcomes were treatment failure and adverse events 14 days after diagnosis. In the prospective cohort, the primary outcomes were quality of life, other patient-centered outcomes, and patient-reported adverse events. Results: Of 30 159 children in the retrospective cohort (19 179 with acute otitis media; 6746, group A streptococcal pharyngitis; and 4234, acute sinusitis), 4307 (14%) were prescribed broad-spectrum antibiotics including amoxicillin-clavulanate, cephalosporins, and macrolides. Broad-spectrum treatment was not associated with a lower rate of treatment failure (3.4% for broad-spectrum antibiotics vs 3.1% for narrow-spectrum antibiotics; risk difference for full matched analysis, 0.3% [95% CI, -0.4% to 0.9%]). Of 2472 children enrolled in the prospective cohort (1100 with acute otitis media; 705, group A streptococcal pharyngitis; and 667, acute sinusitis), 868 (35%) were prescribed broad-spectrum antibiotics. Broad-spectrum antibiotics were associated with a slightly worse child quality of life (score of 90.2 for broad-spectrum antibiotics vs 91.5 for narrow-spectrum antibiotics; score difference for full matched analysis, -1.4% [95% CI, -2.4% to -0.4%]) but not with other patient-centered outcomes. Broad-spectrum treatment was associated with a higher risk of adverse events documented by the clinician (3.7% for broad-spectrum antibiotics vs 2.7% for narrow-spectrum antibiotics; risk difference for full matched analysis, 1.1% [95% CI, 0.4% to 1.8%]) and reported by the patient (35.6% for broad-spectrum antibiotics vs 25.1% for narrow-spectrum antibiotics; risk difference for full matched analysis, 12.2% [95% CI, 7.3% to 17.2%]). Conclusions and Relevance: Among children with acute respiratory tract infections, broad-spectrum antibiotics were not associated with better clinical or patient-centered outcomes compared with narrow-spectrum antibiotics, and were associated with higher rates of adverse events. These data support the use of narrow-spectrum antibiotics for most children with acute respiratory tract infections.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Otite Média/tratamento farmacológico
Qualidade de Vida
Infecções Respiratórias/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Combinação Amoxicilina e Clavulanato de Potássio/efeitos adversos
Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico
Antibacterianos/uso terapêutico
Cefalosporinas/efeitos adversos
Cefalosporinas/uso terapêutico
Criança
Pré-Escolar
Feminino
Seres Humanos
Macrolídeos/efeitos adversos
Macrolídeos/uso terapêutico
Masculino
Faringite/tratamento farmacológico
Atenção Primária à Saúde
Estudos Retrospectivos
Sinusite/tratamento farmacológico
Infecções Estreptocócicas/tratamento farmacológico
Streptococcus pyogenes
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Macrolides); 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.18715


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[PMID]:29388833
[Au] Autor:Honda JR; Bai X; Chan ED
[Ad] Endereço:1 National Jewish Health Denver, Colorado and.
[Ti] Título:Elucidating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease: Lesson from the Six Blind Men and the Elephant.
[So] Source:Am J Respir Cell Mol Biol;58(2):142-143, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Micobactéria não Tuberculosa/patologia
Micobactérias não Tuberculosas/patogenicidade
Mucosa Respiratória/microbiologia
Infecções Respiratórias/patologia
[Mh] Termos MeSH secundário: Células Epiteliais/metabolismo
Seres Humanos
Pulmão/microbiologia
Infecções por Micobactéria não Tuberculosa/microbiologia
Mucosa Respiratória/citologia
Mucosa Respiratória/metabolismo
Infecções Respiratórias/microbiologia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0317ED


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[PMID]:29385161
[Au] Autor:Zheng H; Woodall WH; Carlson AL; DeLisle S
[Ad] Endereço:Department of Medicine, Veterans Affairs Maryland Health Care System, Baltimore, MD, United States of America.
[Ti] Título:Can long-term historical data from electronic medical records improve surveillance for epidemics of acute respiratory infections? A systematic evaluation.
[So] Source:PLoS One;13(1):e0191324, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: As the deployment of electronic medical records (EMR) expands, so is the availability of long-term datasets that could serve to enhance public health surveillance. We hypothesized that EMR-based surveillance systems that incorporate seasonality and other long-term trends would discover outbreaks of acute respiratory infections (ARI) sooner than systems that only consider the recent past. METHODS: We simulated surveillance systems aimed at discovering modeled influenza outbreaks injected into backgrounds of patients with ARI. Backgrounds of daily case counts were either synthesized or obtained by applying one of three previously validated ARI case-detection algorithms to authentic EMR entries. From the time of outbreak injection, detection statistics were applied daily on paired background+injection and background-only time series. The relationship between the detection delay (the time from injection to the first alarm uniquely found in the background+injection data) and the false-alarm rate (FAR) was determined by systematically varying the statistical alarm threshold. We compared this relationship for outbreak detection methods that utilized either 7 days (early aberrancy reporting system (EARS)) or 2-4 years of past data (seasonal autoregressive integrated moving average (SARIMA) time series modeling). RESULTS: In otherwise identical surveillance systems, SARIMA detected epidemics sooner than EARS at any FAR below 10%. The algorithms used to detect single ARI cases impacted both the feasibility and marginal benefits of SARIMA modeling. Under plausible real-world conditions, SARIMA could reduce detection delay by 5-16 days. It also was more sensitive at detecting the summer wave of the 2009 influenza pandemic. CONCLUSION: Time series modeling of long-term historical EMR data can reduce the time it takes to discover epidemics of ARI. Realistic surveillance simulations may prove invaluable to optimize system design and tuning.
[Mh] Termos MeSH primário: Registros Eletrônicos de Saúde
Monitoramento Epidemiológico
Infecções Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Doença Aguda/epidemiologia
Seres Humanos
Influenza Humana/epidemiologia
Pandemias
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191324


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[PMID]:29325306
[Au] Autor:Xing B; Lin JT; Tang HP; Yang L; Yuan YD; Gu YH; Chen P; Liu XJ; Zhang J; Liu HG; Wang CZ; Zhou W; Sun DJ; Chen YQ; Chen ZC; Huang M; Lin QC; Hu CP; Yang XH; Huo JM; Ye XW; Zhou X; Jiang P; Zhang W; Huang YJ; Dai LM; Liu RY; Cai SX; Xu JY; Zhou JY
[Ti] Título:[A retrospective study of the inducing factors and clinical characteristics of patients hospitalized for asthma exacerbation in China in 2013-2014].
[So] Source:Zhonghua Nei Ke Za Zhi;57(1):21-26, 2018 Jan 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To study the inducing factors and clinical characteristics of patients hospitalized for asthma exacerbation in China. Patients hospitalized for asthma exacerbation at 29 hospitals in China were retrospectively recruited during 2013-2014. Clinical data of 3 240 asthmatic patients were collected and analyzed including 1 369(42.3%) males and 1 871(57.7%) females. The patients hospitalized for asthma exacerbation counted for 2.95% (6 375/215 955) of all patients hospitalized during the same period. The leading six inducing factors, in sequence, were acute upper respiratory tract infection [42.3%(1 370/3 240)], changes of weather [22.8%(738/3 240)], noxious gas [(4.3%(140/3 240), allergy challenges [3.5%(115/3 240)], strenuous exercise [1.8%(57/3 240)], and air pollution [1.5%(49/3 240)]. In older patients, more exacerbations were induced by weather changes, yet less sensitive to allergy challenges. As to middle-aged patients, they were less sensitive to upper respiratory tract infections, however the difference was not statistically significant ( >0.05). In winter more asthma patients were induced by upper respiratory tract infections, while in autumn more patients were induced by weather changes, strenuous exercise and air pollution. In spring and summer more patients were induced by allergy challenges, but the differences failed to achieve statistical significance ( >0.05). In northern cities more patients were induced by upper respiratory infections, whereas in southern cities more by noxious gases. Allergy challenges and air pollution tended to affect more patients in northern cities, but the difference was of no significance ( >0.05). The differences of inducing factors among patients of different gender, with or without a smoking history, and with different exacerbation severity didn't show any statistical significance. The patients with severe and life-threatening exacerbations counted for 20.1% (652/3 240). The percentage of patients older than 60 years was higher in patients with severe or life-threatening exacerbations than in whose with mild or moderate exacerbations, so did the percentage of male patients, of patients with disease duration longer than 10 years, with smoking history, and with a history of hospitalization or emergency department visits due to asthma exacerbation during the last year. The acute upper respiratory tract infection ranks top among all the inducing factors. Senility, male gender, long duration of disease, smoking history, and a history of frequent hospital visits might be the risk factors for severe or life-threatening asthma exacerbations.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Hospitalização
Infecções Respiratórias/complicações
[Mh] Termos MeSH secundário: Poluição do Ar/efeitos adversos
Antiasmáticos/administração & dosagem
Asma/diagnóstico
Asma/epidemiologia
Asma/etiologia
China/epidemiologia
Feminino
Seres Humanos
Hipersensibilidade
Masculino
Meia-Idade
Infecções Respiratórias/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Estações do Ano
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.01.004


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[PMID]:29254301
[Au] Autor:Shu M; Wang BY; Zhang J; Guo CY; Wang XH
[Ad] Endereço:Orthopedic Surgery Section 4, the 2nd Affiliated of Harbin Medical University, Harbin, China.
[Ti] Título:Analysis of specialized nursing on respiratory functions in thoracotomy patients.
[So] Source:J Biol Regul Homeost Agents;31(4):971-976, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:To analyze the nursing effect on the respiratory function of thoracotomy patients, sixty thoracotomy hospitalized patients were studied. The subjects were divided into a normal group (A) and an observation group (B). The patients in group A received routine nursing only, while those in group B received chest physiotherapy as well as routine nursing. Afterwards, the respiratory function indicators of the two groups were compared and a data analysis was performed. The results showed that the partial pressure of oxygen (PO2) value of the patients in group B was greater than that of the patients in group A while the partial pressure of carbon dioxide (PCO2) value in group B was smaller than that in group A, and there was a significant difference between the two groups (p less than 0.05). The vital capacity under normal circumstances and forced breathing of group B were greater than that of group A and the difference was statistically significant (p less than 0.05). The incidence of complications (atelectasis, respiratory infections, pleural effusion) was statistically significant between the two groups (p less than 0.05). The degree of autonomic respiratory dysfunction in group B was lower than that in group A, and there was a significant difference (p less than 0.05), suggesting that the respiratory function in patients receiving chest physiotherapy improved significantly.
[Mh] Termos MeSH primário: Exercícios Respiratórios/métodos
Drenagem Postural/métodos
Enfermagem em Pós-Anestésico/métodos
Enfermagem em Reabilitação/métodos
Toracotomia/reabilitação
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Massagem/métodos
Meia-Idade
Derrame Pleural/etiologia
Derrame Pleural/prevenção & controle
Atelectasia Pulmonar/etiologia
Atelectasia Pulmonar/prevenção & controle
Respiração
Testes de Função Respiratória
Infecções Respiratórias/etiologia
Infecções Respiratórias/prevenção & controle
Toracotomia/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29173358
[Au] Autor:Uzoamaka M; Ngozi O; Johnbull OS; Martin O
[Ad] Endereço:Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria.
[Ti] Título:Bacterial Etiology of Lower Respiratory Tract Infections and Their Antimicrobial Susceptibility.
[So] Source:Am J Med Sci;354(5):471-475, 2017 11.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lower respiratory tract infection (LRTI) is one of the common major health problems in Nigeria causing morbidity and mortality. The study was conducted to determine the current trends of bacterial etiology of LRTIs among patients who attended the University of Nigeria Teaching Hospital (UNTH) and their antimicrobial susceptibility profile with special interest on pandrug resistance. MATERIALS AND METHODS: The study was conducted between February 2014 and June 2016 in the bacteriology laboratory of UNTH. Sputum samples of 954 patients with suspected LRTIs were received, after obtaining patients' informed consent and ethical clearance from the UNTH. The samples were collected and processed according to standard laboratory procedures. RESULTS: The mean age of the patients was 42.6 ± 16.8 years. Of the total 954 sputum samples, 431 (45.2%) were positive for micro-organisms. A single, unique pathogen was recovered in 415 patients (96.3%), and 16 (3.7%) were polymicrobial. The most predominant single pathogen was Klebsiella pneumoniae, 215 (49.9%), and the most prevalent bacterial combination was Klebsiella spp and Pseudomonas aeruginosa, 6 (1.4%). Antimicrobial susceptibility testing shows that most isolates of K pneumoniae were susceptible to imipenem (94.8%). Among the bacteria, Escherichia coli (13.3%) ranked highest, followed by P aeruginosa (12.5%), and the least was Staphylococcus aureus (2.1%). CONCLUSIONS: Knowledge of the diversity of pathogens responsible for LRTIs and their susceptibility patterns to antibiotics, as well as antibiotic resistance surveillance, are important in the effective management of LRTI with prompt clinical and laboratory diagnosis along with appropriate treatment strategies.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Farmacorresistência Bacteriana
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/microbiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Nigéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE



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