Base de dados : MEDLINE
Pesquisa : C01.703.160 [Categoria DeCS]
Referências encontradas : 18370 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1837 ir para página                         

  1 / 18370 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29274492
[Au] Autor:Çavusoglu BK; Yurttas L; Cantürk Z
[Ad] Endereço:Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey. Electronic address: betulkaya@anadolu.edu.tr.
[Ti] Título:The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species.
[So] Source:Eur J Med Chem;144:255-261, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:In search of potent and safe antifungal agents, herein, we report the synthesis, characterization and biological activities of triazole-oxadiazole compounds. The structural verification of the molecules was carried out by H NMR, C NMR and mass spectral data. The in vitro antifungal and apoptotic activity were investigated against C. albicans, C. parapsilosis, C. krusei and C. glabrata. The compounds namely N-(4-nitrophenyl)-2-[(5-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-1,3,4-oxadiazol-2-yl)thio]acetamide (4e) and N-(6-fluorobenzothiazol-2-yl)-2-[(5-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-1,3,4-oxadiazol-2-yl)thio]acetamide (4i) were detected as the most potent compounds against C. albicans and C. glabrata (MIC = 62.5 µg/mL). According to studies on their mechanism of action, it was confirmed that compound 4i has apoptotic effect on four Candida via Annexin V-PI with flow cytometry. The MTT assay revealed that all compounds were determined to be non-toxic against healthy cells in the tested concentrations.
[Mh] Termos MeSH primário: Antifúngicos/química
Antifúngicos/farmacologia
Candida/efeitos dos fármacos
Oxidiazóis/química
Oxidiazóis/farmacologia
Triazóis/química
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Antifúngicos/síntese química
Candidíase/tratamento farmacológico
Seres Humanos
Testes de Sensibilidade Microbiana
Oxidiazóis/síntese química
Relação Estrutura-Atividade
Triazóis/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Oxadiazoles); 0 (Triazoles)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  2 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29480879
[Au] Autor:Dermawan JKT; Ghosh S; Keating MK; Gopalakrishna KV; Mukhopadhyay S
[Ad] Endereço:Department of Pathology, Pathology and Laboratory Medicine Institute.
[Ti] Título:Candida pneumonia with severe clinical course, recovery with antifungal therapy and unusual pathologic findings: A case report.
[So] Source:Medicine (Baltimore);97(2):e9650, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Candida is frequently isolated from the respiratory tract and usually reflects airway colonization. True Candida pneumonia is rare. Our aim is to document a case of Candida pneumonia confirmed by cultures, molecular techniques, and surgical lung biopsy, and to highlight a previously unreported pathologic manifestation of this infection. CASE SUMMARY: A 59-year-old man with a history of chronic obstructive pulmonary disease (COPD) presented with dry cough, low-grade fever, and progressive dyspnea. He was eventually diagnosed with sarcoidosis based on bilateral lung infiltrates and granulomas in a transbronchial biopsy. His condition worsened after immunosuppression, prompting surgical lung biopsy, which revealed suppurative granulomas containing Candida albicans, confirmed by cultures and polymerase chain reaction. Despite multiple episodes of respiratory failure and a prolonged course in intensive care, he recovered fully after antifungal therapy and is currently alive with COPD-related dyspnea 3 years after his initial presentation. CONCLUSION: Candida can rarely cause clinically significant pneumonia in adults, and should be considered in the differential diagnosis of suppurative granulomas in the lung.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Candida albicans
Candidíase/tratamento farmacológico
Candidíase/patologia
Pneumonia/tratamento farmacológico
Pneumonia/patologia
[Mh] Termos MeSH secundário: Candidíase/fisiopatologia
Cuidados Críticos
Diagnóstico Diferencial
Seres Humanos
Masculino
Meia-Idade
Pneumonia/microbiologia
Pneumonia/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009650


  3 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29274212
[Au] Autor:Modrzewska BD; Kurnatowska, AJ; Khalid K
[Ad] Endereço:Department of Biology and Medical Parasitology, Medical University of Lodz, Hallera Sq. 1, 90-647 Lodz, Poland
[Ti] Título:Drug susceptibility of fungi isolated from ICU patients
[So] Source:Ann Parasitol;63(3):189-198, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Candida species can be a reason of infections associated with high morbidity and mortality. The risk of invasive candidosis for patients admitted to intensive care units (ICUs) is increased due to immunosuppressive states, prolonged length of stay, broad-spectrum antibiotics and Candida colonization. The aim of the study was to determine selected properties of fungi isolated from patients treated in the ICUs of hospitals in Lodz. The materials were collected from the oral cavity, the tracheostomy or endotracheal tube and urine from 16 children and 35 adult. In total, 127 samples were examined to differentiate the fungal strains with used morphological and biochemical methods. Candida species were isolated from adult patients (82.9%), but were not isolated from any of the children; C. albicans was the predominant fungus (61.7%), much less frequent were C. glabrata (12.8%), C. tropicalis (6.4%) and C. kefyr, C. dubliniensis (4.3% each).The susceptibility of fungi to antimycotic drugs revealed that almost all of the strains were susceptible to nystatin (97.9%) and to amphotericin B (72.3%), and resistant to fluconazole (72.3%) and ketoconazole (57.5%). No isolation of fungi from children remaining in ICU may be an evidence of high sanitary regime at these wards; fungi from the genus Candida are the etiological factors for ICU infections; 3/5 of them are caused by C. albicans, mostly of the code 2 576 174, characteristic for strains isolated from hospitalized patients; it is necessary to determine the species of the fungus and its susceptibility to drugs, which allows to conduct effective therapy; prophylactic administration of fluconazole leads to an increase in the number of strains resistant to this chemotherapeutic agent; in the antifungal local treatment, nystatin should be a drug of choice as the drug to which most fungi are susceptible.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida/efeitos dos fármacos
Candidíase/microbiologia
Farmacorresistência Fúngica
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Antifúngicos/uso terapêutico
Criança
Pré-Escolar
Infecção Hospitalar/microbiologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Unidades de Terapia Intensiva
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.17420/ap6303.105


  4 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29324230
[Au] Autor:Minns MS; Pearlman E
[Ad] Endereço:Institute for Immunology, University of California, Irvine, CA, USA.
[Ti] Título:Neutrophils Cause an Intravascular Traffic Jam.
[So] Source:Cell Host Microbe;23(1):6-8, 2018 01 10.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neutrophil swarming is defined by large numbers of cells simultaneously and rapidly migrating to a site of injury or infection. In this issue of Cell Host & Microbe, Lee et al. (2018) demonstrate that intravascular swarming of neutrophils occurs in response to Candida albicans infection and causes vascular occlusion and pathological sequelae.
[Mh] Termos MeSH primário: Candidíase
Neutrófilos
[Mh] Termos MeSH secundário: Candida albicans
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  5 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28457835
[Au] Autor:Tetz G; Cynamon M; Hendricks G; Vikina D; Tetz V
[Ad] Endereço:TGV-inhalonix, 303 5th Avenue #2012, New York, NY 10016, USA. Electronic address: tets@tgvlabs.com.
[Ti] Título:In vitro activity of a novel compound, Mul-1867, against clinically significant fungi Candida spp. and Aspergillus spp.
[So] Source:Int J Antimicrob Agents;50(1):47-54, 2017 Jul.
[Is] ISSN:1872-7913
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as well as resistant clinical isolates, with minimum fungicidal concentrations (MFCs) varying from 0.06 µg/mL to 0.5 µg/mL. It was also highly effective against pre-formed 48-h-old biofilms formed by yeasts and moulds. The half-minimal biofilm eradication concentration (MBEC ) was equal to the MFC. The minimum biofilm eradication concentration to eliminate 90% of biofilms (MBEC ) varied from 1 × to 4 × MFC. Scanning electron microscopy revealed morphological changes accompanied by the release of intracellular material from the fungal cells following exposure to Mul-1867. Furthermore, an increased concentration of nucleic acids was found in the medium after 5 min and 20 min of Mul-1867 treatment, indicating leakage of cytoplasmic contents. Overall, these data indicate that Mul-1867 may be a promising inhaled antifungal agent for the treatment and prevention of fungal respiratory infections.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus/efeitos dos fármacos
Candida/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aspergilose/microbiologia
Aspergillus/isolamento & purificação
Aspergillus/fisiologia
Biofilmes/efeitos dos fármacos
Candida/isolamento & purificação
Candida/fisiologia
Candidíase/microbiologia
Meios de Cultura/química
DNA Fúngico/análise
Seres Humanos
Testes de Sensibilidade Microbiana
Viabilidade Microbiana/efeitos dos fármacos
Microscopia Eletrônica de Varredura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Culture Media); 0 (DNA, Fungal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  6 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390542
[Au] Autor:Murgu AM; Criscov IG; Fotea S; Baciu G; Chiriac A; Tarca E; Streanga V
[Ad] Endereço:University of Medicine and Pharmacy "Gr. T. Popa".
[Ti] Título:Particularities of the management and the treatment in a rare sepsis with Candida tropicalis of a Collodion baby: Case report.
[So] Source:Medicine (Baltimore);96(51):e9387, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Collodion baby is a rare autosomal recessive disorder. It can be the first expression of some forms of ichthyosis. PATIENT CONCERNS: The authors present the case of a newborn diagnosed with severe Collodion baby syndrome who required prolonged hospitalization in the intensive care unit because of infectious complications like the fungal sepsis and other bacterial superinfections. DIAGNOSES: The case has many diagnostic and therapeutic particularities and management difficulties. Skin culture, dermatological and genetic exam were required. INTERVENTIONS: The treatment required multidisciplinary involvement: neonatologist, pediatrician, geneticist, dermatologist, psychologist, ophthalmologist, audiologist. OUTCOMES: The evolution during hospitalization was slowly favorable, but later, after a few months, it developed some complications. LESSONS: In our case, skin injuries, total parenteral nutrition, aggressive and prolonged antibiotic therapy, intravenous devices, high hospitalization duration were risk factors for colonization and sepsis with fungi, especially in the neonatal period, sometimes with severe evolution and prognosis.
[Mh] Termos MeSH primário: Candida tropicalis
Candidíase/terapia
Ictiose Lamelar/complicações
Sepse/terapia
[Mh] Termos MeSH secundário: Candidíase/diagnóstico
Candidíase/etiologia
Seres Humanos
Ictiose Lamelar/diagnóstico
Recém-Nascido
Masculino
Sepse/diagnóstico
Sepse/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009387


  7 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29320620
[Au] Autor:Koncar IB; Dragas M; Sabljak P; Pesko P; Markovic M; Davidovic L
[Ti] Título:Aortoesophageal and aortobronchial fistula caused by Candida albicans after thoracic endovascular aortic repair.
[So] Source:Vojnosanit Pregl;73(9):684-7, 2016 Sep.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Endovascular stent-graft placement has emerged as a minimally invasive alternative to open surgery for the treatment of aortic aneurysms and dissections. There are few reports of stent graft infections and aortoenteric fistula after endovascular thoracic aortic aneurysm repair, and the first multicentric study (Italian survey) showed the incidence of about 2%. Case report: We presented a 69-year-old male patient admitted to our hospital 9 months after thoracic endovascular aortic repair, due to severe chest pain in the left hemithorax and arm refractory to analgesic therapy. Multislice computed tomography (MSCT) showed a collection between the stent graft and the esophagus with thin layers of gas while gastroendoscopy showed visible blood jet 28 cm from incisive teeth. Surgical treatment was performed in collaboration of two teams (esophageal and vascular surgical team). After explantation of the stent graft and in situ reconstruction by using Dacron graft subsequent esophagectomy and graft omentoplasty were made. After almost four weeks patient developed hemoptisia as a sign of aorto bronchial fistula. Treatment with implantation of another aortic cuff of 26 mm was performed. The patient was discharged to the regional center with negative blood culture, normal inflammatory parameters and respiratory function. Three months later the patient suffered deterioration with the severe weight loss and pneumonia caused by Candida albicans and unfortunately died. The survival time from the surgical treatment of aortoesophageal fistula was 4 months Conclusion: Even if endovascular repair of thoracic aortic diseases improves early results, risk of infection should not be forgotten. Postoperative respiratory deterioration and finally hemoptisia could be the symptoms of another fistula.
[Mh] Termos MeSH primário: Aneurisma da Aorta Torácica/cirurgia
Implante de Prótese Vascular/efeitos adversos
Prótese Vascular/efeitos adversos
Fístula Brônquica/microbiologia
Candida albicans/isolamento & purificação
Candidíase/microbiologia
Procedimentos Endovasculares/efeitos adversos
Fístula Esofágica/microbiologia
Infecções Relacionadas à Prótese/microbiologia
Stents/efeitos adversos
Fístula Vascular/microbiologia
[Mh] Termos MeSH secundário: Idoso
Aortografia/métodos
Implante de Prótese Vascular/instrumentação
Fístula Brônquica/diagnóstico por imagem
Fístula Brônquica/cirurgia
Candidíase/diagnóstico
Candidíase/cirurgia
Angiografia por Tomografia Computadorizada
Remoção de Dispositivo
Procedimentos Endovasculares/instrumentação
Fístula Esofágica/diagnóstico por imagem
Fístula Esofágica/cirurgia
Esofagectomia
Evolução Fatal
Seres Humanos
Masculino
Tomografia Computadorizada Multidetectores
Infecções Relacionadas à Prótese/diagnóstico por imagem
Infecções Relacionadas à Prótese/cirurgia
Fatores de Tempo
Resultado do Tratamento
Fístula Vascular/diagnóstico por imagem
Fístula Vascular/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141209074K


  8 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29244019
[Au] Autor:Charalambous LT; Premji A; Tybout C; Hunt A; Cutshaw D; Elsamadicy AA; Yang S; Xie J; Giamberardino C; Pagadala P; Perfect JR; Lad SP
[Ad] Endereço:1​Department of Neurosurgery, Duke University Medical Center, NC, USA.
[Ti] Título:Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.
[So] Source:J Med Microbiol;67(2):215-227, 2018 Feb.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States. METHODOLOGY: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012. Patients with a primary diagnosis of cryptococcal, Coccidioides, Histoplasma, or Candida meningitis were included in the analysis. Data concerning healthcare resource utilization, prevalence and length of stay were collected for up to 5 years following the original diagnosis. RESULTS: Cryptococcal meningitis was the most prevalent type of fungal meningitis (70.1 % of cases over the duration of the study), followed by coccidioidomycosis (16.4 %), histoplasmosis (6.0 %) and candidiasis (7.6 %). Cryptococcal meningitis and candidiasis patients accrued the largest average charges ($103 236 and $103 803, respectively) and spent the most time in the hospital on average (70.6 and 79 days). Coccidioidomycosis and histoplasmosis patients also accrued substantial charges and time in the hospital ($82 439, 48.1 days; $78 609, 49.8 days, respectively). CONCLUSION: Our study characterizes the largest longitudinal cohort of fungal meningitis in the United States. Importantly, the health economic impact and long-term morbidity from these infections are quantified and reviewed. The healthcare resource utilization of fungal meningitis patients in the United States is substantial.
[Mh] Termos MeSH primário: Efeitos Psicossociais da Doença
Recursos em Saúde/utilização
Meningite Fúngica/epidemiologia
Meningite Fúngica/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Candidíase/economia
Candidíase/epidemiologia
Candidíase/microbiologia
Coccidioidomicose/economia
Coccidioidomicose/epidemiologia
Coccidioidomicose/microbiologia
Feminino
Histoplasmose/economia
Histoplasmose/epidemiologia
Histoplasmose/microbiologia
Seres Humanos
Masculino
Meningite Criptocócica/economia
Meningite Criptocócica/epidemiologia
Meningite Criptocócica/microbiologia
Meningite Fúngica/diagnóstico
Meningite Fúngica/economia
Meia-Idade
Prevalência
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000656


  9 / 18370 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29241891
[Au] Autor:Pagès A; Iriart X; Molinier L; Georges B; Berry A; Massip P; Juillard-Condat B
[Ad] Endereço:CHU de Toulouse, Pharmacie, Toulouse, France. Electronic address: pages.ar@chu-toulouse.fr.
[Ti] Título:Cost Effectiveness of Candida Polymerase Chain Reaction Detection and Empirical Antifungal Treatment among Patients with Suspected Fungal Peritonitis in the Intensive Care Unit.
[So] Source:Value Health;20(10):1319-1328, 2017 12.
[Is] ISSN:1524-4733
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mortality from intra-abdominal candidiasis in intensive care units (ICUs) is high. It takes many days for peritoneal-fluid fungal culture to become positive, and the recommended empirical antifungal therapy involves excessive costs. Polymerase chain reaction (PCR) should produce results more rapidly than fungal culture. OBJECTIVES: To perform a cost-effectiveness analysis of the combination of several diagnostic and therapeutic strategies to manage Candida peritonitis in non-neutropenic adult patients in ICUs. METHODS: We constructed a decision tree model to evaluate the cost effectiveness. Cost and effectiveness were taken into account in a 1-year time horizon and from the French National Health Insurance perspective. Six strategies were compared: fluconazole or echinocandin as an empirical therapy, plus diagnosis by fungal culture or detection by PCR of all Candida species, or use of PCR to detect most fluconazole-resistant Candida species (i.e., Candida krusei and Candida glabrata). RESULTS: The use of fluconazole empirical treatment and PCR to detect all Candida species is more cost effective than using fluconazole empirical treatment without PCR (incremental cost-effectiveness ratio of €40,055/quality-adjusted life-year). Empirical treatment with echinocandin plus PCR to detect C. krusei and C. glabrata is the most effective strategy, but has an incremental cost-effectiveness ratio of €93,776/quality-adjusted life-year. If the cost of echinocandin decreases, then strategies involving PCR plus empirical echinocandin become more cost-effective. CONCLUSIONS: Detection by PCR of all Candida species and of most fluconazole-resistant Candida species could improve the cost-effectiveness of fluconazole and echinocandin given to non-neutropenic patients with suspected peritoneal candidiasis in ICUs.
[Mh] Termos MeSH primário: Antifúngicos/administração & dosagem
Candida/isolamento & purificação
Candidíase/diagnóstico
Peritonite/diagnóstico
Reação em Cadeia da Polimerase/métodos
[Mh] Termos MeSH secundário: Adulto
Antifúngicos/economia
Candidíase/tratamento farmacológico
Candidíase/microbiologia
Análise Custo-Benefício
Árvores de Decisões
Farmacorresistência Fúngica
Equinocandinas/administração & dosagem
Equinocandinas/economia
Fluconazol/administração & dosagem
Fluconazol/economia
Seres Humanos
Unidades de Terapia Intensiva
Peritonite/tratamento farmacológico
Peritonite/microbiologia
Reação em Cadeia da Polimerase/economia
Anos de Vida Ajustados por Qualidade de Vida
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Echinocandins); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  10 / 18370 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:27779268
[Au] Autor:Hazra S; Meyrelles R; Charmier AJ; Rijo P; Guedes da Silva MF; Pombeiro AJ
[Ad] Endereço:Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal. h.susanta@gmail.com fatima.guedes@tecnico.ulisboa.pt pombeiro@tecnico.ulisboa.pt.
[Ti] Título:N-HO and N-HCl supported 1D chains of heterobimetallic Cu /Ni -Sn cocrystals.
[So] Source:Dalton Trans;45(44):17929-17938, 2016 Nov 28.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Schiff base H L [N,N'-ethylenebis(3-methoxysalicylaldimine)] or H L [N,N'-ethylenebis(3-ethoxysalicylaldimine)] was reacted with MCl ·xH O and SnCl ·5H O to afford the supramolecular heterobimetallic systems (H ED) ·2[ML]·[SnCl ] [M = Cu, L = L (1), L = L (2); M = Ni, L = L (3), L = L (4); ED = 1,2-ethylenediamine], whose structures were established by single crystal X-ray analyses. Each structure includes different entities, viz. a mononuclear [CuL]/[NiL] neutral complex (coformer), a hexachlorostannate dianion [SnCl ] , a 1,2-ethylenediammonium dication (H ED ) and, only in 2 and 4, a methanol molecule. Based on the work of Grothe et al. (Cryst. Growth Des., 2016, 16, 3237-3243), compounds 1 and 3 are cocrystal salts, 2 and 4 are cocrystal salt solvates. The ionic pairs (H ED) ·[SnCl ] in 1-4 are encapsulated by the Cu- or Ni-complexes, and stabilized by N-HO and one N-HCl bond interactions leading to infinite 1D chains. The antimicrobial studies of 1-4 against yeasts (C. albicans and S. cerevisiae) and Gram-positive (S. aureus and E. faecalis) and -negative bacteria (P. aeruginosa and E. coli) indicate that the Ni Sn systems (3 and 4) are more active than the analogous Cu Sn ones (1 and 2).
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Complexos de Coordenação/química
Cobre/química
Níquel/química
Bases de Schiff/química
Estanho/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Bactérias/efeitos dos fármacos
Candidíase/tratamento farmacológico
Complexos de Coordenação/farmacologia
Cobre/farmacologia
Cristalização
Cristalografia por Raios X
Seres Humanos
Modelos Moleculares
Níquel/farmacologia
Bases de Schiff/farmacologia
Estanho/farmacologia
Leveduras/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Coordination Complexes); 0 (Schiff Bases); 7440-31-5 (Tin); 789U1901C5 (Copper); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE



página 1 de 1837 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde