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[PMID]:29195765
[Au] Autor:Walkty A; Keynan Y; Karlowsky J; Dhaliwal P; Embil J
[Ad] Endereço:Department of Medical Microbiology & Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada. Electronic address: AWalkty@dsmanitoba.ca.
[Ti] Título:Central nervous system blastomycosis diagnosed using the MVista® Blastomyces quantitative antigen enzyme immunoassay test on cerebrospinal fluid: A case report and review of the literature.
[So] Source:Diagn Microbiol Infect Dis;90(2):102-104, 2018 Feb.
[Is] ISSN:1879-0070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Blastomyces dermatitidis is a thermally dimorphic fungus that is capable of causing pulmonary and extra-pulmonary disease, including infections of the central nervous system (CNS). Diagnosis of CNS blastomycosis with non-invasive testing can be difficult, and a surgical biopsy may ultimately be required for microbiological and/or histopathological confirmation. A case of B. dermatitidis meningitis is presented where the diagnosis was made by testing cerebrospinal fluid (CSF) using the MVista® Blastomyces Quantitative Antigen Enzyme Immunoassay test. The utility of performing this test on CSF for diagnosis of CNS mass lesions/abscesses caused by B. dermatitidis in the absence of associated meningitis remains unclear. Cross reaction of the Blastomyces antigen test with other dimorphic fungi is a concern, necessitating that positive test results are interpreted in the context of the patient's exposure and travel history.
[Mh] Termos MeSH primário: Antígenos de Fungos/líquido cefalorraquidiano
Blastomicose/diagnóstico
Infecções Fúngicas do Sistema Nervoso Central/diagnóstico
Técnicas Imunoenzimáticas/métodos
[Mh] Termos MeSH secundário: Idoso
Blastomyces
Blastomicose/líquido cefalorraquidiano
Blastomicose/microbiologia
Infecções Fúngicas do Sistema Nervoso Central/líquido cefalorraquidiano
Infecções Fúngicas do Sistema Nervoso Central/microbiologia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antigens, Fungal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


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[PMID]:29382019
[Au] Autor:Wang Y; Li D; Qiao L; Zhao F
[Ad] Endereço:Department of Pediatric.
[Ti] Título:Infant Central Nervous System Aspergillosis with First-episode of Intracranial Hemorrhage: A case report.
[So] Source:Medicine (Baltimore);96(47):e8893, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Central nervous system (CNS) aspergillosis has the characteristics of multifocality, polymorphism, and coexistence of pathological types, and missed diagnosis and misdiagnosis frequently occur at the initial stage. The thesis reports a rare case of infant infection of CNS aspergillosis with the first-episode of intracranial hemorrhage. PATIENT CONCERNS: An 11-month-old female infant suffered convulsion and coma two days after the onset of fever and emesis. Its cranial computed tomography (CT) displayed subdural hemorrhage in the left tentorium cerebelli and tests indicated normal cerebrospinal fluid (CSF). Three days after being hospitalized, the infant had difficulty breathing and its CT presents consolidation in the right lung. However, treatment with ceftriaxone (ivgtt) had no effect on the baby. DIAGNOSIS: The patient's bronchoalveolar lavage fluid (BALF) was cultured into Aspergillus spp, its galactomannan (GM) antigen in CSF counted 3.0, higher than that in BALF which counted 2.6, and cranial magnetic resonance imaging (MRI) revealed multiple ring reinforced tubercles in sulci. Hence it was clinically diagnosed with CNS aspergillosis. INTERVENTIONS: Voriconazole for intravenous injection. After the intravenous injection, its trough concentration was 4.2 µg/mL, and it was within the recommended range. OUTCOMES: After one week's treatment with voriconazole, the infant's consciousness was improved. Four weeks later, with normothermia and clear consciousness, the patient was discharged. With oral administration of voriconazole up to 16 weeks, its physical state suggests no relapse and cranial MRI indicated disappearance of nodules in sulci. LESSONS: CNS aspergillosis with first-episode of intracranial hemorrhage probably leads to misdiagnosis and GM test combined with cranial MRI can augment its accuracy in the early diagnosis.
[Mh] Termos MeSH primário: Infecções Fúngicas do Sistema Nervoso Central/complicações
Hemorragias Intracranianas/parasitologia
Neuroaspergilose/complicações
[Mh] Termos MeSH secundário: Antifúngicos/administração & dosagem
Infecções Fúngicas do Sistema Nervoso Central/tratamento farmacológico
Seres Humanos
Lactente
Neuroaspergilose/tratamento farmacológico
Voriconazol/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008893


  3 / 452 MEDLINE  
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[PMID]:28731916
[Au] Autor:Lashkari HP; Fernandes N; Alva K; Rai S
[Ad] Endereço:*KMC Hospitals, Manipal University †K S Hegde Medical College Academy, Nitte University, Mangalore, India.
[Ti] Título:Central Nervous System Fungal Infection and Acute Lymphoblastic Leukemia in Children: What is the Optimal Duration of Antifungal Therapy?
[So] Source:J Pediatr Hematol Oncol;39(6):e312-e317, 2017 Aug.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Invasive fungal infections are rare in children with acute lymphoblastic leukemia. It compromises the antileukemia therapy should it happen. Central nervous system fungal infections carry high mortality. We here report the case of a 6.5-year-old girl who developed multiple central nervous system fungal abscesses possibly due to Aspergillus infection during induction therapy for acute lymphoblastic leukemia who has been successfully managed without compromising antileukemia therapy. She has been receiving antifungal therapy and maintenance chemotherapy for 20 months from diagnosis. We reviewed literature about the optimal duration of therapy for such children as the reported cases duration ranged between 4 and 24 months.
[Mh] Termos MeSH primário: Infecções Fúngicas do Sistema Nervoso Central/tratamento farmacológico
Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações
[Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico
Antineoplásicos/uso terapêutico
Aspergilose/tratamento farmacológico
Aspergilose/etiologia
Infecções Fúngicas do Sistema Nervoso Central/etiologia
Criança
Feminino
Seres Humanos
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antineoplastic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000855


  4 / 452 MEDLINE  
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[PMID]:28673256
[Au] Autor:Wang RY; Chen YQ; Wu JQ; Wang X; Cao YH; Zhao HZ; Zhu LP
[Ad] Endereço:Department of Infectious Diseases, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai, China.
[Ti] Título:Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital.
[So] Source:BMC Infect Dis;17(1):463, 2017 Jul 03.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cryptococcal infection has become a public health challenge globally. However, information about cryptococcal infection in patients with hematological diseases remains relatively rare. METHODS: HIV-uninfected cryptococcosis cases with hematological diseases admitted to Huashan Hospital from January 2001 to December 2014 were reviewed. RESULTS: In total, 33 cryptococcosis patients were enrolled, including 12 malignant and 21 non-malignant hematological cases. Twenty-six patients had central nervous system (CNS) involvement, which was observed more often in patients with non-malignancies than with malignancies (20/21 vs. 6/12, P = 0.001) Most patients (25/26) with CNS infection were confirmed by cerebrospinal fluid (CSF) culture or smear, and 100% (20/20) of them tested positive for the CSF cryptococcal antigen test. Eighteen out of 26 cryptococcal meningitis patients were treated with amphotericin B (AmB)-based therapy, 16 of them with AmB deoxycholate (d-AmB) and 2 patients with liposomal AmB. The clinical success rate was 55.6%. D-AmB was well-tolerated at 0.35-0.59 mg/kg/d (median 0.43 mg/kg/d) and only 12 patients had mild adverse events. CONCLUSIONS: CNS cryptococcal infection was more frequent in patients with hematological non-malignancies, and cryptococcal antigen test as well as the CSF fungal culture or smear are suggested for early diagnosis. D-AmB could be used as an alternative therapy for CNS-infected patients with hematological diseases.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Criptococose/etiologia
Doenças Hematológicas/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Anfotericina B/uso terapêutico
Infecções Fúngicas do Sistema Nervoso Central/tratamento farmacológico
Infecções Fúngicas do Sistema Nervoso Central/microbiologia
Criptococose/tratamento farmacológico
Ácido Desoxicólico/uso terapêutico
Combinação de Medicamentos
Feminino
Doenças Hematológicas/complicações
Neoplasias Hematológicas/complicações
Neoplasias Hematológicas/microbiologia
Seres Humanos
Masculino
Meningite Criptocócica/tratamento farmacológico
Meia-Idade
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Centros de Atenção Terciária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Drug Combinations); 0 (liposomal amphotericin B); 005990WHZZ (Deoxycholic Acid); 7XU7A7DROE (Amphotericin B); 87687-70-5 (amphotericin B, deoxycholate drug combination)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2561-z


  5 / 452 MEDLINE  
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[PMID]:27923750
[Au] Autor:Hazama A; Galgano M; Fullmer J; Hall W; Chin L
[Ad] Endereço:Department of Neurosurgery, Upstate Medical University Hospital, Syracuse, New York, USA. Electronic address: hazamaa@upstate.edu.
[Ti] Título:Affinity of Mucormycosis for Basal Ganglia in Intravenous Drug Users: Case Illustration and Review of Literature.
[So] Source:World Neurosurg;98:872.e1-872.e3, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Central nervous system mucormycosis is an aggressive fungal infection often ending in fatality. The usual circumstance is an immunocompromised individual presenting with rapidly progressive rhinocerebral involvement. An extremely rare variant of central nervous system mucormycosis isolated to the basal ganglia in an immunocompetent intravenous drug user is detailed in this manuscript. The patient was aggressively treated with aspiration of the fungal abscess and long-term intravenous antifungal agents.
[Mh] Termos MeSH primário: Gânglios da Base/patologia
Infecções Fúngicas do Sistema Nervoso Central/etiologia
Imunoglobulinas Intravenosas/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Antifúngicos/uso terapêutico
Gânglios da Base/diagnóstico por imagem
Infecções Fúngicas do Sistema Nervoso Central/diagnóstico por imagem
Infecções Fúngicas do Sistema Nervoso Central/terapia
Diabetes Mellitus Tipo 1/complicações
Diabetes Mellitus Tipo 1/tratamento farmacológico
Feminino
Seres Humanos
Hipertensão/complicações
Hipertensão/tratamento farmacológico
Hospedeiro Imunocomprometido
Espectroscopia de Ressonância Magnética
Procedimentos Neurocirúrgicos/métodos
Gravidez
Rhizopus/patogenicidade
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Immunoglobulins, Intravenous)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE


  6 / 452 MEDLINE  
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[PMID]:27718161
[Au] Autor:de Almeida SM; Roza TH
[Ad] Endereço:Universidade Federal do Paraná, Curitiba, Paraná, Brazil. sergio.ma@ufpr.br.
[Ti] Título:HIV Immune Recovery Inflammatory Syndrome and Central Nervous System Paracoccidioidomycosis.
[So] Source:Mycopathologia;182(3-4):393-396, 2017 Apr.
[Is] ISSN:1573-0832
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The immune reconstitution inflammatory syndrome (IRIS) is a deregulated inflammatory response to invading microorganisms. It is manifested when there is an abrupt change in host immunity from an anti-inflammatory and immunosuppressive state to a pro-inflammatory state as a result of rapid depletion or removal of factors that promote immune suppression or inhibition of inflammation. The aim of this paper is to discuss and re-interpret the possibility of association of paracoccidioidomycosis (PCM) with IRIS in the central nervous system (CNS) in a case from Brazil published by Silva-Vergara ML. et al. (Mycopathologia 177:137-141, 6). An AIDS patient who was not receiving medical care developed pulmonary PCM successfully treated with itraconazole. The patient developed central nervous system PCM (NPCM) after starting the ARV therapy with recovery of immunity and control of HIV viral load, although it was not interpreted as IRIS by the authors, it fulfills the criteria for CNS IRIS. This could be the first case of NPCM associated with IRIS described. Although not frequent, IRIS must be considered in PCM patients and HIV, from endemic areas or patients that traveled to endemic areas, receiving ARV treatment and with worsening symptoms.
[Mh] Termos MeSH primário: Antirretrovirais/uso terapêutico
Infecções Fúngicas do Sistema Nervoso Central/diagnóstico
Infecções por HIV/complicações
Infecções por HIV/tratamento farmacológico
Síndrome Inflamatória da Reconstituição Imune/etiologia
Paracoccidioidomicose/diagnóstico
Paracoccidioidomicose/patologia
[Mh] Termos MeSH secundário: Adulto
Brasil
Infecções Fúngicas do Sistema Nervoso Central/patologia
Seres Humanos
Síndrome Inflamatória da Reconstituição Imune/patologia
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Retroviral Agents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-016-0076-6


  7 / 452 MEDLINE  
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[PMID]:27638123
[Au] Autor:Nagashima LA; Sano A; de Almeida Araújo EJ; Álvares E Silva PL; Assolini JP; Itano EN
[Ad] Endereço:State University of Londrina, UEL, Rod. Celso Garcia Cid, km 380, 86057-970, Londrina, PR, Brazil. Electronic address: luciene@tecpar.br.
[Ti] Título:Immunomodulation over the course of experimental Arthrographis kalrae infection in mice.
[So] Source:Comp Immunol Microbiol Infect Dis;48:79-86, 2016 Oct.
[Is] ISSN:1878-1667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Arthrographis kalrae is occasionally described as an opportunistic human pathogen. This study investigated the immune response to A. kalrae during murine experimental infection (7, 14, 28 and 56 days post infection). The fungal load was higher in the early phase and mice presented with neurological syndrome over the course of the infection. There was a gradual increase in the level of anti-A. kalrae IgG and increased levels of DTH at 14 days. There was decreased IFN-γ (14-56 days) and an increase in IL-4 (7 and 56 days). Decreased levels of cytokines (IFN-γ, IL-4, IL-10 and IL-17) were observed in the brain at 56 days p.i. The results suggest that the immune response during murine A. kalrae infection modulates to the pattern of Th2 response. This study shows for the first time the cytokines and cellular immunomodulation that occur in response to an experimental infection with A. kalrae in mice.
[Mh] Termos MeSH primário: Ascomicetos/imunologia
Infecções Fúngicas do Sistema Nervoso Central/imunologia
Imunidade Celular
Imunidade Humoral
Imunomodulação
Micoses/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antifúngicos/sangue
Antígenos de Fungos/imunologia
Encéfalo/imunologia
Infecções Fúngicas do Sistema Nervoso Central/microbiologia
Citocinas/sangue
Citocinas/imunologia
Seres Humanos
Imunoglobulina G/sangue
Camundongos
Camundongos Endogâmicos BALB C
Micoses/microbiologia
Células Th2/química
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Fungal); 0 (Antigens, Fungal); 0 (Cytokines); 0 (Immunoglobulin G)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE


  8 / 452 MEDLINE  
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[PMID]:27570972
[Au] Autor:Kuan CS; Cham CY; Singh G; Yew SM; Tan YC; Chong PS; Toh YF; Atiya N; Na SL; Lee KW; Hoh CC; Yee WY; Ng KP
[Ad] Endereço:Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host.
[So] Source:PLoS One;11(8):e0161008, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cladophialophora bantiana is a dematiaceous fungus with a predilection for causing central nervous system (CNS) infection manifesting as brain abscess in both immunocompetent and immunocompromised patients. In this paper, we report comprehensive genomic analyses of C. bantiana isolated from the brain abscess of an immunocompetent man, the first reported case in Malaysia and Southeast Asia. The identity of the fungus was determined using combined morphological analysis and multilocus phylogeny. The draft genome sequence of a neurotrophic fungus, C. bantiana UM 956 was generated using Illumina sequencing technology to dissect its genetic fundamental and basic biology. The assembled 37.1 Mb genome encodes 12,155 putative coding genes, of which, 1.01% are predicted transposable elements. Its genomic features support its saprophytic lifestyle, renowned for its versatility in decomposing hemicellulose and pectin components. The C. bantiana UM 956 was also found to carry some important putative genes that engaged in pathogenicity, iron uptake and homeostasis as well as adaptation to various stresses to enable the organism to survive in hostile microenvironment. This wealth of resource will further catalyse more downstream functional studies to provide better understanding on how this fungus can be a successful and persistent pathogen in human.
[Mh] Termos MeSH primário: Ascomicetos/patogenicidade
Feoifomicose Cerebral/diagnóstico
Feoifomicose Cerebral/microbiologia
[Mh] Termos MeSH secundário: Animais
Ascomicetos/classificação
Ascomicetos/genética
Abscesso Encefálico/microbiologia
Infecções Fúngicas do Sistema Nervoso Central/microbiologia
Feoifomicose Cerebral/metabolismo
Genoma Fúngico/genética
Genômica
Seres Humanos
Masculino
Meia-Idade
Filogenia
Virulência/genética
Virulência/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161008


  9 / 452 MEDLINE  
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[PMID]:27356665
[Au] Autor:Ali SA; Jagetia A; Gaur K; Sakhuja P
[Ad] Endereço:Department of Neurosurgery, GIPMER, New Delhi, India. E-mail: asmatali82@gmail.com.
[Ti] Título:A diagnostic riddle in an immunocompetent adult: Meningioma or intracranial fungal granuloma?
[So] Source:Neurosciences (Riyadh);21(3):278-80, 2016 Jul.
[Is] ISSN:1319-6138
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Mh] Termos MeSH primário: Aspergilose/diagnóstico por imagem
Infecções Fúngicas do Sistema Nervoso Central/diagnóstico por imagem
Granuloma/diagnóstico por imagem
Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
[Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico
Aspergilose/tratamento farmacológico
Aspergilose/patologia
Infecções Fúngicas do Sistema Nervoso Central/tratamento farmacológico
Infecções Fúngicas do Sistema Nervoso Central/patologia
Diagnóstico Diferencial
Granuloma/tratamento farmacológico
Granuloma/patologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Tomografia Computadorizada por Raios X
Voriconazol/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.17712/nsj.2016.3.20150532


  10 / 452 MEDLINE  
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[PMID]:27335149
[Au] Autor:Leber AL; Everhart K; Balada-Llasat JM; Cullison J; Daly J; Holt S; Lephart P; Salimnia H; Schreckenberger PC; DesJarlais S; Reed SL; Chapin KC; LeBlanc L; Johnson JK; Soliven NL; Carroll KC; Miller JA; Dien Bard J; Mestas J; Bankowski M; Enomoto T; Hemmert AC; Bourzac KM
[Ad] Endereço:Nationwide Children's Hospital, Columbus, Ohio, USA amy.leber@nationwidechildrens.org.
[Ti] Título:Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.
[So] Source:J Clin Microbiol;54(9):2251-61, 2016 Sep.
[Is] ISSN:1098-660X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rapid diagnosis and treatment of infectious meningitis and encephalitis are critical to minimize morbidity and mortality. Comprehensive testing of cerebrospinal fluid (CSF) often includes Gram stain, culture, antigen detection, and molecular methods, paired with chemical and cellular analyses. These methods may lack sensitivity or specificity, can take several days, and require significant volume for complete analysis. The FilmArray Meningitis/Encephalitis (ME) Panel is a multiplexed in vitro diagnostic test for the simultaneous, rapid (∼1-h) detection of 14 pathogens directly from CSF specimens: Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae, cytomegalovirus, enterovirus, herpes simplex virus 1 and 2, human herpesvirus 6, human parechovirus, varicella-zoster virus, and Cryptococcus neoformans/Cryptococcus gattii We describe a multicenter evaluation of 1,560 prospectively collected CSF specimens with performance compared to culture (bacterial analytes) and PCR (all other analytes). The FilmArray ME Panel demonstrated a sensitivity or positive percentage of agreement of 100% for 9 of 14 analytes. Enterovirus and human herpesvirus type 6 had agreements of 95.7% and 85.7%, and L. monocytogenes and N. meningitidis were not observed in the study. For S. agalactiae, there was a single false-positive and false-negative result each, for a sensitivity and specificity of 0 and 99.9%, respectively. The specificity or negative percentage of agreement was 99.2% or greater for all other analytes. The FilmArray ME Panel is a sensitive and specific test to aid in diagnosis of ME. With use of this comprehensive and rapid test, improved patient outcomes and antimicrobial stewardship are anticipated.
[Mh] Termos MeSH primário: Líquido Cefalorraquidiano/microbiologia
Líquido Cefalorraquidiano/virologia
Encefalite/diagnóstico
Meningite/diagnóstico
Técnicas de Diagnóstico Molecular/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Bactérias/classificação
Bactérias/isolamento & purificação
Infecções Bacterianas/diagnóstico
Infecções Bacterianas/microbiologia
Infecções Fúngicas do Sistema Nervoso Central/diagnóstico
Infecções Fúngicas do Sistema Nervoso Central/microbiologia
Criança
Pré-Escolar
Encefalite/etiologia
Feminino
Fungos/classificação
Fungos/isolamento & purificação
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meningite/etiologia
Meia-Idade
Estudos Prospectivos
Sensibilidade e Especificidade
Fatores de Tempo
Viroses/diagnóstico
Viroses/virologia
Vírus/classificação
Vírus/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1128/JCM.00730-16



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