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  1 / 9141 MEDLINE  
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[PMID]:28453844
[Au] Autor:Suwarto S; Sasmono RT; Sinto R; Ibrahim E; Suryamin M
[Ad] Endereço:Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.
[Ti] Título:Association of Endothelial Glycocalyx and Tight and Adherens Junctions With Severity of Plasma Leakage in Dengue Infection.
[So] Source:J Infect Dis;215(6):992-999, 2017 03 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: The role of vascular endothelial (VE) components in dengue infection with plasma leakage is unknown. Therefore, we conducted a study to determine the adjusted association of the endothelial glycocalyx layer (EGL) and tight and adherens junction markers with plasma leakage. Methods: A prospective observational study was conducted at Cipto Mangunkusumo Hospital and Persahabatan Hospital, Jakarta, Indonesia. Adult dengue patients admitted to the hospital on the third day of fever from November 2013 through August 2015 were included in the study. Multiple regression analysis was used to determine the adjusted association of the VE biomarkers with the severity of the plasma leakage. Results: A total of 103 dengue-infected patients participated in the study. In the critical phase, levels of syndecan-1 (odds ratio [OR] = 1.004; 95% confidence interval [CI] = 1.001-1.007) and chondroitin sulfate (OR = 1.157; 95% CI = 1.025-1.307) had an adjusted association with plasma leakage, whereas levels of syndecan-1 (OR = 1.004; 95% CI = 1.000-1.008) and claudin-5 (OR = 1.038; 95% CI = 1.004-1.074) had an adjusted association with severe plasma leakage. Conclusions: In dengue-infected patients, elevated levels of syndecan-1 and chondroitin sulfate are strongly associated with plasma leakage, and elevated levels of syndecan-1 and claudin-5 are strongly associated with severe plasma leakage.
[Mh] Termos MeSH primário: Sulfatos de Condroitina/sangue
Claudina-5/sangue
Dengue/sangue
Glicocálix/metabolismo
Sindecana-1/sangue
Junções Íntimas/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biomarcadores/sangue
Permeabilidade Capilar
Quimiocinas/sangue
Endotélio Vascular/metabolismo
Feminino
Febre
Seres Humanos
Indonésia
Masculino
Razão de Chances
Estudos Prospectivos
Análise de Regressão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Chemokines); 0 (Claudin-5); 0 (Syndecan-1); 9007-28-7 (Chondroitin Sulfates)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix041


  2 / 9141 MEDLINE  
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[PMID]:29274215
[Au] Autor:Sayono S; Nurullita U; Sumanto D; Handoyo W
[Ad] Endereço:Department of Epidemiology, Faculty of Public Health, Universitas Muhammadiyah Semarang, Jalan Kedungmundu Raya 18, 50273, Semarang, Indonesia
[Ti] Título:Altitudinal distribution of Aedes indices during dry season in the dengue endemic area of Central Java, Indonesia
[So] Source:Ann Parasitol;63(3):213­221, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Aedes mosquitoes, mainly Aedes aegypti and Aedes albopictus, are the primary and secondary vectors of dengue viruses in Indonesia, with transmission occurring by sucking blood. The density of the vectors is influenced by season and rainfall, but limited by altitude. The aim of the study is to describe the density and distribution of dengue vectors during the dry season based on the altitudes of recent dengue cases in five regencies of Central Java Province, Indonesia. Mosquito larvae and pupae were collected from the indoor and outdoor water containers from 253 houses within 50 m of houses occupied by a dengue patient. A considerable dengue vector population was found in all localities and altitudes based on the Aedes indices: an HI of 41.7% (15.0­70.6), CI of 33.6% (8.1­69.6) and BI of 57.1 (15.0­94.1). The highest indices were found in the highest altitude settlement; as the most common larval habitat in this village was a large-sized cement tank, larvivorous fish can act as effective predators in this case. This finding indicates an expansion of the dengue problem from low to high altitudes, causing a high potential for dengue transmission in all of the localities.
[Mh] Termos MeSH primário: Aedes/fisiologia
Altitude
Distribuição Animal/fisiologia
Dengue/epidemiologia
Estações do Ano
[Mh] Termos MeSH secundário: Animais
Dengue/transmissão
Seres Humanos
Indonésia
Mosquitos Vetores
Chuvas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.17420/ap6303.108


  3 / 9141 MEDLINE  
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[PMID]:28450651
[Au] Autor:Agarwal R; Wahid MH; Yausep OE; Angel SH; Lokeswara AW
[Ad] Endereço:Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. raksheeth@hotmail.com.
[Ti] Título:The Immunogenicity and Safety of CYD-Tetravalent Dengue Vaccine (CYD-TDV) in Children and Adolescents: A Systematic Review.
[So] Source:Acta Med Indones;49(1):24-33, 2017 Jan.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:AIM: to assess the immunogenicity and safety of CYD-tetravalent dengue vaccine (CYD-TDV) in children. METHODS: comprehensive literature searches were conducted on various databases. Randomized-controlled trials on children with CYD-TDV as intervention were selected based on inclusion and exclusion criteria. Data extracted from selected trials included safety of vaccine and immunogenicity in terms of Geometric Mean Titres (GMT) of antibodies. RESULTS:   six clinical trials were selected based on preset criteria. GMT values were obtained using 50% Plaque Reduction Neutralization Test (PRNT) and safety was semi-quantitatively assessed based on adverse effects. Additional data processing was done to obtain a better understanding on the trends among the studies. The results showed that the groups vaccinated with CYD-TDV showed higher immunogenicity against dengue virus antigens than the control groups. Safety results were satisfactory in all trials, and most severe side effects were unrelated to the vaccine. CONCLUSION: CYD-TDV is both effective and safe for patients in endemic regions. This gives promise for further development and large-scale research on this vaccine to assess its efficacy in decreasing dengue prevalence, and its pervasive implementation in endemic countries, such as Indonesia.
[Mh] Termos MeSH primário: Vacinas contra Dengue/imunologia
Vacinas contra Dengue/uso terapêutico
Dengue/prevenção & controle
Imunogenicidade da Vacina
[Mh] Termos MeSH secundário: Adolescente
Criança
Vacinas contra Dengue/efeitos adversos
Seres Humanos
Esquemas de Imunização
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dengue Vaccines)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  4 / 9141 MEDLINE  
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[PMID]:27774649
[Au] Autor:Tezuka K; Kuramitsu M; Okuma K; Nojima K; Araki K; Shinohara N; Matsumoto C; Satake M; Takasaki T; Saijo M; Kurane I; Hamaguchi I
[Ad] Endereço:Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan.
[Ti] Título:Development of a novel dengue virus serotype-specific multiplex real-time reverse transcription-polymerase chain reaction assay for blood screening.
[So] Source:Transfusion;56(12):3094-3100, 2016 12.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dengue fever is caused by four related RNA viruses of the genus Flavivirus, dengue virus (DENV)-1, -2, -3, and -4, which are transmitted to humans by mosquitoes. Although DENV is not endemic in Japan, an autochthonous dengue outbreak occurred in 2014. Several transfusion-transmitted cases have also been reported after the use of blood and plasma products in DENV-endemic countries. The aim of this study was to develop a novel multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for DENV blood screening. STUDY DESIGN AND METHODS: Large-scale oligonucleotide screening was performed to obtain DENV-specific primers and probes using a variety of DENV clinical isolates. A multiplex RT-PCR assay was then developed using the identified oligonucleotides and the ability of this assay to detect DENV RNA was evaluated. RESULTS: A number of oligonucleotides suitable for DENV RNA detection were identified and a novel DENV serotype-specific multiplex RT-PCR assay was successfully established. Comparative analysis revealed that the multiplex assay could detect levels of viral contamination as low as 100 viral copies/mL. CONCLUSION: This established serotype-specific multiplex RT-PCR assay provides a simple, sensitive, and quantitative detection method for DENV, which could be applied in the screening of blood samples to prevent transfusion-transmitted DENV infection.
[Mh] Termos MeSH primário: Vírus da Dengue/genética
Dengue/diagnóstico
Reação em Cadeia da Polimerase/métodos
Sorogrupo
Reação Transfusional
[Mh] Termos MeSH secundário: Segurança do Sangue
Dengue/prevenção & controle
Dengue/transmissão
Seres Humanos
Reação em Cadeia da Polimerase Multiplex
RNA Viral/análise
RNA Viral/sangue
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13875


  5 / 9141 MEDLINE  
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[PMID]:29233814
[Au] Autor:Dyer O
[Ad] Endereço:Montreal.
[Ti] Título:Philippines halts dengue immunisation campaign owing to safety risk.
[So] Source:BMJ;359:j5759, 2017 12 12.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Vacinas contra Dengue/efeitos adversos
Dengue/prevenção & controle
Programas de Imunização/utilização
Imunização/efeitos adversos
Avaliação de Programas e Projetos de Saúde/métodos
[Mh] Termos MeSH secundário: Dengue/epidemiologia
Dengue/terapia
Vacinas contra Dengue/administração & dosagem
Seres Humanos
Filipinas/epidemiologia
Medição de Risco
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Dengue Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5759


  6 / 9141 MEDLINE  
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[PMID]:29293624
[Au] Autor:Chang CJ; Chen CS; Tien CJ; Lu MR
[Ad] Endereço:Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
[Ti] Título:Epidemiological, clinical and climatic characteristics of dengue fever in Kaohsiung City, Taiwan with implication for prevention and control.
[So] Source:PLoS One;13(1):e0190637, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The early identification of dengue infection is essential for timely and effective quarantine and vector control measures for preventing outbreaks of the disease. Kaohsiung City is responsible for most of the dengue cases in Taiwan. Thus, this study aims to identify major factors involved in the prevalence of dengue fever by analyzing the epidemiological and clinical characteristics, and to establish associations between weather parameters and dengue occurrence in this City. METHODS: A retrospective study was conducted with 3,322 confirmed dengue cases. Appropriate statistical methods were used to compare differences and correlations between dengue occurrence and demographic, clinical and weather parameters. RESULTS: The outbreak of dengue fever was found to be initiated by imported cases of dengue viruses from other endemic countries. Most of the confirmed cases were not reported to the health authority during the first visit to a doctor, and it took a median of 5 days after the appearance of the first syndromes for medical personnel to report suspected dengue cases. Accordingly, Aedes mosquitoes would have enough time to be infected and transmit the dengue virus. The diagnosis and notification criteria should not only include common symptoms of fever, myalgia, headache, skin rash and arthralgia, but should also be adjusted to include the most frequent symptoms of loss of appetite and feeling thirsty to shorten the notification time. Significantly positive correlations were found between the number of confirmed cases and weather parameters (i.e., temperature, rainfall and relative humidity) at a time lag of 1 month and 2 months. The predictive models for dengue occurrence using these three parameters at a 2-month lag time were established. CONCLUSIONS: The surveillance of imported cases, adjustment of notification criteria and application of climatic predictive models would be helpful in strengthening the dengue early warning surveillance system.
[Mh] Termos MeSH primário: Clima
Dengue/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Dengue/patologia
Dengue/prevenção & controle
Surtos de Doenças
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Taiwan/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190637


  7 / 9141 MEDLINE  
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[PMID]:29384851
[Au] Autor:Soe HJ; Yong YK; Al-Obaidi MMJ; Raju CS; Gudimella R; Manikam R; Sekaran SD
[Ad] Endereço:Department of Medical Microbiology.
[Ti] Título:Identifying protein biomarkers in predicting disease severity of dengue virus infection using immune-related protein microarray.
[So] Source:Medicine (Baltimore);97(5):e9713, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dengue virus is one of the most widespread flaviviruses that re-emerged throughout recent decades. The progression from mild dengue to severe dengue (SD) with the complications such as vascular leakage and hemorrhage increases the fatality rate of dengue. The pathophysiology of SD is not entirely clear. To investigate potential biomarkers that are suggestive of pathogenesis of SD, a small panel of serum samples selected from 1 healthy individual, 2 dengue patients without warning signs (DWS-), 2 dengue patients with warning signs (DWS+), and 5 patients with SD were subjected to a pilot analysis using Sengenics Immunome protein array. The overall fold changes of protein expressions and clustering heat map revealed that PFKFB4, TPM1, PDCL3, and PTPN20A were elevated among patients with SD. Differential expression analysis identified that 29 proteins were differentially elevated greater than 2-fold in SD groups than DWS- and DWS+. From the 29 candidate proteins, pathways enrichment analysis also identified insulin signaling and cytoskeleton pathways were involved in SD, suggesting that the insulin pathway may play a pivotal role in the pathogenesis of SD.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Dengue/sangue
Dengue/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
Projetos Piloto
Análise Serial de Proteínas
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009713


  8 / 9141 MEDLINE  
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[PMID]:29195536
[Au] Autor:Baenziger NL
[Ti] Título:Mountains, Melting Pot, and Microcosm: Health Care Delay and Dengue/Zika Interplay on Hawaii Island.
[So] Source:Creat Nurs;22(4):233-242, 2016 Nov 01.
[Is] ISSN:1078-4535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human history in the Hawaiian Islands offers a sobering study in the population dynamics of infectious disease. The indigenous population numbering an estimated half million people prior to Western contact in 1778 was reduced to less than 24,000 by 1920. Much of the decline occurred in the earliest decades after contact with Western diseases including measles, chicken pox, polio, tuberculosis, and venereal disease. A recent outbreak on the Island of Hawaii (also called the Big Island) of imported dengue fever, an illness endemic in 100 countries affecting an estimated 100-400 million people worldwide, provides insights into the problems and prospects for health care policy in managing mosquito-borne disease in a multicultural setting of geographic isolation and health care provider shortage. This incident represents in microcosm a practice run, applicable in many contexts, for an initial localized appearance of Zika virus infection, with important lessons for effective health care management in a rapidly moving and fluid arena.
[Mh] Termos MeSH primário: Diagnóstico Tardio/psicologia
Dengue/tratamento farmacológico
Surtos de Doenças/prevenção & controle
Grupos Étnicos/psicologia
Aceitação pelo Paciente de Cuidados de Saúde/psicologia
Infecção pelo Zika virus/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Dengue/diagnóstico
Feminino
Geografia
Hawaii/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Infecção pelo Zika virus/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1891/1078-4535.22.4.233


  9 / 9141 MEDLINE  
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[PMID]:27770704
[Au] Autor:Wichit S; Ferraris P; Choumet V; Missé D
[Ad] Endereço:Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
[Ti] Título:The effects of mosquito saliva on dengue virus infectivity in humans.
[So] Source:Curr Opin Virol;21:139-145, 2016 12.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
[Mh] Termos MeSH primário: Culicidae/virologia
Vírus da Dengue/patogenicidade
Dengue/transmissão
Transmissão de Doença Infecciosa
Interações Hospedeiro-Patógeno
Saliva/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  10 / 9141 MEDLINE  
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[PMID]:28453962
[Au] Autor:Iswardy E; Tsai TC; Cheng IF; Ho TC; Perng GC; Chang HC
[Ad] Endereço:Institute of Biomedical Engineering, National Cheng Kung University, Tainan 70101, Taiwan; Department of Physics, Syiah Kuala University, Banda Aceh 23111, Indonesia.
[Ti] Título:A bead-based immunofluorescence-assay on a microfluidic dielectrophoresis platform for rapid dengue virus detection.
[So] Source:Biosens Bioelectron;95:174-180, 2017 Sep 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The proof of concept of utilizing a microfluidic dielectrophoresis (DEP) chip was conducted to rapidly detect a dengue virus (DENV) in vitro based on the fluorescence immunosensing. The mechanism of detection was that the DEP force was employed to capture the modified beads (mouse anti-flavivirus monoclonal antibody-coated beads) in the microfluidic chip and the DENV modified with fluorescence label, as the detection target, can be then captured on the modified beads by immunoreaction. The fluorescent signal was then obtained through fluorescence microscopy, and then quantified by ImageJ freeware. The platform can accelerate an immuno-reaction time, in which the on-chip detection time was 5min, and demonstrating an ability for DENV detection as low as 10 PFU/mL. Furthermore, the required volume of DENV samples dramatically reduced, from the commonly used ~50µL to ~15µL, and the chip was reusable (>50x). Overall, this platform provides a rapid detection (5min) of the DENV with a low sample volume, compared to conventional methods. This proof of concept with regard to a microfluidic dielectrophoresis chip thus shows the potential of immunofluorescence based-assay applications to meet diagnostic needs.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Vírus da Dengue/isolamento & purificação
Dengue/diagnóstico
Microfluídica
[Mh] Termos MeSH secundário: Bioensaio
Dengue/virologia
Vírus da Dengue/genética
Vírus da Dengue/patogenicidade
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE



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