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[PMID]:29281639
[Au] Autor:Alkan C; Moin Vaziri V; Ayhan N; Badakhshan M; Bichaud L; Rahbarian N; Javadian EA; Alten B; de Lamballerie X; Charrel RN
[Ad] Endereço:UMR "Unité des Virus Emergents" (UVE Aix-Marseille Univ-IRD 190-Inserm 1207-EHESP), Marseille, France.
[Ti] Título:Isolation and sequencing of Dashli virus, a novel Sicilian-like virus in sandflies from Iran; genetic and phylogenetic evidence for the creation of one novel species within the Phlebovirus genus in the Phenuiviridae family.
[So] Source:PLoS Negl Trop Dis;11(12):e0005978, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phlebotomine sandflies are vectors of phleboviruses that cause sandfly fever or meningitis with significant implications for public health. Although several strains of these viruses had been isolated in Iran in the late 1970's, there was no recent data about the present situation at the outset of this study. Entomological investigations performed in 2009 and 2011 in Iran collected 4,770 sandflies from 10 different regions. Based on morphological identification, they were sorted into 315 pools according to species, sex, trapping station and date of capture. A phlebovirus, provisionally named Dashli virus (DASHV), was isolated from one pool of Sergentomyia spp, and subsequently DASHV RNA was detected in a second pool of Phlebotomus papatasi. Genetic and phylogenetic analyses based on complete coding genomic sequences indicated that (i) DASHV is most closely related to the Iranian isolates of Sandfly fever Sicilian virus [SFSV], (ii) there is a common ancestor to DASHV, Sandfly fever Sicilian- (SFS) and SFS-like viruses isolated in Italy, India, Turkey, and Cyprus (lineage I), (iii) DASHV is more distantly related with Corfou and Toros viruses (lineage II) although common ancestry is supported with 100% bootstrap, (iii) lineage I can be subdivided into sublineage Ia including all SFSV, SFCV and SFTV except those isolated in Iran which forms sublineage Ib (DASHV). Accordingly, we suggest to approve Sandfly fever Sicilian virus species consisting of the all aforementioned viruses. Owing that most of these viruses have been identified in human patients with febrile illness, DASHV should be considered as a potential human pathogen in Iran.
[Mh] Termos MeSH primário: Genoma Viral/genética
Phlebovirus
Psychodidae/virologia
RNA Viral/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Feminino
Seres Humanos
Insetos Vetores/virologia
Irã (Geográfico)
Masculino
Febre por Flebótomos/transmissão
Febre por Flebótomos/virologia
Phlebovirus/classificação
Phlebovirus/genética
Phlebovirus/isolamento & purificação
Filogenia
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005978


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[PMID]:28820686
[Au] Autor:Silvas JA; Aguilar PV
[Ad] Endereço:Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.
[Ti] Título:The Emergence of Severe Fever with Thrombocytopenia Syndrome Virus.
[So] Source:Am J Trop Med Hyg;97(4):992-996, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Severe fever with thrombocytopenia syndrome (SFTS) is a newly recognized hemorrhagic fever disease found throughout Asia with a case fatality rate between 12% and 30%. Since 2009, SFTS has been reported in China throughout 14 Chinese Provinces. In addition, SFTS has been recognized in South Korea and Japan with the first confirmed cases reported in 2012. A similar disease, caused by the closely related Heartland virus, was also reported in the United States in 2009. SFTS is caused by SFTS virus, a novel tick-borne virus in the family , genus . Unlike other mosquito- and sandfly-borne bunyaviruses, SFTS virus has not been extensively studied due to its recent emergence and many unknowns regarding its pathogenesis, life cycle, transmission, and options for therapeutics remains. In this review, we report the most current findings in SFTS virus research.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/fisiopatologia
Doenças Transmissíveis Emergentes/fisiopatologia
Febre por Flebótomos/fisiopatologia
Phlebovirus/fisiologia
Trombocitopenia/fisiopatologia
Doenças Transmitidas por Carrapatos/fisiopatologia
Zoonoses/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Vetores Artrópodes
Ásia/epidemiologia
Infecções por Bunyaviridae/epidemiologia
Doenças Transmissíveis Emergentes/epidemiologia
Doenças Transmissíveis Emergentes/virologia
Seres Humanos
Doenças Transmitidas por Carrapatos/epidemiologia
Carrapatos
Zoonoses/epidemiologia
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0967


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[PMID]:28722592
[Au] Autor:Huang D; Jiang Y; Liu X; Wang B; Shi J; Su Z; Wang H; Wang T; Tang S; Liu H; Hu Z; Deng F; Shen S
[Ad] Endereço:Department of Infectious Diseases, Qilu hospital of Shandong University, Qingdao, People's Republic of China.
[Ti] Título:A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission.
[So] Source:Am J Trop Med Hyg;97(2):396-402, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of the emerging infectious disease, severe fever with thrombocytopenia syndrome (SFTS). SFTSV could be transmitted through tick bite. Transmission of SFTSV among humans has also been reported mainly through direct blood contact. In July 2014, a cluster of six suspected SFTS cases occurred in Shandong Province, China. In this cluster, both symptomatic and asymptomatic persons were included. By analyzing the clinical data and results of laboratory tests, and conducting the epidemiological interviews with the cases and their families, risk factors responsible for the transmission were evaluated. The findings suggested that SFTSV transmission among humans may cause asymptomatic infection via personal contact without blood exposure.
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/transmissão
Doenças Transmissíveis Emergentes/virologia
Febre/fisiopatologia
Febre/virologia
Febre por Flebótomos/fisiopatologia
Febre por Flebótomos/transmissão
Trombocitopenia/fisiopatologia
Trombocitopenia/virologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Infecções Assintomáticas
China
Doenças Transmissíveis Emergentes/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0059


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[PMID]:28719252
[Au] Autor:Tian H; Yu P; Chowell G; Li S; Wei J; Tian H; Lv W; Han Z; Yang J; Huang S; Zhou S; Brownstein JS; Wang J; Xu B
[Ad] Endereço:State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.
[Ti] Título:Severe Fever with Thrombocytopenia Syndrome Virus in Humans, Domesticated Animals, Ticks, and Mosquitoes, Shaanxi Province, China.
[So] Source:Am J Trop Med Hyg;96(6):1346-1349, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractThe first human infection with severe fever with thrombocytopenia syndrome virus (SFTSV) was detected in Shaanxi Province, China, in 2013, although the virus had been reported in 13 other provinces of China since 2010. We collected and analyzed a total of 4,011 samples, including 936 human serum samples, 155 animal serum samples, 895 ticks, 1,950 mosquitoes, 30 midges, and 20 sandflies. SFTSV antibodies were found in 44 human samples (4.7%) with no significant differences between males and females or across counties. The incidence rate of severe fever with thrombocytopenia syndrome was significantly higher among individuals 20-60 years of age. Moreover, SFTSV-specific antibodies were detected in goats (66.7%), cattle (13.2%), and dogs (15.0%), but not in pigs (0%). We detected the virus in ticks with a prevalence rate of 21.3% (17/80 pools). All mosquito, midge, and sandfly samples were negative for SFTSV. These results support wide circulation of the virus in western China. ticks may serve as a novel SFTSV vector, and the role of these ticks requires further investigation.
[Mh] Termos MeSH primário: Animais Domésticos/virologia
Culicidae/virologia
Febre/epidemiologia
Ixodidae/virologia
Febre por Flebótomos/epidemiologia
Phlebovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Anticorpos Antivirais/sangue
Bovinos
Criança
China/epidemiologia
Cães
Feminino
Febre/virologia
Cabras
Seres Humanos
Incidência
Insetos Vetores/virologia
Masculino
Meia-Idade
Febre por Flebótomos/virologia
Fatores Socioeconômicos
Suínos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0333


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[PMID]:28678811
[Au] Autor:Hu J; Li Z; Hong L; Bao C; Zhang Z; Zhang H; He H; Wang X; Liu W; Peng Z; Shi L; Zhu F
[Ad] Endereço:Department of Acute Infectious Disease Control and Prevention, Jiangsu provincial Center for Disease Control and Prevention, Nanjing, China.
[Ti] Título:Preliminary fast diagnosis of severe fever with thrombocytopenia syndrome with clinical and epidemiological parameters.
[So] Source:PLoS One;12(7):e0180256, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To identify specific clinical and epidemiological parameters for clinical diagnosis of SFTSV infection with relatively higher accuracy. METHODS: 231 suspected cases of SFTS were reported by various medical institutions from 2011 to 2013 in Jiangsu Province, China. They were followed with SFTSV diagnosis tests and interview-administered questionnaires about demographic characteristics, clinical symptoms and epidemiological exposure factors. Univariate and multivariable logistic regression analysis were used to examine the diagnostic value of these parameters. RESULTS: SFTSV infection occurred only from April to October annually and usually in hilly areas of specific regions. Three prediction models of SFTSV infection were constructed. Model 3 with clinical and epidemiological parameters combined the benefits of both Model 1and Model 2, which was optimal and had an overall accuracy of 80.2%. Independent indicators for clinical diagnosis of SFTSV infection in Model 3 were as follows: lymphadenopathy (P = 0.01), leucopenia (P<0.01), age >50 years (P = 0.01), tick bites (P<0.01), raising domestic animals in the residential areas (P<0.01) and farming (P = 0.03). CONCLUSIONS: Our results show that using a combination of clinical and epidemiological parameters may be a feasible strategy to provide preliminary fast diagnosis as differentiating SFTSV infection from SFTS-like diseases, thus reducing the risk of misdiagnosis.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/diagnóstico
Programas de Rastreamento/métodos
Febre por Flebótomos/diagnóstico
Trombocitopenia/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Agricultura
Animais
Bunyaviridae/fisiologia
Infecções por Bunyaviridae/epidemiologia
Infecções por Bunyaviridae/virologia
China/epidemiologia
Estudos de Viabilidade
Feminino
Geografia
Interações Hospedeiro-Patógeno
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Febre por Flebótomos/epidemiologia
Febre por Flebótomos/virologia
Inquéritos e Questionários
Síndrome
Trombocitopenia/epidemiologia
Trombocitopenia/virologia
Picadas de Carrapatos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180256


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[PMID]:28348452
[Au] Autor:Kim UJ; Oh TH; Kim B; Kim SE; Kang SJ; Park KH; Jung SI; Jang HC
[Ad] Endereço:Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
[Ti] Título:Hyperferritinemia as a Diagnostic Marker for Severe Fever with Thrombocytopenia Syndrome.
[So] Source:Dis Markers;2017:6727184, 2017.
[Is] ISSN:1875-8630
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in East Asia with high mortality. Few studies have examined markers that suggest SFTS in febrile patients. To determine useful biochemical markers for SFTS, patients aged 18 years or older with SFTS or microbiologically confirmed community-onset bacteremia with thrombocytopenia (BT) at presentation between June 2013 and December 2015 were included from two tertiary university hospitals in Republic of Korea retrospectively. Eleven patients with SFTS and 62 patients with bacteremia and thrombocytopenia were identified in the study period. Age and sex did not show significant difference among two groups. Fever was more commonly observed but comorbidities were less common in SFTS than in BT ( < 0.05, each). The areas under the curves of serum ferritin, C-reactive protein, white blood cell count, serum procalcitonin, and fibrinogen were above 0.9, indicating the discriminative power of these biomarkers (1.000, 0.991, 0.963, 0.931, and 0.934, resp., all < 0.05). The optimal cutoff value of serum ferritin was 3,822 ng/mL in this study. These results suggest that hyperferritinemia is a typical laboratory feature of SFTS, and the serum ferritin level can be used as a marker for clinicians suspecting SFTS.
[Mh] Termos MeSH primário: Ferritinas/sangue
Febre por Flebótomos/sangue
Trombocitopenia/sangue
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Proteína C-Reativa/metabolismo
Calcitonina/sangue
Estudos de Casos e Controles
Feminino
Fibrinogênio/metabolismo
Seres Humanos
Masculino
Meia-Idade
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 9001-32-5 (Fibrinogen); 9007-12-9 (Calcitonin); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1155/2017/6727184


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[PMID]:28244301
[Au] Autor:Song TY; Yang EM; Kim CJ
[Ad] Endereço:Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
[Ti] Título:A Pediatric Case of Severe Fever with Thrombocytopenia Syndrome in Korea.
[So] Source:J Korean Med Sci;32(4):704-707, 2017 Apr.
[Is] ISSN:1598-6357
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease and elderly people living in rural areas have the greatest risk of infection. We report the first pediatric case of SFTS in Korea and the clinical characteristics and disease progression in children. A 10-year-old child from Chonnam province visited the hospital with myalgia and a history of fever over the previous 8 days. Her father noticed a tick on her head and removed it before fever developed. Because the symptoms continued, her father consulted the community health center and SFTS virus was detected both from the tick (Haemaphysalis longicornis) and the patient's blood. On hospitalization, fever and severe myalgia were improved and no gastrointestinal and hemorrhagic symptoms were observed. The patient was successfully treated with a combination of steroids, IVIG, and ribavirin. In this report, a pediatric case of SFTS presents a mild clinical course but close attention must be paid to the screening of children with mild symptoms consisting of SFTS.
[Mh] Termos MeSH primário: Febre por Flebótomos/diagnóstico
Phlebovirus/isolamento & purificação
Trombocitopenia/diagnóstico
[Mh] Termos MeSH secundário: Animais
Antivirais/uso terapêutico
Criança
Feminino
Seres Humanos
Mialgia/etiologia
Febre por Flebótomos/complicações
Febre por Flebótomos/tratamento farmacológico
Febre por Flebótomos/virologia
República da Coreia
Ribavirina/uso terapêutico
Esteroides/uso terapêutico
Trombocitopenia/complicações
Carrapatos/virologia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Steroids); 49717AWG6K (Ribavirin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.3346/jkms.2017.32.4.704


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[PMID]:28153057
[Au] Autor:Kaneko M; Maruta M; Shikata H; Asou K; Shinomiya H; Suzuki T; Hasegawa H; Shimojima M; Saijo M
[Ad] Endereço:Department of Internal Medicine, Uwajima City Hospital, 1-1 Goten-machi, Uwajima City, Ehime, 798-8510, Japan. kaneko@uwajima-mh.jp.
[Ti] Título:Unusual presentation of a severely ill patient having severe fever with thrombocytopenia syndrome: a case report.
[So] Source:J Med Case Rep;11(1):27, 2017 Feb 03.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Severe fever with thrombocytopenia syndrome is an emerging infectious disease caused by a novel phlebovirus belonging to the family Bunyaviridate. Emergence of encephalitis/encephalopathy during severe fever with thrombocytopenia syndrome progression has been identified as a major risk factor associated with a poor prognosis. Here we report the case of a severely ill patient with severe fever with thrombocytopenia syndrome virus-associated encephalitis/encephalopathy characterized by a lesion of the splenium, which resolved later. CASE PRESENTATION: A 56-year-old Japanese man presented with fever and diarrhea, followed by dysarthria. Diffusion-weighted magnetic resonance imaging demonstrated high signal intensity in the splenium of the corpus callosum. The severe fever with thrombocytopenia syndrome virus genome was detected in our patient's serum, and the clinical course was characterized by convulsion, stupor, and hemorrhagic manifestations, with disseminated intravascular coagulation and hemophagocytic lymphohistiocytosis. Supportive therapy not including administration of corticosteroids led to gradual improvement of the clinical and laboratory findings, and magnetic resonance imaging demonstrated resolution of the splenial lesion. The serum severe fever with thrombocytopenia syndrome viral copy number, which was determined with the quantitative reverse-transcription polymerase chain reaction, rapidly decreased despite the severe clinical course. Our patient's overall condition improved, allowing him to be eventually discharged. CONCLUSIONS: Patients with encephalitis/encephalopathy due to severe fever with thrombocytopenia syndrome virus infection may have a favorable outcome, even if they exhibit splenial lesions and a severe clinical course; monitoring the serum viral load may be of value for prediction of outcome and potentially enables the avoidance of corticosteroids to intentionally cause opportunistic infection.
[Mh] Termos MeSH primário: Encefalopatias/virologia
Corpo Caloso/virologia
Imagem de Difusão por Ressonância Magnética
Febre/virologia
Linfo-Histiocitose Hemofagocítica/diagnóstico
Febre por Flebótomos/diagnóstico
Trombocitopenia/virologia
[Mh] Termos MeSH secundário: Medula Óssea/patologia
Medula Óssea/virologia
Encefalopatias/patologia
Corpo Caloso/patologia
Diarreia/etiologia
Diarreia/virologia
Febre/etiologia
Hidratação
Seres Humanos
Linfo-Histiocitose Hemofagocítica/patologia
Masculino
Meia-Idade
Transfusão de Plaquetas
Convulsões/virologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-016-1192-0


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[PMID]:27914128
[Au] Autor:Kim KH; Ko MK; Kim N; Kim HH; Yi J
[Ad] Endereço:Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
[Ti] Título:Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in Southeastern Korea, 2015.
[So] Source:J Korean Med Sci;32(1):29-32, 2017 Jan.
[Is] ISSN:1598-6357
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease characterized by fever, thrombocytopenia and diarrhea. SFTS was firstly reported in Korea in 2013 but its seroprevalence in the country has yet to be investigated. Here, we investigate the seroprevalence of SFTS in a Korean population. A cross-sectional study was conducted on patients who had their sera tested for various reasons at a tertiary university hospital on particular days in May 2015. This study was conducted in a tertiary hospital in southeastern Korea. Total antibodies including immunoglobulin G (IgG) and immunoglobulin M (IgM), specific to SFTS virus (SFTSV) in serum samples were detected by a double-antigen sandwich enzyme-linked immunosorbent assay (ELISA). A total of 1,069 serum samples were tested. Median age was 59 years (range 12-96 years), and 51.5% were male. Overall, 22 patients (2.1%) were tested positive for anti-SFTSV antibodies. The SFTS seroprevalence increased significantly with age (P = 0.034). The seropositive rate of rural area was higher than that of urban area (7.7% vs. 1.9%, P = 0.040). Seropositive rates were not significantly different among underlying diseases. None of the antibody-positive patients showed typical symptoms or laboratory findings of SFTS at the time of sample collection. Results of real-time reverse transcription polymerase chain reaction (RT-PCR) were negative for all the seropositive patients. Our study shows 2.1% SFTS seroprevalence among the patients visiting a tertiary hospital in Korea. Seroprevalence is higher in older and rural population.
[Mh] Termos MeSH primário: Febre por Flebótomos/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antivirais/sangue
Criança
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Masculino
Meia-Idade
Febre por Flebótomos/diagnóstico
Febre por Flebótomos/virologia
Phlebovirus/imunologia
Phlebovirus/isolamento & purificação
RNA Viral/genética
RNA Viral/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
República da Coreia/epidemiologia
Centros de Atenção Terciária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G); 0 (Immunoglobulin M); 0 (RNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE
[do] DOI:10.3346/jkms.2017.32.1.29


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[PMID]:27297411
[Au] Autor:Lee H; Kim EJ; Cho IS; Song JY; Choi JS; Lee JY; Shin YK
[Ad] Endereço:Viral Disease Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
[Ti] Título:A serological study of severe fever with thrombocytopenia syndrome using a virus neutralization test and competitive enzyme-linked immunosorbent assay.
[So] Source:J Vet Sci;18(1):33-38, 2017 Mar 30.
[Is] ISSN:1976-555X
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Severe fever with thrombocytopenia syndrome (SFTS) is caused by the SFTS virus (SFTSV). The SFTSV appears to have a wide host range, as SFTSV-positive ticks have been isolated from both farm animals and wild rodents. Therefore, it is important to monitor SFTSV-positive animals to prevent the transmission of SFTSV from animals to humans. Previously, we developed a competitive enzyme-linked immunosorbent assay (cELISA) to detect SFTSV-specific antibodies from field animals and compared the cELISA results to those from an indirect immunofluorescence assay (IFA). In this study, cELISA results were compared to and evaluated against the results from both an IFA and a virus neutralization (VN) test of 193 bovine serum samples (including two bovine positive control sera) and 70 horse serum samples. The consistency (98.9%) between cELISA and VN results was higher than that (97.4%) between cELISA and IFA for the bovine serum samples. Similarly, for the horse serum samples, the consistency (88.6%) between cELISA and VN results was higher than that (84.3%) between the cELISA and IFA. These findings indicate that our newly developed cELISA can be used for surveillance or epidemiological studies of SFTSV in animals.
[Mh] Termos MeSH primário: Doenças dos Bovinos/diagnóstico
Ensaio de Imunoadsorção Enzimática/veterinária
Técnica Indireta de Fluorescência para Anticorpo/veterinária
Doenças dos Cavalos/diagnóstico
Testes de Neutralização/veterinária
Febre por Flebótomos/veterinária
Phlebovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/virologia
Doenças dos Cavalos/virologia
Cavalos
Febre por Flebótomos/diagnóstico
Febre por Flebótomos/virologia
Trombocitopenia/diagnóstico
Trombocitopenia/veterinária
Trombocitopenia/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.4142/jvs.2017.18.1.33



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