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Pesquisa : C02.081.885.430 [Categoria DeCS]
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[PMID]:29261651
[Au] Autor:Goedhals D; Paweska JT; Burt FJ
[Ad] Endereço:Division of Virology, National Health Laboratory Service/University of the Free State, Bloemfontein, South Africa.
[Ti] Título:Long-lived CD8+ T cell responses following Crimean-Congo haemorrhagic fever virus infection.
[So] Source:PLoS Negl Trop Dis;11(12):e0006149, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo haemorrhagic fever virus (CCHFV) is a member of the Orthonairovirus genus of the Nairoviridae family and is associated with haemorrhagic fever in humans. Although T lymphocyte responses are known to play a role in protection from and clearance of viral infections, specific T cell epitopes have yet to be identified for CCHFV following infection. A panel of overlapping peptides covering the CCHFV nucleoprotein and the structural glycoproteins, GN and GC, were screened by ELISpot assay to detect interferon gamma (IFN-γ) production in vitro by peripheral blood mononuclear cells from eleven survivors with previous laboratory confirmed CCHFV infection. Reactive peptides were located predominantly on the nucleoprotein, with only one survivor reacting to two peptides from the glycoprotein GC. No single epitope was immunodominant, however all but one survivor showed reactivity to at least one T cell epitope. The responses were present at high frequency and detectable several years after the acute infection despite the absence of continued antigenic stimulation. T cell depletion studies confirmed that IFN-γ production as detected using the ELISpot assay was mediated chiefly by CD8+ T cells. This is the first description of CD8+ T cell epitopic regions for CCHFV and provides confirmation of long-lived T cell responses in survivors of CCHFV infection.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Vírus da Febre Hemorrágica da Crimeia-Congo/imunologia
Febre Hemorrágica da Crimeia/imunologia
Imunidade Inata
[Mh] Termos MeSH secundário: Adulto
Idoso
Sequência de Aminoácidos
Estudos de Coortes
ELISPOT
Epitopos/imunologia
Feminino
Glicoproteínas/imunologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Leucócitos Mononucleares/imunologia
Masculino
Meia-Idade
Nucleoproteínas/imunologia
Biblioteca de Peptídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Epitopes); 0 (Glycoproteins); 0 (Nucleoproteins); 0 (Peptide Library)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006149


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[PMID]:29028804
[Au] Autor:Bonney LC; Watson RJ; Afrough B; Mullojonova M; Dzhuraeva V; Tishkova F; Hewson R
[Ad] Endereço:National Infection Service, Public Health England, Porton Down, Salisbury, United Kingdom.
[Ti] Título:A recombinase polymerase amplification assay for rapid detection of Crimean-Congo Haemorrhagic fever Virus infection.
[So] Source:PLoS Negl Trop Dis;11(10):e0006013, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crimean-Congo Haemorrhagic fever Virus (CCHFV) is a rapidly emerging vector-borne pathogen and the cause of a virulent haemorrhagic fever affecting large parts of Europe, Africa, the Middle East and Asia. METHODOLOGY/PRINCIPLE FINDINGS: An isothermal recombinase polymerase amplification (RPA) assay was successfully developed for molecular detection of CCHFV. The assay showed rapid (under 10 minutes) detection of viral extracts/synthetic virus RNA of all 7 S-segment clades of CCHFV, with high target specificity. The assay was shown to tolerate the presence of inhibitors in crude preparations of mock field samples, indicating that this assay may be suitable for use in the field with minimal sample preparation. The CCHFV RPA was successfully used to screen and detect CCHFV positives from a panel of clinical samples from Tajikistan. CONCLUSIONS/SIGNIFICANCE: The assay is a rapid, isothermal, simple-to-perform molecular diagnostic, which can be performed on a light, portable real-time detection device. It is ideally placed therefore for use as a field-diagnostic or in-low resource laboratories, for monitoring of CCHF outbreaks at the point-of-need, such as in remote rural regions in affected countries.
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/diagnóstico
Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Sistemas Automatizados de Assistência Junto ao Leito
[Mh] Termos MeSH secundário: África/epidemiologia
Ásia/epidemiologia
Europa (Continente)/epidemiologia
Vírus da Febre Hemorrágica da Crimeia-Congo/enzimologia
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Febre Hemorrágica da Crimeia/epidemiologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Oriente Médio/epidemiologia
Técnicas de Diagnóstico Molecular/economia
Técnicas de Diagnóstico Molecular/instrumentação
Técnicas de Amplificação de Ácido Nucleico/economia
Técnicas de Amplificação de Ácido Nucleico/instrumentação
RNA Viral/análise
RNA Viral/genética
Recombinases/metabolismo
Sensibilidade e Especificidade
Tadjiquistão/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral); 0 (Recombinases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006013


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[PMID]:28922426
[Au] Autor:Garrison AR; Shoemaker CJ; Golden JW; Fitzpatrick CJ; Suschak JJ; Richards MJ; Badger CV; Six CM; Martin JD; Hannaman D; Zivcec M; Bergeron E; Koehler JW; Schmaljohn CS
[Ad] Endereço:Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
[Ti] Título:A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models.
[So] Source:PLoS Negl Trop Dis;11(9):e0005908, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. There are currently no licensed vaccines to prevent CCHFV-associated disease. We developed a DNA vaccine expressing the M-segment glycoprotein precursor gene of CCHFV and assessed its immunogenicity and protective efficacy in two lethal mouse models of disease: type I interferon receptor knockout (IFNAR-/-) mice; and a novel transiently immune suppressed (IS) mouse model. Vaccination of mice by muscle electroporation of the M-segment DNA vaccine elicited strong antigen-specific humoral immune responses with neutralizing titers after three vaccinations in both IFNAR-/- and IS mouse models. To compare the protective efficacy of the vaccine in the two models, groups of vaccinated mice (7-10 per group) were intraperitoneally (IP) challenged with a lethal dose of CCHFV strain IbAr 10200. Weight loss was markedly reduced in CCHFV DNA-vaccinated mice as compared to controls. Furthermore, whereas all vector-control vaccinated mice succumbed to disease by day 5, the DNA vaccine protected >60% of the animals from lethal disease. Mice from both models developed comparable levels of antibodies, but the IS mice had a more balanced Th1/Th2 response to vaccination. There were no statistical differences in the protective efficacies of the vaccine in the two models. Our results provide the first comparison of these two mouse models for assessing a vaccine against CCHFV and offer supportive data indicating that a DNA vaccine expressing the glycoprotein genes of CCHFV elicits protective immunity against CCHFV.
[Mh] Termos MeSH primário: Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Vírus da Febre Hemorrágica da Crimeia-Congo/imunologia
Febre Hemorrágica da Crimeia/prevenção & controle
Imunogenicidade da Vacina
Vacinas de DNA/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Glicoproteínas/genética
Glicoproteínas/imunologia
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/imunologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Imunidade Humoral
Hospedeiro Imunocomprometido
Camundongos
Camundongos Knockout
Receptor de Interferon alfa e beta/deficiência
Receptor de Interferon alfa e beta/genética
Células Th1/imunologia
Células Th2/imunologia
Vacinação
Vacinas de DNA/administração & dosagem
Proteínas Virais/genética
Proteínas Virais/imunologia
Vacinas Virais/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Glycoproteins); 0 (Vaccines, DNA); 0 (Viral Proteins); 0 (Viral Vaccines); 156986-95-7 (Receptor, Interferon alpha-beta)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005908


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[PMID]:28886039
[Au] Autor:Fletcher TE; Gulzhan A; Ahmeti S; Al-Abri SS; Asik Z; Atilla A; Beeching NJ; Bilek H; Bozkurt I; Christova I; Duygu F; Esen S; Khanna A; Kader Ç; Mardani M; Mahmood F; Mamuchishvili N; Pshenichnaya N; Sunbul M; Yalcin TY; Leblebicioglu H
[Ad] Endereço:Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
[Ti] Título:Infection prevention and control practice for Crimean-Congo hemorrhagic fever-A multi-center cross-sectional survey in Eurasia.
[So] Source:PLoS One;12(9):e0182315, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crimean Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection that presents significant risk of nosocomial transmission to healthcare workers. AIM: Evaluation of CCHF infection prevention and control (IP&C) practices in healthcare facilities that routinely manage CCHF cases in Eurasia. METHODS: A cross-sectional CCHF IP&C survey was designed and distributed to CCHF centers in 10 endemic Eurasian countries in 2016. RESULTS: Twenty-three responses were received from centers in Turkey, Pakistan, Russia, Georgia, Kosovo, Bulgaria, Oman, Iran, India and Kazakhstan. All units had dedicated isolation rooms for CCHF, with cohorting of confirmed cases in 15/23 centers and cohorting of suspect and confirmed cases in 9/23 centers. There was adequate personal protective equipment (PPE) in 22/23 facilities, with 21/23 facilities reporting routine use of PPE for CCHF patients. Adequate staffing levels to provide care reported in 14/23 locations. All centers reported having a high risk CCHFV nosocomial exposure in last five years, with 5 centers reporting more than 5 exposures. Education was provided annually in most centers (13/23), with additional training requested in PPE use (11/23), PPE donning/doffing (12/23), environmental disinfection (12/23) and waste management (14/23). CONCLUSIONS: Staff and patient safety must be improved and healthcare associated CCHF exposure and transmission eliminated. Improvements are recommended in isolation capacity in healthcare facilities, use of PPE and maintenance of adequate staffing levels. We recommend further audit of IP&C practice at individual units in endemic areas, as part of national quality assurance programs.
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo
Febre Hemorrágica da Crimeia/prevenção & controle
Vigilância em Saúde Pública
[Mh] Termos MeSH secundário: Ásia/epidemiologia
Estudos Transversais
Desinfecção
Europa (Continente)/epidemiologia
Geografia
Febre Hemorrágica da Crimeia/epidemiologia
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Equipamento de Proteção Individual
Gerenciamento de Resíduos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182315


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[PMID]:28719259
[Au] Autor:Maiga O; Sas MA; Rosenke K; Kamissoko B; Mertens M; Sogoba N; Traore A; Sangare M; Niang M; Schwan TG; Maiga HM; Traore SF; Feldmann H; Safronetz D; Groschup MH
[Ad] Endereço:International Center for Excellence in Research, Malaria Research and Training Center, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
[Ti] Título:Serosurvey of Crimean-Congo Hemorrhagic Fever Virus in Cattle, Mali, West Africa.
[So] Source:Am J Trop Med Hyg;96(6):1341-1345, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractCrimean-Congo hemorrhagic fever is a tick-borne disease caused by the arbovirus Crimean-Congo hemorrhagic fever virus (CCHFV, family Bunyaviridae, genus ). CCHFV can cause a severe hemorrhagic fever with high-case fatality rates in humans. CCHFV has a wide geographic range and has been described in around 30 countries in the Middle East, Asia, Europe, and Africa including Mali and neighboring countries. To date, little is known about the prevalence rates of CCHFV in Mali. Here, using banked bovine serum samples from across the country, we describe the results of a seroepidemiological study for CCHFV aimed at identifying regions of circulation in Mali. In total, 1,074 serum samples were tested by a modified in-house CCHFV-IgG-enzyme-linked immunosorbent assay (ELISA) with confirmatory testing by commercial ELISA and immunofluorescence assay. Overall, 66% of samples tested were positive for CCHFV-specific IgG antibodies. Regional seroprevalence rates ranged from 15% to 95% and seemed to correlate with cattle density. Our results demonstrate that CCHFV prevalence is high in many regions in Mali and suggest that CCHFV surveillance should be established.
[Mh] Termos MeSH primário: Doenças dos Bovinos/epidemiologia
Bovinos/virologia
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/epidemiologia
Febre Hemorrágica da Crimeia/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Doenças dos Bovinos/virologia
Imunofluorescência
Febre Hemorrágica da Crimeia/virologia
Imunoglobulina G/sangue
Mali/epidemiologia
Reprodutibilidade dos Testes
Estudos Soroepidemiológicos
Carrapatos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0818


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[PMID]:28700846
[Au] Autor:Spengler JR; Bente DA
[Ad] Endereço:From the Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta (J.R.S.); and the Department of Microbiology and Immunology and Galveston National Laboratory, University of Texas Medical Branch, Galveston (D.A.B.).
[Ti] Título:Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident?
[So] Source:N Engl J Med;377(2):106-108, 2017 Jul 13.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Endêmicas
Vírus da Febre Hemorrágica da Crimeia-Congo
Febre Hemorrágica da Crimeia
[Mh] Termos MeSH secundário: Animais
Vetores Aracnídeos
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/transmissão
Seres Humanos
Ixodidae/virologia
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1707436


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[PMID]:28700843
[Au] Autor:Negredo A; de la Calle-Prieto F; Palencia-Herrejón E; Mora-Rillo M; Astray-Mochales J; Sánchez-Seco MP; Bermejo Lopez E; Menárguez J; Fernández-Cruz A; Sánchez-Artola B; Keough-Delgado E; Ramírez de Arellano E; Lasala F; Milla J; Fraile JL; Ordobás Gavín M; Martinez de la Gándara A; López Perez L; Diaz-Diaz D; López-García MA; Delgado-Jimenez P; Martín-Quirós A; Trigo E; Figueira JC; Manzanares J; Rodriguez-Baena E; Garcia-Comas L; Rodríguez-Fraga O; García-Arenzana N; Fernández-Díaz MV; Cornejo VM; Emmerich P; Schmidt-Chanasit J; Arribas JR; Crimean Congo Hemorrhagic Fever@Madrid Working Group
[Ad] Endereço:From the Arbovirus and Imported Viral Diseases Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III (A.N., M.P.S.-S., E.R.A., F.L.), Red de Investigación Colaborativa en Enfermedades Tropicales (A.N., M.P.S.-S., E.R.A., F.L.), High Level Isolation Unit (F.C.-P., M.M.-R., A.M.-Q., E.
[Ti] Título:Autochthonous Crimean-Congo Hemorrhagic Fever in Spain.
[So] Source:N Engl J Med;377(2):154-161, 2017 07 13.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus. (Funded by Red de Investigación Cooperativa en Enfermedades Tropicales [RICET] and Efficient Response to Highly Dangerous and Emerging Pathogens at EU [European Union] Level [EMERGE].).
[Mh] Termos MeSH primário: Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia
[Mh] Termos MeSH secundário: Colo/patologia
Busca de Comunicante
Evolução Fatal
Feminino
Vírus da Febre Hemorrágica da Crimeia-Congo/classificação
Vírus da Febre Hemorrágica da Crimeia-Congo/genética
Febre Hemorrágica da Crimeia/patologia
Febre Hemorrágica da Crimeia/transmissão
Febre Hemorrágica da Crimeia/virologia
Seres Humanos
Transmissão de Doença Infecciosa do Paciente para o Profissional
Fígado/patologia
Masculino
Meia-Idade
Necrose
Reação em Cadeia da Polimerase
Espanha
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1615162


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[PMID]:28514225
[Au] Autor:Bazanów BA; Pacon J; Gadzala L; Fracka A; Welz M; Paweska J
[Ad] Endereço:1 Department of Microbiology, Wroclaw University of Environmental and Life Sciences , Wroclaw, Poland .
[Ti] Título:Vector and Serologic Survey for Crimean-Congo Hemorrhagic Fever Virus in Poland.
[So] Source:Vector Borne Zoonotic Dis;17(7):510-513, 2017 Jul.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In contrast to animals, Crimean-Congo hemorrhagic fever (CCHF) causes a severe disease in humans with a high mortality rate. The etiological agent, CCHF virus (CCHFV), can be transmitted by argasid and ixodid ticks, but arachnids of the genus Hyalomma, followed by Rhipicephalus and Dermacentor serve as the major vectors of this virus. The goal of the study was to assess the epidemiological situation of CCHFV infection in cattle in south-east Poland, and survey for potential tick vector species. A total of 592 bovine blood samples from animals located in the southernmost region in Poland were tested by IgG sandwich enzyme-linked immunosorbent assay. Ticks (n = 993) from south-east Poland were collected from dogs, cats, cattle, and horses and tested by RT-PCR. All 592 serum samples were negative for IgG antibodies to CCHFV. Of the ticks collected, 125 were Dermacentor reticulatus and 868 represented Ixodes ricinus, both species are regarded as potential vectors of CCHFV. All tick samples were negative for the presence of CCHFV. Considering the zoonotic nature, public health importance, and the virus increasing spread, it was prudent to assess the seroprevalence of CCHFV in the south-east area of Poland, bordering with CCHFV endemic areas. It seems unlikely that CCHFV infection will suddenly spread in Poland, but considering the multiple possibilities of the virus introduction, serosurveys and vector biosurveillance should be conducted at regular intervals.
[Mh] Termos MeSH primário: Vetores Aracnídeos/virologia
Vírus da Febre Hemorrágica da Crimeia-Congo/isolamento & purificação
Febre Hemorrágica da Crimeia/sangue
Estudos Soroepidemiológicos
Carrapatos/virologia
[Mh] Termos MeSH secundário: Animais
Febre Hemorrágica da Crimeia/epidemiologia
Seres Humanos
Polônia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2016.2075


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[PMID]:28335777
[Au] Autor:Atif M; Saqib A; Ikram R; Sarwar MR; Scahill S
[Ad] Endereço:The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
[Ti] Título:The reasons why Pakistan might be at high risk of Crimean Congo haemorrhagic fever epidemic; a scoping review of the literature.
[So] Source:Virol J;14(1):63, 2017 Mar 23.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pakistan has faced a number of significant healthcare challenges over the past decade. In 2000, one of these events - a deadly epidemic of Crimean Congo Haemorrhagic Fever (CCHF) - struck Pakistan. The people of Pakistan are at a very high risk of acquiring CCHF, due to a number of factors which emerge from a scoping review of the literature. First, the underdeveloped healthcare system of the country is currently not prepared to cope with challenges of this nature. Healthcare professionals and medical institutes are not sufficiently equipped to properly diagnose, manage and prevent CCHF. Second, a large percentage of the general public is unaware of the spread and control of the vector. The agricultural sector of Pakistan is vast and thus many people are involved in animal husbandry and the handling of livestock which can lead to the transmission of the CCHF virus. Even in urban areas the risk of transmission is significantly higher around the time of Eid-ul-Azha, when Muslims slaughter animals. Finally, the political upheavals faced by the country have also increased Pakistan's vulnerability because a large number of refugees from Afghanistan, a CCHF endemic country, have migrated to Pakistan as a result of the Afghan war. Most of the refugees and their animals settle in Baluchistan and Khyber Pakhtunkhwa provinces, which consequently have a higher prevalence of CCHF. This scoping review of the literature highlights the potential causes of high risk CCHF and draws conclusions and makes recommendations that policy-makers in Pakistan may wish to consider in-order to improve on the current situation.
[Mh] Termos MeSH primário: Epidemias
Febre Hemorrágica da Crimeia/epidemiologia
[Mh] Termos MeSH secundário: Conhecimentos, Atitudes e Prática em Saúde
Acesso aos Serviços de Saúde
Seres Humanos
Exposição Ocupacional
Paquistão/epidemiologia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1186/s12985-017-0726-4


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[PMID]:28259724
[Au] Autor:Al-Abri SS; Abaidani IA; Fazlalipour M; Mostafavi E; Leblebicioglu H; Pshenichnaya N; Memish ZA; Hewson R; Petersen E; Mala P; Nhu Nguyen TM; Rahman Malik M; Formenty P; Jeffries R
[Ad] Endereço:Ministry of Health, Oman.
[Ti] Título:Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions.
[So] Source:Int J Infect Dis;58:82-89, 2017 May.
[Is] ISSN:1878-3511
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Crimean-Congo haemorrhagic fever (CCHF) is the most widespread, tick-borne viral disease affecting humans. The disease is endemic in many regions, such as Africa, Asia, Eastern and Southern Europe, and Central Asia. Recently, the incidence of CCHF has increased rapidly in the countries of the World Health Organization Eastern Mediterranean Region (WHO EMR), with sporadic human cases and outbreaks of CCHF being reported from a number of countries in the region. Despite the rapidly growing incidence of the disease, there are currently no accurate data on the burden of the disease in the region due to the different surveillance systems used for CCHF in these countries. In an effort to increase our understanding of the epidemiology and risk factors for the transmission of the CCHF virus (CCHFV; a Nairovirus of the family Bunyaviridae) in the WHO EMR, and to identify the current knowledge gaps that are hindering effective control interventions, a sub-regional meeting was organized in Muscat, Oman, from December 7 to 9, 2015. This article summarizes the current knowledge of the disease in the region, identifies the knowledge gaps that present challenges for the prevention and control of CCHFV, and details a strategic framework for research and development activities that would be necessary to curb the ongoing and new threats posed by CCHFV.
[Mh] Termos MeSH primário: Saúde Global
Febre Hemorrágica da Crimeia/epidemiologia
[Mh] Termos MeSH secundário: Previsões
Vírus da Febre Hemorrágica da Crimeia-Congo
Seres Humanos
Incidência
Região do Mediterrâneo/epidemiologia
Fatores de Risco
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE



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