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[PMID]:28457675
[Au] Autor:Wichgers Schreur PJ; van Keulen L; Kant J; Kortekaas J
[Ad] Endereço:Department of Virology, Wageningen Bioveterinary Research, Lelystad, The Netherlands. Electronic address: paul.wichgersschreur@wur.nl.
[Ti] Título:Four-segmented Rift Valley fever virus-based vaccines can be applied safely in ewes during pregnancy.
[So] Source:Vaccine;35(23):3123-3128, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Rift Valley fever virus (RVFV) causes severe and recurrent outbreaks on the African continent and the Arabian Peninsula and continues to expand its habitat. This mosquito-borne virus, belonging to the genus Phlebovirus of the family Bunyaviridae contains a tri-segmented negative-strand RNA genome. Previously, we developed four-segmented RVFV (RVFV-4s) variants by splitting the M-genome segment into two M-type segments each encoding one of the structural glycoproteins; Gn or Gc. Vaccination/challenge experiments with mice and lambs subsequently showed that RVFV-4s induces protective immunity against wild-type virus infection after a single administration. To demonstrate the unprecedented safety of RVFV-4s, we here report that the virus does not cause encephalitis after intranasal inoculation of mice. A study with pregnant ewes subsequently revealed that RVFV-4s does not cause viremia and does not cross the ovine placental barrier, as evidenced by the absence of teratogenic effects and virus in the blood and organs of the fetuses. Altogether, these results show that the RVFV-4s vaccine virus can be applied safely in pregnant ewes.
[Mh] Termos MeSH primário: Febre do Vale de Rift/prevenção & controle
Vírus da Febre do Vale do Rift/genética
Vírus da Febre do Vale do Rift/imunologia
Doenças dos Ovinos/prevenção & controle
Vacinas Virais/administração & dosagem
Vacinas Virais/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Encefalite Viral/etiologia
Encefalite Viral/veterinária
Feminino
Genoma Viral/genética
Genoma Viral/imunologia
Camundongos
Gravidez
Febre do Vale de Rift/virologia
Vírus da Febre do Vale do Rift/química
Ovinos
Carneiro Doméstico/imunologia
Teratogênios
Vacinas Atenuadas/administração & dosagem
Vacinas Atenuadas/efeitos adversos
Vacinas Atenuadas/imunologia
Vacinas Virais/imunologia
Viremia/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Teratogens); 0 (Vaccines, Attenuated); 0 (Viral Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28453063
[Au] Autor:Tique V; Mattar S; Freire M; Illian E; Camargo F; Vergara O; Moraes-Figueiredo LT
[Ad] Endereço:Universidad de Cordoba, Monteria, Colombia, overgara@correo.unicordoba.edu.co.
[Ti] Título:Epidemiological surveillance of herpes viral encephalitis in Cordoba, Colombia.
[So] Source:Rev Salud Publica (Bogota);18(4):581-591, 2016 Aug.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:Objective To establish an epidemiological surveillance of viral herpes encephalitis in major hospitals of Monteria, Cordoba. Methods From September 2009 to December 2011, a descriptive study of cases of viral encephalitis was made in three hospitals in the city of Monteria. Cerebrospinal fluid (CSF) samples from 118 patients were included in the study. Clinical aspects, as well as cytochemical and microbiological analysis (Gram stain and culture) of CSF, were used for selecting the patients. Virus detection was performed by using multiplex nested PCR for Herpes simplex virus 1 and 2, Epstein Barr virus, Cytomegalovirus and Varicella zoster virus. Results Viral DNA of herpesvirus was detected in the CSFs of 30 (25.4 %) participants, as follows: 22 (18.6 %) Herpes simplex 1 and 2 viruses, 4 (3.3 %) Cytomegalovirus and 1 (0.8 %) Varicella zoster virus. Co-infections were observed in 3 patients (2.5 %), 1 case by HSV-VZV and 2 cases by CMV/HSV. The clinical manifestations of the patients included: headache (18.6 %), fever (14.4 %), asthenia (10.1 %), seizures (9.3 %), vomiting (8.4 %), and stiff neck (5.9 %). Thirty percent of the patients also had HIV-AIDS. A case fatality rate of 20 % was observed for the patients. Conclusions This paper shows that herpesvirus is a cause of infection of the CNS in patients from Cordoba. This study contributes to the epidemiology of encephalitis, as well as to patient management.
[Mh] Termos MeSH primário: Encefalite Viral/epidemiologia
Infecções por Herpesviridae/epidemiologia
Vigilância da População
[Mh] Termos MeSH secundário: Coinfecção/líquido cefalorraquidiano
Coinfecção/epidemiologia
Coinfecção/virologia
Colômbia/epidemiologia
Citomegalovirus/isolamento & purificação
Infecções por Citomegalovirus/líquido cefalorraquidiano
Infecções por Citomegalovirus/epidemiologia
Encefalite por Herpes Simples/líquido cefalorraquidiano
Encefalite por Herpes Simples/epidemiologia
Encefalite por Varicela Zoster/líquido cefalorraquidiano
Encefalite por Varicela Zoster/epidemiologia
Encefalite Viral/líquido cefalorraquidiano
Infecções por Herpesviridae/líquido cefalorraquidiano
Herpesvirus Humano 3
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:27771495
[Au] Autor:Karrasch M; Fischer E; Scholten M; Sauerbrei A; Henke A; Renz DM; Mentzel HJ; Böer K; Böttcher S; Diedrich S; Krumbholz A; Zell R
[Ad] Endereço:Institute of Medical Microbiology, Jena University Hospital, Jena, Germany. Electronic address: matthias.karrasch@med.uni-jena.de.
[Ti] Título:A severe pediatric infection with a novel enterovirus A71 strain, Thuringia, Germany.
[So] Source:J Clin Virol;84:90-95, 2016 11.
[Is] ISSN:1873-5967
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Infection by Enterovirus A71 (EV-A71) is an important cause of hand, foot, and mouth disease (HFMD). Outbreaks including severe cases with neurological and cardiopulmonary complications have been reported particularly from Southeast Asia. In Europe, the epidemiology of EV-A71 is not well understood. In summer 2015, a two-year-old girl from Thuringia, Germany, presented with rhombencephalitis/brainstem encephalitis associated with severe neurological and cardiopulmonary complications. EV-A71 was detected in stool and almost the entire viral genome was amplified and sequenced. While the capsid protein VP1-encoding region belongs to the EV-A71 subgenogroup C1, the 3D polymerase encoding region represents a unique lineage. Thus, the data suggest that the Thuringian EV-A71 sequence likely represents a recombinant. The case underlines the importance of intensified EV-A71 surveillance in Germany and Europe including analysis of full-genome data.
[Mh] Termos MeSH primário: Encefalite Viral/virologia
Enterovirus Humano A/isolamento & purificação
Infecções por Enterovirus/virologia
[Mh] Termos MeSH secundário: Proteínas do Capsídeo/genética
Pré-Escolar
Surtos de Doenças
Encefalite Viral/diagnóstico
Encefalite Viral/epidemiologia
Enterovirus Humano A/classificação
Enterovirus Humano A/genética
Enterovirus Humano A/patogenicidade
Infecções por Enterovirus/diagnóstico
Infecções por Enterovirus/epidemiologia
Fezes/virologia
Feminino
Genoma Viral
Alemanha/epidemiologia
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Recombinação Genética
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28919237
[Au] Autor:Vercellino M; Trebini C; Capello E; Mancardi GL; Giordana MT; Cavalla P
[Ad] Endereço:Città della Salute e della Scienza di Torino University Hospital, Department of Neuroscience, Via Cherasco 15, 10126 Torino, Italy. Electronic address: mvercellino@cittadellasalute.to.it.
[Ti] Título:Inflammatory responses in Multiple Sclerosis normal-appearing white matter and in non-immune mediated neurological conditions with wallerian axonal degeneration: A comparative study.
[So] Source:J Neuroimmunol;312:49-58, 2017 Nov 15.
[Is] ISSN:1872-8421
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Inflammatory-like changes in the white matter (WM) are commonly observed in conditions of axonal degeneration by different etiologies. This study is a systematic comparison of the principal features of the inflammatory-like changes in the WM in different pathological conditions characterized by axonal damage/degeneration, focusing in particular on Multiple Sclerosis (MS) normal-appearing white matter (NAWM) compared to non immune-mediated disorders. The study was performed on sections of NAWM from 15 MS cases, 11 cases of non immune-mediated disorders with wallerian axonal degeneration (stroke, trauma, amyotrophic lateral sclerosis), 3 cases of viral encephalitis, 6 control cases. Common features of the inflammatory-like changes observed in all of the conditions of WM pathology were diffuse endothelial expression of VCAM-1, microglial activation with expression of M2 markers, increased expression of sphingosine receptors. Inflammation in MS NAWM was characterized, compared to non immune-mediated conditions, by higher VCAM-1 expression, higher density of perivascular lymphocytes, focal perivascular inflammation with microglial expression of M1 markers, ongoing acute axonal damage correlating with VCAM-1 expression but not with microglia activation. Inflammatory changes in MS NAWM share all the main features observed in the WM in non immune-mediated conditions with wallerian axonal degeneration (with differences to a large extent more quantitative than qualitative), but with superimposition of disease-specific perivascular inflammation and ongoing acute axonal damage.
[Mh] Termos MeSH primário: Inflamação/etiologia
Esclerose Múltipla/complicações
Degeneração Walleriana/complicações
Substância Branca/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos CD/metabolismo
Barreira Hematoencefálica/fisiopatologia
Encefalite Viral/metabolismo
Encefalite Viral/patologia
Endotélio/metabolismo
Endotélio/patologia
Feminino
Seres Humanos
Linfócitos/metabolismo
Linfócitos/patologia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Esclerose Múltipla/patologia
Óxido Nítrico Sintase Tipo II/metabolismo
Molécula 1 de Adesão de Célula Vascular/metabolismo
Degeneração Walleriana/patologia
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Vascular Cell Adhesion Molecule-1); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28705180
[Au] Autor:Ai J; Xie Z; Liu G; Chen Z; Yang Y; Li Y; Chen J; Zheng G; Shen K
[Ad] Endereço:Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing,
[Ti] Título:Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study.
[So] Source:BMC Infect Dis;17(1):494, 2017 Jul 14.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5.88 ± 3.60 years and 6.39 ± 3.57 years, respectively. Real-time reverse transcription PCR and multiplex PCR were used to detect human enteroviruses and herpes viruses in cerebrospinal fluid (CSF) of patients with encephalitis or meningitis. The enzyme-linked immune absorbent assay (ELISA) was used for detecting IgM antibody against Japanese encephalitis virus (JEV) in CSF and against mumps virus, tick-borne encephalitis virus (TBEV), dengue virus and rubella virus in acute serum. The clinical and outcome data were collected during patients' hospitalization. RESULTS: The etiology of viral encephalitis was confirmed in 52.5% patients. The primary pathogen was human enteroviruses (27.7%) in viral encephalitis. The incidence of sequelae and the fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The etiology of viral meningitis was identified in 42.8% cases. The leading pathogen was also human enteroviruses (37.7%) in viral meningitis. The prognosis of viral meningitis was favorable with only 0.7% patients had neurological sequelae. CONCLUSIONS: Human enteroviruses were the leading cause both in acute viral encephalitis and viral meningitis in children. The incidence of sequelae and fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The prognosis of viral meningitis was favorable compared to viral encephalitis.
[Mh] Termos MeSH primário: Encefalite Viral/etiologia
Meningite Viral/etiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
China/epidemiologia
Vírus da Encefalite Japonesa (Espécie)/imunologia
Vírus da Encefalite Japonesa (Espécie)/patogenicidade
Vírus da Encefalite Transmitidos por Carrapatos/imunologia
Vírus da Encefalite Transmitidos por Carrapatos/patogenicidade
Encefalite Viral/epidemiologia
Enterovirus/genética
Enterovirus/imunologia
Enterovirus/patogenicidade
Feminino
Seres Humanos
Incidência
Lactente
Masculino
Meningite Viral/epidemiologia
Reação em Cadeia da Polimerase Multiplex
Prognóstico
Estudos Prospectivos
Vírus da Rubéola/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2572-9


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[PMID]:28700066
[Au] Autor:Lucena-Silva N; Assunção MELSM; Ramos FAP; Azevedo F; Lessa R; Cordeiro MT; Brito CAA
[Ad] Endereço:Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
[Ti] Título:Encephalitis associated with inappropriate antidiuretic hormone secretion due to chikungunya infection in Recife, State of Pernambuco, Brazil.
[So] Source:Rev Soc Bras Med Trop;50(3):417-422, 2017 May-Jun.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The symptoms of chikungunya virus (CHIKV) infection include fever, headache, muscle aches, skin rash, and polyarthralgia, characterized by intense pain, edema, and temporary functional impairment. This is the first report of encephalitis caused by CHIKV infection associated with an atypical presentation of syndrome of inappropriate antidiuretic hormone secretion, evolving to cognitive impairment and apraxia of speech.
[Mh] Termos MeSH primário: Febre de Chikungunya/complicações
Encefalite Viral/diagnóstico por imagem
Encefalite Viral/virologia
Síndrome de Secreção Inadequada de HAD/virologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Síndrome de Secreção Inadequada de HAD/diagnóstico por imagem
Imagem por Ressonância Magnética
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28700065
[Au] Autor:Pereira LP; Villas-Bôas R; Scott SSO; Nóbrega PR; Sobreira-Neto MA; Castro JDV; Cavalcante B; Braga-Neto P
[Ad] Endereço:Divisão de Neurorradiologia, Departamento de Radiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
[Ti] Título:Encephalitis associated with the chikungunya epidemic outbreak in Brazil: report of 2 cases with neuroimaging findings.
[So] Source:Rev Soc Bras Med Trop;50(3):413-416, 2017 May-Jun.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Chikungunya, an alphavirus infection presenting with fever, rash, and polyarthritis, is most often an acute febrile illness. Neurologic complications of chikungunya infection have been reported. Here we report the clinical and neuroimaging data of 2 patients with chikungunya-associated encephalitis during the recent Brazilian epidemic.
[Mh] Termos MeSH primário: Febre de Chikungunya/complicações
Encefalite Viral/virologia
[Mh] Termos MeSH secundário: Idoso
Brasil/epidemiologia
Febre de Chikungunya/epidemiologia
Surtos de Doenças
Encefalite Viral/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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Martelli, Celina Maria Turchi
Texto completo SciELO Brasil
[PMID]:28700057
[Au] Autor:Tassara MP; Guilarde AO; Rocha BAMD; Féres VCR; Martelli CMT
[Ad] Endereço:Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
[Ti] Título:Neurological manifestations of dengue in Central Brazil.
[So] Source:Rev Soc Bras Med Trop;50(3):379-382, 2017 May-Jun.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: : The incidence of dengue has increased throughout the 2000s with a consequent global increase in atypical clinical forms. METHODS: : This study reports a series of cases of neurological dengue out of 498 confirmed cases of laboratory dengue in Goiânia, Brazil. Cases were confirmed based on viral RNA detection via polymerase chain reaction or IgM antibody capture. RESULTS: : Neurological symptoms occurred in 5.6% of cases, including paresthesia (3.8%), encephalitis (2%), encephalopathy (1%), seizure (0.8%), meningoencephalitis (0.4%), and paresis (0.4%). DENV-3 was the predominant circulating serotype (93%). CONCLUSIONS: : We reported dengue cases with neurological manifestations in endemic area.
[Mh] Termos MeSH primário: Dengue/complicações
Encefalite Viral/virologia
Meningoencefalite/virologia
Parestesia/virologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Anticorpos Antivirais/sangue
Brasil/epidemiologia
Pré-Escolar
Dengue/epidemiologia
Vírus da Dengue/genética
Vírus da Dengue/imunologia
Encefalite Viral/epidemiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Masculino
Meningoencefalite/epidemiologia
Meia-Idade
Parestesia/epidemiologia
Reação em Cadeia da Polimerase
RNA Viral/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (RNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28654561
[Au] Autor:Britton PN; Dale RC; Blyth CC; Macartney K; Crawford NW; Marshall H; Clark JE; Elliott EJ; Webster RI; Cheng AC; Booy R; Jones CA; ACE study investigators and PAEDS network
[Ad] Endereço:From the *Sydney Medical School, University of Sydney, NSW, Australia; †Marie Bashir Institute of Infectious Diseases and Biosecurity Institute, University of Sydney, NSW, Australia; ‡The Children's Hospital at Westmead, NSW, Australia; §Department of Infectious Diseases, Princess Margaret Hospital, Subiaco, Western Australia, Australia; ¶School of Medicine, University of Western Australia, Australia; ‖Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Australia; **National Centre for Immunisation Research and Surveillance, NSW, Australia; ††Royal Children's Hospital, Melbourne, Victoria, Australia; ‡‡Murdoch Children's Research Institute and University of Melbourne, Victoria, Australia; §§Women's and Children's Hospital, Robinson Research Institute and School of Medicine, University of Adelaide, Adelaide, South Australia, Australia; ¶¶Infection Management and Prevention service, Lady Cilento Children's Hospital, Queensland, Australia; ‖‖Australian Paediatric Surveillance Unit, NSW, Australia; ***School of Public Health and Preventive Medicine, Monash University, Victoria, Australia; and †††Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Victoria, Australia.
[Ti] Título:Influenza-associated Encephalitis/Encephalopathy Identified by the Australian Childhood Encephalitis Study 2013-2015.
[So] Source:Pediatr Infect Dis J;36(11):1021-1026, 2017 Nov.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Influenza-associated encephalitis/encephalopathy (IAE) is an important cause of acute encephalitis syndrome in children. IAE includes a series of clinicoradiologic syndromes or acute encephalopathy syndromes that have been infrequently reported outside East Asia. We aimed to describe cases of IAE identified by the Australian Childhood Encephalitis study. METHODS: Children ≤ 14 years of age with suspected encephalitis were prospectively identified in 5 hospitals in Australia. Demographic, clinical, laboratory, imaging, and outcome at discharge data were reviewed by an expert panel and cases were categorized by using predetermined case definitions. We extracted cases associated with laboratory identification of influenza virus for this analysis; among these cases, specific IAE syndromes were identified where clinical and radiologic features were consistent with descriptions in the published literature. RESULTS: We identified 13 cases of IAE during 3 southern hemisphere influenza seasons at 5 tertiary children's hospitals in Australia; 8 children with specific acute encephalopathy syndromes including: acute necrotizing encephalopathy, acute encephalopathy with biphasic seizures and late diffusion restriction, mild encephalopathy with reversible splenial lesion, and hemiconvulsion-hemiplegia syndrome. Use of influenza-specific antiviral therapy and prior influenza vaccination were infrequent. In contrast, death or significant neurologic morbidity occurred in 7 of the 13 children (54%). CONCLUSIONS: The conditions comprising IAE are heterogeneous with varied clinical features, magnetic resonance imaging changes, and outcomes. Overall, outcome of IAE is poor emphasizing the need for optimized prevention, early recognition, and empiric management.
[Mh] Termos MeSH primário: Encefalopatias/virologia
Encefalite Viral/virologia
Influenza Humana/virologia
[Mh] Termos MeSH secundário: Adolescente
Austrália/epidemiologia
Encéfalo/diagnóstico por imagem
Encéfalo/patologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Influenza Humana/complicações
Masculino
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001650


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[PMID]:28631601
[Au] Autor:Holz CL; Nelli RK; Wilson ME; Zarski LM; Azab W; Baumgardner R; Osterrieder N; Pease A; Zhang L; Hession S; Goehring LS; Hussey SB; Soboll Hussey G
[Ad] Endereço:1​Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:Viral genes and cellular markers associated with neurological complications during herpesvirus infections.
[So] Source:J Gen Virol;98(6):1439-1454, 2017 Jun.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Despite the importance of neurological disorders associated with herpesviruses, the mechanism by which these viruses influence the central nervous system (CNS) has not been definitively established. Owing to the limitations of studying neuropathogenicity of human herpesviruses in their natural host, many aspects of their pathogenicity and immune response are studied in animal models. Here, we present an important model system that enables studying neuropathogenicity of herpesviruses in the natural host. Equine herpesvirus type 1 (EHV-1) is an alphaherpesvirus that causes a devastating neurological disease (EHV-1 myeloencephalopathy; EHM) in horses. Like other alphaherpesviruses, our understanding of virus neuropathogenicity in the natural host beyond the essential role of viraemia is limited. In particular, information on the role of different viral proteins for virus transfer to the spinal cord endothelium in vivo is lacking. In this study, the contribution of two viral proteins, DNA polymerase (ORF30) and glycoprotein D (gD), to the pathogenicity of EHM was addressed. Furthermore, different cellular immune markers, including alpha-interferon (IFN-α), gamma-interferon (IFN-γ), interleukin-10 (IL-10) and interleukin-1 beta (IL-1ß), were identified to play a role during the course of the disease.
[Mh] Termos MeSH primário: Biomarcadores/análise
Encefalite Viral/patologia
Infecções por Herpesviridae/complicações
Infecções por Herpesviridae/virologia
Herpesvirus Equídeo 1/patogenicidade
Interações Hospedeiro-Patógeno
Proteínas Virais/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Infecções por Herpesviridae/patologia
Cavalos
Masculino
Modelos Animais
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Viral Proteins); 0 (Virulence Factors)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000773



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