Base de dados : MEDLINE
Pesquisa : C02.256.466.382.290 [Categoria DeCS]
Referências encontradas : 4415 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 442 ir para página                         

  1 / 4415 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29385170
[Au] Autor:Hazel A; Holland Jones J
[Ad] Endereço:Department of Earth System Science, Stanford University, Stanford, California, United States of America.
[Ti] Título:Remoteness influences access to sexual partners and drives patterns of viral sexually transmitted infection prevalence among nomadic pastoralists.
[So] Source:PLoS One;13(1):e0191168, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sexually transmitted infections (STIs) comprise a significant portion of the infectious-disease burden among rural people in the Global South. Particular characteristics of ruralness-low-density settlements and poor infrastructure-make healthcare provision difficult, and remoteness, typically a characteristic of ruralness, often compounds the difficultly. Remoteness may also accelerate STI transmission, particularly that of viral STIs, through formation of small, highly connected sexual networks through which pathogens can spread rapidly, especially when partner concurrency is broadly accepted. Herein, we explored the effect of remoteness on herpes simplex virus type-2 (HSV-2) epidemiology among semi-nomadic pastoralists in northwestern (Kaokoveld) Namibia, where, in 2009 we collected HSV-2-specific antibody status, demographic, sexual network, and travel data from 446 subjects (women = 213, men = 233) in a cross-sectional study design. HSV-2 prevalence was high overall in Kaokoveld (>35%), but was heterogeneously distributed across locally defined residential regions: some regions had significantly higher HSV-2 prevalence (39-48%) than others (21-33%). Using log-linear models, we asked the following questions: 1) Are sexual contacts among people in high HSV-2-prevalence regions more likely to be homophilous (i.e., from the same region) than those among people from low-prevalence regions? 2) Are high-prevalence regions more "functionally" remote, in that people from those regions are more likely to travel within their own region than outside, compared to people from other regions? We found that high-prevalence regions were more sexually homophilous than low-prevalence regions and that those regions also had higher rates of within-region travel than the other regions. These findings indicate that remoteness can create contact structures for accelerated STI transmission among people who are already disproportionately vulnerable to consequences of untreated STIs.
[Mh] Termos MeSH primário: Parceiros Sexuais
Doenças Virais Sexualmente Transmissíveis/epidemiologia
Migrantes
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Herpes Genital/epidemiologia
Herpesvirus Humano 2
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
Namíbia/epidemiologia
Prevalência
População Rural
Comportamento Sexual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191168


  2 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27771977
[Au] Autor:Young S; Body B; Moore F; Dunbar S
[Ad] Endereço:a TriCore Reference Laboratories , Research and Clinical Trials , Albuquerque , NM , USA.
[Ti] Título:Multicenter evaluation of the Luminex® ARIES® HSV 1&2 Assay for the detection of herpes simplex virus types 1 and 2 in cutaneous and mucocutaneous lesion specimens.
[So] Source:Expert Rev Mol Diagn;16(12):1241-1249, 2016 12.
[Is] ISSN:1744-8352
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The ARIES® HSV 1&2 Assay is a new FDA cleared real-time PCR test for detection and differentiation of HSV-1 and HSV-2 DNA from cutaneous and mucocutaneous lesions. The test is performed on the ARIES® System, an automated sample to answer real-time PCR instrument that provides a closed system and simple workflow for performing molecular testing. Areas covered: This article reports the clinical performance of the ARIES® HSV 1&2 Assay assessed on 1963 prospectively collected specimens. Assay sensitivities were 91.1-95% (cutaneous) and 97-98.5% (mucocutaneous), and specificities were 88.8-94.2% (cutaneous) and 93.2-95.4% (mucocutaneous), as compared to the ELVIS® HSV test system. Expert commentary: Detection of HSV DNA by PCR is rapid and more sensitive than traditional culture and immunoassay methods and is being widely adopted in many laboratory settings. Sample to answer molecular platforms like ARIES® will enable routine and non-molecular labs to perform sensitive and rapid molecular testing with ease.
[Mh] Termos MeSH primário: Herpes Simples/diagnóstico
Herpes Simples/virologia
Herpesvirus Humano 1/genética
Herpesvirus Humano 2/genética
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
DNA Viral
Feminino
Herpes Genital/diagnóstico
Herpes Genital/virologia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Técnicas de Amplificação de Ácido Nucleico/métodos
Técnicas de Amplificação de Ácido Nucleico/normas
Reação em Cadeia da Polimerase em Tempo Real/instrumentação
Reação em Cadeia da Polimerase em Tempo Real/normas
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  3 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29190738
[Au] Autor:McGee D; Smith A; Poncil S; Patterson A; Bernstein AI; Racicot K
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America.
[Ti] Título:Cervical HSV-2 infection causes cervical remodeling and increases risk for ascending infection and preterm birth.
[So] Source:PLoS One;12(11):e0188645, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. HSV2 infection resulted in histological changes in the cervix mimicking cervical ripening, including significant collagen remodeling and increased hyaluronic acid synthesis. Viral infection also caused aberrant expression of estrogen and progesterone receptor in the cervical epithelium. Further analysis using human ectocervical cells demonstrated a role for Src kinase in virus-mediated changes in estrogen receptor and hyaluronic acid expression. In conclusion, HSV2 affects proteins involved in tissue hormone responsiveness, causes significant changes reminiscent of premature cervical ripening, and increases risk of preterm birth. Studies such as this improve our chances of identifying clinical interventions in the future.
[Mh] Termos MeSH primário: Medida do Comprimento Cervical
Herpes Genital/patologia
Herpesvirus Humano 2/patogenicidade
Nascimento Prematuro
[Mh] Termos MeSH secundário: Animais
Infecções por Escherichia coli/complicações
Infecções por Escherichia coli/fisiopatologia
Feminino
Herpes Genital/complicações
Herpes Genital/fisiopatologia
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Modelos Animais
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188645


  4 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29323854
[Au] Autor:Glukhovets BI; Glukhovets NG; Belitchenko NV; Sosunova OA
[Ti] Título:Immunofluorescence diagnosis of the herpesvirus stillborn infection.
[So] Source:Vopr Virusol;61(5):219-21, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Congenital herpes infection belongs to the category of actual problems of Perinatal Medicine. Pathological diagnosis of this disease is not effective in the routine method of autopsy studies without virological research. Objective. Determination of the value of the fluorescent antibody technique in the diagnosis of congenital herpes infection of the stillborn is a promising approach to medical diagnosis. subjects and methods. In 96 cases of stillbirth immunofluorescent identification of herpes simplex virus types 1 and 2 and cytomegalovirus in the placenta and internal organs (brain, heart, lungs, and liver) was implemented. The findings were compared with the results of a complete histological examination of the heart, including its rhythmogenic centers. Results. The herpes viruses were found in 51 observations (53.1%). Among them, HSV-1 were found in 16 observations (16.7%), HSV-2, in 19 (19.7%), CMV, in 16 (16.7%). In 34 stillbirths (35.8%) the pathological signs of herpetic atrial myocarditis were observed, which were regarded as the cause of death. Conclusion. The use of the fluorescent antibody technique in the autopsy practice is an effective way of diagnosis of intrauterine infection caused by the herpes simplex virus and cytomegalovirus.
[Mh] Termos MeSH primário: Anticorpos Antivirais/análise
Infecções por Citomegalovirus/diagnóstico
Herpes Genital/diagnóstico
Herpes Simples/diagnóstico
Natimorto
[Mh] Termos MeSH secundário: Adulto
Autopsia
Encéfalo/patologia
Encéfalo/virologia
Citomegalovirus/imunologia
Citomegalovirus/isolamento & purificação
Infecções por Citomegalovirus/mortalidade
Infecções por Citomegalovirus/patologia
Infecções por Citomegalovirus/virologia
Feminino
Imunofluorescência/métodos
Coração/virologia
Herpes Genital/mortalidade
Herpes Genital/patologia
Herpes Genital/virologia
Herpes Simples/mortalidade
Herpes Simples/patologia
Herpes Simples/virologia
Herpesvirus Humano 1/imunologia
Herpesvirus Humano 1/isolamento & purificação
Herpesvirus Humano 2/imunologia
Herpesvirus Humano 2/isolamento & purificação
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Fígado/patologia
Fígado/virologia
Pulmão/patologia
Pulmão/virologia
Masculino
Placenta/patologia
Placenta/virologia
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  5 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28470128
[Au] Autor:Parsons BF; Ryder N
[Ad] Endereço:1 Pacific Clinic Newcastle, HNE Sexual Health, Newcastle, NSW, Australia.
[Ti] Título:Pseudoepitheliomatous hyperplasia causing a painful plaque in a HIV-infected female.
[So] Source:Int J STD AIDS;28(7):723-725, 2017 06.
[Is] ISSN:1758-1052
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dermatological conditions are more common and can present atypically, in human immunodeficiency virus-infected individuals. This case report describes a 22-year-old human immunodeficiency virus-positive Caucasian female who presented with a vulval lesion eight weeks after starting antiretroviral treatment. Clinical examination revealed a 2 cm well-demarcated plaque on the outer aspect of the left labium minus. The lesion was tender, no contact bleeding or ulceration present. She was presumptively treated for chancroid and herpes simplex with 500 mg ceftriaxone IM stat, 1 g azithromycin PO stat, and valacyclovir 500 mg BD for five days. The lesion persisted despite treatment, and during follow-up, a punch biopsy was carried out. She was diagnosed with pseudoepitheliomatous hyperplasia of the epidermis. In addition to highlighting this condition that has been previously reported in human immunodeficiency virus/herpes simplex virus co-infection, this case demonstrates that unusual skin presentations must be considered in human immunodeficiency virus-infected individuals and illustrates the importance of biopsy for any non-healing lesions.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Herpes Genital/diagnóstico
Hiperplasia/patologia
Vulva/patologia
Doenças da Vulva/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Fármacos Anti-HIV/uso terapêutico
Biópsia
Coinfecção/virologia
Feminino
Infecções por HIV/tratamento farmacológico
Herpes Genital/complicações
Herpes Genital/tratamento farmacológico
Herpes Genital/microbiologia
Seres Humanos
Hospedeiro Imunocomprometido
Simplexvirus
Resultado do Tratamento
Doenças da Vulva/complicações
Doenças da Vulva/tratamento farmacológico
Doenças da Vulva/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1177/0956462416676020


  6 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28982161
[Au] Autor:Smith JM; Moss JA; Srinivasan P; Butkyavichene I; Gunawardana M; Fanter R; Miller CS; Sanchez D; Yang F; Ellis S; Zhang J; Marzinke MA; Hendrix CW; Kapoor A; Baum MM
[Ad] Endereço:Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
[Ti] Título:Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model.
[So] Source:PLoS One;12(10):e0185946, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Here we describe a coitally independent, long-acting pod-IVR MPT that could potentially prevent HIV and HSV infection as well as unintended pregnancy. The pharmacokinetics of MPT pod-IVRs delivering tenofovir alafenamide hemifumarate (TAF2) to prevent HIV, acyclovir (ACV) to prevent HSV, and etonogestrel (ENG) in combination with ethinyl estradiol (EE), FDA-approved hormonal contraceptives, were evaluated in pigtailed macaques (N = 6) over 35 days. Pod IVRs were exchanged at 14 days with the only modification being lower ENG release rates in the second IVR. Plasma progesterone was monitored weekly to determine the effect of ENG/EE on menstrual cycle. The mean in vivo release rates (mg d-1) for the two formulations over 30 days ranged as follows: TAF2 0.35-0.40; ACV 0.56-0.70; EE 0.03-0.08; ENG (high releasing) 0.63; and ENG (low releasing) 0.05. Mean peak progesterone levels were 4.4 ± 1.8 ng mL-1 prior to IVR insertion and 0.075 ± 0.064 ng mL-1 for 5 weeks after insertion, suggesting that systemic EE/ENG levels were sufficient to suppress menstruation. The TAF2 and ACV release rates and resulting vaginal tissue drug concentrations (medians: TFV, 2.4 ng mg-1; ACV, 0.2 ng mg-1) may be sufficient to protect against HIV and HSV infection, respectively. This proof of principle study demonstrates that MPT-pod IVRs could serve as a potent biomedical prevention tool to protect women's sexual and reproductive health and may increase adherence to HIV PrEP even among younger high-risk populations.
[Mh] Termos MeSH primário: Antivirais/administração & dosagem
Dispositivos Anticoncepcionais Femininos
Infecções por HIV/prevenção & controle
Herpes Genital/prevenção & controle
Gravidez não Planejada
[Mh] Termos MeSH secundário: Administração Intravaginal
Animais
Antivirais/farmacocinética
Feminino
Seres Humanos
Macaca nemestrina
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185946


  7 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28893956
[Au] Autor:Eriksson K; Svensson A; Hait AS; Schlüter K; Tunbäck P; Nordström I; Padyukov L; Liljeqvist JÅ; Mogensen TH; Paludan SR
[Ad] Endereço:Department of Rheumatology and Inflammation Research, University of Gothenburg, 40530 Gothenburg, Sweden.
[Ti] Título:Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-ß Expression.
[So] Source:J Immunol;199(8):2613-2617, 2017 Oct 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic bacteria and DNA viruses. The IFN response induced by HSV-2 was particularly dependent on IFI16. In a cohort of patients with genital herpes and healthy controls, the minor G allele of the single nucleotide polymorphism rs2276404 was associated with resistance to infection. Furthermore, the combination of this allele with the C allele of rs1417806 was significantly overrepresented in uninfected individuals. Cells from individuals with the protective GC haplotype expressed higher levels of IFI16 and induced more IFN-ß upon HSV-2 infection. These data provide genetic evidence for a role for IFI16 in protection against genital herpes.
[Mh] Termos MeSH primário: Genótipo
Herpes Genital/imunologia
Herpesvirus Humano 2/imunologia
Interferon beta/metabolismo
Proteínas Nucleares/genética
Fosfoproteínas/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Linhagem Celular
Estudos de Coortes
DNA Viral/imunologia
Frequência do Gene
Estudos de Associação Genética
Seres Humanos
Masculino
Camundongos
Meia-Idade
Proteínas Nucleares/metabolismo
Fosfoproteínas/metabolismo
Polimorfismo de Nucleotídeo Único
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Nuclear Proteins); 0 (Phosphoproteins); 148998-64-5 (IFI16 protein, human); 77238-31-4 (Interferon-beta)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700385


  8 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28821230
[Au] Autor:Domercant JW; Jean Louis F; Hulland E; Griswold M; Andre-Alboth J; Ye T; Marston BJ
[Ad] Endereço:Centers for Disease Control and Prevention, Tabarre, Haiti.
[Ti] Título:Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti.
[So] Source:BMC Infect Dis;17(1):577, 2017 Aug 18.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population. METHODS: Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies. We evaluated rates of HSV-2 seropositivity and HSV-2/HIV co-infection, associations between HSV-2 and demographic characteristics using multivariable Cox proportional hazards modeling, and HSV-2 test performance in this population. RESULTS: Serum samples from 1000 pregnant women (all 164 HIV positive and 836 random HIV negative) were selected. The overall weighted prevalence of HSV-2 was 31.4% (95% CI: 27.7-35.4) and the prevalence of HIV-positivity among HSV-2 positive pregnant women was five times higher than the prevalence among HSV-2 negative women (4.8% [95% CI: 3.9-6.0] vs. 0.9% [95% CI: 0.6-1.3], respectively). Factors significantly associated with HSV-2 positivity were HIV-positivity (PR: 2.27 [95% CI: 1.94-2.65]) and older age (PRs: 1.41 [95% CI: 1.05-1.91] for 20-24 years, 1.71 [95% CI:1.13-2.60] for 30-34 years, and 1.55 [95% CI: 1.10-2.19] for 35 years or greater]), while rural residence was negatively associated with HSV-2 positivity (PR 0.83 [95% CI: 0.69-1.00]), after controlling for other covariables. For this study a conservative Focus index cutoff of 3.5 was used, but among samples with a Focus index value ≥2.5, 98.4% had positive Kalon tests. CONCLUSION: The prevalence of HSV-2 is relatively high among pregnant women in Haiti. Public health interventions to increase access to HSV-2 screening in antenatal services are warranted.
[Mh] Termos MeSH primário: Herpes Genital/epidemiologia
Herpes Simples/epidemiologia
Herpesvirus Humano 2
Complicações Infecciosas na Gravidez/virologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticorpos Antivirais/sangue
Coinfecção
Feminino
Infecções por HIV/epidemiologia
Haiti/epidemiologia
Herpesvirus Humano 2/imunologia
Herpesvirus Humano 2/patogenicidade
Seres Humanos
Transmissão Vertical de Doença Infecciosa
Meia-Idade
Gravidez
Complicações Infecciosas na Gravidez/epidemiologia
Gestantes
Prevalência
População Rural
Estudos Soroepidemiológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2674-4


  9 / 4415 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28711653
[Au] Autor:Johnston C; Magaret A; Roychoudhury P; Greninger AL; Cheng A; Diem K; Fitzgibbon MP; Huang ML; Selke S; Lingappa JR; Celum C; Jerome KR; Wald A; Koelle DM
[Ad] Endereço:Department of Medicine, University of Washington, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, USA. Electronic address: cjohnsto@uw.edu.
[Ti] Título:Highly conserved intragenic HSV-2 sequences: Results from next-generation sequencing of HSV-2 U and U regions from genital swabs collected from 3 continents.
[So] Source:Virology;510:90-98, 2017 Oct.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Understanding the variability in circulating herpes simplex virus type 2 (HSV-2) genomic sequences is critical to the development of HSV-2 vaccines. METHODS: Genital lesion swabs containing ≥ 10 log copies HSV DNA collected from Africa, the USA, and South America underwent next-generation sequencing, followed by K-mer based filtering and de novo genomic assembly. Sites of heterogeneity within coding regions in unique long and unique short (U _U ) regions were identified. Phylogenetic trees were created using maximum likelihood reconstruction. RESULTS: Among 46 samples from 38 persons, 1468 intragenic base-pair substitutions were identified. The maximum nucleotide distance between strains for concatenated U U segments was 0.4%. Phylogeny did not reveal geographic clustering. The most variable proteins had non-synonymous mutations in < 3% of amino acids. CONCLUSIONS: Unenriched HSV-2 DNA can undergo next-generation sequencing to identify intragenic variability. The use of clinical swabs for sequencing expands the information that can be gathered directly from these specimens.
[Mh] Termos MeSH primário: Sequência Conservada
Genes Virais
Variação Genética
Herpes Genital/virologia
Herpesvirus Humano 2/classificação
Herpesvirus Humano 2/genética
[Mh] Termos MeSH secundário: África
Análise por Conglomerados
Genitália/virologia
Sequenciamento de Nucleotídeos em Larga Escala
Filogenia
Homologia de Sequência
América do Sul
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


  10 / 4415 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28683784
[Au] Autor:Korr G; Thamm M; Czogiel I; Poethko-Mueller C; Bremer V; Jansen K
[Ad] Endereço:Postgraduate Training for Applied Epidemiology (PAE, German Field Epidemiology Training Programme), Robert Koch Institute, Berlin, Germany. geritsolveig.korr@web.de.
[Ti] Título:Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control.
[So] Source:BMC Infect Dis;17(1):471, 2017 Jul 06.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are scarce. A previous study found higher HSV1/2 seroprevalences in women in East Germany than in women in West Germany. We assessed changes in the HSV1/2 seroprevalences over time and investigated determinants associated with HSV1/2 seropositivity to guide prevention and control. METHODS: The study was based on the German Health Interview and Examination Survey for Adults (DEGS; 2008-2011) and the German National Health Interview and Examination Survey (GNHIES; 1997-1999). We tested serum samples from DEGS participants for HSV1 and HSV2 immunoglobulin G. We used Pearson's χ test to compare the HSV1/HSV2 seroprevalences in terms of sex, age, and region of residence (East/West Germany) and investigated potential determinants by calculating prevalence ratios (PR) with log-binomial regression. All statistical analyses included survey weights. RESULTS: In total, 6627 DEGS participants were tested for HSV1, and 5013 were also tested for HSV2. Overall, HSV1 seroprevalence decreased significantly from 1997-1999 (82.1%; 95%CI 80.6-83.6) to 2008-2011 (78.4%; 95%CI 77.8-79.7). In the same period, overall HSV2 seroprevalence decreased significantly from 13.3% (95%CI 11.9-14.9) to 9.6% (95%CI 8.6-10.8), notably in 18-24-year-old men (10.4 to 0%) in East Germany. Women were more likely than men to be seropositive for HSV1 (PR 1.1) or HSV2 (PR 1.6). A lower level of education, smoking, and not speaking German were associated with HSV1 in both sexes. Women of older age, who smoked, or had a history of abortion and men of older age or who had not attended a nursery school during childhood were more often seropositive for HSV2. CONCLUSION: The reduced seroprevalences of HSV1 and HSV2 leave more people susceptible to genital HSV1/2 infections. Practitioners should be aware of HSV infection as a differential diagnosis for genital ulcers. We recommend educational interventions to raise awareness of the sexual transmission route of HSV1/2, possible consequences, and prevention. Interventions should especially target pregnant women, their partners, and people at risk of HIV.
[Mh] Termos MeSH primário: Herpes Genital/epidemiologia
Herpes Simples/epidemiologia
Herpesvirus Humano 1
Herpesvirus Humano 2
[Mh] Termos MeSH secundário: Aborto Induzido/efeitos adversos
Adolescente
Adulto
Idoso
Feminino
Alemanha/epidemiologia
Inquéritos Epidemiológicos
Herpesvirus Humano 1/imunologia
Herpesvirus Humano 1/patogenicidade
Herpesvirus Humano 2/imunologia
Herpesvirus Humano 2/patogenicidade
Seres Humanos
Imunoglobulina G/sangue
Masculino
Meia-Idade
Gravidez
Gestantes
Prevalência
Estudos Soroepidemiológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2527-1



página 1 de 442 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde