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[PMID]: 27772619 [Au] Autor: Abad CL; Razonable RR [Ad] Endereço: Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN. [Ti] Título: α Herpes Virus Infections Among Renal Transplant Recipients. [So] Source: Semin Nephrol;36(5):344-350, 2016 09. [Is] ISSN: 1558-4488 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The α herpes viruses HSV-1, HSV-2, and VZV often reactivate in the setting of immune suppression after solid organ transplantation. Oral or genital mucocutaneous disease is the most common clinical manifestation of HSV disease while VZV manifests as varicella (or chickenpox) or reactivation herpes zoster, characterized by a diffuse rash, or a painful unilateral vesicular eruption in a dermatomal distribution, respectively. The diagnosis of HSV and VZV is primarily based on history and clinical presentation, although diagnostic tests may be necessary for atypical presentations of disease. Treatment usually involves oral or intravenous antiviral therapy, depending on severity of illness. [Mh] Termos MeSH primário: Varicela/induzido quimicamente Rejeição de Enxerto/prevenção & controle Herpes Simples/induzido quimicamente Herpes Zoster/induzido quimicamente Imunossupressores/efeitos adversos Falência Renal Crônica/cirurgia Transplante de Rim [Mh] Termos MeSH secundário: Antivirais/uso terapêutico Varicela/diagnóstico Varicela/tratamento farmacológico Varicela/prevenção & controle Vacina contra Varicela/uso terapêutico Técnicas de Cultura Técnica Direta de Fluorescência para Anticorpo Herpes Simples/diagnóstico Herpes Simples/tratamento farmacológico Herpes Zoster/diagnóstico Herpes Zoster/tratamento farmacológico Herpes Zoster/prevenção & controle Herpesvirus Humano 1 Herpesvirus Humano 2 Herpesvirus Humano 3 Seres Humanos Reação em Cadeia da Polimerase Testes Sorológicos Ativação Viral [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antiviral Agents); 0 (Chickenpox Vaccine); 0 (Immunosuppressive Agents) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 29278902 [Au] Autor: Oh HS; Bae JM [Ad] Endereço: Jeju Heathcare Center of Jeju-si, Jeju, Korea. [Ti] Título: Vaccination history in elementary school children enrolled in the varicella epidemic investigations held in Jeju-si, Korea in the first half of 2017. [So] Source: Epidemiol Health;39:e2017053, 2017. [Is] ISSN: 2092-7193 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: OBJECTIVES: The reported incidence rate of varicella infection in Jeju-do is higher compared with the national average. This study aimed to examine varicella vaccination history and evaluate clinical manifestation of varicella cases in Jeju-do. METHODS: Based on the guideline suggested by the Korea Centers for Disease Control and Prevention (KCDC), two epidemic investigations for varicella infection were conducted in the first half of 2017. The history of varicella vaccination was confirmed using the Integrated Control System for Diseases and Health operated by the KCDC. RESULTS: Out of a total of 60 elementary school children as the study subjects, all had been previously vaccinated against varicella. Twenty cases (33%) showed mild clinical manifestations and no complications. CONCLUSIONS: As the government of Jeju-do has supplied a single-labeled vaccine since 2011, there is a need to evaluate the type of vaccination failure such as primary or secondary. [Mh] Termos MeSH primário: Vacina contra Varicela/administração & dosagem Varicela/prevenção & controle Epidemias/prevenção & controle Vacinação/estatística & dados numéricos [Mh] Termos MeSH secundário: Varicela/epidemiologia Criança Seres Humanos Programas de Imunização República da Coreia/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chickenpox Vaccine) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171228 [St] Status: MEDLINE [do] DOI: 10.4178/epih.e2017053

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[PMID]: 28746535 [Au] Autor: Rea G; Costigliola A; Calabrese C [Ad] Endereço: . Dipartimento di Radiologia, A.O. dei Colli, Ospedale Monaldi di Napoli, Napoli, Italia. [Ti] Título: A storm of stones in the lungs: an uncommon sequela of varicella pneumonia. [So] Source: J Bras Pneumol;43(3):246, 2017 May-Jun. [Is] ISSN: 1806-3756 [Cp] País de publicação: Brazil [La] Idioma: eng; por [Mh] Termos MeSH primário: Varicela/complicações Pneumonia Viral/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Feminino Seres Humanos Pneumonia Viral/etiologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171211 [Lr] Data última revisão: 171211 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170727 [St] Status: MEDLINE

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[PMID]: 28748773 [Au] Autor: Jin L; Xu S; Maple PAC; Xu W; Brown KE [Ad] Endereço: Virus Reference Department,National Infections Service,Public Health England,London,UK. [Ti] Título: Differentiation between wild-type and vaccines strains of varicella zoster virus (VZV) based on four single nucleotide polymorphisms. [So] Source: Epidemiol Infect;145(12):2618-2625, 2017 09. [Is] ISSN: 1469-4409 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Varicella-zoster virus (VZV) infection (chickenpox) results in latency and subsequent reactivation manifests as shingles. Effective attenuated vaccines (vOka) are available for prevention of both illnesses. In this study, an amplicon-based sequencing method capable of differentiating between VZV wild-type (wt) strains and vOka vaccine is described. A total of 44 vesicular fluid specimens collected from 43 patients (16 from China and 27 from the UK) with either chickenpox or shingles were investigated, of which 10 had received previous vaccination. Four sets of polymerase chain reactions were set up simultaneously with primers amplifying regions encompassing four single nucleotide polymorphisms (SNPs), '69349-106262-107252-108111'. Nucleotide sequences were generated by Sanger sequencing. All samples except one had a wt SNP profile of 'A-T-T-T'. The sample collected from a patient who received vaccine 7-10 days ago, along with VZV vaccine preparations, Zostavax and Baike-varicella gave a SNP profile 'G-C-C-C'. The results show that this method can distinguish vaccine-derived virus from wt viruses from main four clades, (clades 1-4) and should be of utility worldwide. [Mh] Termos MeSH primário: Vacina contra Varicela/genética Herpesvirus Humano 3/genética Reação em Cadeia da Polimerase Polimorfismo de Nucleotídeo Único [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Varicela/virologia Vacina contra Varicela/classificação Criança Pré-Escolar China Inglaterra Feminino Herpes Zoster/virologia Herpesvirus Humano 3/classificação Seres Humanos Lactente Masculino Meia-Idade Escócia Análise de Sequência de DNA Vacinas Atenuadas/classificação Vacinas Atenuadas/genética Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chickenpox Vaccine); 0 (Vaccines, Attenuated) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171125 [Lr] Data última revisão: 171125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1017/S0950268817001509

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[PMID]: 28853391 [Au] Autor: Walker JL; Andrews NJ; Mathur R; Smeeth L; Thomas SL [Ad] Endereço: Statistics,Modelling and Economics Department,Public Health England,61 Colindale Avenue,London NW9 5EQ,UK. [Ti] Título: Trends in the burden of varicella in UK general practice. [So] Source: Epidemiol Infect;145(13):2678-2682, 2017 10. [Is] ISSN: 1469-4409 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Childhood varicella vaccination has not yet been introduced in the UK. To inform decision-making about future vaccine programmes, data on the burden of varicella in general practice over a 10-year period (01/01/2005-31/12/2014) was calculated by age and ethnicity, using anonymised data from >8 million individuals in the Clinical Practice Research Datalink. Varicella consultations peaked at 20 603 in 2007, then decreased annually in all age groups to 11 243 in 2014. Each year, consultation rates were common among infants, were highest among 1-3 year olds (61·2 consultations/1000 person-years in 2007, 39·7/1000 person-years in 2014) and then fell with increasing age to <1·0/1000 person-years at ages ⩾20 years. Varicella acquisition appeared to be delayed in some ethnic groups, with lower consultation rates for children aged <3 years but increased rates for older children and adults aged ⩽40 years among those of black African, Afro-Caribbean, South Asian or other Asian ethnicity. Decreasing general practice consultation rates over time could reflect changes in healthcare utilisation, with patients seeking care in alternative settings such as Accident and Emergency Departments, although current data prevent full assessment of this. Availability of data on varicella diagnoses across all health settings would enable estimation of the total healthcare burden due to varicella and the cost-effectiveness of introducing varicella vaccination. [Mh] Termos MeSH primário: Varicela/epidemiologia Medicina Geral Encaminhamento e Consulta/tendências [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Varicela/virologia Criança Pré-Escolar Medicina Geral/estatística & dados numéricos Herpesvirus Humano 3/fisiologia Seres Humanos Lactente Recém-Nascido Meia-Idade Reino Unido/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171125 [Lr] Data última revisão: 171125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170831 [St] Status: MEDLINE [do] DOI: 10.1017/S0950268817001649

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[PMID]: 28826422 [Au] Autor: Bollaerts K; Riera-Montes M; Heininger U; Hens N; Souverain A; Verstraeten T; Hartwig S [Ad] Endereço: P95 Pharmacovigilance and Epidemiology Services,Koning Leopold III Laan 1,Leuven 3001,Belgium. [Ti] Título: A systematic review of varicella seroprevalence in European countries before universal childhood immunization: deriving incidence from seroprevalence data. [So] Source: Epidemiol Infect;145(13):2666-2677, 2017 10. [Is] ISSN: 1469-4409 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Surveillance systems for varicella in Europe are highly heterogeneous or completely absent. We estimated the varicella incidence based on seroprevalence data, as these data are largely available and not biased by under-reporting or underascertainment. We conducted a systematic literature search for varicella serological data in Europe prior to introduction of universal varicella immunization. Age-specific serological data were pooled by country and serological profiles estimated using the catalytic model with piecewise constant force of infection. From the estimated profiles, we derived the annual incidence of varicella infection (/100·000) for six age groups (<5, 5-9, 10-14, 15-19, 20-39 and 40-65 years). In total, 43 studies from 16 countries were identified. By the age of 15 years, over 90% of the population has been infected by varicella in all countries except for Greece (86·6%) and Italy (85·3%). Substantial variability across countries exists in the age-specific annual incidence of varicella primary infection among the <5 years old (from 7052 to 16 122 per 100 000) and 5-9 years old (from 3292 to 11 798 per 100 000). The apparent validity and robustness of our estimates highlight the importance of serological data for the characterization of varicella epidemiology, even in the absence of sampling or assay standardization. [Mh] Termos MeSH primário: Varicela/história Herpesvirus Humano 3/fisiologia Imunização/história [Mh] Termos MeSH secundário: Fatores Etários Varicela/epidemiologia Varicela/prevenção & controle Europa (Continente)/epidemiologia História do Século XX Seres Humanos Imunização/estatística & dados numéricos Incidência Estudos Soroepidemiológicos [Pt] Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171125 [Lr] Data última revisão: 171125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170823 [St] Status: MEDLINE [do] DOI: 10.1017/S0950268817001546

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[PMID]: 28803571 [Au] Autor: Helmuth IG; Poulsen A; Mølbak K [Ad] Endereço: Department of Paediatrics and Adolescent Medicine,Rigshospitalet,Copenhagen,Denmark. [Ti] Título: A national register-based study of paediatric varicella hospitalizations in Denmark 2010-2016. [So] Source: Epidemiol Infect;145(13):2683-2693, 2017 10. [Is] ISSN: 1469-4409 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Varicella, usually a mild disease of childhood, can also cause complications and hospitalization. Universal varicella immunization is implemented in several countries worldwide, but not in Denmark. Taking advantage of unique national registers, we aimed to estimate the incidence of paediatric varicella hospitalizations and assess determinants for hospitalization. For this purpose, we designed a nationwide, retrospective register study of paediatric varicella hospitalizations and applied a case-cohort design and logistic regression analysis comparing hospitalized varicella patients to a sample of the entire paediatric population in Denmark. Varicella patients were identified in The Danish National Patient Register and referents were randomly selected from the Danish Civil Registration System. The incidence of paediatric varicella admissions was 11/100 000 children 0-18 years of age/year. Of admitted children 67·1% had complications and 30·0% had underlying disease. All categories of underlying disease significantly increased the odds of hospitalization as well as male gender and not having been born in Denmark. In conclusion, we found a considerable burden of paediatric varicella disease in Danish hospitals, of similar magnitude as in other European countries comparable to Denmark. With this study we have provided epidemiological data needed for considering implementation of varicella vaccine in Denmark. [Mh] Termos MeSH primário: Varicela/epidemiologia Hospitalização/estatística & dados numéricos [Mh] Termos MeSH secundário: Adolescente Varicela/virologia Criança Pré-Escolar Estudos de Coortes Dinamarca/epidemiologia Feminino Seres Humanos Incidência Lactente Recém-Nascido Modelos Logísticos Masculino Sistema de Registros Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171125 [Lr] Data última revisão: 171125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170815 [St] Status: MEDLINE [do] DOI: 10.1017/S0950268817001777

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[PMID]: 28783042 [Au] Autor: Ogunjimi B; Zhang SY; Sørensen KB; Skipper KA; Carter-Timofte M; Kerner G; Luecke S; Prabakaran T; Cai Y; Meester J; Bartholomeus E; Bolar NA; Vandeweyer G; Claes C; Sillis Y; Lorenzo L; Fiorenza RA; Boucherit S; Dielman C; Heynderickx S; Elias G; Kurotova A; Auwera AV; Verstraete L; Lagae L; Verhelst H; Jansen A; Ramet J; Suls A; Smits E; Ceulemans B; Van Laer L; Plat Wilson G; Kreth J; Picard C; Von Bernuth H; Fluss J; Chabrier S; Abel L; Mortier G; Fribourg S; Mikkelsen JG; Casanova JL; Paludan SR; Mogensen TH [Ad] Endereço: Centre for Health Economics Research & Modeling Infectious Diseases, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium. [Ti] Título: Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. [So] Source: J Clin Invest;127(9):3543-3556, 2017 Sep 01. [Is] ISSN: 1558-8238 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Varicella zoster virus (VZV) typically causes chickenpox upon primary infection. In rare cases, VZV can give rise to life-threatening disease in otherwise healthy people, but the immunological basis for this remains unexplained. We report 4 cases of acute severe VZV infection affecting the central nervous system or the lungs in unrelated, otherwise healthy children who are heterozygous for rare missense mutations in POLR3A (one patient), POLR3C (one patient), or both (two patients). POLR3A and POLR3C encode subunits of RNA polymerase III. Leukocytes from all 4 patients tested exhibited poor IFN induction in response to synthetic or VZV-derived DNA. Moreover, leukocytes from 3 of the patients displayed defective IFN production upon VZV infection and reduced control of VZV replication. These phenotypes were rescued by transduction with relevant WT alleles. This work demonstrates that monogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in otherwise healthy children, providing evidence for an essential role of a DNA sensor in human immunity. [Mh] Termos MeSH primário: Varicela/genética Herpes Zoster/genética Mutação RNA Polimerase III/genética RNA Polimerase III/metabolismo [Mh] Termos MeSH secundário: Alelos Animais Criança Análise Mutacional de DNA Regulação Enzimológica da Expressão Gênica Células HEK293 Herpesvirus Humano 3 Heterozigoto Seres Humanos Leucócitos/metabolismo Camundongos Mutação de Sentido Incorreto Fenótipo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: EC 2.7.7.6 (RNA Polymerase III) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171024 [Lr] Data última revisão: 171024 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170808 [St] Status: MEDLINE

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[PMID]: 28774264 [Au] Autor: Chen B; Sumi A; Wang L; Zhou W; Kobayashi N [Ad] Endereço: Department of Infectious Diseases Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, Hubei, China. [Ti] Título: Role of meteorological conditions in reported chickenpox cases in Wuhan and Hong Kong, China. [So] Source: BMC Infect Dis;17(1):538, 2017 Aug 03. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Chickenpox is a common contagious disease that remains an important public health issue worldwide. Over 90% of unvaccinated individuals become infected, but infection occurs at different ages in different parts of the world. Many people have been infected by 20 to 30 years of age in China, and adults and pregnant women who become infected often develop severe infection. Furthermore, a mortality rate of 2-3 per 100,000 infected persons has been reported. In this study, we explore the temperature-dependent transition of patterns of reported chickenpox cases in two large subtropical climate cities, Wuhan and Hong Kong, China, to aid in the prediction of epidemics and preparation for the effects of climatic changes on epidemiology of chickenpox in China. METHODS: We used a time series analysis comprising a spectral analysis based on the maximum entropy method in the frequency domain and the nonlinear least squares method in the time domain. Specifically, the following time series data were analyzed: data of reported chickenpox cases and meteorological data, including the mean temperature, relative humidity and total rainfall in Wuhan and Hong Kong from January 2008 to June 2015. RESULTS: The time series data of chickenpox for both Wuhan and Hong Kong have two peaks per year, one in winter and another in spring, indicating a bimodal cycle. To investigate the source of the bimodal cycle of the chickenpox data, we defined the contribution ratio of the 1-year cycle, Q , and the 6-month cycle, Q , as the contribution of the amplitude of a 1-year cycle and a 6-month cycle, respectively, to the entire amplitude of the time-series data. The Q values of Wuhan and Hong Kong were positively correlated with the annual mean temperature and rainfall of each city. Conversely, the Q values of Wuhan and Hong Kong were negatively correlated with the annual mean temperature and rainfall of Wuhan and Hong Kong. CONCLUSION: Our results showed that the mean temperature and rainfall have a significant influence on the incidence of chickenpox, and might be important predictors of chickenpox incidence in Wuhan and Hong Kong. [Mh] Termos MeSH primário: Varicela/epidemiologia [Mh] Termos MeSH secundário: Adolescente Adulto Distribuição por Idade Criança Pré-Escolar China/epidemiologia Hong Kong/epidemiologia Seres Humanos Incidência Análise dos Mínimos Quadrados Chuvas Estações do Ano Temperatura Ambiente Tempo (Meteorologia) Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170805 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2640-1

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[PMID]: 28705150 [Au] Autor: Meszner Z; Molnar Z; Rampakakis E; Yang HK; Kuter BJ; Wolfson LJ [Ad] Endereço: St. László Hospital for Infectious Diseases, National Institute of Child Health, Budapest, Hungary. [Ti] Título: Economic burden of varicella in children 1-12 Years of age in Hungary, 2011-2015. [So] Source: BMC Infect Dis;17(1):495, 2017 Jul 14. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Although live-attenuated varicella-zoster virus (VZV) vaccines have been proven to be safe and effective in preventing varicella and real-word evidence shows routine childhood immunization programs are effective in dramatically reducing varicella associated morbidity and mortality, varicella vaccine is not included in the National Immunization Program (NIP) in Hungary. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Hungary. METHODS: This was a multicenter, retrospective, chart review study of patients aged 1-12 years with a primary varicella diagnosis between 2011 and 2015. Healthcare resource utilization (HCRU) associated with varicella, unit costs, and work loss were used to estimate direct and indirect costs. All costs are presented in 2015 HUF / Euros (€). RESULTS: 156 children with varicella were included (75 outpatients, 81 inpatients), with a mean age of 4.4 (SD: 2.0) and 3.7 (SD: 2.1) years, respectively. One or more complications were reported by 12.0% of outpatients and 92.6% of inpatients, the most common being dehydration, skin and soft tissue infections, pneumonia, keratoconjunctivitis, and cerebellitis. HCRU estimates included use of over-the-counter (OTC) medications (96.0% outpatients, 53.1% inpatients), prescription medications (9.3% outpatients, 70.4% inpatients), tests/procedures (4.0% outpatients, 97.5% inpatients), and consultation with allied health professionals (2.7% outpatients, 30.9% inpatients). The average duration of hospital stay (inpatients) was 3.6 (95% CI: 3.2, 4.1) days. The total combined direct and indirect cost per varicella case was 228,146.7 Hungarian Forint (HUF)/€ 736.0 for inpatients and 49,790.6 HUF/€ 106.6 for outpatients. The overall annual cost of varicella in Hungary for children aged <15 years in 2015 was estimated at 1,903,332,524.3 HUF/ € 6,139,980.4. CONCLUSION: Varicella is associated with substantial clinical burden in Hungary, resulting in the utilization of a significant amount of healthcare resources. These results support the need for routine vaccination of all healthy children to reduce the varicella-associated disease burden. [Mh] Termos MeSH primário: Varicela/economia Varicela/epidemiologia [Mh] Termos MeSH secundário: Varicela/prevenção & controle Varicela/terapia Vacina contra Varicela/economia Vacina contra Varicela/uso terapêutico Criança Pré-Escolar Custos e Análise de Custo Feminino Seres Humanos Hungria/epidemiologia Programas de Imunização/economia Lactente Pacientes Internados Tempo de Internação Masculino Morbidade Pacientes Ambulatoriais Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Chickenpox Vaccine) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170715 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2575-6

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