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  1 / 4032 MEDLINE  
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[PMID]:29256289
[Au] Autor:Keros T; Jemersic L; Toplak I; Prpic J
[Ad] Endereço:1 Department of Virology, Croatian Veterinary Institute , Savska cesta 143, HR-10 000 Zagreb , Croatia.
[Ti] Título:The silent spread of Porcine Bocavirus in Croatian pigs: should we be concerned?
[So] Source:Acta Vet Hung;65(4):565-573, 2017 12.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:A survey was conducted to evaluate the presence and prevalence of Porcine Bocavirus (PBoV) in Croatian domestic pigs by means of PCR targeting the NS1 gene fragment of PBoV. This study included testing of faecal samples collected from 10 small commercial farms and 11 small backyard holdings in Croatia. The presence of PBoV was confirmed by PCR in 24 out of 57 composite faecal samples from small commercial farms and in 12 out of 43 composite faecal samples from small backyard holdings. The PCR products of 18 positive samples were sequenced for genotyping. PBoV sequences grouped into the PBoV-a, PBoV-b and PBoV-c groups with 90.81% to 99.25% nucleotide identity. All Croatian PBoV sequences showed a high nucleotide and amino acid identity with PBoV sequences from China and Hong Kong, the United States, Sweden, and Slovenia. These results clearly show that PBoV is circulating among the domestic pig population in Croatia.
[Mh] Termos MeSH primário: Bocavirus/isolamento & purificação
Infecções por Parvoviridae/veterinária
Doenças dos Suínos/virologia
[Mh] Termos MeSH secundário: Animais
Croácia
Infecções por Parvoviridae/epidemiologia
Infecções por Parvoviridae/virologia
Filogenia
Suínos
Doenças dos Suínos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.055


  2 / 4032 MEDLINE  
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[PMID]:27772627
[Au] Autor:Razonable RR
[Ad] Endereço:Division of Infectious Diseases and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN. Electronic address: razonable.raymund@mayo.edu.
[Ti] Título:Not the Usual Viral Suspects: Parvovirus B19, West Nile Virus, and Human T-Cell Lymphotrophic Virus Infections After Kidney Transplantation.
[So] Source:Semin Nephrol;36(5):428-434, 2016 09.
[Is] ISSN:1558-4488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. In this review article, the epidemiology, clinical manifestations, diagnosis and treatment of less common viruses are discussed in the setting of kidney transplantation.
[Mh] Termos MeSH primário: Eritema Infeccioso/induzido quimicamente
Rejeição de Enxerto/prevenção & controle
Infecções por HTLV-I/induzido quimicamente
Imunossupressores/efeitos adversos
Falência Renal Crônica/cirurgia
Transplante de Rim
Leucemia-Linfoma de Células T do Adulto/induzido quimicamente
Febre do Nilo Ocidental/induzido quimicamente
[Mh] Termos MeSH secundário: Antivirais/uso terapêutico
Eritema Infeccioso/diagnóstico
Eritema Infeccioso/terapia
Infecções por HTLV-I/diagnóstico
Infecções por HTLV-I/terapia
Seres Humanos
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Leucemia-Linfoma de Células T do Adulto/terapia
Leucemia-Linfoma de Células T do Adulto/virologia
Paraparesia Espástica Tropical/induzido quimicamente
Paraparesia Espástica Tropical/diagnóstico
Paraparesia Espástica Tropical/terapia
Paraparesia Espástica Tropical/virologia
Infecções por Parvoviridae/induzido quimicamente
Infecções por Parvoviridae/diagnóstico
Infecções por Parvoviridae/terapia
Febre do Nilo Ocidental/diagnóstico
Febre do Nilo Ocidental/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  3 / 4032 MEDLINE  
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[PMID]:29213152
[Au] Autor:Valencia Pacheco G; Nakazawa Ueji YE; Rodríguez Dzul EA; Angulo Ramírez AV; López Villanueva RF; Quintal Ortiz IG; Rosado Paredes EP
[Ad] Endereço:Laboratorio de Hematología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán. Mérida, Yucatán, México.
[Ti] Título:Serological and molecular analysis of parvovirus B19 infection in Mayan women with systemic lupus erythematosus in Mexico.
[So] Source:Colomb Med (Cali);48(3):105-112, 2017 Sep 30.
[Is] ISSN:1657-9534
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that mainly affects women, characterized by the production of autoantibodies. Its causal agent is unknown, but the combination of environmental, hormonal and genetic factors may favor the development of the disease. Parvovirus B19 has been associated with the development of SLE, since it induces the production of anti-single stranded DNA antibodies. It is unknown whether PV-B19 infection is an environmental factor that trigger or reactivate SLE in the Mexican Mayan population. Aim: A preliminary serological and molecular study of PV-B19 infection in Mayan women with established SLE was done. Methods: IgG and IgM anti PV-B19 were evaluated in 66 SLE patients and 66 control subjects, all women of Mayan origin. Viral DNA and viral load were analyzed by qPCR. Results: Insignificant levels of IgM were observed in 14.3% (4/28) of the patients and 11.4% (4/35) of control subjects. IgG was detected in 82.1% (23/28) of the patients and 82.9% (29/35) of control subjects, but were significantly higher in patients. Viral DNA was found in 86.0% (57/66) of the patients and 81.0% (54/66) of control subjects. Viral load, quantified in 28/66 patients and 31/66 controls which were positive for IgM and IgG, was significantly higher in controls. Conclusion: The high prevalence of PV-B19 in Yucatan, and the presence of IgM, IgG, and viral load in Mayan women with established SLE suggest that PV-B19 infection could be an environmental factor to trigger or reactivate SLE.
[Mh] Termos MeSH primário: Índios Norte-Americanos
Lúpus Eritematoso Sistêmico/virologia
Infecções por Parvoviridae/complicações
Parvovirus B19 Humano
[Mh] Termos MeSH secundário: Adulto
Anticorpos Antivirais/sangue
Estudos de Casos e Controles
DNA Viral/sangue
Feminino
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Índios Norte-Americanos/etnologia
Índios Norte-Americanos/genética
Lúpus Eritematoso Sistêmico/etnologia
México/etnologia
Infecções por Parvoviridae/diagnóstico
Parvovirus B19 Humano/genética
Parvovirus B19 Humano/imunologia
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral); 0 (Immunoglobulin G); 0 (Immunoglobulin M)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.25100/cm.v48i3.2981


  4 / 4032 MEDLINE  
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[PMID]:29049413
[Au] Autor:Zhou P; Zhang X; Zeng W; Zheng Q; Hao X; Lin X; Zheng Y; Wang L; Zhang G; Li S
[Ad] Endereço:College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
[Ti] Título:MicroRNA expression analysis of feline and canine parvovirus infection in vivo (felis).
[So] Source:PLoS One;12(10):e0185698, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Feline panleukopenia is a common contagious disease with high morbidity and mortality. At present, feline parvovirus (FPV) and canine parvovirus (CPV) variants are the pathogens of feline panleukopenia. Many studies have shown that miRNAs are involved in virus-host interactions. Nevertheless, miRNA expression profiling of FPV (original virus) or CPV-2b (new virus) in cats has not been reported. To investigate these profiles, three 10-week-old cats were orally inoculated with 106 TCID50 of the viruses (FPV and CPV-2b), and the jejunums of one cat in each group were sectioned for miRNA sequencing at 5 days post-inoculation (dpi). This study is the first attempt to use miRNA analysis to understand the molecular basis of FPV and CPV infection in cats. The miRNA expression profiles of the jejunums of cats infected with FPV and CPV were obtained, and a subset of miRNAs was validated by real-time qPCR. The results show that a variety of metabolism-related pathways, cytokine- and pathogen-host interaction-related pathways, and pathology- and cellar structure-related pathways, as well as others, were affected. Specifically, the JAK-STAT signaling pathway, which is critical for cytokines and growth factors, was enriched. This description of the miRNAs involved in regulating FPV and CPV infection in vivo provides further insight into the mechanisms of viral infection and adaptation and might provide an alternative antiviral strategy for disease control and prevention.
[Mh] Termos MeSH primário: Doenças do Gato/genética
Doenças do Cão/genética
MicroRNAs/genética
Infecções por Parvoviridae/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/virologia
Gatos
Doenças do Cão/virologia
Cães
Infecções por Parvoviridae/virologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185698


  5 / 4032 MEDLINE  
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[PMID]:28984228
[Au] Autor:Sehata G; Sato H; Yamanaka M; Takahashi T; Kainuma R; Igarashi T; Oshima S; Noro T; Oishi E
[Ad] Endereço:Kyoto Biken Laboratories, Inc., 24-16 Makishima, Uji, Kyoto 611-0041, Japan.
[Ti] Título:Substitutions at residues 300 and 389 of the VP2 capsid protein serve as the minimal determinant of attenuation for canine parvovirus vaccine strain 9985-46.
[So] Source:J Gen Virol;98(11):2759-2770, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Identifying molecular determinants of virulence attenuation in live attenuated canine parvovirus (CPV) vaccines is important for assuring their safety. To this end, we identified mutations in the attenuated CPV 9985-46 vaccine strain that arose during serial passage in Crandell-Rees feline kidney cells by comparison with the wild-type counterpart, as well as minimal determinants of the loss of virulence. Four amino acid substitutions (N93K, G300V, T389N and V562L) in VP2 of strain 9985-46 significantly restricted infection in canine A72 cells. Using an infectious molecular clone system, we constructed isogenic CPVs of the parental virulent 9985 strain carrying single or double mutations. We observed that only a single amino acid substitution in VP2, G300V or T389N, attenuated the virulent parental virus. Combinations of these mutations further attenuated CPV to a level comparable to that of 9985-46. Strains with G300V/T389N substitutions did not induce clinical symptoms in experimentally infected pups, and their ability to infect canine cells was highly restricted. We found that another G300V/V562L double mutation decreased affinity of the virus for canine cells, although its pathogenicity to dogs was maintained. These results indicate that mutation of residue 300, which plays a critical role in host tropism, is not sufficient for viral attenuation in vivo, and that attenuation of 9985-46 strain is defined by at least two mutations in residues 300 and 389 of the VP2 capsid protein. This finding is relevant for quality control of the vaccine and provides insight into the rational design of second-generation live attenuated vaccine candidates.
[Mh] Termos MeSH primário: Substituição de Aminoácidos
Proteínas do Capsídeo/genética
Proteínas do Capsídeo/metabolismo
Parvovirus Canino/genética
Parvovirus Canino/patogenicidade
Vacinas Virais/genética
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Linhagem Celular
Análise Mutacional de DNA
Doenças do Cão/patologia
Doenças do Cão/virologia
Cães
Infecções por Parvoviridae/patologia
Infecções por Parvoviridae/veterinária
Infecções por Parvoviridae/virologia
Inoculações Seriadas
Vacinas Atenuadas/genética
Fatores de Virulência/genética
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (Vaccines, Attenuated); 0 (Viral Vaccines); 0 (Virulence Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000936


  6 / 4032 MEDLINE  
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[PMID]:28934425
[Au] Autor:Schlaberg R; Ampofo K; Tardif KD; Stockmann C; Simmon KE; Hymas W; Flygare S; Kennedy B; Blaschke A; Eilbeck K; Yandell M; McCullers JA; Williams DJ; Edwards K; Arnold SR; Bramley A; Jain S; Pavia AT
[Ad] Endereço:Department of Pathology.
[Ti] Título:Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia.
[So] Source:J Infect Dis;216(6):688-696, 2017 Sep 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: The role of human bocavirus (HBoV) in respiratory illness is uncertain. HBoV genomic DNA is frequently detected in both ill and healthy children. We hypothesized that spliced viral capsid messenger RNA (mRNA) produced during active replication might be a better marker for acute infection. Methods: As part of the Etiology of Pneumonia in the Community (EPIC) study, children aged <18 years who were hospitalized with community-acquired pneumonia (CAP) and children asymptomatic at the time of elective outpatient surgery (controls) were enrolled. Nasopharyngeal/oropharyngeal specimens were tested for HBoV mRNA and genomic DNA by quantitative polymerase chain reaction. Results: HBoV DNA was detected in 10.4% of 1295 patients with CAP and 7.5% of 721 controls (odds ratio [OR], 1.4 [95% confidence interval {CI}, 1.0-2.0]); HBoV mRNA was detected in 2.1% and 0.4%, respectively (OR, 5.1 [95% CI, 1.6-26]). When adjusted for age, enrollment month, and detection of other respiratory viruses, HBoV mRNA detection (adjusted OR, 7.6 [95% CI, 1.5-38.4]) but not DNA (adjusted OR, 1.2 [95% CI, .6-2.4]) was associated with CAP. Among children with no other pathogens detected, HBoV mRNA (OR, 9.6 [95% CI, 1.9-82]) was strongly associated with CAP. Conclusions: Detection of HBoV mRNA but not DNA was associated with CAP, supporting a pathogenic role for HBoV in CAP. HBoV mRNA could be a useful target for diagnostic testing.
[Mh] Termos MeSH primário: Bocavirus/isolamento & purificação
Proteínas do Capsídeo/genética
Infecções por Parvoviridae/diagnóstico
Pneumonia Viral/diagnóstico
RNA Mensageiro/isolamento & purificação
RNA Viral/isolamento & purificação
[Mh] Termos MeSH secundário: Doença Aguda
Bocavirus/genética
Estudos de Casos e Controles
Criança
Pré-Escolar
Infecções Comunitárias Adquiridas/diagnóstico
Infecções Comunitárias Adquiridas/virologia
Hospitalização
Seres Humanos
Lactente
Masculino
Nasofaringe/virologia
Orofaringe/virologia
Estudos Prospectivos
Manejo de Espécimes
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (RNA, Messenger); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix352


  7 / 4032 MEDLINE  
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[PMID]:28910409
[Au] Autor:De R; Liu L; Qian Y; Zhu R; Deng J; Wang F; Sun Y; Dong H; Jia L; Zhao L
[Ad] Endereço:Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing, China.
[Ti] Título:Risk of acute gastroenteritis associated with human bocavirus infection in children: A systematic review and meta-analysis.
[So] Source:PLoS One;12(9):e0184833, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human bocaviruses (HBoVs), which were first identified in 2005 and are composed of genotypes 1-4, have been increasingly detected worldwide in pediatric patients with acute gastroenteritis. To investigate if HBoV infection is a risk factor of acute gastroenteritis in children younger than 5 years old, we searched PubMed, Embase (via Ovid), the Chinese Biomedical Literature Database (CBM), and the Cochrane Library for studies assessing the prevalence of HBoVs in individuals from Oct 25, 2005 to Oct 31, 2016. We included studies using PCR-based diagnostics for HBoVs from stool specimens of patients with or without acute gastroenteritis that carried out research for over 1 year on pediatric patients aged younger than 5 years old. The primary outcome was the HBoV prevalence among all cases with acute gastroenteritis. Pooled estimates of the HBoV prevalence were then generated by fitting linear mixed effect meta-regression models. Of the 36 studies included, the pooled HBoV prevalence in 20,591 patients with acute gastroenteritis was 6.90% (95% confidence interval (95% CI): 5.80-8.10%). In the ten studies with a control group, HBoVs were detected in 12.40% of the 3,620 cases with acute gastroenteritis and in 12.22% of the 2,030 control children (odds ratio (OR): 1.44; 95% CI: 0.95-2.19, p = 0.09 between case and control groups). HBoV1 and HBoV2 were detected in 3.49% and 8.59% of acute gastroenteritis cases, respectively, and in 2.22% and 5.09% of control children, respectively (OR: 1.40; 95% CI: 0.61-3.25; p = 0.43 and OR: 1.68; 95% CI: 1.21-2.32; p = 0.002, respectively). Current evidence suggests that the overall HBoV prevalence in children younger than 5 years old is not significantly different between groups with or without acute gastroenteritis. However, when HBoV1 was excluded, the HBoV2 prevalence was significantly different between these two groups, which may imply that HBoV2 is a risk factor of acute gastroenteritis in children younger than 5 years old.
[Mh] Termos MeSH primário: Gastroenterite/virologia
Bocavirus Humano/genética
Infecções por Parvoviridae/epidemiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Genótipo
Bocavirus Humano/classificação
Seres Humanos
Lactente
Recém-Nascido
Masculino
Infecções por Parvoviridae/complicações
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184833


  8 / 4032 MEDLINE  
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[PMID]:28864597
[Au] Autor:Fullerton HJ; Luna JM; Wintermark M; Hills NK; Tokarz R; Li Y; Glaser C; DeVeber GA; Lipkin WI; Elkind MSV; and the VIPS Investigators*
[Ad] Endereço:From the Department of Neurology (H.J.F.), Department of Pediatrics (H.J.F.), and Department of Biostatistics and Epidemiology (N.K.H.), University of California, San Francisco; Department of Epidemiology (J.M.L., R.T., W.I.L., M.S.V.E.) and Department of Neurology (M.S.V.E.), Columbia University Co
[Ti] Título:Parvovirus B19 Infection in Children With Arterial Ischemic Stroke.
[So] Source:Stroke;48(10):2875-2877, 2017 Oct.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Case-control studies suggest that acute infection transiently increases the risk of childhood arterial ischemic stroke. We hypothesized that an unbiased pathogen discovery approach utilizing MassTag-polymerase chain reaction would identify pathogens in the blood of childhood arterial ischemic stroke cases. METHODS: The multicenter international VIPS study (Vascular Effects of Infection in Pediatric Stroke) enrolled arterial ischemic stroke cases, and stroke-free controls, aged 29 days through 18 years. Parental interview included questions on recent infections. In this pilot study, we used MassTag-polymerase chain reaction to test the plasma of the first 161 cases and 34 controls enrolled for a panel of 28 common bacterial and viral pathogens. RESULTS: Pathogen DNA was detected in no controls and 14 cases (8.7%): parvovirus B19 (n=10), herpesvirus 6 (n=2), adenovirus (n=1), and rhinovirus 6C (n=1). Parvovirus B19 infection was confirmed by serologies in all 10; infection was subclinical in 8. Four cases with parvovirus B19 had underlying congenital heart disease, whereas another 5 had a distinct arteriopathy involving a long-segment stenosis of the distal internal carotid and proximal middle cerebral arteries. CONCLUSIONS: Using MassTag-polymerase chain reaction, we detected parvovirus B19-a virus known to infect erythrocytes and endothelial cells-in some cases of childhood arterial ischemic stroke. This approach can generate new, testable hypotheses about childhood stroke pathogenesis.
[Mh] Termos MeSH primário: Isquemia Encefálica/epidemiologia
Infecções por Parvoviridae/epidemiologia
Parvovirus B19 Humano
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Isquemia Encefálica/diagnóstico
Isquemia Encefálica/virologia
Estudos de Casos e Controles
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Infecções por Parvoviridae/diagnóstico
Parvovirus B19 Humano/isolamento & purificação
Projetos Piloto
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.018272


  9 / 4032 MEDLINE  
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Miagostovich, Marize Pereira
Leite, José Paulo Gagliardi
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[PMID]:28854225
[Au] Autor:Portes SAR; Carvalho-Costa FA; Rocha MS; Fumian TM; Maranhão AG; de Assis RM; Xavier MDPTP; Rocha MS; Miagostovich MP; Leite JPG; Volotão EM
[Ad] Endereço:Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:Enteric viruses in HIV-1 seropositive and HIV-1 seronegative children with diarrheal diseases in Brazil.
[So] Source:PLoS One;12(8):e0183196, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diarrheal diseases (DD) have distinct etiological profiles in immune-deficient and immune-competent patients. This study compares detection rates, genotype distribution and viral loads of different enteric viral agents in HIV-1 seropositive (n = 200) and HIV-1 seronegative (n = 125) children hospitalized with DD in Rio de Janeiro, Brazil. Except for group A rotavirus (RVA), which were detected through enzyme immunoassay, the other enteric viruses (norovirus [NoV], astrovirus [HAstV], adenovirus [HAdV] and bocavirus [HBoV]) were detected through PCR or RT-PCR. A quantitative PCR was performed for RVA, NoV, HAstV, HAdV and HBoV. Infections with NoV (19% vs. 9.6%; p<0.001), HBoV (14% vs. 7.2%; p = 0.042) and HAdV (30.5% vs. 14.4%; p<0.001) were significantly more frequent among HIV-1 seropositive children. RVA was significantly less frequent among HIV-1 seropositive patients (6.5% vs. 20%; p<0.001). Similarly, frequency of infection with HAstV was lower among HIV-1 seropositive children (5.5% vs. 12.8%; p = 0.018). Among HIV-1 seropositive children 33 (16.5%) had co-infections, including three enteric viruses, such as NoV, HBoV and HAdV (n = 2) and NoV, HAstV and HAdV (n = 2). The frequency of infection with more than one virus was 17 (13.6%) in the HIV-1 negative group, triple infection (NoV + HAstV + HBoV) being observed in only one patient. The median viral load of HAstV in feces was significantly higher among HIV-1 positive children compared to HIV-1 negative children. Concerning children infected with RVA, NoV, HBoV and HAdV, no statistically significant differences were observed in the medians of viral loads in feces, comparing HIV-1 seropositive and HIV-1 seronegative children. Similar detection rates were observed for RVA, HAstV and HAdV, whilst NoV and HBoV were significantly more prevalent among children with CD4+ T lymphocyte count below 200 cells/mm3. Enteric viruses should be considered an important cause of DD in HIV-1 seropositive children, along with pathogens more classically associated with intestinal infections in immunocompromised hosts.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/epidemiologia
Infecções por Astroviridae/epidemiologia
Infecções por Caliciviridae/epidemiologia
Diarreia/epidemiologia
Gastroenterite/epidemiologia
Infecções por HIV/epidemiologia
Infecções por Parvoviridae/epidemiologia
Infecções por Rotavirus/epidemiologia
[Mh] Termos MeSH secundário: Adenoviridae/crescimento & desenvolvimento
Adenoviridae/isolamento & purificação
Infecções por Adenoviridae/imunologia
Infecções por Adenoviridae/virologia
Infecções por Astroviridae/imunologia
Infecções por Astroviridae/virologia
Brasil/epidemiologia
Contagem de Linfócito CD4
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD4-Positivos/virologia
Infecções por Caliciviridae/imunologia
Infecções por Caliciviridae/virologia
Criança
Pré-Escolar
Coinfecção
Diarreia/imunologia
Diarreia/virologia
Fezes/virologia
Feminino
Gastroenterite/imunologia
Gastroenterite/virologia
Infecções por HIV/imunologia
Infecções por HIV/virologia
HIV-1/crescimento & desenvolvimento
HIV-1/isolamento & purificação
Bocavirus Humano/crescimento & desenvolvimento
Bocavirus Humano/isolamento & purificação
Seres Humanos
Lactente
Masculino
Mamastrovirus/crescimento & desenvolvimento
Mamastrovirus/isolamento & purificação
Norovirus/crescimento & desenvolvimento
Norovirus/isolamento & purificação
Infecções por Parvoviridae/imunologia
Infecções por Parvoviridae/virologia
Prevalência
Rotavirus/crescimento & desenvolvimento
Rotavirus/isolamento & purificação
Infecções por Rotavirus/imunologia
Infecções por Rotavirus/virologia
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183196


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[PMID]:28731923
[Au] Autor:Tanir Basaranoglu S; Aykac K; Ozsurekci Y; Bajin I; Tavil B; Gumruk F; Ceyhan M
[Ad] Endereço:*Hacettepe University Faculty of Medicine, Departmemt of Pediatric Infectious Diseases †Hacettepe University Faculty of Medicine, Department of Pediatric Hematology.
[Ti] Título:Human Bocavirus: Can It Trigger Hemophagocytic Lymphohistiocytosis?
[So] Source:J Pediatr Hematol Oncol;39(8):e504-e507, 2017 Nov.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With improvements in molecular diagnostic methods, report of Human bocavirus (HBoV) as an etiologic agent in many studies on viral respiratory and gastrointestinal infections has been increasing. Two pediatric patients who presented with secondary hemophagocytic lymphohistiocytosis were examined for etiologic causes, including viruses. Whole bacterial and fungal cultures and viral serological studies were negative. Viral polymerase chain reaction of nasopharyngeal secretions showed HBoV. One was successfully treated with intravenous immunoglobulins, whereas the other died with multiorgan failure. Here we report 2 pediatric patients with secondary hemophagocytic lymphohistiocytosis and detection of HBoV as the sole agent, predicting an association.
[Mh] Termos MeSH primário: Bocavirus Humano
Linfo-Histiocitose Hemofagocítica/diagnóstico
Linfo-Histiocitose Hemofagocítica/etiologia
Infecções por Parvoviridae/complicações
[Mh] Termos MeSH secundário: Biomarcadores
Medula Óssea/patologia
Pré-Escolar
Exantema/patologia
Evolução Fatal
Feminino
Bocavirus Humano/genética
Seres Humanos
Imunoglobulinas Intravenosas/uso terapêutico
Lactente
Linfo-Histiocitose Hemofagocítica/tratamento farmacológico
Masculino
Infecções por Parvoviridae/diagnóstico
Infecções por Parvoviridae/virologia
Reação em Cadeia da Polimerase
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Immunoglobulins, Intravenous)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000877



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