Base de dados : MEDLINE
Pesquisa : C02.256.743.193 [Categoria DeCS]
Referências encontradas : 526 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 53 ir para página                         

  1 / 526 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28468200
[Au] Autor:Ata N; Gögüs HE; Kiliç S
[Ad] Endereço:*Department of Otorhinolaryngology, Gaziantep 25 Aralik State Hospital, Gaziantep †National Tularemia Reference Laboratory, Public Health Institution of Turkey, Ankara, Turkey.
[Ti] Título:Giant Orf on the Nose.
[So] Source:J Craniofac Surg;28(3):e234-e235, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orf is a zoonotic infectious disease caused by parapoxvirus. Orf lesions are typically seen on the hand, but they have rarely been reported on the nose. Herein, the authors report a rare patient of an orf lesion on the nose of a 52-year-old man after the Muslim celebration of the feast of the sacrifice. The lesion spontaneously recovered 8 weeks after the initial appearance and showed no evidence of recurrence after 1 year of follow-up. Orf virus infections may occur more often after the celebration of the feast of the sacrifice in Muslim countries.
[Mh] Termos MeSH primário: Ectima Contagioso/diagnóstico
Dermatoses Faciais/patologia
Dermatoses Faciais/virologia
Doenças Nasais/patologia
Doenças Nasais/virologia
[Mh] Termos MeSH secundário: Ectima Contagioso/etiologia
Ectima Contagioso/terapia
Dermatoses Faciais/terapia
Seres Humanos
Masculino
Meia-Idade
Doenças Nasais/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003441


  2 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28787456
[Au] Autor:Khatiwada S; Delhon G; Nagendraprabhu P; Chaulagain S; Luo S; Diel DG; Flores EF; Rock DL
[Ad] Endereço:Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
[Ti] Título:A parapoxviral virion protein inhibits NF-κB signaling early in infection.
[So] Source:PLoS Pathog;13(8):e1006561, 2017 Aug.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor κB (NF-κB) signaling pathway, which is an essential regulatory pathway of host innate immune responses. Here, we describe a NF-κB inhibitory virion protein of orf virus (ORFV), ORFV073, which functions very early in infected cells. Infection with ORFV073 gene deletion virus (OV-IA82Δ073) led to increased accumulation of NF-κB essential modulator (NEMO), marked phosphorylation of IκB kinase (IKK) subunits IKKα and IKKß, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). Expression of ORFV073 alone was sufficient to inhibit TNFα induced activation of the NF-κB signaling in uninfected cells. Consistent with observed inhibition of IKK complex activation, ORFV073 interacted with the regulatory subunit of the IKK complex NEMO. Infection of sheep with OV-IA82Δ073 led to virus attenuation, indicating that ORFV073 is a virulence determinant in the natural host. Notably, ORFV073 represents the first poxviral virion-associated NF-κB inhibitor described, highlighting the significance of viral inhibition of NF-κB signaling very early in infection.
[Mh] Termos MeSH primário: Ectima Contagioso/virologia
Evasão da Resposta Imune/fisiologia
NF-kappa B/imunologia
Vírus do Orf/patogenicidade
Vírion/imunologia
[Mh] Termos MeSH secundário: Animais
Ectima Contagioso/imunologia
Células HeLa
Seres Humanos
Imunoprecipitação
Vírus do Orf/imunologia
Vírus do Orf/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Ovinos
Transdução de Sinais/imunologia
Proteínas Virais/imunologia
Virulência/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); 0 (Viral Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006561


  3 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28378295
[Au] Autor:Simulundu E; Mtine N; Kapalamula TF; Kajihara M; Qiu Y; Ngoma J; Zulu V; Kwenda G; Chisanga C; Phiri IK; Takada A; Mweene AS
[Ad] Endereço:Department of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia. esikabala@yahoo.com.
[Ti] Título:Genetic characterization of orf virus associated with an outbreak of severe orf in goats at a farm in Lusaka, Zambia (2015).
[So] Source:Arch Virol;162(8):2363-2367, 2017 Aug.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Orf or contagious ecthyma is a neglected and economically important zoonotic disease caused by a dermatotropic parapoxvirus that commonly affects domestic small ruminants. Although orf is globally distributed, there is a paucity of information on the disease in many African countries. Here, a suspected severe outbreak of orf in goats at a farm in Lusaka was investigated. Orf virus (ORFV) infection was confirmed by PCR amplification of viral DNA (RNA polymerase, B2L and virus interferon-resistance genes) in clinical samples. Some detected genes were sequenced and phylogenetically analyzed. This is the first report on molecular characterization of ORFV in goats in Zambia.
[Mh] Termos MeSH primário: Ectima Contagioso/virologia
Doenças das Cabras/virologia
Vírus do Orf/genética
Vírus do Orf/patogenicidade
[Mh] Termos MeSH secundário: Animais
DNA Viral/genética
Ectima Contagioso/epidemiologia
Doenças das Cabras/epidemiologia
Cabras
Sequenciamento de Nucleotídeos em Larga Escala
Gado/virologia
Vírus do Orf/isolamento & purificação
Filogenia
Reação em Cadeia da Polimerase
Zoonoses/epidemiologia
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3352-y


  4 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27995337
[Au] Autor:Yogisharadhya R; Kumar A; Ramappa R; Venkatesan G; Bhanuprakash V; Shivachandra SB
[Ad] Endereço:ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, 560 064, Karnataka, India.
[Ti] Título:Functional characterization of recombinant major envelope protein (rB2L) of orf virus.
[So] Source:Arch Virol;162(4):953-962, 2017 Apr.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Orf, or contagious ecthyma, a highly contagious transboundary disease of sheep and goats, is caused by a double-stranded DNA virus (ORFV) belonging to the genus Parapoxvirus of the family Poxviridae. The ORFV genome encodes the major envelope proteins B2L and F1L, which have been found to be highly immunogenic and have multiple functional characteristics. In order to investigate the functional properties of the B2L protein, in this study, the B2L gene of ORFV strain 59/05, encoding recombinant mature B2L (aa M-D ), was produced as a fusion protein in Escherichia coli. The functional characteristics of purified rB2L fusion protein (~60 kDa) were evaluated in vivo and in vitro, showing that this protein had lipase and immunomodulatory activities. Immunization trials involving laboratory animals (mice, rabbits and guinea pigs) using either constant or graded doses of rB2L fusion protein with or without adjuvants (FCA, alum) as well as co-administration with candidate rErns-Ag protein of classical swine fever virus (CSFV) indicated that the rB2L protein is immunogenic and has immunomodulatory properties. This study shows the potential utility of the rB2L protein as a safe and novel adjuvant in veterinary vaccine formulations.
[Mh] Termos MeSH primário: Ectima Contagioso/virologia
Vírus do Orf/imunologia
Proteínas do Envelope Viral/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Ectima Contagioso/imunologia
Escherichia coli/genética
Escherichia coli/metabolismo
Feminino
Cobaias
Imunização
Lipase/administração & dosagem
Lipase/genética
Lipase/imunologia
Masculino
Camundongos
Vírus do Orf/genética
Coelhos
Proteínas Recombinantes/administração & dosagem
Proteínas Recombinantes/genética
Proteínas Recombinantes/imunologia
Recombinação Genética
Proteínas do Envelope Viral/administração & dosagem
Proteínas do Envelope Viral/genética
Vacinas Virais/administração & dosagem
Vacinas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Recombinant Proteins); 0 (Viral Envelope Proteins); 0 (Viral Vaccines); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3178-z


  5 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27938811
[Au] Autor:Adisen E; Önder M
[Ad] Endereço:Gazi University, Faculty of Medicine, Department of Dermatology, Besevler, Ankara, Turkey. Electronic address: Eozsoy@gazi.edu.tr.
[Ti] Título:Acral manifestations of viral infections.
[So] Source:Clin Dermatol;35(1):40-49, 2017 Jan - Feb.
[Is] ISSN:1879-1131
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viruses are considered intracellular obligates with a nucleic acid RNA or DNA. They have the ability to encode proteins involved in viral replication and production of the protective coat within the host cells but require host cell ribosomes and mitochondria for translation. The members of the families Herpesviridae, Poxviridae, Papovaviridae, and Picornaviridae are the most commonly known agents for cutaneous viral diseases, but other virus families, such as Adenoviridae, Togaviridae, Parvoviridae, Paramyxoviridae, Flaviviridae, and Hepadnaviridae, can also infect the skin. Herpetic whitlow should be considered under the title of special viral infections of the acral region, where surgical incision is not recommended; along with verruca plantaris with its resistance to treatment and the search for a new group of treatments, including human papillomavirus vaccines; HIV with maculopapular eruptions and palmoplantar desquamation; orf and milker's nodule with its nodular lesions; papular-purpuric gloves and socks syndrome with its typical clinical presentation; necrolytic acral erythema with its relationship with zinc; and hand, foot, and mouth disease with its characteristics of causing infection with its strains, with high risk for complication.
[Mh] Termos MeSH primário: Dermatoses do Pé/virologia
Dermatoses da Mão/virologia
Infecções por Herpesviridae/complicações
Verrugas/complicações
[Mh] Termos MeSH secundário: Animais
Ectima Contagioso/complicações
Infecções por Flaviviridae/complicações
Infecções por HIV/complicações
Doença de Mão, Pé e Boca/complicações
Seres Humanos
Molusco Contagioso/complicações
Infecções por Parvoviridae/complicações
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  6 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27628591
[Au] Autor:Inoshima Y; Takasu M; Ishiguro N
[Ad] Endereço:Laboratory of Food and Environmental Hygiene, Cooperative Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan.
[Ti] Título:Establishment of an on-site diagnostic procedure for detection of orf virus from oral lesions of Japanese serows (Capricornis crispus) by loop-mediated isothermal amplification.
[So] Source:J Vet Med Sci;78(12):1841-1845, 2017 Jan 10.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Orf virus infection has been prevalent continuously in the population of wild Japanese serows (Capricornis crispus), goat-like grazing cloven-hoofed mammal species that live mainly in mountainous areas of Japan. Currently, definitive diagnosis of infection requires time-consuming laboratory work. To diagnose rapidly on-site, we developed a field-friendly procedure for the detection of orf virus from oral cavity lesions. DNA was extracted from goat saliva spiked with orf virus as a proxy for Japanese serows by a commercial kit without the use of electricity, and the quality of the extracted DNA was evaluated by conventional polymerase chain reaction (PCR). Extracted DNA was amenable to DNA amplification, the same as when extracted in a laboratory. Next, to find optimal conditions for DNA amplification by loop-mediated isothermal amplification (LAMP), Bst and Csa DNA polymerases and 3 colorimetric indicators for visual diagnosis, hydroxy naphthol blue (HNB), malachite green and D-QUICK, were compared using a portable cordless incubator. The combination of Bst or Csa DNA polymerase with HNB was found to be easiest for visual diagnosis by the naked eye, and viral DNA was successfully amplified from all orf virus strains used. These results suggest that the procedure established here can work completely on-site and can be useful for definitive diagnosis and differentiation of orf virus infection in Japanese serows in remote mountainous areas.
[Mh] Termos MeSH primário: Ectima Contagioso/diagnóstico
Cabras/virologia
Vírus do Orf/isolamento & purificação
Ruminantes/virologia
Saliva/virologia
[Mh] Termos MeSH secundário: Animais
DNA Viral/genética
Ectima Contagioso/virologia
Japão
Técnicas de Amplificação de Ácido Nucleico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.16-0268


  7 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27770097
[Au] Autor:Angell J; Grove-White D; Williams H; Duncan J
[Ad] Endereço:University of Liverpool, Neston, Wirral CH64 7TE. e-mail: Joseph.Angell@liverpool.ac.uk.
[Ti] Título:Treatment of contagious ovine digital dermatitis.
[So] Source:Vet Rec;179(16):416, 2016 10 22.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Digital
Pododermatite Necrótica dos Ovinos
[Mh] Termos MeSH secundário: Animais
Dermatite
Ectima Contagioso
Ovinos
Doenças dos Ovinos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1136/vr.i5647


  8 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27770096
[Au] Autor:Laven R
[Ad] Endereço:Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. e-mail: R.Laven@massey.ac.nz.
[Ti] Título:Treatment of contagious ovine digital dermatitis.
[So] Source:Vet Rec;179(16):416, 2016 10 22.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Digital
Pododermatite Necrótica dos Ovinos
[Mh] Termos MeSH secundário: Animais
Dermatite
Ectima Contagioso
Ovinos
Doenças dos Ovinos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1136/vr.i5646


  9 / 526 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27663376
[Au] Autor:Tian H; Chen Y; Wu J; Lin T; Liu X
[Ad] Endereço:Key Laboratory of Animal Virology of Ministry of Agriculture/State Key Laboratory of Veterinary Etiological Biology/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China. Electronic address: tianhong@caas.cn.
[Ti] Título:Identification and function analysis of the host cell protein that interacted with Orf virus Bcl-2-like protein ORFV125.
[So] Source:Res Vet Sci;108:93-7, 2016 Oct.
[Is] ISSN:1532-2661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Orf virus (ORFV) causes contagious ecthyma, a non-systemic skin disease in sheep and goat. Bioinformatics analysis showed that ORFV125 has Bcl-2-like homologous domain and 3D structurally, it is generally known that Bcl-2 protein is known to be a key protein to control cell apoptosis. Maybe ORFV125 act as a Bcl-2-like manner to control cell apoptosis, but its exact function isn't very clear. So in this study, we use yeast two-hybrid system to identity the putative host cell protein interacting partners of ORFV125, and meanwhile using the data obtained from the Gene Ontology, Uniprot, and Kyoto Encyclopedia of Genes and Genomes databases to analysis the functions and pathways associated with them. Finally, five host proteins were shown to be interacted with ORFV125, including cytochrome b (cytb) gene, GUCY2C, BIRC5, GTF3C6 and SERBP1, we also found that BIRC5 has complex biological functions, can inhibit apoptosis, promote cell transformation and are involved in mitosis, and the interaction network of BIRC5 and ORFV125 were constructed. These findings provide a foundation to better understand the biology of the interactions between ORFV125 and the host proteins with which it directly interacts with and resultant downstream events.
[Mh] Termos MeSH primário: Ectima Contagioso/genética
Proteínas Inibidoras de Apoptose/genética
Vírus do Orf/fisiologia
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Animais
Ectima Contagioso/virologia
Interações Hospedeiro-Patógeno
Proteínas Inibidoras de Apoptose/metabolismo
Masculino
Vírus do Orf/genética
Ovinos
Testículo/metabolismo
Testículo/virologia
Técnicas do Sistema de Duplo-Híbrido/veterinária
Proteínas Virais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inhibitor of Apoptosis Proteins); 0 (Viral Proteins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  10 / 526 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27599926
[Au] Autor:Lan Y; Wang G; Song D; He W; Zhang D; Huang H; Bi J; Gao F; Zhao K
[Ad] Endereço:College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
[Ti] Título:Role of autophagy in cellular response to infection with Orf virus Jilin isolate.
[So] Source:Vet Microbiol;193:22-7, 2016 Sep 25.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Autophagy is a conserved catabolic process of the cell, which has been described to be involved in the development of various viral diseases. However, the role of autophagy in Orf virus (ORFV) replication remains unknown. In this study, we provide the first evidence that ORFV infection triggered autophagy in primary ovine fetal turbinate cells (OFTu) based on the appearance of abundant double- and single-membrane vesicles, the accumulation of LC3 fluorescent puncta, the enhancement of LC3-I/-II conversion, and autophagic flux. Moreover, modulation of ORFV-induced autophagy by rapamycin (RAPA), Earle's balanced salts solution (EBSS), chloroquine (CQ) or 3-methyladenime (3-MA) does not affect virus production. In conclusion, these results suggest that autophagy can be induced in host cells by ORFV infection, but which maybe not essential for ORFV replication.
[Mh] Termos MeSH primário: Autofagia
Ectima Contagioso/virologia
Interações Hospedeiro-Patógeno
Vírus do Orf/fisiologia
[Mh] Termos MeSH secundário: Adenina/análogos & derivados
Adenina/farmacologia
Animais
Células Cultivadas
Cloroquina/farmacologia
Ectima Contagioso/diagnóstico
Ectima Contagioso/patologia
Microscopia Eletrônica de Transmissão/veterinária
Ovinos
Sirolimo/farmacologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5142-23-4 (3-methyladenine); 886U3H6UFF (Chloroquine); JAC85A2161 (Adenine); W36ZG6FT64 (Sirolimus)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE



página 1 de 53 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde