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[PMID]:29402251
[Au] Autor:Kim JY; Lee JH; Lee CS; Lee SC
[Ad] Endereço:Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, South Korea.
[Ti] Título:Varicella zoster virus-associated Chorioretinitis: a case report.
[So] Source:BMC Ophthalmol;18(1):28, 2018 Feb 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution. CASE PRESENTATION: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead. Slit lamp biomicroscopy, funduscopy, OCT, and intraocular fluid analysis were performed. The right eye exhibited multiple inflammatory lesions at the posterior pole, macular edema, and disc swelling on the fundus examination. OCT revealed predominant involvement of the choroid and the retinal pigment epithelium (RPE). Intraocular fluid analysis showed positivity for VZV. The patient was admitted and treated with intravenous acyclovir. Additional oral prednisolone was used to reduce the inflammatory reaction. After 2 weeks of treatment with acyclovir, the lesion resolved, with undulation of the RPE. Her final visual acuity was 20/20. CONCLUSIONS: VZV-associated posterior uveitis may present as multifocal chorioretinitis. Intraocular fluid analysis is important to detect an infectious origin.
[Mh] Termos MeSH primário: Coriorretinite/virologia
Infecções Oculares Virais/virologia
Herpesvirus Humano 3/isolamento & purificação
Uveíte Posterior/virologia
Infecção pelo Vírus da Varicela-Zoster/virologia
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Administração Oral
Antivirais/uso terapêutico
Coriorretinite/diagnóstico
Coriorretinite/tratamento farmacológico
Terapia Combinada
Infecções Oculares Virais/diagnóstico
Infecções Oculares Virais/tratamento farmacológico
Feminino
Angiofluoresceinografia
Glucocorticoides/uso terapêutico
Seres Humanos
Meia-Idade
Prednisolona/uso terapêutico
Tomografia de Coerência Óptica
Uveíte Posterior/diagnóstico
Uveíte Posterior/tratamento farmacológico
Infecção pelo Vírus da Varicela-Zoster/diagnóstico
Infecção pelo Vírus da Varicela-Zoster/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Glucocorticoids); 9PHQ9Y1OLM (Prednisolone); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0696-3


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[PMID]:29206240
[Au] Autor:Treat BR; Bidula SM; Ramachandran S; St Leger AJ; Hendricks RL; Kinchington PR
[Ad] Endereço:Molecular Virology and Microbiology Graduate Program, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
[Ti] Título:Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells.
[So] Source:PLoS Pathog;13(12):e1006732, 2017 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+ T cells (gB-CD8s) recognize a single epitope on glycoprotein B (gB498-505), while the remainder (non-gB-CD8s) recognize, in varying proportions, 19 subdominant epitopes on 12 viral proteins. The gB-CD8s remain functional in TG throughout latency, while non-gB-CD8s exhibit varying degrees of functional compromise. To understand how dominance hierarchies relate to CD8+ T cell function during latency, we characterized the TG-associated CD8+ T cells following corneal infection with a recombinant HSV-1 lacking the immunodominant gB498-505 epitope (S1L). S1L induced a numerically equivalent CD8+ T cell infiltrate in the TG that was HSV-specific, but lacked specificity for gB498-505. Instead, there was a general increase of non-gB-CD8s with specific subdominant epitopes arising to codominance. In a latent S1L infection, non-gB-CD8s in the TG showed a hierarchy targeting different epitopes at latency compared to at acute times, and these cells retained an increased functionality at latency. In a latent S1L infection, these non-gB-CD8s also display an equivalent ability to block HSV reactivation in ex vivo ganglionic cultures compared to TG infected with wild type HSV-1. These data indicate that loss of the immunodominant gB498-505 epitope alters the dominance hierarchy and reduces functional compromise of CD8+ T cells specific for subdominant HSV-1 epitopes during viral latency.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/virologia
Herpes Simples/imunologia
Herpesvirus Humano 1/imunologia
Epitopos Imunodominantes/metabolismo
Gânglio Trigeminal/virologia
Proteínas do Envelope Viral/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Animais
Linfócitos T CD8-Positivos/imunologia
Linfócitos T CD8-Positivos/patologia
Linhagem Celular
Células Cultivadas
Cercopithecus aethiops
DNA Recombinante/metabolismo
Infecções Oculares Virais/imunologia
Infecções Oculares Virais/metabolismo
Infecções Oculares Virais/patologia
Infecções Oculares Virais/virologia
Feminino
Deleção de Genes
Herpes Simples/metabolismo
Herpes Simples/patologia
Herpes Simples/virologia
Herpesvirus Humano 1/fisiologia
Camundongos Endogâmicos C57BL
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/metabolismo
Mutação Puntual
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
Gânglio Trigeminal/imunologia
Gânglio Trigeminal/patologia
Células Vero
Proteínas do Envelope Viral/química
Proteínas do Envelope Viral/genética
Ativação Viral
Latência Viral
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Recombinant); 0 (Immunodominant Epitopes); 0 (Peptide Fragments); 0 (Recombinant Fusion Proteins); 0 (Viral Envelope Proteins); 0 (glycoprotein B, human herpesvirus 1)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006732


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[PMID]:28742618
[Au] Autor:Kepez Yildiz B; Urvasizoglu S; Yildirim Y; Agca A; K Besek N; Fazil K; Eris E; Aygit ED; Taskapili M; Demirok A
[Ad] Endereço:Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
[Ti] Título:Changes in Higher-Order Aberrations After Phototherapeutic Keratectomy for Subepithelial Corneal Infiltrates After Epidemic Keratoconjunctivitis.
[So] Source:Cornea;36(10):1233-1236, 2017 Oct.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate how corneal aberrations change after phototherapeutic keratectomy (PTK) for subepithelial infiltrates after adenoviral keratoconjunctivitis. METHODS: The records of patients who underwent transepithelial PTK for subepithelial infiltrates were retrospectively reviewed. Preoperative best-corrected visual acuity (VA) and the results of slit-lamp biomicroscopy examinations were recorded. The PTK procedure was performed under topical anesthesia with an Amaris excimer laser. Patients' manifest refraction values, topographical examination results, and corneal aberrations before and after surgery were analyzed. RESULTS: Twenty-four eyes of 16 women (84.3%) and 3 men (15.7%) were treated. The mean follow-up time was 6.0 ± 2.5 (range: 3-12) months, and the mean ablation depth was 82.3 ± 1.0 (range: 80-88) µm. Postoperative median best-corrected VA increased from 0.6 (range: 0.4-1.0) logarithm of the minimum angle of resolution to 0.2 (range: 0.1-0.5) logarithm of the minimum angle of resolution (P = 0.048), coma decreased from 0.56 (range: 0.29-0.37) to 0.44 (range: 0.07-0.74), secondary astigmatism decreased from 0.45 (range: 0.12-1.9) to 0.17 (range: 0.03-0.49), and total higher-order aberrations decreased from 1.24 (range: 0.61-6.74) to 0.9 (range: 0.33-1.64) (P = 0.008, 0.0032, and 0.018, respectively). CONCLUSIONS: PTK is an effective method for treating corneal opacity after epidemic keratoconjunctivitis, which yields significant improvements in both VA and visual quality.
[Mh] Termos MeSH primário: Infecções por Adenovirus Humanos/cirurgia
Aberrações de Frente de Onda da Córnea/fisiopatologia
Infecções Oculares Virais/cirurgia
Ceratoconjuntivite/cirurgia
Lasers de Excimer/uso terapêutico
Ceratectomia Fotorrefrativa
[Mh] Termos MeSH secundário: Infecções por Adenovirus Humanos/fisiopatologia
Infecções por Adenovirus Humanos/virologia
Adulto
Topografia da Córnea
Infecções Oculares Virais/fisiopatologia
Infecções Oculares Virais/virologia
Feminino
Seguimentos
Seres Humanos
Ceratoconjuntivite/fisiopatologia
Ceratoconjuntivite/virologia
Masculino
Meia-Idade
Refração Ocular/fisiologia
Estudos Retrospectivos
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001296


  4 / 1303 MEDLINE  
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[PMID]:29212473
[Au] Autor:Aaltonen V; Alavesa M; Pirilä L; Vesti E; Al-Juhaish M
[Ad] Endereço:Department of Ophthalmology, Turku University Hospital, PO Box 52, FIN-20521, Turku, Finland. vesa.aaltonen@tyks.fi.
[Ti] Título:Case report: bilateral Mooren ulcer in association with hepatitis C.
[So] Source:BMC Ophthalmol;17(1):239, 2017 Dec 06.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mooren ulcer has been considered as an idiopathic autoimmune keratitis. However, it has been in some cases suggested to be associated with hepatitis C, although the evidence is very vague. CASE PRESENTATION: We present a case of a man who was diagnosed with a primary Mooren ulcer in his right eye. The eye became blind despite of intensive treatment with local medications and extensive surgical procedures. After 10 years, the patient was diagnosed with the same disease, now in his left, previously healthy eye. There was no history that would suggest a secondary Mooren ulcer, but a chronic hepatitis C infection was detected. Treatment was targeted against hepatitis C (ribavirin and interferon) in addition to immunosuppressive medical and surgical treatment which resulted in a full and more than 6 years lasting remission of the disease. CONCLUSIONS: Whether the immunomodulatory and immunosuppressive medication against hepatitis C was the key reason for the good results in the treatment of the second eye, remains elusive. The causality of hepatitis C with respect to the pathogenesis of Mooren ulcer on this patient remains open, but should be considered as one of the possible etiological factors of the disease.
[Mh] Termos MeSH primário: Úlcera da Córnea/virologia
Infecções Oculares Virais/complicações
Hepatite C/complicações
[Mh] Termos MeSH secundário: Idoso
Antivirais/uso terapêutico
Doenças da Túnica Conjuntiva/virologia
Seres Humanos
Interferon-alfa/uso terapêutico
Masculino
Polietilenoglicóis/uso terapêutico
Proteínas Recombinantes/uso terapêutico
Ribavirina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Interferon-alpha); 0 (Recombinant Proteins); 30IQX730WE (Polyethylene Glycols); 49717AWG6K (Ribavirin); G8RGG88B68 (peginterferon alfa-2b)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0633-x


  5 / 1303 MEDLINE  
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[PMID]:28451758
[Au] Autor:Qiu J; Huang F; Wang Z; Xu J; Zhang C
[Ad] Endereço:Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
[Ti] Título:The evaluation of diagnostic efficiency for stromal herpes simplex keratitis by the combination of tear HSV-sIgA and HSV-DNA.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(7):1409-1415, 2017 Jul.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the differential diagnostic values for stromal herpes simplex keratitis (HSK) by using tear HSV-sIgA, tear HSV-DNA, and the combination. METHODS: Tear samples for both eyes and the paired serum were collected from 187 stromal HSK and 56 controls. Enzyme-linked immune sorbent assay (ELISA) was used to analyze the tear HSV-sIgA and serum IgG/IgM/IgA. The levels of tear HSV-DNA were measured by polymerase chain reaction (PCR). RESULTS: The positive rates for tear HSV-sIgA and HSV-DNA were 36.90% and 10.96% respectively in stromal HSK patients. Twelve showed positivity for both sIgA and DNA, while 46 cases were positive for sIgA or DNA. The sensitivity, specificity, PPV, and NPV for simultaneous measurement were 39.73%, 98.21%, 98.31%, and 38.46%. The total negative conversion rate of sIgA was 95.71%. CONCLUSIONS: The diagnostic efficiency of HSV-sIgA only is nearly equal to the combination of HSV-sIgA and HSV-DNA, and the positive result is optimum to achieve a reliable diagnosis of stromal HSK even in atypical or unsuspected cases.
[Mh] Termos MeSH primário: Substância Própria/patologia
DNA Viral/análise
Infecções Oculares Virais/diagnóstico
Imunoglobulina A Secretora/metabolismo
Ceratite Herpética/diagnóstico
Simplexvirus/genética
Lágrimas/virologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Substância Própria/diagnóstico por imagem
Substância Própria/virologia
Ensaio de Imunoadsorção Enzimática
Infecções Oculares Virais/metabolismo
Infecções Oculares Virais/virologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Ceratite Herpética/metabolismo
Ceratite Herpética/virologia
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Reprodutibilidade dos Testes
Estudos Retrospectivos
Lágrimas/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Immunoglobulin A, Secretory)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3653-6


  6 / 1303 MEDLINE  
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[PMID]:28880978
[Au] Autor:Aleman TS; Ventura CV; Cavalcanti MM; Serrano LW; Traband A; Nti AA; Gois AL; Bravo-Filho V; Martins TT; Nichols CW; Maia M; Belfort R
[Ad] Endereço:Scheie Eye Institute at the Perelman Center for Advanced Medicine, Perelman School of Medicine, Department of Ophthalmology, University of Pennsylvania, Philadelphia.
[Ti] Título:Quantitative Assessment of Microstructural Changes of the Retina in Infants With Congenital Zika Syndrome.
[So] Source:JAMA Ophthalmol;135(10):1069-1076, 2017 Oct 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: A better pathophysiologic understanding of the neurodevelopmental abnormalities observed in neonates exposed in utero to Zika virus (ZIKV) is needed to develop treatments. The retina as an extension of the diencephalon accessible to in vivo microcopy with spectral-domain optical coherence tomography (SD-OCT) can provide an insight into the pathophysiology of congenital Zika syndrome (CZS). Objective: To quantify the microstructural changes of the retina in CZS and compare these changes with those of cobalamin C (cblC) deficiency, a disease with potential retinal maldevelopment. Design, Setting, and Participants: This case series included 8 infants with CZS and 8 individuals with cblC deficiency. All patients underwent ophthalmologic evaluation at 2 university teaching hospitals and SD-OCT imaging in at least 1 eye. Patients with cblC deficiency were homozygous or compound heterozygotes for mutations in the methylmalonic aciduria and homocystinuria type C (MMACHC) gene. Data were collected from January 1 to March 17, 2016, for patients with CZS and from May 4, 2015, to April 23, 2016, for patients with cblC deficiency. Main Outcomes and Measures: The SD-OCT cross-sections were segmented using automatic segmentation algorithms embedded in the SD-OCT systems. Each retinal layer thickness was measured at critical eccentricities using the position of the signal peaks and troughs on longitudinal reflectivity profiles. Results: Eight infants with CZS (5 girls and 3 boys; age range, 3-5 months) and 8 patients with cblC deficiency (3 girls and 5 boys; age range, 4 months to 15 years) were included in the analysis. All 8 patients with CZS had foveal abnormalities in the analyzed eyes (8 eyes), including discontinuities of the ellipsoid zone, thinning of the central retina with increased backscatter, and severe structural disorganization, with 3 eyes showing macular pseudocolobomas. Pericentral retina with normal lamination showed a thinned (<30% of normal thickness) ganglion cell layer (GCL) that colocalized in 7 of 8 eyes with a normal photoreceptor layer. The inner nuclear layer was normal or had borderline thinning. The central retinal degeneration was similar to that of cblC deficiency. Conclusions and Relevance: Congenital Zika syndrome showed a central retinal degeneration with severe GCL loss, borderline inner nuclear layer thinning, and less prominent photoreceptor loss. The findings provide the first, to date, in vivo evidence in humans for possible retinal maldevelopment with a predilection for retinal GCL loss in CZS, consistent with a murine model of the disease and suggestive of in utero depletion of this neuronal population as a consequence of Zika virus infection.
[Mh] Termos MeSH primário: Infecções Oculares Virais/diagnóstico
Complicações Infecciosas na Gravidez
Degeneração Retiniana/diagnóstico
Células Ganglionares da Retina/patologia
Infecção pelo Zika virus/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Anticorpos Antivirais/sangue
Criança
Pré-Escolar
Infecções Oculares Virais/congênito
Infecções Oculares Virais/virologia
Feminino
Seres Humanos
Lactente
Masculino
Células Fotorreceptoras de Vertebrados/patologia
Gravidez
Degeneração Retiniana/congênito
Degeneração Retiniana/virologia
Células Ganglionares da Retina/virologia
Estudos Retrospectivos
Tomografia de Coerência Óptica
Acuidade Visual
Deficiência de Vitamina B 12/diagnóstico
Zika virus/imunologia
Infecção pelo Zika virus/congênito
Infecção pelo Zika virus/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.3292


  7 / 1303 MEDLINE  
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[PMID]:28872492
[Au] Autor:Shantha JG; Crozier I; Yeh S
[Ad] Endereço:aDepartment of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, USA bWorld Health Organization, Geneva, Switzerland cEmory Global Health Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
[Ti] Título:An update on ocular complications of Ebola virus disease.
[So] Source:Curr Opin Ophthalmol;28(6):600-606, 2017 Nov.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: This review provides a summary of our current understanding of the ophthalmic manifestations of Ebola virus disease (EVD), pathogenesis, treatment options and directions for future study. The individual, public health and global health implications of eye disease in EVD survivors are discussed. RECENT FINDINGS: The West Africa EVD outbreak was of unprecedented magnitude, leading to the largest survivor cohort since the first documented EVD outbreak in 1976. Because of the magnitude of the recent outbreak, thousands of survivors are at-risk of systemic and ophthalmic sequelae termed the 'post Ebola virus disease syndrome'. Uveitis is the most common finding during EVD convalescence and may lead to severe vision impairment or blindness in 40% of affected individuals. Ocular complications leading to vision loss include cataract, retinal scarring, optic neuropathy, hypotony and phthisis bulbi. The pathogenesis of eye disease in EVD survivors likely involves Ebola virus persistence, severe inflammation and tissue edema, which present as acute, rapidly progressive disease or chronic, smoldering disease. Further studies into disease pathogenesis including mechanisms of viral persistence may provide guidance into therapies for uveitis secondary to EVD. SUMMARY: Uveitis is the most common ophthalmic finding in EVD survivors and can lead to vision loss. Further studies into the clinical manifestations and mechanisms of disease are needed to improve therapies for EVD survivors who often have limited access to ophthalmic medical and surgical care.
[Mh] Termos MeSH primário: Ebolavirus
Infecções Oculares Virais/virologia
Doença pelo Vírus Ebola/complicações
Uveíte/virologia
[Mh] Termos MeSH secundário: Infecções Oculares Virais/diagnóstico
Doença pelo Vírus Ebola/diagnóstico
Seres Humanos
Uveíte/diagnóstico
Transtornos da Visão/diagnóstico
Transtornos da Visão/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000426


  8 / 1303 MEDLINE  
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[PMID]:28810265
[Au] Autor:Zhao Z; Yang M; Azar SR; Soong L; Weaver SC; Sun J; Chen Y; Rossi SL; Cai J
[Ad] Endereço:Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
[Ti] Título:Viral Retinopathy in Experimental Models of Zika Infection.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4355­4365, 2017 08 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Emerging evidence has shown that both congenital and adult Zika virus (ZIKV) infection can cause eye diseases. The goals of the current study were to explore mechanisms and pathophysiology of ZIKV-induced eye defects. Methods: Wild-type or A129 interferon type I receptor-deficient mice were infected by either FSS13025 or Mex1-7 strain of ZIKV. Retinal histopathology was measured at different time points after infection. The presence of viral RNA and protein in the retina was determined by in situ hybridization and immunofluorescence staining, respectively. Growth curves of ZIKV in permissive retinal cells were assessed in cultured retinal pigment epithelial (RPE) and Müller glial cells. Results: ZIKV-infected mice developed a spectrum of ocular pathologies that affected multiple layers of the retina. A primary target of ZIKV in the eye was Müller glial cells, which displayed decreased neurotrophic function and increased expression of proinflammatory cytokines after infection. ZIKV also infected RPE; and both the RPE and Müller cells expressed viral entry receptors TYRO3 and AXL. Retinitis, focal retinal degeneration, and ganglion cell loss were observed after the clearance of viral particles. Conclusions: Our data suggest that ZIKV can infect infant eyes with immature blood-retinal barrier and cause structural damages to the retina. The ocular findings in microcephalic infants may not be solely caused by ZIKV-induced impairment of neurodevelopment.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Células Ependimogliais/virologia
Infecções Oculares Virais/virologia
Doenças Retinianas/virologia
Epitélio Pigmentado da Retina/virologia
Infecção pelo Zika virus/virologia
[Mh] Termos MeSH secundário: Animais
Barreira Hematorretiniana
Células Cultivadas
Células Ependimogliais/patologia
Infecções Oculares Virais/patologia
Citometria de Fluxo
Hibridização in Situ Fluorescente
Camundongos
Camundongos Endogâmicos C57BL
RNA Viral/genética
Reação em Cadeia da Polimerase em Tempo Real
Doenças Retinianas/patologia
Epitélio Pigmentado da Retina/patologia
Uveíte Posterior/patologia
Uveíte Posterior/virologia
Proteínas não Estruturais Virais/metabolismo
Replicação Viral/fisiologia
Zika virus/fisiologia
Infecção pelo Zika virus/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NS1 protein, zika virus); 0 (RNA, Viral); 0 (Viral Nonstructural Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22016


  9 / 1303 MEDLINE  
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[PMID]:28810044
[Au] Autor:Khairallah M; Kahloun R; Gargouri S; Jelliti B; Sellami D; Ben Yahia S; Feki J
[Ti] Título:Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;48(8):672-675, 2017 Aug 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 65-year-old man with diabetes and a history of fever of unknown origin 2 weeks earlier complained of sudden decreased vision in the left eye. The patient was diagnosed with bilateral West Nile virus (WNV) chorioretinitis associated with occlusive retinal vasculitis in the left eye. Swept-source optical coherence tomography angiography (SS-OCTA) of the left eye showed extensive, well-delineated, hypointense non-perfusion areas and perifoveal capillary arcade disruption in the superficial capillary plexus, as well as larger non-perfusion areas, capillary rarefaction, and diffuse capillary network attenuation and disorganization in the deep capillary plexus. OCTA may be a valuable tool for noninvasively assessing occlusive retinal vasculitis associated with WNV infection. It allows an accurate detection and precise delineation of areas of retinal capillary nonperfusion in both the superficial and deep capillary plexuses. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:672-675.].
[Mh] Termos MeSH primário: Coriorretinite/diagnóstico
Corioide/patologia
Infecções Oculares Virais/diagnóstico
Angiofluoresceinografia/métodos
Retina/patologia
Tomografia de Coerência Óptica/métodos
Febre do Nilo Ocidental/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Anticorpos Antivirais/imunologia
Coriorretinite/virologia
Diagnóstico Diferencial
Infecções Oculares Virais/virologia
Fundo de Olho
Seres Humanos
Masculino
Febre do Nilo Ocidental/virologia
Vírus do Nilo Ocidental/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20170802-11


  10 / 1303 MEDLINE  
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[PMID]:28795959
[Au] Autor:de Paula Freitas B; Ventura CV; Maia M; Belfort R
[Ad] Endereço:aVision Institute, Department of Ophthalmology, Paulista Medical School, Federal University of São Paulo, São Paulo bDepartment of Ophthalmology, Hospital Geral Roberto Santos, Salvador cDepartment of Ophthalmology, Altino Ventura Foundation dDepartment of Ophthalmology, HOPE Eye Hospital, Recife, Pernambuco, Brazil.
[Ti] Título:Zika virus and the eye.
[So] Source:Curr Opin Ophthalmol;28(6):595-599, 2017 Nov.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The aim of this study was to review the ocular findings related to the Zika virus (ZIKV) based on the main studies published to date, describe the patterns of the lesions and risk factors, and identify the public health implications and scientific importance of this emerging disease. RECENT FINDINGS: In most studies, the ZIKV seems related to congenital ocular lesions and most mothers reported mild symptoms during the first pregnancy trimester. Five fundus patterns were seen most often: macular chorioretinal atrophy, chorioretinal atrophy elsewhere, focal pigmentary changes in the macular region, optic nerve abnormalities and combined types. A few studies have suggested that the ZIKV might damage the anterior segment of these babies' eyes. Few reports have described the ocular complications seen in adults during the acute infection, including conjunctivitis, iridocyclitis and chorioretinitis. SUMMARY: Infants with congenital Zika syndrome might have vision-threatening fundus abnormalities. Although the full spectrum of ocular lesions caused by the ZIKV infection is not yet determined, a distinctive new disease has been observed. Recognition of these lesions by ophthalmologists can help ensure appropriate etiologic evaluation and clinical investigation to define the range of anomalies in an affected infant and determine essential follow-up and ongoing care.
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes
Infecções Oculares Virais/diagnóstico
Complicações Infecciosas na Gravidez/diagnóstico
Infecção pelo Zika virus/diagnóstico
Zika virus
[Mh] Termos MeSH secundário: Coriorretinite/diagnóstico
Coriorretinite/virologia
Infecções Oculares Virais/virologia
Feminino
Seres Humanos
Doenças do Nervo Óptico/diagnóstico
Doenças do Nervo Óptico/virologia
Gravidez
Complicações Infecciosas na Gravidez/virologia
Infecção pelo Zika virus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000420



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