Base de dados : MEDLINE
Pesquisa : C02.407 [Categoria DeCS]
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[PMID]:29022866
[Au] Autor:Purdy MA; Harrison TJ; Jameel S; Meng XJ; Okamoto H; Van der Poel WHM; Smith DB; Ictv Report Consortium
[Ad] Endereço:1​Division of Viral Hepatitis, Centers for Disease Control and Prevention, MS-A33, 1600 Clifton Rd NE, Atlanta, GA 30329, USA.
[Ti] Título:ICTV Virus Taxonomy Profile: Hepeviridae.
[So] Source:J Gen Virol;98(11):2645-2646, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and birds. Members of the genus Orthohepevirus include hepatitis E virus, which is responsible for self-limiting acute hepatitis in humans and several mammalian species; the infection may become chronic in immunocompromised individuals. Extrahepatic manifestations of Guillain-Barré syndrome, neuralgic amyotrophy, glomerulonephritis and pancreatitis have been described in humans. Avian hepatitis E virus causes hepatitis-splenomegaly syndrome in chickens. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Hepeviridae, which is available at www.ictv.global/report/hepeviridae.
[Mh] Termos MeSH primário: Hepatite Viral Animal/virologia
Hepatite Viral Humana/virologia
Hepevirus/classificação
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000940


  2 / 1484 MEDLINE  
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[PMID]:28982029
[Au] Autor:Ahn HS; Han SH; Kim YH; Park BJ; Kim DH; Lee JB; Park SY; Song CS; Lee SW; Choi C; Myoung J; Choi IS
[Ad] Endereço:Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
[Ti] Título:Adverse fetal outcomes in pregnant rabbits experimentally infected with rabbit hepatitis E virus.
[So] Source:Virology;512:187-193, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatitis E virus (HEV) causes severe hepatitis in pregnant women, with associated poor fetal outcomes. To study HEV viral pathogenesis, pregnant rabbits were infected with low- and high-dose rabbit HEV at 2 weeks gestation. HEV was identified in the serum, feces, and liver tissue of infected rabbits, and dose-dependent fetal mortality rates ranging from 67% to 80% were observed. The aspartate transaminase (AST)/alanine transaminase ratio was significantly higher (P < 0.01) in high-dose infected rabbits than low-dose infected and negative control rabbits 14 days post infection (dpi). Tumor necrosis factor-α (TNF-α) was significantly higher in low-dose (P < 0.01) and high-dose infected rabbits (P < 0.001) than in negative controls 7 dpi. High-dose HEV-infected rabbits produced significantly more interferon-γ (IFN-γ; P < 0.05) than negative control rabbits at 7 and 14 dpi. High levels of AST, TNF-α, and IFN-γ may substantially influence adverse fetal outcomes in pregnant rabbits infected with high-dose HEV.
[Mh] Termos MeSH primário: Vírus da Hepatite E/classificação
Hepatite E/virologia
Hepatite Viral Animal/patologia
Complicações Infecciosas na Gravidez/virologia
Coelhos/anormalidades
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Citocinas/genética
Citocinas/metabolismo
Feminino
Regulação da Expressão Gênica/imunologia
Hepatite E/patologia
Vírus da Hepatite E/patogenicidade
Gravidez
Complicações Infecciosas na Gravidez/patologia
Organismos Livres de Patógenos Específicos
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Cytokines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE


  3 / 1484 MEDLINE  
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[PMID]:28915405
[Au] Autor:Manickam C; Martinot AJ; Jones RA; Varner V; Reeves RK
[Ad] Endereço:Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
[Ti] Título:Hepatic immunopathology during occult hepacivirus re-infection.
[So] Source:Virology;512:48-55, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite drug advances for Hepatitis C virus (HCV), re-infections remain prevalent in high-risk populations. Unfortunately, the role of preexisting viral immunity and how it modulates re-infection is unclear. GBV-B infection of common marmosets is a useful model to study tissue immune responses in hepacivirus infections, and in this study we re-challenged 4 animals after clearance of primary viremia. Although only low-to-absent viremia was observed following re-challenge, GBV-B viral RNA was detectable in liver, confirming re-infection. Microscopic hepatic lesions indicated severe-to-mild lymphocyte infiltration and fibrosis in 3 out of 4 animals. Further, GBV-B-specific T cells were elevated in animals with moderate-to-severe hepatopathology, and up to 3-fold increases in myeloid dendritic and activated natural killer cells were observed after infection. Our data indicate that occult hepacivirus re-infections occur and that new liver pathology is possible even in the presence of anti-hepacivirus T cells and in the absence of high viremia.
[Mh] Termos MeSH primário: Infecções por Flaviviridae/imunologia
Vírus GB B/fisiologia
Hepatite Viral Animal/imunologia
[Mh] Termos MeSH secundário: Animais
Callithrix
Infecções por Flaviviridae/patologia
Hepatite Viral Animal/patologia
Imunidade Inata/fisiologia
Fígado/patologia
Fígado/virologia
Linfócitos T/fisiologia
Carga Viral
Viremia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


  4 / 1484 MEDLINE  
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[PMID]:28665737
[Au] Autor:Morshed R; Hosseini H; Langeroudi AG; Fard MHB; Charkhkar S
[Ad] Endereço:A Agriculture and Veterinary Group, Iran Encyclopedia Compiling Foundation, Ministry of Science, Research and Technology, Tehran, Iran, Mail Box: 14655478.
[Ti] Título:Fowl Adenoviruses D and E Cause Inclusion Body Hepatitis Outbreaks in Broiler and Broiler Breeder Pullet Flocks.
[So] Source:Avian Dis;61(2):205-210, 2017 Jun.
[Is] ISSN:1938-4351
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Twenty-four fowl adenoviruses (FAdVs) were isolated from broiler and broiler breeder pullet flocks in Iran during 2013-2016 and were identified and characterized. All FAdVs were from inclusion body hepatitis (IBH) cases, showing an enlarged and pale yellow liver with multiple petechial hemorrhages. Phylogenetic analyses of partial hexon gene sequences are an adequate and quick method for differentiation and genotyping. The isolates were subjected to PCR to amplify a 590-bp fragment from the hexon gene. Sequence analysis revealed the presence of two species D and E. Eighty FAdV isolates were genetically related to the strain EU979378 of FAdV-11 (96.5% to 97.6% identity), and six isolates were related to the strain EU979375 of FAdV-8b (97% identity). The results indicated that two FAdV serotypes (11 and 8b) are high prevalence serotypes of FAdVs in Iran and are pathogenic enough to cause IBH in young chicks. Therefore, preventive measures against FAdV infection on poultry farms should be implemented.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Aviadenovirus/isolamento & purificação
Hepatite Viral Animal/virologia
Corpos de Inclusão/virologia
Doenças das Aves Domésticas/virologia
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/epidemiologia
Infecções por Adenoviridae/virologia
Animais
Aviadenovirus/classificação
Aviadenovirus/genética
Galinhas
Surtos de Doenças
Feminino
Hepatite Viral Animal/epidemiologia
Irã (Geográfico)/epidemiologia
Masculino
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1637/11551-120516-Reg.1


  5 / 1484 MEDLINE  
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[PMID]:28638862
[Au] Autor:Song M; Chen Y; Du H; Zhang S; Wang Y; Zeng L; Yang J; Shi J; Wu Y; Wang D; Hu Y; Liu J
[Ad] Endereço:Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P R China.
[Ti] Título:RAW REHMANNIA RADIX POLYSACCHARIDE CAN EFFECTIVELY RELEASE PEROXIDATIVE INJURY INDUCED BY DUCK HEPATITIS A VIRUS.
[So] Source:Afr J Tradit Complement Altern Med;14(4):8-21, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Duck viral hepatitis (DVH), caused by duck hepatitis A virus (DHAV), is a fatal contagious infectious disease which spreads rapidly with high morbidity and high mortality, and there is no effective clinical drug against DVH. MATERIALS AND METHODS: Raw Rehmannia Radix Polysaccharide (RRRP), Lycii Fructus polysaccharides and Astragalus Radix polysaccharides were experimented in vitro and in vivo. Mortality rate, livers change, liver lesion scoring, peroxidative injury evaluation indexes in vitro and in vivo, and hepatic injury evaluation indexes of optimal one were detected and observed in this experiment. RESULTS: RRRP could reduce mortality with the protection rate about 20.0% compared with that of the viral control (VC) group, finding that RRRP was the most effective against DHAV. The average liver scoring of the VC, blank control (BC), RRRP groups were 3.5, 0, 2.1. Significant difference ( <0.05) appeared between any two groups, demonstrating that it can alleviate liver pathological change. RRRP could make the hepatic injury evaluation indexes similar to BC group while the levels of the VC group were higher than other two groups in general. The levels of SOD, GSH-Px, CAT of RRRP group showed significant higher than that of VC group while the levels of NOS and MDA showed the opposite tendency, thus, RRRP could release peroxidative injury. CONCLUSION: RRRP was the most effective against duck hepatitis A virus (DHAV). RRRP could reduce mortality, alleviate liver pathological change, down-regulate liver lesion score, release peroxidative injury and hepatic injury. The antiviral and peroxidative injury releasing activity of RRRP for DHAV provided a platform to test novel drug strategies for hepatitis A virus in human beings.
[Mh] Termos MeSH primário: Antivirais/administração & dosagem
Vírus da Hepatite do Pato/efeitos dos fármacos
Hepatite Viral Animal/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Polissacarídeos/administração & dosagem
Doenças das Aves Domésticas/tratamento farmacológico
Rehmannia/química
[Mh] Termos MeSH secundário: Animais
Astrágalo (Planta)/química
Patos
Vírus da Hepatite do Pato/fisiologia
Hepatite Viral Animal/diagnóstico por imagem
Hepatite Viral Animal/metabolismo
Hepatite Viral Animal/virologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/virologia
Raízes de Plantas/química
Doenças das Aves Domésticas/metabolismo
Doenças das Aves Domésticas/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); 0 (Polysaccharides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.2


  6 / 1484 MEDLINE  
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[PMID]:28614378
[Au] Autor:Ou X; Mao S; Cao J; Cheng A; Wang M; Zhu D; Chen S; Jia R; Liu M; Sun K; Yang Q; Wu Y; Chen X
[Ad] Endereço:Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu City, Sichuan, People's Republic of China.
[Ti] Título:Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1.
[So] Source:PLoS One;12(6):e0178993, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Because of their better immunogenicity and the improved protection they afford, live attenuated vaccines derived from serial passaging in an abnormal host are widely used to protect humans or animals from certain pathogens. Here, we used a virulent and a chicken embryo-attenuated duck hepatitis A virus genotype 1 to compare the different regulated immune responses induced by viruses with differing virulence. In this study, the attenuated strains had lower protein expression levels than the virulent strains as identified by immunohistochemistry. This may be caused by apparent codon usage bias selected during passage. Furthermore, lower translation efficiency led to decreased viral replication, which is highly dependent on non-structural viral protein expression. Although the two strains had differing levels of virulence, both could induce strong innate immune responses and robust Tc or Th cell populations during the early stages of the immune response. However, due to fixed single nucleotide polymorphisms (SNPs) selected by passage, the virulent and attenuated strains may induce differing immune responses, with stronger Tc cell immunity induced by the attenuated strain in the spleen and thymus and stronger Tc cell immunity induced by the virulent strain in the liver, lung, bursa of Fabricius and Harderian gland. Four immune related genes (RIG-1, MDA5, IFN-ß, and IL-6) were highly differentially expressed in the Harderian gland, bursa of Fabricius and thymus. This study has provided further information about differences in virus-host interactions between duck hepatitis A viruses of differing virulence.
[Mh] Termos MeSH primário: Vírus da Hepatite do Pato/imunologia
Hepatite Viral Animal/imunologia
Infecções por Picornaviridae/imunologia
Doenças das Aves Domésticas/virologia
Vacinas Atenuadas/imunologia
[Mh] Termos MeSH secundário: Animais
Embrião de Galinha
Patos
Genótipo
Vírus da Hepatite do Pato/genética
Vírus da Hepatite do Pato/fisiologia
Interações Hospedeiro-Patógeno
Imunidade Inata
Doenças das Aves Domésticas/imunologia
Vacinas Atenuadas/genética
Replicação Viral
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines, Attenuated)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178993


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[PMID]:28494352
[Au] Autor:Yu H; Liu Y; Huang J; Wang H; Yan W; Xi D; Shen G; Luo X; Ning Q
[Ad] Endereço:Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:IL-33 protects murine viral fulminant hepatitis by targeting coagulation hallmark protein FGL2/fibroleukin expression.
[So] Source:Mol Immunol;87:171-179, 2017 Jul.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fulminant hepatitis (FH) is characterized by rapid liver failure and high mortality. The pathogenesis of viral FH includes virus-induced immune activation, inflammation, and subsequent hepatic apoptosis and necrosis. However, the mechanisms that underlie FH progression are unclear. IL-33 is a member of the IL-1-related cytokines, considered to be an "alarmin" that participates in various diseases, but its precise role in the coagulation of FH is not very clear. In our study, we found that IL-33 is significantly elevated in mice infected with murine hepatitis virus strain 3 (MHV-3). This is accompanied by an increase in pro-coagulant fibrinogen-like protein 2 (FGL2) in the liver. Previous studies have suggested that an increase in FGL2 is diagnostic of FH and liver necrosis, and animals with no FGL2 had better survivorship during FH. Our studies showed that IL-33 administration in a MHV-3 infection promoted survival during FH, with a significant reduction in FGL2 expression and liver inflammation. In vitro IL-33 treatment abrogated MHV-3 and IFN-γ induced FGL2 expression in RAW264.7 and THP-1 cells, respectively. In conclusion, our research suggests that IL-33 protects against viral fulminant hepatitis in mice by antagonizing expression of the pro-coagulant protein FGL2.
[Mh] Termos MeSH primário: Coagulação Sanguínea/fisiologia
Fibrinogênio/metabolismo
Hepatite Viral Animal/metabolismo
Interleucina-33/metabolismo
Vírus da Hepatite Murina/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose/fisiologia
Feminino
Inflamação/metabolismo
Inflamação/virologia
Interferon gama/metabolismo
Interleucina-1/metabolismo
Fígado/metabolismo
Fígado/virologia
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fgl2 protein, mouse); 0 (Il33 protein, mouse); 0 (Interleukin-1); 0 (Interleukin-33); 82115-62-6 (Interferon-gamma); 9001-32-5 (Fibrinogen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


  8 / 1484 MEDLINE  
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[PMID]:28413174
[Au] Autor:Kamomae M; Kameyama M; Ishii J; Nabe M; Ogura Y; Iseki H; Yamamoto Y; Mase M
[Ad] Endereço:Himeji Livestock Hygiene Service Center, 595-15 Nakamura, Koderacho, Himeji, Hyogo 679-2166, Japan.
[Ti] Título:An outbreak of duck hepatitis A virus type 1 infection in Japan.
[So] Source:J Vet Med Sci;79(5):917-920, 2017 May 23.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In June 2015, a highly fatal and acute disease broke out in a duckling farm in Hyogo Prefecture, Japan. The birds exhibited poor growth, reduced movement, lying in a dorsal recumbent position, depression, lethargy, ataxia and opisthotonus, with a high mortality rate of approximately 76%. By performing a reverse transcription-polymerase chain reaction (RT-PCR) using primers specific for duck hepatitis A virus type 1 (DHAV-1), we obtained the PCR products of a predicted size. The nucleotide sequences of the PCR products showed a >96% identity with that of the DHAV-1, HB02 strain, which was isolated in China. To our knowledge, this is the first time that the DHAV-1 virus has been isolated since its outbreak in Japan in 1963.
[Mh] Termos MeSH primário: Surtos de Doenças/veterinária
Vírus da Hepatite A
Hepatite A/veterinária
Hepatite Viral Animal/epidemiologia
Doenças das Aves Domésticas/epidemiologia
[Mh] Termos MeSH secundário: Animais
Patos/virologia
Hepatite A/epidemiologia
Hepatite A/virologia
Vírus da Hepatite A/genética
Hepatite Viral Animal/patologia
Hepatite Viral Animal/virologia
Japão/epidemiologia
Fígado/patologia
Filogenia
Doenças das Aves Domésticas/patologia
Doenças das Aves Domésticas/virologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.16-0646


  9 / 1484 MEDLINE  
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[PMID]:28394931
[Au] Autor:Du H; Yang J; Bai J; Ming K; Shi J; Yao F; Zhang W; Yu Y; Chen Y; Xiong W; Wu Y; Wang D; Hu Y; Liu J
[Ad] Endereço:Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P R China.
[Ti] Título:A flavone-polysaccharide based prescription attenuates the mitochondrial dysfunction induced by duck hepatitis A virus type 1.
[So] Source:PLoS One;12(4):e0175495, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The principal target organ of duck hepatitis A virus type 1 (DHAV-1) is duckling liver, which is an energy-intensive organ and plays important roles in body's energy metabolism and conversion. As the "power house" of the hepatocytes, mitochondria provide more than 90% of the energy. However, mitochondria are much vulnerable to the oxidative stress for their rich in polyunsaturated fatty acids. Although previous researches have demonstrated that DHAV-1 could induce the oxidative stress in the serum of the infected ducklings, no related study on the mitochondria during the pathological process of DVH has been reported by far. To address this issue, we examined the HE stained tissue pathological slices, detected the hepatic SOD, CAT and GPX activities and MDA contents and analyzed the ATP content, mitochondrial ultrastructure and the mitochondrial SOD, GPX activities and MDA content in the liver tissues. The results showed that the hepatic redox status was significantly disturbed so that causing the mitochondrial dysfunction, ATP depletion and mitochondrial oxidative stress during the process of the DHAV-1 infection, and a prescription formulated with Hypericum japonicum flavone, Radix Rehmanniae Recens polysaccharide and Salvia plebeia flavone (HRS), which had been demonstrated with good anti-oxidative activity in serum, could effectively alleviate the hepatic injury and the oxidative stress in liver tissue induced by DHAV-1 thus alleviating the mitochondrial injury and oxidative stress. In a word, this research discovers the oxidative stress induced mitochondrial dysfunction and oxidative stress during the DVH pathological process and demonstrates HRS exerts good anti-oxidative activity in liver tissue to protect mitochondria against reactive oxygen species (ROS).
[Mh] Termos MeSH primário: Antivirais/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Vírus da Hepatite do Pato
Hepatite Viral Animal/tratamento farmacológico
Mitocôndrias/efeitos dos fármacos
Infecções por Picornaviridae/tratamento farmacológico
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/metabolismo
Animais
Patos
Flavonas/farmacologia
Glutationa Peroxidase/metabolismo
Hepatite Viral Animal/metabolismo
Hepatite Viral Animal/mortalidade
Hepatite Viral Animal/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Peroxidação de Lipídeos/fisiologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Malondialdeído/metabolismo
Mitocôndrias/metabolismo
Mitocôndrias/ultraestrutura
Estresse Oxidativo/efeitos dos fármacos
Infecções por Picornaviridae/metabolismo
Infecções por Picornaviridae/mortalidade
Infecções por Picornaviridae/patologia
Polissacarídeos/farmacologia
Distribuição Aleatória
Superóxido Dismutase/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Drugs, Chinese Herbal); 0 (Flavones); 0 (Polysaccharides); 4Y8F71G49Q (Malondialdehyde); 8L70Q75FXE (Adenosine Triphosphate); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175495


  10 / 1484 MEDLINE  
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[PMID]:28363907
[Au] Autor:Jie Z; Liang Y; Yi P; Tang H; Soong L; Cong Y; Zhang K; Sun J
[Ad] Endereço:Department of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-1070.
[Ti] Título:Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
[So] Source:J Immunol;198(9):3448-3460, 2017 May 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although large amounts of vitamin A and its metabolite all- retinoic acid (RA) are stored in the liver, how RA regulates liver immune responses during viral infection remains unclear. In this study, we demonstrated that IL-22, mainly produced by hepatic γδ T cells, attenuated liver injury in adenovirus-infected mice. RA can promote γδ T cells to produce mTORC1-dependent IL-22 in the liver, but inhibits IFN-γ and IL-17. RA also affected the aptitude of T cell responses by modulating dendritic cell (DC) migration and costimulatory molecule expression. These results suggested that RA plays an immunomodulatory role in viral infection. Proteomics data revealed that RA downregulated S100 family protein expression in DCs, as well as NF-κB/ERK pathway activation in these cells. Furthermore, adoptive transfer of S100A4-repressed, virus-pulsed DCs into the hind foot of naive mice failed to prime T cell responses in draining lymph nodes. Our study has demonstrated a crucial role for RA in promoting IL-22 production and tempering DC function through downregulating S100 family proteins during viral hepatitis.
[Mh] Termos MeSH primário: Adenoviridae/imunologia
Células Dendríticas/efeitos dos fármacos
Hepatite Viral Animal/tratamento farmacológico
Fatores Imunológicos/uso terapêutico
Interleucinas/metabolismo
Fígado/imunologia
Proteína A4 de Ligação a Cálcio da Família S100/metabolismo
Tretinoína/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Células Dendríticas/imunologia
Células Dendríticas/virologia
Feminino
Imunidade Celular/efeitos dos fármacos
Imunidade Celular/genética
Interleucinas/genética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
NF-kappa B/metabolismo
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
Linfócitos T/imunologia
Linfócitos T/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunologic Factors); 0 (Interleukins); 0 (NF-kappa B); 0 (S100 Calcium-Binding Protein A4); 0 (S100a4 protein, mouse); 0 (interleukin-22); 5688UTC01R (Tretinoin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601891



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